증례 : 신장 ; 일산화탄소 중독 후 동시에 발생한 급성 신손상과 횡문근융해증 1예

노신영 ( Sin Young Nho ),이인희 ( In Hee Lee ),안기성 ( Ki Sung Ahn ),현대성 ( Dae Seong Hyeon ),강건우 ( Gun Woo Kang ) 대한내과학회 2015 대한내과학회지 Vol.89 No.4

일산화탄소 중독 후 급성 신손상 및 횡문근 융해증이 동시에 발생한 예는 매우 드물게 보고되고 있다. 이에 저자 등은 자살 목적으로 연탄가스 흡입 후 일산화탄소 중독과 관련된 급성 신손상 및 횡문근융해증으로 진단하였고 고압산소치료 없이 고농도 산소 및 보존적 치료만으로 호전된 증례를 경험하였기에 문헌고찰과 함께 이를 보고하는 바이다. Carbon monoxide (CO) poisoning has increased rapidly in South Korea and may cause a variety of clinical effects. The most common complications are neurologic and neuropsychological disturbances. However, in rare cases, CO poisoning may also be associated with acute kidney injury and non-traumatic rhabdomyolysis. Here, we report a case of acute kidney injury and rhabdomyolysis complicating CO poisoning. A 32-year-old woman was admitted to our emergency department with dyspnea and confused consciousness after exposure to CO during a suicide attempt involving charcoal briquettes. Laboratory findings revealed a carboxyhemoglobin (COHb) level of 44.8%, a blood urea nitrogen level of 20.5 mg/dL, a serum creatinine level of 1.4 mg/dL, and a creatine phosphokinase level of 8,688.3 IU/L. Acute kidney injury and rhabdomyolysis complicating CO poisoning were diagnosed. This case was managed with normobaric oxygen therapy and hydration. The patient recovered completely with respect to renal function and muscle enzyme level, and COHb level returned to 0%. (Korean J Med 2015;89:461-464)

족삼리(足三里) 침자(鍼刺)가 동통억제(疼痛抑制)에 미치는 영향(影響)

신권성,변재영,안수기,황우준,Sin Gun-Seong,Byun Jae-Young,Ahn Soo-Gi,Hwang Woo-Jun 대한침구의학회 1998 대한침구의학회지 Vol.15 No.2

The purpose of this study was finding the pain inhibitory effect of acupuncture at ST-36. The pain at dentes incisor was evoked by noxious electric stimulation and EMG changes based on time interval were measured. To do this, the opioid antagonist was administered intraperitoneally. Followings are some of the results. 1. The pain inhibitory effect of acupuncture at ST-36 was 93.82%, 87.00%, 75.30%, 69.76% at 10 20, 30 and 40 minutes respectively. All the data were calculated based on 100% at 0 minute. The effect was very significant at 40 minutes. 2. The continuous effect of acupuncture at ST-36 after taking out the needle was 77.46%, 79.66%, 87.60%, 91.50%, 95.14%, 99.48% at 50, 60, 70, 80, 90 and 100 minutes respectively. The overall continuous effect was shown its maximum 20 minutes after taking out the needle and reached to the initial value at 60 minutes. 3. The pain inhibitory effect following the naloxone administration and acupuncture application ST-36 was 93.44%, 94.58%, 90.80%, 88.04% at 10, 20, 30 and 40 minutes respectively. All values showed similar tendency to the initial data. 4. The continuous effect of acupuncture at ST-36 after taking out the needle which was preceded by the naloxone administration was 91.26%, 91.90%, 92.06%, 93.66%, 94.12%, 93.50% at 50, 60, 70, 80, 90 and 100 minutes respectively. This trend was not a significant fluctuation. It Was concluded that effect of acupuncture at ST-36 was shown in conjunction with secretion of analgesic substance. Therefore it is implied that the acupuncture application will play a major role in treating many diseases with more revelation of scientific acupuncture mechanism. Further studies of acupuncture manipulation are needed in the future based on our study.

