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Effect of Ginseng Saponin on Hypothalamus - Pituitary - Adrenal Axis under Stress in Mice
(Do Hoon Kim),(Jun Sub Jung),(Hong Won Suh),(Sung Oh Huh),(Sung Kil Min),(Bong Ki Son),(Yung Hi Kim),(Jung Il Park),(Nak Doo Kim),(Dong Keun Song) 고려인삼학회 1998 Advances in Ginseng Research - Proceedings of the Vol.- No.-
co-sputtering 시스템의 증착조건에 따른 MgZnO 박막의 조성 특성에 관한 연구
손지훈(Ji-hoon Son),성효성(Hyo-seung Seung),김우성(Woo-sung Kim),장낙원(Nak-won Jang) 한국마린엔지니어링학회 2010 한국마린엔지니어링학회 학술대회 논문집 Vol.2010 No.4
In this paper, we have investigated about MgZnO thin films on Si(100) substrate by RF magnetron co-sputtering system. MgZnO thin films were affected by RF input power of each target, gas pressure, gas composition, and substrate temperatures. So, we focused on most effective RF input power of each target in deposition condition. Thickness of MgZnO thin films was measured by surface profiler. And structural analysis carried out by X-ray Diffraction(XRD), content of Mg in MgZnO thin films was measured by energy dispersive spectroscopy(EDS). Physical characteristics and content of Mg in MgZnO thin films changed with RF input power.
Mg<sub>x</sub>Zn<sub>1-x</sub>O를 활용한 Multi-layer 구조 LED 특성에 관한 연구
손지훈,김상현,장낙원,김홍승,Son, Ji-Hoon,Kim, Sang-Hyun,Jang, Nak-Won,Kim, Hong-Seong 한국전기전자재료학회 2012 전기전자재료학회논문지 Vol.25 No.10
The effect of co-sputtering condition on the structural properties of $Mg_xZn_{1-x}O$ thin films grown by RF magnetron co-sputtering system was investigated for manufacturing ZnO/MgZnO structure LED. $Mg_xZn_{1-x}O$ thin films were grown with ZnO and MgO target varying RF power. Structural properties were investigated by X-ray diffraction (XRD) and Energy dispersive spectroscopy (EDS). The ZnO thin films have sufficient crystallinity on the high RF power. As RF power of ZnO target increased, the contents of MgO in the $Mg_xZn_{1-x}O$ film decreased. LED was manufactured using ZnO/MgZnO multi-layer on p-GaN/$Al_2O_3$ substrate. Threshold voltage of multi-layer LED was appeared at 8 V, and it was luminesced at wave length of 550 nm.
Cheal Wung Huh,Nak Hoon Son,Young Hoon Youn,Da Hyun Jung,Min Kyung Kim,Eun Jeong Gong,Kyu Chan Huh,Seung Young Kim,Moo In Park,Ju Yup Lee,Joong Goo Kwon,Jae Hak Kim,Cheol Min Shin,Kee Wook Jung,Su Jin 대한소화기 기능성질환∙운동학회 2023 Journal of Neurogastroenterology and Motility (JNM Vol.29 No.4
Background/AimsGastroesophageal reflux disease (GERD) is a common chronic gastrointestinal disorder that typically requires long-term maintenance therapy. However, little is known about patient preferences and satisfaction and real-world prescription patterns regarding maintenance therapy for GERD. MethodsThis observational, cross-sectional, multicenter study involved patients from 18 referral hospitals in Korea. We surveyed patients who had been prescribed proton pump inhibitors (PPIs) for GERD for at least 90 days with a minimum follow-up duration of 1 year. The main outcome was overall patient satisfaction with different maintenance therapy modalities. ResultsA total of 197 patients were enrolled. Overall patient satisfaction, patient preferences, and GERD health-related quality of life scores did not significantly differ among the maintenance therapy modality groups. However, the on-demand therapy group experienced a significantly longer disease duration than the continuous therapy group. The continuous therapy group demonstrated a lower level of awareness of potential adverse effects associated with PPIs than the on-demand therapy group but received higher doses of PPIs than the on-demand therapy group. The prescribed doses of PPIs also varied based on the phenotype of GERD, with higher doses prescribed for non-erosive reflux disease than erosive reflux disease. ConclusionAlthough overall patient satisfaction did not significantly differ among the different PPI maintenance therapy modality groups, awareness of potential adverse effects was significantly different between the on-demand and continuous therapy groups.
