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Jiwon Park,Kyoung Sim Kim,Yong Wook Kim,Eun Young Kim,Young Kim,Hae In Jang,Hyoung Min Cho 조선대학교 의학연구원 2022 Medical Bilogical Science and Engineering Vol.5 No.1
Congenital tuberculosis infection is very rare, but fatal. Congenital tuberculosis should always be considered among the many causes of pneumonia, especially if the newborn has pneumonia that does not respond to treatment. We report a case of a premature infant born to a mother who had no evidence of tuberculosis infection. The patient was the first of the twins born by cesarean section at 30 weeks and 1 day of gestation. The 21st day after birth, the patient developed apnea, tachycardia, and tachypnea. The medical staff assumed sepsis and bacterial pneumonia. Despite antibiotic treatment, the patient’s condition worsened. On the 63rd day after birth, the mother of the infant visited the emergency room complaining of fever and decreased consciousness and was diagnosed with tuberculous meningitis. Mycobacterium tuberculosis was detected in the AFB stain, TB PCR, and TB culture.
Jiwon Kim,Sunghwan Kim,Yoo Hyun Um,Sheng-Min Wang,Regina EY Kim,Yeong Sim Choe,Jiyeon Lee,Donghyeon Kim,Hyun Kook Lim,Chang Uk Lee,Dong Woo Kang 대한정신약물학회 2024 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.22 No.1
Objective: Cognitive reserve has emerged as a concept to explain the variable expression of clinical symptoms in the pathology of Alzheimer’s disease (AD). The association between years of education, a proxy of cognitive reserve, and resting-state functional connectivity (rFC), a representative intermediate phenotype, has not been explored in the preclinical phase, considering risk factors for AD. We aimed to evaluate whether the relationship between years of education and rFC in cognitively preserved older adults differs depending on amyloid-beta deposition and APOE ε4 carrier status as effect modifiers. Methods: A total of 121 participants underwent functional magnetic resonance imaging, [18F] flutemetamol positron emission tomography-computed tomography, APOE genotyping, and a neuropsychological battery. Potential interactions between years of education and AD risk factors for rFC of AD-vulnerable neural networks were assessed with wholebrain voxel-wise analysis. Results: We found a significant education years-by-APOE ε4 carrier status interaction for the rFC from the seed region of the central executive (CEN) and dorsal attention networks. Moreover, there was a significant interaction of rFC between right superior occipital gyrus and the CEN seed region by APOE ε4 carrier status for memory performances and overall cognitive function. Conclusion: In preclinical APOE ε4 carriers, higher years of education were associated with higher rFC of the AD vulnerable network, but this contributed to lower cognitive function. These results contribute to a deeper understanding of the impact of cognitive reserve on sensitive functional intermediate phenotypic markers in the preclinical phase of AD.
IoT 기반의 반려묘 일상활동 모니터링 어플리케이션 구현 및 개발에 관한 연구
정지원(Jiwon Jung),심성준(Sungjun Sim),유지상(Jisang Yoo),권순철(Soonchul Kwon) 한국통신학회 2021 한국통신학회 학술대회논문집 Vol.2021 No.6
기존 반려동물 어플리케이션은 사용자가 직접 반려묘의 상태 데이터를 입력하여 관리한다는 문제점을 가지고 있다. 상기의 문제점을 해결하기 위해 본 논문에서는 IoT 기기를 이용하여 반려묘를 모니터링 하는 IoT 기반 어플리케이션을 제안하고 구현한다. 제안된 애플리케이션의 클라이언트는 모바일 기반 안드로이드 플랫폼을 기반으로 개발되며 서버는 MYSQL과 node.js로 개발된다. IoT 기기에서 수신한 데이터를 처리하여 사용자에게 8가지 항목(운동, 걷기, 휴식, 햇빛 노출, 빛 공해, 자외선, 칼로리)에 대한 정보를 제공한다.
