Acute and Sub-chronic Oral Toxicity Study of Ammonium Persulfate in Spraque-Dawley Rats

Yong Soon Kim,Min Won Baek,Jae Hyuck Sung,Hyun Youl Ryu,Jin Sik Kim,Hyun Sun Cho,Byung Gil Choi,Min Sub Song,Moon Yong Song,Eun Ju Baik,Young Kuk Choi,Jong Kyu Kim,Il Je Yu,Kyung Seuk Song 한국독성학회 2009 Toxicological Research Vol.25 No.3

The toxicity test of ammonium persulfate was conducted to ensure of its potential toxic effects according to the single-dose acute oral toxicity study (OECD Guideline 423) and 90-day repeated dose sub-chronic oral toxicity study guideline (OECD Guideline 408) for establishing national chemical management system, and matching in the Globally Harmonized Classification System (GHS) category. In acute oral toxicity study, pasty stool, perineal contamination and temporary body weight decrease were observed after dosing 1st and 2nd challenge (300 ㎎/㎏ body weight). All test animals were dead within 6 hours after dosing at 3rd challenge (2000 ㎎/㎏ body weight). Therefore, the GHS class of test substance is considered class 4. In sub-chronic toxicity study, body weight changes, food consumptions, hematological, biochemical and pathological examination did not show any noticeable and significant differences between the administered (5, 20, 80 ㎎/㎏ body weight) and control (vehicle only) group animals. Based on these results, the no observed adverse effect level (NOAEL) is considered above 80 mg/kg body weight.

Acute and Sub-chronic Oral Toxicity Study of Ammonium Persulfate in Spraque-Dawley Rats

Kim, Yong-Soon,Baek, Min-Won,Sung, Jae-Hyuck,Ryu, Hyun-Youl,Kim, Jin-Sik,Cho, Hyun-Sun,Choi, Byung-Gil,Song, Min-Sub,Song, Moon-Yong,Baik, Eun-Ju,Choi, Young-Kuk,Kim, Jong-Kyu,Yu, Il-Je,Song, Kyung-Se Korean Society of ToxicologyKorea Environmental Mu 2009 Toxicological Research Vol.26 No.3

The toxicity test of ammonium persulfate was conducted to ensure of its potential toxic effects according to the single-dose acute oral toxicity study (OECD Guideline 423) and 90-day repeated dose sub-chronic oral toxicity study guideline (OECD Guideline 408) for establishing national chemical management system, and matching in the Globally Harmonized Classification System (GHS) category. In acute oral toxicity study, pasty stool, perineal contamination and temporary body weight decrease were observed after dosing 1st and 2nd challenge (300 mg/kg body weight). All test animals were dead within 6 hours after dosing at 3rd challenge (2000 mg/kg body weight). Therefore, the GHS class of test substance is considered class 4. In sub-chronic toxicity study, body weight changes, food consumptions, hematological, biochemical and pathological examination did not show any noticeable and significant differences between the administered (5, 20, 80 mg/kg body weight) and control (vehicle only) group animals. Based on these results, the no observed adverse effect level (NOAEL) is considered above 80 mg/kg body weight.

일부 직업인의 건강증진생활양식에 영향을 미치는 요인 연구

이은경,안병상,유택수,김성천,정재열,박용신,장두섭,송용선,이기남,Lee Eun-Kyoung,An Byung-Sang,Yu Taek-Su,Kim Seoung-Cheon,Jeung Jea-Yeal,Park Young-Shin,Jahng Doo-Sub,Song Yung-Sun,Lee Ki-Nam 대한예방한의학회 2000 대한예방한의학회지 Vol.4 No.2