( Eun Hye Lee ),( Nak-hoon Son ),( Ji Soo Choi ),( Chang Hwan Seol ),( Sung-ryeol Kim ),( Byung Hoon Park ),( Moo Suk Park ),( Young Ae Kang ) 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-
Purpose Healthcare workers (HCWs) are at high risk of tuberculosis (TB) infection due to their occupational exposure. Many guidelines recommended to perform routine screening for latent tuberculosis infection (LTBI) of HCWs to receive appropriate treatment. This study aimed to identify the risk factors of positive interferon-gamma (IFN-γ) release assay (IGRA) of HCWs in intermediate TB burden country. Methods This was a retrospective study in a tertiary hospital in South Korea. Form May 2017 to March 2018, HCWs were tested IGRA. We estimated the prevalence of TB infection and the annual risk of TB infection (ARI) based on their IGRA Results according to age group. Multivariate logistic regression analysis was performed to evaluate the risk factors for IGRA positivity. High-risk departments were defined as TB related departments. Results Total 3233 HCWs were analyzed. Median age of participants was 38.0 and female was predominant (72.6%). Overall positive rate of IGRA was 24.1%. According to age group, IGRA positive rates were 6.6% in the 20s, 14.4% in the 30s, 34.3% in the 40s, and around 50% in the 50s and 60s, respectively. The ARIs were 0.349% - 0.034% between 1986 and 2005, midyear of TB infection, have gradually decreased over approximately three decades. The area under the curve (AUC) predicting LTBI using IGRA was 0.749 with age cut-off point at 40. In multivariate analysis, older age, healed TB lesion in x-ray, male gender were risk factors of IGRA positivity, whereas high-risk TB department was not a significant risk factor for positive IGRA Results. Conclusions This study suggests that in intermediate TB burden countries, the LTBI test Result of HCWs might be greatly affected by age itself, rather than occupational exposure, thus careful interpretation considering the age structure is required.
Chung, Jae-Seung,Son, Nak Hoon,Lee, Sang Eun,Hong, Sung Kyu,Jeong, Chang Wook,Kwak, Cheol,Kim, Hyeon Hoe,Hong, Sung Hoo,Kim, Yong June,Kang, Seok Ho,Chung, Jinsoo,Kwon, Tae Gyun,Hwang, Eu Chang,Byun, The Korean Academy of Medical Sciences 2018 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.33 No.43
<P><B>Background</B></P><P>To examine survival rates and renal function after partial nephrectomy (PN) and radical nephrectomy (RN) in patients with chronic kidney disease (CKD).</P><P><B>Methods</B></P><P>We studied 4,332 patients who underwent PN or RN for pathological T1a-T2N0M0 renal cell carcinoma from 1988 to 2014. Patients were divided into two subgroups of CKD stage I–II and stage III. Kidney function, and survival outcomes were compared between groups.</P><P><B>Results</B></P><P>We included 1,756 patients with CKD I–II and 276 patients with CKD III in the final pair-matched analysis. Kidney function was significantly better preserved in the PN than in the RN group among all patients. However, the beneficial effect of PN on kidney function gradually disappeared over time in CKD III patients. The 5-year overall survival (OS) rates after PN and RN differed in patients with CKD I–II disease (99.4% vs. 96.5%, respectively, <I>P</I> = 0.015). The 5-year OS rates after surgery were not affected by mode of nephrectomy in CKD III patients (97.8% vs. 93.5%, <I>P</I> = 0.103). The 5-year cancer-specific survival rates did not differ between treatment groups in all CKD stage. Cox hazard analysis showed that the operative method was a significant factor for OS in CKD I–II patients (hazard ratio [HR], 0.320; confidence interval [CI], 0.122–0.840; <I>P</I> = 0.021). However, PN was not beneficial in terms of OS in CKD III patients (HR, 0.395; CI, 0.086–1.172; <I>P</I> = 0.117).</P><P><B>Conclusion</B></P><P>PN is associated with a higher OS rate and better kidney function in patients with preoperative CKD stage I and II, but not in those with CKD stage III.</P>
Comparison of anticancer activities of Korean Red Ginseng-derived fractions