유아의 기질 특성과 어머니의 양육스트레스 및 양육행동이 유아의 외현화 문제행동에 미치는 영향*
윤지원(Yoon, Jiwon),도현심(Doh, Hyun-Sim) 한국인간발달학회 2018 人間發達硏究 Vol.25 No.2
본 연구는 유아의 기질 특성과 어머니의 양육스트레스 및 양육행동이 유아의 외현화 문제행동에 미치는 영향 과 관련하여, 기질이 외현화 문제행동에 미치는 직접적 영향과 어머니의 양육스트레스 및 양육행동을 통해 미 치는 간접적 영향을 살펴보았다. 본 연구의 참가자는 한국연구재단의 사회과학연구지원 사업에 의해 지원된 ‘아동가족연구단’ 연구에 참가한 유아기 자녀를 둔 155명의 어머니들이며, 조사자료는 질문지법에 의해 수집되 었다. SPSS PROCESS macro v2.16을 사용하여 경로분석을 실시한 결과, 유아의 기질 특성에 따라 다소 다른 결과 가 발견되었다. 첫째, 규칙성과 활동성은 외현화 문제행동에 각각 부적 영향과 정적 영향을 미쳤다. 둘째, 적응 성, 규칙성 및 활동성 모두 양육스트레스를 통해 외현화 문제행동에 영향을 미쳤다. 적응성 및 규칙성과 활동성 은 양육스트레스에 각각 부적 영향과 정적 영향을 미쳤으며, 양육스트레스는 외현화 문제행동에 정적 영향을 미쳤다. 셋째, 활동성은 어머니의 양육행동을 통해 외현화 문제행동에 영향을 미쳤다. 활동성은 어머니의 부정 적 양육행동에 정적 영향을 미쳤으며, 어머니의 부정적 양육행동은 외현화 문제행동에 정적 영향을 미쳤다. 마 지막으로, 세 가지 기질 특성은 모두 순차적으로 양육스트레스와 양육행동을 통해 외현화 문제행동에 영향을 미쳤다. 본 연구는 어머니의 양육스트레스 및 양육행동과 같은 양육 관련 변인의 중요성을 비롯하여 이러한 변 인들과 외현화 문제행동에 대한 각 기질 특성의 영향력을 강조하였다. This study explored both direct and indirect effects of temperamental dimensions such as adaptability, regularity, and activity on preschoolers’ externalizing problem behavior through maternal parenting stress and parenting behavior. A total of 155 mothers of 3- to 4-year-olds participated in the study that were drawn from the 2010 Child and Family Study, a project supported by the National Research Foundation of Korea. Data were collected by means of questionnaires, and were analyzed by path analyses using SPSS PROCESS macro v2.16. The results are summarized as follows: First, regularity and activity had negative and positive effects on externalizing problem behavior, respectively. Second, adaptability and regularity had negative effects but activity had a positive effect on externalizing problem behavior through parenting stress. Third, activity had a positive effect on externalizing problem behavior through parenting behavior. Finally, adaptability and regularity had negative effects but activity had a positive effect on externalizing problem behavior sequentially through parenting stress and behavior. This study emphasizes the importance of child rearing-related variables such as parenting stress and behavior, and differential influences of each temperamental dimension on those parenting variables and externalizing problem behavior.
Min-Sang Lee,Jiwon Yoon,김지웅,Yoo Seob Shin,Hae Sim Park,Hyun-Young Lee,예영민 대한천식알레르기학회 2020 Allergy, Asthma & Immunology Research Vol.12 No.4
Purpose: A need for useful measures reflective of the socio-economic burden of chronic urticaria (CU) has arisen. To obtain utility estimates for CU, we investigated EuroQol-5-Dimension (EQ-5D) indices according to urticaria control status and urticaria severity. Methods: In this prospective observational study, we administered patient-oriented questionnaires on EQ-5D and urticaria outcomes, including Urticaria Activity Score over 7 days (UAS7), Urticaria Control Test (UCT), and CU-specific quality of life (CU-QOL). EQ-5D utility index scores were compared according to urticaria control status and disease severity. Conditional process analysis (CPA) was used to map EQ-5D utility scores from UAS7 and UCT. Results: Greater EQ-5D utility values were obtained in patients with better urticaria control (0.91 ± 0.10 for well controlled CU, 0.84 ± 0.12 for partly controlled, 0.77 ± 0.14 for uncontrolled, P < 0.001). According to CU severity, mean utility values were ranged from 0.746 (severe, UAS7 ≥ 28) to 0.860 (moderate), 0.878 (mild), and 0.953 (urticaria free). CPA suggested that UAS7 was directly correlated with UCT (regression coefficient, −0.251; 95% confidence interval [CI], −0.278, −0.223; P < 0.001) and EQ-5D utility (−0.002; 95% CI, −0.003, −0.001; P = 0.007) after controlling for age, sex, urticaria duration, and combined allergic diseases. Conclusions: EQ-5D values increased with improvement in urticaria control and decreased with urticaria severity. A predictive model mapping EQ-5D utility from UAS7 and UCT scores suggested that EQ-5D can be useful for the pharmacoeconomic evaluation of individualized treatments for CU patients.
High Incidence of Bell’s Palsy After Mastoidectomy: A Longitudinal Follow-up Study
Choi, Hyo Geun,Sim, Songyong,Hong, Sung Kwang,Park, Su-kyoung,Lee, Hyo-Jeong,Chang, Jiwon Lippincott Williams Wilkins 2017 Otology & Neurotology Vol.38 No.10
OBJECTIVE:: The objective of this study was to compare the prevalence of Bell’s palsy in participants who underwent mastoidectomy (to treat chronic otitis media) and nonmastoidectomy participants (control). METHODS:: Using the national cohort study from the Korean Health Insurance Review and Assessment Service, mastoidectomy patients (2,045) and control participants (8,180) were matched 1:4 for age, sex, income, and region of residence. The prevalence of Bell’s palsy in both the groups was measured from 0 to 10 years postoperation. RESULTS:: In a sample of 1,025,340 Korean individuals, 7,070 were diagnosed or treated with Bell’s palsy between 2002 and 2013; the annual incidence of Bell’s palsy was 0.057%. The overall prevalence of Bell’s palsy was three times higher in the mastoidectomy group (1.27%) than control group (0.49%) (p < 0.001). The prevalence of Bell’s palsy was different between the two groups in postoperative 0 year: 0.78% for the mastoidectomy group versus 0.01% for the control group (p < 0.001). CONCLUSION:: Although we could not verify the laterality, the prevalence of Bell’s palsy was increased in chronic otitis media patients treated with mastoidectomy patients compared with controls, especially within a year after surgery.