The current industrial health service is shifting to health improvement business with 1st primary prevention-focused service from secondary and tertiary prevention-focused business, and Oriental medicine can provide such primary prevention-focused service due to the characteristics of its science. In particular, the advanced concept of health improvement can match the science of health care of Oriental medicine. Notably, what is most important in health improvement is our lifestyle, This does not underestimate the socio-environmental factors, which have lessened their importance due to modernism. The approach of Oriental medicine weighs more individuals' lifestyle and health care through self-cultivation. This matches the new model of advanced health business. Oriental medicine is less systemized than Western medicine, but it can provide ample contents that enhance health. If we conceive health-improvement program based on the advantages provided by these two medical systems, this will influence workers to the benefit of their health. Also, health Program needs to define factors that determine individual lives, and to provide information and technologies essential to our lives. The Oriental medicine approach puts more stress on a subject's capabilities than it does on the effect his surrounding environment can have. This needs to be supported theoretically by not only defining the relations between an individual's health state and his lifestyle, but also identifying the degree to which an individual in the industrial work place practices health improvement lifestyle . This is the first step toward initiating health-improvement business . In order to do this, this researcher conducted a survey by taking random samplings from workers, and can draw the following conclusions from it. 1 The sampled group is categorized into', by sender, female 6.6%, and male 93.4%, with males dominant; by marriage status , unmarried 43.9% and married 55.6%, with both similar percentage, and, by age, below 30, 48.4%, between 30 and 39, 27.4%, between 40 and 49, 18.2%, and over 50, 6.0%. The group further is categorized into; by education, middle school or under 1.7%, high school 30.5%, and junior college or higher 65.8% with high school and higher dominant: and by income, below 1.7 million won 24.2%, below 2.4 million won 14.8%, and above 2.4 million 6.3% Still, the group by job is categorized into collegians with 23.9%, office worker with 10.3%, and professionals with 65.8% , and this group does not include workers engaged in production that are needed for this research, but mostly office workers . 2. The subjects selected for this survey show their degree of practicing health-improvement lifestyle at an average of 2.63, health management pattern at 2.64, and health-related awareness at 2.62 The sub-divisions of health-improvement lifestyle show social emotion (2.87), food (2.66). favorite food (2.59), and leisure activities (2.52), in this order for higher points. It further shows health awareness (2.47) and safety awareness (2.40), lower points than those in health management pattern . 3. In the area of using leisure time for health-improvement, males, older people, married, and people with higher income earn higher marks. And, in the area of food management, the older and married earn higher marks . In the area of favorite food management, females, lower-income bracket, and lower-educated show higher degree of practice , while in the area of social emotion management, the older. married, and higher-income bracket show higher marks. In addition, in the area of health awareness, the older, married, and people with higher-income show higher degree of practice. 4. To look at correlation by overall and divisional health-improvement practice degree , this researcher has analyzed the data using Person's correlation coefficient. The lifestyle shows significant correlation with its six sub-divisions, and use of leisure time, food, and health awareness al

Downsizing gas sensors based on semiconducting metal oxide: Effects of electrodes on gas sensing properties

Song, Young Geun,Shim, Young-Seok,Kim, Sangtae,Han, Soo Deok,Moon, Hi Gyu,Noh, Myoung Sub,Lee, Kwangjae,Lee, Hae Ryong,Kim, Jin-Sang,Ju, Byeong-Kwon,Kang, Chong-Yun Elsevier Sequoia 2017 Sensors and actuators. B Chemical Vol.248 No.-

<P><B>Abstract</B></P> <P>We report the highly sensitive and selective downsized gas sensors for the IoT application. Sensing areas of Pt-interdigitated electrodes (IDEs) were varied to investigate the relation between sensing materials and electrodes. In<SUB>2</SUB>O<SUB>3</SUB> nanocolumns were deposited on the pre-patterned Pt IDEs using glancing angle deposition (GLAD). The effect of the interface resistance between electrodes and sensing materials, and the intergrain resistance between nanocolumns is analyzed by linear regression at different sensing area and incident angle of GLAD. In<SUB>2</SUB>O<SUB>3</SUB> (angle: 85°, sensing area: 0.3mm×0.3mm) nanocolumns with double Schottky barriers show the highest response and selectivity with fast response time of 10s to VOCs among the samples fabricated in this study. The analysis reveals that the intrinsic response of In<SUB>2</SUB>O<SUB>3</SUB> (angle: 85°, sensing area: 0.3mm×0.3mm) nanocolumns are dominantly affected by intergrain resistance, resulting in a high response. Our demonstration for the fundamental aspect of downsizing gas sensor makes an important contribution to the chemical sensor field with broad interest.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The sensing areas are varied to investigate the relation between sensing materials and electrodes. </LI> <LI> The effect of the interface resistance and the intergrain resistance are analyzed by linear regression. </LI> <LI> The performance of the downsizing gas sensor is greatly influenced by the interface resistance. </LI> </UL> </P>

