Group nearest-neighbor queries in the L₁ plane

Son, W.,Bae, S.W.,Ahn, H.K. North-Holland Pub. Co ; Elsevier Science Ltd 2015 Theoretical computer science Vol.592 No.-

<P>Let P be a set of n points in the plane. The k-nearest-neighbor (abbreviated as k-NN) query problem is to preprocess P into a data structure that quickly reports k closest points in P for a query point q. This paper addresses a generalization of the k-NN query problem to a query set Q of points, namely, the group k-nearest-neighbor query problem, in the L-1 plane. More precisely, a query is assigned with a set Q of at most m points and a positive integer k with k <= n, and the distance between a point p of P and a query set Q is defined as the sum of L-1 distances from p to all q is an element of Q. The maximum number m of query points Q is assumed to be known in advance and to be at most n. In this paper, we propose two algorithms, one based on the range tree and the other based on a data structure for segment dragging queries, and obtain the following complexity bounds: (1) a group k-NN query can be handled in O (T-min log n + (k + m(2))(log logn + logm)) time after preprocessing P using O(m(2)nlog(2)n) space, where T-min = min {k + m, m(2)}, or (2) a group k-NN query can be handled in O ((k + m)log(2) n + m(2)(log(is an element of) n + log m)) time after preprocessing P using O (m(2)n) space, where is an element of > 0 is an arbitrarily small constant. We also show that our approach can be applied to the weighted group k-nearest-neighbor query problem and the group k-farthest-neighbor query problem. (C) 2015 Elsevier B.V. All rights reserved.</P>

放射菌을 利用한 異種間 原形質體 融合과 그 融合體의 安定性에 관한 硏究(Ⅱ)

閔洪基,金昌珉,孫麗源,韓惠勝,崔英珠,丁大映,韓康玄,李相燮,李欽淑,元奉必 국립보건연구원 1992 국립보건원보 Vol.29 No.2

Relationship between Stress Gene Polymorphisms and Litter Size by AI in Pigs

Jin, H.J.,Kim, I.C.,Wee, M.S.,Yeon, S.H.,Kim, C.D.,Lee, S.S.,Cho, C.Y.,Cho, S.R.,Son, D.S.,Park, C.K. 韓國受精卵移植學會 2007 한국동물생명공학회지 Vol.22 No.4

This study was performed to investigate the relationship between PSS-HSP70 gene polymorphism and artificial insemination (AI) reproductivity in the pigs. The RFLP polymorphism of PSS and the SSCP polymorphisms of HSP70 K1, K3 and K4 PCR product were detected different patterns. In the experiment for AI of fresh semen, spring and fall season showed higher litter size born of 10.89 head than 10.47 head of summer season. Landrace was showed higher litter size of 9.96 head than that of Duroc and Yorkshire (p<0.05). Stress relating PSS and HSP70 polymorphism of PSS-Normal, HSP70 K1-BB, K3-AB, K4-AA showd a highest litter size born of 10.97 head and litter size born alive of 10.69 head than that of the other polymorphisms(p<0.05). In the experiment for AI of frozen semen, effects of season and pig breeds were not showed for litter size born. The stress relating polymorphism of PSS-Carrier, HSP70 K1-BB, K3-BB, K4-AB showed highest litter size born of 11.29 head and litter size born alive of 10.82 head and PSS-Normal, HSP70 K1-BB, K3-AB, K4-AA showed the lowest litter size born of 8.48 head and litter size born alive of 7.33 head than that of the other polymorphisms(p<0.05). These results suggest that AI litter size born for the stress of forzen thawed semen may be affected by PSS and HSP70 polymorphism in pigs.