Characteristics of Symptomatic Belching in Patients With Belching Disorder and Patients Who Exhibit Gastroesophageal Reflux Disease With Belching

( Shin Ok Jeong ),( Joon Seong Lee ),( Tae Hee Lee ),( Su Jin Hong ),( Young Sin Cho ),( Junseok Park ),( Seong Ran Jeon ),( Hyun Gun Kim ),( Jin-oh Kim ) 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2021 Journal of Neurogastroenterology and Motility (JNM Vol.27 No.2

Background/Aims Belching disorder (BD) is clinically distinct from gastroesophageal reflux disease (GERD) with belching. Supragastric belching (SGB) is closely associated with reflux episodes. This study investigates belch characteristics in association with reflux, compared between patients with BD and those who had GERD with belching. Methods Impedance pH monitoring data from 10 patients with BD and 10 patients with GERD who exhibited belching were retrospectively analyzed. Belches were considered “isolated“ or “reflux-related” and acidic/non-acidic. Belch characteristics were compared between patients with BD and those with GERD. Results Symptomatic belches were more frequent in patients with BD than in patients with GERD (median, 160.5 vs 56.0, P < 0.05). SGB was the most common type in both groups; common subtypes comprised “isolated“ in patients with BD and “isolated during the reflux period” in patients with GERD. Reflux-related SGB was more common in patients with GERD than in BD (78.3% vs 45.2%, P < 0.005). Both “preceding belching” including the reflux period and acidic SGB were more common in patients with GERD than in BD (31.8% vs 8.6% and 38.1% vs 8.9%, both P < 0.05). Supragastric belch number positively correlated with all reflux episodes in patients with GERD (adjusted R² = 0.572, P = 0.007). Conclusions BD is characterized by more belching, compared to GERD. SGB is more frequently associated with reflux in GERD than in BD; acidity may be related to GERD. In BD, SGB is typically non-acidic and unrelated to reflux. Distinct SGB characteristics may reflect different pathogenic mechanisms of reflux and associated symptoms. (J Neurogastroenterol Motil 2021;27:231-239)

정적 시간 분석을 이용한 저전력 태스크내 전압 스케줄링

신동군,김지홍,이성수,Sin, Dong-Gun,Kim, Ji-Hong,Lee, Seong-Su 한국정보과학회 2001 정보과학회논문지 : 시스템 및 이론 Vol.28 No.11

CMOS 회로의 전력 소모는 공급 전압의 제곱에 비례하기 때문에 공급 전압을 낮추는 것이 전력 소모를 줄이는 데 매우 효과적이다. 본 논문에서는 저전력 경성 실시간 응용프로그램을 위한 태스크내 전압 스케줄링 알고리즘을 제안한다. 정적 시간 분석 기법을 바탕으로 제안된 이 알고리즘은 각각의 태스크 내부에서 프로세서의 공급 전압을 조정한다. 제안된 알고리즘에 의해 전압 스케줄링된 프로그램은 모든 유휴 시간을 완전히 이용함으로써 항상 프로그램의 수행을 마감 시간에 근접하여 끝나도록 하여 많은 전력 감소 효과를 얻을 수 있다. 제안된 알고리즘의 효과를 검증하기 위해 일반적인 프로그램을 동적 전압을 사용하는 같은 기능의 프로그램으로 자동으로 변환하는 소프트웨어 도구도 개발되었다. 실험 결과, 자동화 소프트웨어 도구에 의해 변환된 MPEG-4 부호기와 복호기의 저전력 버전이 전원 차단 기능을 가진 고정 전압 시스템에서 실행된 원래 프로그램에 비하여 전력 소모가 7~25%에 불과함을 알 수 있었다. Since energy consumption of CMOS circuits has a quadratic dependency on the supply voltage, lowering the supply voltage is the most effective way of reducing energy consumption. We propose an intra-task voltage scheduling algorithm for low-energy hard real-time applications. Based on a static timing analysis technique, the proposed algorithm controls the supply voltage within an individual task boundary. By fully exploiting all the slack times, as scheduled program by the proposed algorithm always complete its execution near the deadline, thus achieving a high energy reduction ratio. In order to validate the effectiveness of the proposed algorithm, we built a software tool that automatically converts a DVS-unaware program into an equivalent low-energy program. Experimental results show that the low-energy version of an MPEG-4 encoder/decoder (converted by the software tool) consumes less than 7~25% of the original program running on a fixed-voltage system with a power-down mode.