Rate capability for Na-doped Li_1.167Ni_0.18Mn_0.548Co_0.105O₂ cathode material and characterization of Li-ion diffusion using galvanostatic intermittent titration technique

Lim, Sung Nam,Seo, Jung Yoon,Jung, Dae Soo,Ahn, Wook,Song, Hoon Sub,Yeon, Sun-Hwa,Park, Seung Bin Elsevier 2015 JOURNAL OF ALLOYS AND COMPOUNDS Vol.623 No.-

<P><B>Abstract</B></P> <P>Spherical Li<SUB>1.167</SUB> <SUB>−</SUB> <I> <SUB>x</SUB> </I>Na<I> <SUB>x</SUB> </I>Ni<SUB>0.18</SUB>Mn<SUB>0.548</SUB>Co<SUB>0.105</SUB>O<SUB>2</SUB> (0⩽ <I>x</I> ⩽0.1) particles were prepared by spray pyrolysis, and subjected to electrochemical characterization for lithium battery applications. It was confirmed that Na doping enhances the charge/discharge rate capability. The structure of prepared samples was characterized by XRD: the <I>c</I>-axis lattice parameter increases with increase in the amount of Na ions (parameterized by <I>x</I>, above). The Na-doped sample with <I>x</I> =0.05 shows capacities of 208 and 184mAhg<SUP>−1</SUP> at high current densities of 1.0C and 2.0C, respectively. These values are enhanced, compared to values of 189 and 167mAhg<SUP>−1</SUP> for the bare sample. The ratio of the capacity at 1.0C to that at 0.1C is enhanced from 77% for the bare sample to 84% for the Na-doped sample with <I>x</I> =0.05. The Li diffusion coefficients obtained from the galvanostatic intermittent titration technique (GITT) are higher for Na-doped samples than for the bare sample. In particular, the Na-doped sample (<I>x</I> =0.05), in the potential range around 4V, has a higher <I>D</I> <SUB>Li+</SUB> value of 3.34×10<SUP>−9</SUP> cm<SUP>2</SUP> s<SUP>−1</SUP>, compared with 1.35×10<SUP>−9</SUP> cm<SUP>2</SUP> s<SUP>−1</SUP> for the bare sample. The Na-doped samples (0< <I>x</I> <0.075) show high capacity retention: the Na-doped sample (<I>x</I> =0.05) shows a capacity retention of 92% compared to 83% for the bare sample.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Spherical Na-doped Li-rich cathode material prepared by spray pyrolysis. </LI> <LI> Na-doped samples show better rate capability than that of bare sample. </LI> <LI> Na-doped sample has higher <I>D</I> <SUB>Li+</SUB> value at 4V compared with that of the bare sample. </LI> <LI> The cycle performance was enhanced from 83% to 92%. </LI> </UL> </P>

Correlations of 3T DCE-MRI Quantitative Parameters with Microvessel Density in a Human-Colorectal-Cancer Xenograft Mouse Model

Ahn, Sung Jun,An, Chan Sik,Koom, Woong Sub,Song, Ho-Taek,Suh, Jin-Suck The Korean Society of Radiology 2011 KOREAN JOURNAL OF RADIOLOGY Vol.12 No.6