Syntheses, crystal structures, circular dichroism, and magnetic properties of chiral dinuclear and polymeric nickel(II) compounds

Shin, J.W.,Son, H.J.,Kim, S.K.,Min, K.S. Pergamon Press 2013 Polyhedron Vol.52 No.-

Chiral dinuclear nickel(II) complexes, [Ni(L<SUP>R,R</SUP>)(C<SUB>2</SUB>O<SUB>4</SUB>)Ni(L<SUP>R,R</SUP>)](ClO<SUB>4</SUB>)<SUB>2</SUB>.4CH<SUB>3</SUB>CN (3) and [Ni(L<SUP>S,S</SUP>)(C<SUB>2</SUB>O<SUB>4</SUB>)Ni(L<SUP>S,S</SUP>)](ClO<SUB>4</SUB>)<SUB>2</SUB>.4CH<SUB>3</SUB>CN (4) and chiral polymeric compounds, [Ni(L<SUP>R,R</SUP>)(CrO<SUB>4</SUB>)]<SUB>n</SUB>.2H<SUB>2</SUB>O.CH<SUB>3</SUB>CN (5) and [Ni(L<SUP>S,S</SUP>)(CrO<SUB>4</SUB>)]<SUB>n</SUB>.2H<SUB>2</SUB>O.CH<SUB>3</SUB>CN (6) have been synthesized and characterized (L<SUP>R,R/S,S</SUP>=1,8-di((R/S)-α-methylbenzyl)-1,3,6,8,10,13-hexaazacyclotetradecane). These chiral compounds were characterized by X-ray crystallography, circular dichroism, and molecular magnetism. The nickel(II) ions in 3 and 4 have a distorted octahedral geometry by coordination with four nitrogens of a macrocyclic ligand with chiral pendents in a folded conformation and two oxygens of an oxalate ion in the cis positions. The nickel(II) ions in 5 and 6 have a distorted octahedral geometry by coordination with four nitrogens of a macrocyclic ligand in a planar conformation and two oxygens of two chromate ions in the axial positions. Complexes 3 and 4 show strong antiferromagnetic interactions [3: g=2.36, J/k<SUB>B</SUB>=-29.9K (-20.8cm<SUP>-1</SUP>); 4: g=2.18, J/k<SUB>B</SUB>=-25.5K (-17.7cm<SUP>-1</SUP>)], while 5 and 6 exhibit weak antiferromagnetic couplings [5: g=2.25, J/k<SUB>B</SUB>=-1.20K (-0.83cm<SUP>-1</SUP>); 6: g=2.25, J/k<SUB>B</SUB>=-0.68K (-0.47cm<SUP>-1</SUP>)]. The former complexes occur strong antiferromagnetic interactions via the oxalato bridges within the nickel(II) dimers, the latter compounds are weak antiferromagnetic interactions through the chromate ions within the 1D polymers. The circular dichroism (CD) spectrum of 3 has exhibited two negative peaks at 336 and 533nm, and that of 4 has displayed an enantiomeric pattern. The CD spectrum of 5 has appeared a negative absorption above ca. 550nm, while that of 6 has shown an enantiomeric pattern in the same wavelength region.

Relationship between Stress Gene Polymorphisms and Litter Size by AI in Pigs

H. J. Jin,I. C. Kim,M. S. Wee,S. H. Yeon,C. D. Kim,S. S. Lee,C. Y. Cho,S. R. Cho,D. S. Son,C. K. Park,Z. D. Li 사단법인 한국동물생명공학회 2007 한국동물생명공학회지 Vol.22 No.4

This study was performed to investigate the relationship between PSS-HSP70 gene polymorphism and artificial insemination (AI) reproductivity in the pigs. The RFLP polymorphism of PSS and the SSCP polymorphisms of HSP70 K1, K3 and K4 PCR product were detected different patterns. In the experiment for AI of fresh semen, spring and fall season showed higher litter size born of 10.89 head than 10.47 head of summer season. Landrace was showed higher litter size of 9.96 head than that of Duroc and Yorkshire(p<0.05). Stress relating PSS and HSP70 polymorphism of PSS-Normal, HSP70 K1-BB, K3-AB, K4-AA showd a highest litter size born of 10.97 head and litter size born alive of 10.69 head than that of the other polymorphisms(p<0.05). In the experiment for AI of frozen semen, effects of season and pig breeds were not showed for litter size born. The stress relating polymorphism of PSS-Carrier, HSP70 K1-BB, K3-BB, K4-AB showed highest litter size born of 11.29 head and litter size born alive of 10.82 head and PSS-Normal, HSP70 K1-BB, K3-AB, K4-AA showed the lowest litter size born of 8.48 head and litter size born alive of 7.33 head than that of the other polymorphisms(p<0.05). These results suggest that AI litter size born for the stress of forzen thawed semen may be affected by PSS and HSP70 polymorphism in pigs.