Spontaneous Internal Anal Sphincter Relaxation During High-resolution Anorectal Manometry Is Associated With Peripheral Neuropathy and Higher Charlson Comorbidity Scores in Patients With Defecatory Disorders

( Tae Hee Lee ),( Joon Seong Lee ),( Jeeyeon Kim ),( Jin-oh Kim ),( Hyun Gun Kim ),( Seong Ran Jeon ),( Su Jin Hong ),( Young Sin Cho ),( Suyeon Park ) 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2020 Journal of Neurogastroenterology and Motility (JNM Vol.26 No.3

Background/Aims We aimed to evaluate associations between comorbidities, peripheral neuropathy, and spontaneous internal anal sphincter relaxation (SAR) in patients with defecatory disorders. Methods A patient was considered to exhibit SAR during high-resolution anorectal manometry (HR-ARM) when the nadir pressure is < 15 mmHg and the time from onset to relaxation was ≥ 15 seconds in the resting pressure frame. A case-control study was performed using HR-ARM data collected from 880 patients from January 2010 to May 2015. We identified 23 cases with SAR (median age 75 years; 15 females; 12 fecal incontinence and 11 constipation). We compared HR-ARM values, Charlson index comorbidity scores, neuropathy, and the prevalence of diseases that potentially cause neuropathy between controls and SAR patients. Each SAR case was compared to 3 controls. Controls were selected to match the age, gender, and examination year of each SAR case. Results Compared to controls (26.1%), SAR patients (52.2%) exhibited a significantly higher frequency of fecal incontinence. SAR patients also had higher Charlson index scores (5 vs 4, P = 0.028). Nine of 23 SAR patients (39.1%) exhibited peripheral neuropathy― this frequency was higher than that for the control group (11.6%; P = 0.003). Diseases that potentially cause neuropathy were observed in 17 of 23 SAR cases and 32 of 69 controls (P = 0.022). Conclusions SAR develops in patients with constipation and fecal incontinence but is more common in patients with fecal incontinence. Our controlled observational study implies that SAR is associated with peripheral neuropathy and more severe comorbidities. (J Neurogastroenterol Motil 2020;26:362-369)

PET/CT SUV Ratios in an Anthropomorphic Torso Phantom

연준호(Joon-Ho Yeon),홍건철(Gun-Chul Hong),강병현(Byung-Hyun Kang),신예지(Ye-Ji Sin),오욱진(Uk-Jin Oh),윤혜란(Hye-Ran Yoon),홍성종(Seong-Jong Hong) 한국방사선학회 2020 한국방사선학회 논문지 Vol.14 No.1