<P><B>Objective</B></P><P>To investigate the correlation between quantitative dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) parameters and microvascular density (MVD) in a human-colon-cancer xenograft mouse model using 3 Tesla MRI.</P><P><B>Materials and Methods</B></P><P>A human-colon-cancer xenograft model was produced by subcutaneously inoculating 1 × 10<SUP>6</SUP> DLD-1 human-colon-cancer cells into the right hind limbs of 10 mice. The tumors were allowed to grow for two weeks and then assessed using MRI. DCE-MRI was performed by tail vein injection of 0.3 mmol/kg of gadolinium. A region of interest (ROI) was drawn at the midpoints along the z-axes of the tumors, and a Tofts model analysis was performed. The quantitative parameters (K<SUP>trans</SUP>, K<SUB>ep</SUB> and V<SUB>e</SUB>) from the whole transverse ROI and the hotspot ROI of the tumor were calculated. Immunohistochemical microvessel staining was performed and analyzed according to Weidner's criteria at the corresponding MRI sections. Additional Hematoxylin and Eosin staining was performed to evaluate tumor necrosis. The Mann-Whitney test and Spearman's rho correlation analysis were performed to prove the existence of a correlation between the quantitative parameters, necrosis, and MVD.</P><P><B>Results</B></P><P>Whole transverse ROI of the tumor showed no significant relationship between the MVD values and quantitative DCE-MRI parameters. In the hotspot ROI, there was a difference in MVD between low and high group of K<SUP>trans</SUP> and K<SUB>ep</SUB> that had marginally statistical significance (<I>ps</I> = 0.06 and 0.07, respectively). Also, K<SUP>trans</SUP> and K<SUB>ep</SUB> were found to have an inverse relationship with MVD (<I>r</I> = -0.61, <I>p</I> = 0.06 in K<SUP>trans</SUP>; <I>r</I> = -0.60, <I>p</I> = 0.07 in K<SUB>ep</SUB>).</P><P><B>Conclusion</B></P><P>Quantitative analysis of T1-weighted DCE-MRI using hotspot ROI may provide a better histologic match than whole transverse section ROI. Within the hotspots, K<SUP>trans</SUP> and K<SUB>ep</SUB> tend to have a reverse correlation with MVD in this colon cancer mouse model.</P>

Versatile approaches to tune a nanocolumnar structure for optimized electrical properties of In₂O₃ based gas sensor

Han, Soo Deok,Noh, Myoung-Sub,Kim, Sangtae,Shim, Young-Seok,Song, Young Geuon,Lee, Kwangjae,Lee, Hae Ryung,Nahm, Sahn,Yoon, Seok-Jin,Kim, Jin-Sang,Kang, Chong-Yun Elsevier 2017 Sensors and actuators. B, Chemical Vol.248 No.-

<P><B>Abstract</B></P> <P>In this study, we demonstrate tuning of electrical properties and sensing responses of In<SUB>2</SUB>O<SUB>3</SUB> nanocolumnar structure via varying glancing angle (GLAD) deposition conditions by e-beam evaporator. The varied deposition conditions include glancing angle, vacuum level and deposition rate. The electrical property of In<SUB>2</SUB>O<SUB>3</SUB> nanostructured thin films, demonstrated by the base resistance, change up to 3 orders of magnitude from 110Ω to 103104Ω depending on the porosity of nanocolumnar structure and oxygen vacancy concentration. This variation in electrical property transfers to the tuning of gas sensing response, and we achieve tuning the same material (In<SUB>2</SUB>O<SUB>3</SUB>) based gas sensors to better perform for specific type of gases (either oxidizing or reducing). The highest responses achieved in this work reached up to 176 for oxidizing gases (5ppm NO<SUB>2</SUB>, R<SUB>gas</SUB>/R<SUB>air</SUB>) and 929 for reducing gases (50ppmC<SUB>2</SUB>H<SUB>5</SUB>OH, R<SUB>air</SUB>/R<SUB>gas</SUB>). Therefore, we demonstrate that gas sensors can be optimized for specific type of target gases with the same material, via simple control of deposition conditions. Along with the high reproduciblility and sensitivity, this puts the nanocolumnar thin film based gas sensors by GLAD with huge potential for further miniaturization and mass production, suitable for the upcoming IoT era.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Nanocolumnar In<SUB>2</SUB>O<SUB>3</SUB> thin film based gas sensor is fabricated by glancing angle deposition (GLAD). </LI> <LI> Electrical properties of In<SUB>2</SUB>O<SUB>3</SUB> can be optimized for specific target gases, tuning simple deposition conditions of GLAD. </LI> <LI> In<SUB>2</SUB>O<SUB>3</SUB> sensors have excellent performances with high repeatability, recovery, and extremely low detection limit. </LI> </UL> </P>