The Use of Collagen Content as Determined by Spectral Domain Polarization-Sensitive Optical Coherence Tomography to Assess Colon Anastomosis Healing in a Rat Model

Son, K.H.,Jeong, H.-W.,Jung, W.-W.,Kim, H.-S.,Lee, S.K.,Kim, K.T.,Ahn, C.B.,Park, K.Y.,Kim, B.-M.,Lee, S.H. S. Karger AG 2014 European surgical research Vol.52 No.1

<P>Abstract</P><P><B><I>Background/Purpose:</I></B> Many studies have been undertaken to prevent anastomosis leakage of the colon, and several methods have been used to assess anastomosis healing, such as measurement of bursting pressure or hydroxyproline (a marker of collagen) content at the anastomosis site. However, these methods are inappropriate for comparing anastomosis healing at two time points in the same animals. In the present study, we measured the collagen level by spectral domain polarization-sensitive optical coherence tomography (SD-PS-OCT) to assess anastomosis healing. <B><I>Methods:</I></B> Sprague-Dawley rats were divided into groups C (saline-administered controls; study group) and M [a 5-fluorouracil (5-FU)-administered experimental group]. Immediately after end-to-end anastomosis of the colon, SD-PS-OCT images of anastomoses were taken (baseline). Animals were administered saline or 5-FU for 7 days. On the 7th postoperative day, SD-PS-OCT images were acquired, a histopathologic exam was performed, and hydroxyproline levels as well as mRNA expressions of collagen-1 and collagen-3 were measured at the anastomosis site. <B><I>Results:</I></B> Fibroblast proliferation and inflammatory cell infiltration were greater in group C than in group M. The mRNA expressions of collagen-1 and collagen-3 were substantially higher in group C. Hydroxyproline levels were higher in group M than in group C. Though collagen levels measured by SD-PS-OCT at 7 days were elevated compared with baseline in group C, no such changes were observed for group M. <B><I>Conclusion:</I></B> Collagen levels at the colon anastomosis site, measured with SD-PS-OCT, were not increased at 7 days postoperatively versus baseline when 5-FU was injected, but were increased in saline-treated controls. The measurement of collagen content by SD-PS-OCT was found to provide a good means of assessing anastomosis healing, because it allows in situ assessment of collagen contents at baseline and during the postoperative period.</P><P>© 2014 S. Karger AG, Basel</P>

Al₂O₃/SiC 세라믹스 균열치유능력에 미치는 첨가제 양의 영향

박성원(S. W. Park),안석환(S. H. Ahn),손창석(C. S. Son),김성광(S. K. Kim),남기우(K. W. Nam) 대한기계학회 2007 대한기계학회 춘추학술대회 Vol.2007 No.10

The four kinds of Al₂O₃ composite ceramics were prepared using a mixture of 85 wt.% Al₂O₃ (mean size 0.5 μm), 15 wt.% SiC powder with Y₂O₃ as an additive powder (0, 1, 3 and 5 wt.%). The crack-healing strengths were studied as functions of crack-healing temperature and amount of Y₂O₃. The in-situ crack-healing behavior was observed at 1,573 K for 1 h in the air. The heat treated specimen with 3 wt.% of Y₂O₃ showed better crack-healing ability than specimen with 1 or 5 wt.% of Y₂O₃. In case of specimen with 3 wt.% of Y₂O₃, the bending strength of the crack-healed specimen at 1,473 K was recovered to the bending strength of smooth specimen treated at 1573 K. The heat-resistance limit temperature of Al₂O₃ composite ceramics was 1,073 K, 1,373 K, 873 K for the specimen with 1, 3, 5 wt.% of Y₂O₃.