Baek, Kwang-Soo,Yi, Young-Su,Son, Young-Jin,Jeong, Deok,Sung, Nak Yoon,Aravinthan, Adithan,Kim, Jong-Hoon,Cho, Jae Youl The Korean Society of Ginseng 2017 Journal of Ginseng Research Vol.41 No.3
Background: Korean Red Ginseng (KRG) is an ethnopharmacological plant that is traditionally used to improve the body's immune functions and ameliorate the symptoms of various diseases. However, the antitumorigenic effects of KRG and its underlying molecular and cellular mechanisms are not fully understood in terms of its individual components. In this study, in vitro and in vivo antitumorigenic activities of KRG were explored in water extract (WE), saponin fraction (SF), and nonsaponin fraction (NSF). Methods: In vitro antitumorigenic activities of WE, SF, and NSF of KRG were investigated in the C6 glioma cell line using cytotoxicity, migration, and proliferation assays. The underlying molecular mechanisms of KRG fractions were determined by examining the signaling cascades of apoptotic cell death by semiquantitative reverse transcriptase polymerase chain reaction and Western blot analysis. The in vivo antitumorigenic activities of WE, SF, and NSF were investigated in a xenograft mouse model. Results: SF induced apoptotic death of C6 glioma cells and suppressed migration and proliferation of C6 glioma cells, whereas WE and NSF neither induced apoptosis nor suppressed migration of C6 glioma cells. SF downregulated the expression of the anti-apoptotic gene B-cell lymphoma-2 (Bcl-2) and upregulated the expression of the pro-apoptotic gene Bcl-2-associated X protein (BAX) in C6 glioma cells but had no effect on the expression of the p53 tumor-suppressor gene. Moreover, SF treatment resulted in activation of caspase-3 as evidenced by increased levels of cleaved caspase-3. Finally, WE, SF, and NSF exhibited in vivo antitumorigenic activities in the xenograft mouse model by suppressing the growth of grafted CT-26 carcinoma cells without decreasing the animal body weight. Conclusion: These results suggest that WE, SF, and NSF of KRG are able to suppress tumor growth via different molecular and cellular mechanisms, including induction of apoptosis and activation of immune cells.
Oh-Hyun Lee,김영대,김중선,Nak-Hoon Son,박희남,정보영,Cheol Woong Yu,Hyun-Jong Lee,Woong Chol Kang,Eun-Seok Shin,Rak-kyeong Choi,Do-Sun Lim,Yo Han Jung,Hye-Yeon Choi,Kyung-Yul Lee,Bang-Hoon Cho,Sang Won Han,Joong 대한심장학회 2021 Korean Circulation Journal Vol.51 No.7
Background and Objectives: Prior studies have shown that stroke patients treated with percutaneous left atrial appendage occlusion (LAAO) for non-valvular atrial fibrillation (NVAF) experience better outcomes than similar patients treated with warfarin. We investigated the impact of percutaneous left atrial appendage closure on post-stroke neurological outcomes in NVAF patients, compared with non-vitamin K antagonist oral anticoagulant (NOAC) therapy. Methods: Medical records for 1,427 patients in multiple registries and for 1,792 consecutive patients at 6 Korean hospitals were reviewed with respect to LAAO or NOAC treatment. Stroke severity in patients who experienced ischemic stroke or transient ischemic attack after either treatment was assessed with modified Rankin Scale (mRS) scoring at hospital discharge and at 3 and 12 months post-stroke. Results: mRS scores were significantly lower in LAAO patients at 3 (p<0.01) and 12 months (p<0.01) post-stroke, despite no significant differences in scores before the ischemic cerebrovascular event (p=0.22). The occurrences of disabling ischemic stroke in the LAAO and NOAC groups were 36.7% and 44.2% at discharge (p=0.47), 23.3% and 44.2% at 3 months post-stroke (p=0.04), and 13.3% and 43.0% at 12 months post-stroke (p=0.01), respectively. Recovery rates for disabling ischemic stroke at discharge to 12 months post-stroke were significantly higher for LAAO patients (50.0%) than for NOAC patients (5.6%) (p<0.01). Conclusions: Percutaneous LAAO was associated with more favorable neurological outcomes after ischemic cerebrovascular event than NOAC treatment.