Evidence of reversible oxygen participation in anomalously high capacity Li- and Mn-rich cathodes for Li-ion batteries

Muhammad, Shoaib,Kim, Hyunchul,Kim, Yunok,Kim, Donghwi,Song, Jay Hyok,Yoon, Jaegu,Park, Jin-Hwan,Ahn, Sung-Jin,Kang, Sun-Ho,Thackeray, Michael M.,Yoon, Won-Sub Elsevier 2016 Nano energy Vol.21 No.-

<P><B>Abstract</B></P> <P>The reaction mechanism of a high capacity lithium- and manganese-rich metal oxide, 0.4Li<SUB>2</SUB>MnO<SUB>3</SUB>–0.6LiMn<SUB>0.5</SUB>Ni<SUB>0.5</SUB>O<SUB>2</SUB>, has been investigated at the atomic level. High-resolution synchrotron X-ray powder diffraction (HRPD) and X-ray absorption spectroscopy (XAS) were used, respectively, to evaluate the electrochemical charge and discharge reactions in terms of local and bulk structural changes, and variations in the oxidation states of the transition metal ions. Ni K-edge XAS data indicate the participation of nickel in reversible redox reactions, whereas Mn K-edge absorption spectra show that the manganese ions do not participate in the electrochemical reactions. Rietveld refinements of the oxygen occupancy during charge and discharge provide evidence of reversible oxygen release and re-accommodation by the host structure; this unique oxygen participation is likely the main reason for the anomalously high capacity of these electrodes. The HRPD data also show that during the early cycles, characteristic peaks of the Li<SUB>2</SUB>MnO<SUB>3</SUB> component disappear when charged to 4.7V, but reappear on discharge to 2.5V, consistent with a reversible lithium and oxygen extraction process. The results provide new insights into the charge compensation mechanisms that occur when high capacity, lithium- and manganese-rich electrode materials are electrochemically cycled – a topic that is currently being hotly debated in the literature.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Anomalous high capacity of Li- and Mn-rich electrodes has been probed by HRPD and XAS. </LI> <LI> Reversible oxygen release and re-accommodation by the host structure accounts, at least in part, for the unusual high capacity. </LI> <LI> The Li<SUB>2</SUB>MnO<SUB>3</SUB> character of Li- and Mn-rich metal oxide structures is preserved during the initial cycles. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

The Effect of Uni-nanoadditive Manufactured Using RF Plasma Processing on Core-shell Structure in MLCC

Song, Soon-Mo,Kim, Hyo-Sub,Park, Kum-Jin,Sohn, Sung-Bum,Kim, Young-Tae,Hur, Kang-Heon The Korean Ceramic Society 2009 한국세라믹학회지 Vol.46 No.2

Radio frequency (RF) plasma treatment is studied for the size reduction and the spheroidization of coarse particles to change them into nano-sized powders of spherical shape in MLCC fields. The uni-nanoadditives manufactured by RF plasma processing for high dispersion have been investigated for the effect on core-shell structure in dielectrics of MLCC. Microstructures have been characterized using scanning electron microscope (SEM), transmission electron microscope (TEM) and Electron Probe Micro Analyzer (EPMA). We compared the distribution of core-shell grains between specimens manufactured using uni-nanoadditive and using mixed additive. In addition, the uniformity of rare earth elements in the core-shell structured grains was analyzed. It was shown, from TEM observations, that the sintered specimen manufactured using uni-nanoadditives had more dense small grains with well-developed core-shell structure than the specimen using mixed additives, which had a homogeneous microstructure without abnormal grain growth and shows broad temperature coefficient of capacitance (TCC) curves in all temperature ranges because of well dispersed additives.

Genetic Relationship of Hibiscus syriacus L. Varieties Analyzed by Physiological and Morphological Characteristics

Sang Hoon Kim,Geung-Joo Lee,In Sook Park,Hi Sup Song,Sung Jin Chung,Dong Sub Kim,Jin Baek Kim,Si-Yong Kang 한국원예학회 2009 한국원예학회 학술발표요지 Vol.2009 No.5