표준섭취계수(SUV) PET과 영상 재구성 방법에 따라 크게 달라진다. 삼성 서울병원 핵의학과에 설치된 GE사의 Discovery MIDR와 Discovery Ste의 영상 재구성 알고리즘을 이용하여 의인화몸통팬텀 내의 심장, 간과 배경영역에서 표준섭취계수를 측정하여 실제 SUV와 비교하였다. 영상 재구성 알고리즘은 MIDR에서는 VPFX-S (TOF+PSF), QCFX-S-350 (Q.Clear+TOF+PSF), QCFX-S-50와 VPHD-S (OSEM+PSF), Ste에서는 VUE Point (OSEM)와 FORE-FBP를 사용하였다. 방사선사의 방사선 피폭을 감소시키기 위하여 소량의 ¹⁸F-FDG 선원을 물과 혼합하였다: 52.5 ml 심장에는 2.28 MBq, 1,290 ml 간에는 20.3 MBq와 9,590 ml 배경영역에는 45.7 MBq을 주입하였다. 심장에서의 표준섭취계수는 MIDR의 VPFX-S, QCFX-S-350, QCFX-S-50, VPHD-S와 Ste의 VUE Point (OSEM)와 FOR-FBP 알고리즘에서 각각 27.1, 28.0, 27.1, 26.5, 8.0와 7.4 이었으며, 기대치는 5.9이었다. 배경역역에서는 4.2, 4.1, 4.2, 4.1, 1.1와 1.2 이었으며, 기대치는 0.8이었다. 각 영역에서 표준섭취계수는 PET과 알고리즘에 따라 크게 차이가 있었지만, 심장과 배경영역의 SUV 비율은 비교적 일정하여 6개 영상 재구성 알고리즘에 대하여 6.5, 6.8, 6.5, 6.5, 7.3와 6.2 이었으며 기대치는 7.8이었다. 심장에서의 평균 신호 대 잡음비(SNR)는 각각 6개 알고리즘에 대하여 8.3, 12.8, 8.3, 8.4, 17.2와 16.6이었다. 결론적으로 PET 성능 평가는 각 영역에서의 절댓값 보다는 두 영역 사이의 SUV 비율이 적절하며, 비교적 소량의 방사능으로도 확인할 수 있는 가능성이 있다. The standard uptake values (SUVs) strongly depend on positron emission tomographs (PETs) and image reconstruction methods. Various image reconstruction algorithms in GE Discovery MIDR (DMIDR) and Discovery Ste (DSte) installed at Department of Nuclear Medicine, Seoul Samsung Medical Center were applied to measure the SUVs in an anthropomorphic torso phantom. The measured SUVs in the heart, liver, and background were compared to the actual SUVs. Applied image reconstruction algorithms were VPFX-S (TOF+PSF), QCFX-S-350 (Q.Clear+TOF+PSF), QCFX-S-50, VPHD-S (OSEM+PSF) for DMIDR, and VUE Point (OSEM) and FORE-FBP for DSte. To reduce the radiation exposure to radiation technologists, only the small amount of radiation source ¹⁸F-FDG was mixed with the distilled water: 2.28 MBq in the 52.5 ml heart, 20.3 MBq in the 1,290 ml liver and 45.7 MBq for the 9,590 ml in the background region. SUV values in the heart with the algorithms of VPFX-S, QCFX-S-350, QCFX-S-50, VPHD-S, VUE Point, and FOR-FBP were 27.1, 28.0, 27.1, 26.5, 8.0, and 7.4 with the expected SUV of 5.9, and in the background 4.2, 4.1, 4.2, 4.1, 1.1, and 1.2 with the expected SUV of 0.8, respectively. Although the SUVs in each region were different for the six reconstruction algorithms in two PET/CTs, the SUV ratios between heart and background were found to be relatively consistent; 6.5, 6.8, 6.5, 6.5, 7.3, and 6.2 for the six reconstruction algorithms with the expected ratio of 7.8, respectively. Mean SNRs (Signal to Noise Ratios) in the heart were 8.3, 12.8, 8.3, 8.4, 17.2, and 16.6, respectively. In conclusion, the performance of PETs may be checked by using with the SUV ratios between two regions and a relatively small amount of radioactivity.

권백물추출물의 선별적인 항암작용에 대한 연구

이성원(Sung Won Lee),안성훈(Seong Hun Ahn),곽근신(Gun Sin Gwak),곽섭(Sup Kwak),이장천(Jang Cheon Lee),문연자(Yean Ja Mun),우원홍(Won Hong Woo) 한의병리학회 2002 동의생리병리학회지 Vol.16 No.6

Synthesis of New Polymeric Antioxidants.

오동륜,김현규,이남군,채규호,강신영,이무성,김택현,O, Dong Ryun,Kim, Hyeon Gyu,Lee, Nam Gun,Chae, Gyu Ho,Gang, Sin Yeong,Lee, Mu Seong,Kim, Taek Hyeon Korean Chemical Society 2001 Bulletin of the Korean Chemical Society Vol.22 No.6