Y₂O₃ 첨가량에 의한 Al₂O₃ 복합재 세라믹스의 균열 치유와 고온 굽힘강도 특성

남기우(K. W. Nam),김해숙(H. S. Kim),손창석(C. S. Son),김성광(S. K. Kim),안석환(S. H. Ahn) 대한기계학회 2007 大韓機械學會論文集A Vol.31 No.11

The four kinds of Al₂O₃ composite ceramics were prepared using a mixture of 85 wt.% Al₂O₃ (mean size 0.5 ㎛), 15 wt.% SiC powder with Y₂O₃ as an additive powder (0, 1, 3 and 5 wt.%). The crack-healing strengths were studied as functions of crack-healing temperature and amount of Y₂O₃. The in-situ crack-healing behavior was observed at 1,573 K for 1 h in the air. The heat treated specimen with 3 wt.% of Y₂O₃ showed better crack-healing ability than specimen with 1 or 5 wt.% of Y₂O₃. In case of specimen with 3 wt.% of Y₂O₃, the bending strength of the crack-healed specimen at 1,473 K was recovered to the bending strength of smooth specimen treated at 1573 K. The heat-resistance limit temperature of Al₂O₃ composite ceramics was 1,073 K, 1,373 K, 873 K for the specimen with 1, 3, 5 wt.% of Y₂O₃.

유전질환 등록 시스템 운영, 유전자 정보 Database 구축 및 유전자 진단 시스템 확립

구수경,이환석,손용규,김성수,이광수,김지인,서일선,진수정,정동기,오범석,정성철,이진성 국립보건연구원 2000 국립보건원보 Vol.37 No.-

Association between HSP70 Genotypes and Oocytes Development on In vitro Maturation/Fertilization in Pig

Wee, M.S.,Park, C.K.,Cho, S.R.,Lee, S.S.,Yeon, S.H.,Kim, C.D.,Cho, C.Y.,Choi, S.H.,Sang, B.D.,Son, D.S.,Li, Z.D.,Jin, H.J. Asian Australasian Association of Animal Productio 2008 Animal Bioscience Vol.21 No.10

This study was performed to clarify whether the variation of stress related heat shock protein 70 (HSP70) (GenBank X68213) gene was associated with the nuclear morphological change of in vitro maturation and in vitro capacitation in oocytes of pig ovaries obtained at the slaughterhouse. The nucleic acid substitution of C to G at the 483rd position was found out in HSP70 K1 (290-512) from X68213. The ovaries were categorized into CC, CG, and GG genotypes using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) (BsiHKA I). After the second in vitro maturation of immature fresh oocytes, the relation of nuclear morphological change in oocytes with the genotype of HSP70 K1 gene was such that the MII ratios of the genotype GG and CG (46.93% and 42.20%, respectively) were significantly higher than that of the CC genotype (10.71%) (p<0.05). With respect to in vitro maturation of frozen-thawed oocytes by an open pulled straw (OPS) method, the percentage of oocytes matured to MII stage of the CG genotype showed a higher trend than CC and GG genotypes. After the in vitro maturation of immature fresh oocytes and frozen-thawed oocytes by the OPS method, the relation of the pronuclei change in oocytes matured in vitro with HSP70 genotype was assessed, and the result showed that the enlarged sperm heads (ESH) of matured fresh oocytes and frozen-thawed oocytes were 80.0% and 60.0% in the CC genotype, respectively. The CC genotype group had a significantly higher rate of ESH than the CG and the GG genotype group (p<0.05). The ratios of polyspermic invasion were not different among HSP70 of the three genotypes. It was considered that the rate of in vitro maturation of fertilized oocytes was expected to differ according to genotype of the stress related gene.