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일본의 연령주의 : 현황과 사회적 대응 (Ageism in Japan)
Okuyama Shoji 한국노년학회 2017 한국노년학회 학술발표논문집 Vol.2017 No.국제학술
Dr. Shoji Okuyama is currently President of Committee for Long-Term Care (LTC) insurance in Higashi-kurume-shi, Tokyo since 2000, and Professor Emeritus at Tokyo Keizai University from April of 2017. He graduated from Chuo University (B.A.), from Seijo University (MA and Ph.D. in Literature) and from Hitotsubashi University in Tokyo, Japan (Ph.D. in Sociology)(Ph.D., social welfare). Since 1972 until 1995, he had been researcher and senior researcher of Tokyo Metropolitan Institute of Gerontology (TMIG, now Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology). This during, he had been as visiting senior researcher at Center for the Study of Aging and Human Development in Duke University(USA). Since 1995 until May 2017, he had been Professor of social gerontology at Tokyo Keizai University and since 1995 until now, president and inspectors of Japan Socio-Erotological Society, Editorial Committee Member in Japanese Society for the Study of Social Welfare and Japan Society of Family Sociology. He also has worked many governmental committees and NGOs in Japan. He also has worked as part-time lecturer at many universities (Ochanomizu Women’s University, Waseda University, Nihon University, Dokkyo University, Toyo University and others). His publications include 30 books (including chapters) and 100 and over papers.
Kaori Shoji,Kaori Shoji,Masanobu Tsubaki,Yuzuru Yamazoe,Takao Satou,Tatsuki Itoh,Yasuhiro Kidera,Yoshihiro Tanimori,Masashi Yanae,Hideaki Matsuda,Atsushi Taga,Haruyuki Nakamura,Shozo Nishida 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.3
Mangiferin, 1,3,6,7-tetrahydroxyxanthone-C2-β-D-glucoside (C-glucosylxanthone), is a xanthone derivative that is widely distributed in higher plants. Recently, mangiferin was found to exhibit potential antitumor effects. However, the molecular mechanisms of this effect have not been elucidated. In the present study, we attempt to clarify the mechanism of mangiferininduced apoptosis in the human acute myeloid leukemia cell line HL-60; mangiferin was found to induce apoptosis. We also observed a concurrent increase in caspase-3 activity and DNA fragmentation. Furthermore, on examining the survival signals expressed during apoptotic induction, we observed that mangiferin caused a remarkable decrease in the nuclear entry of NF-κB p65. However, there were no changes in the expression of other survival signals,such as extracellular signal-regulated kinase 1/2, protein kinase B, and p38 mitogenactivated protein kinase. In addition, mangiferin suppressed the expressions of Bcl-xL and XIAP; however, we did not note any changes in the levels of Bcl-2, Bax, and Bim. These results indicate that mangiferin induces apoptosis by suppressing NF-κB activation and expressions of Bcl-xL and XAIP. These findings suggest that mangiferin may be useful as an anticancer agent and can be used in combination therapy with other anticancer drugs for the treatment of acute myeloid leukemia.
Factor Structure of the Targeted Inventory on Problems in Schizophrenia
Shoji Tanaka,Takanori Nagase,Takefumi Suzuki,Kensuke Nomura,Hiroyoshi Takeuchi,Shinichiro Nakajima,Hiroyuki Uchida,Gohei Yagi,Koichiro Watanabe,Masaru Mimura 대한정신약물학회 2013 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.11 No.1
Objective: The aim of this study was to explore the factor structure of a novel, 10-item rating scale, the Targeted Inventory on Problems in Schizophrenia (TIP-Sz). Determining the factor structure will be useful in the brief evaluation of medication and non-medication treatment of the disease. Methods: An exploratory factor analysis was performed on TIP-Sz scores obtained from 100 patients who met the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) criteria for schizophrenia. Results: The factor analysis extracted four factors that were deemed clinically pertinent, which we labeled: disorganization, social cooperativeness, functional capacity, and emotional state. The items exhibited cross-loadings on the first three factors (i.e.,some items loaded on more than one factor). In particular, the ‘behavioral dyscontrol and disorganization,’ ‘insight and reality testing,’ and ‘overall prognostic impression’ items had comparable cross-loadings on all of the first three factors. The emotional state factor was distinct from the other factors in that the items loading on it did not cross-load on other factors. Conclusion: The TIP-Sz scale comprises factors that are associated with the psychosocial functioning and emotional state of patients, which are important outcome parameters for successful treatment of the disease.
Verification and Mitigation of Seismic Failure in Concrete Piers under Near-field Earthquakes
Shoji Ikeda,Kazuhiko Hayashi,Toshihiko Naganuma 한국지진공학회 2007 한국지진공학회논문집 Vol.11 No.4
This paper verifies the difference of the seismic behavior and seismic damage of the neighboring two reinforced concrete piers damaged by the 1995 Hyogoken Nanbu earthquake. The two piers were almost the same size, carrying slightly different dead load, and were provided with the same reinforcement arrangement except the amount of longitudinal reinforcement at the bottom portion of the piers. The pier with more reinforcement was completely collapsed due to this near field earthquake by shear failure at the longitudinal reinforcement cut-off while the other was only damaged at the bottom by flexure even though the longitudinal reinforcement cut-off was also existed at the mid height of the pier. According to the results of the pseudo dynamic test, the seismic damage was recognized to be greatly dependent on the ground motion characteristics even though the employed ground motions had the same peak acceleration. The severe damage was observed when the test employed the seismic wave that had strong influence to the longer period range compared to the initial natural period of the pier. On the other hand, based on the similar model experiment, the defect of gas-pressure welded splice of longitudinal reinforcement was revealed to save the piers against collapse due to the so-called fail-safe mechanism contrary to the intuitive opinion of some researchers. It was concluded that the primary cause of the collapse of the pier was the extremely strong intensity and peculiar characteristics of the earthquake motion according to both the site-specific and the structure-specific effects.
RECENT DEVELOPMENTS OF MEMBRANE TECHNOLOGY IN JAPAN
Shoji Kimura 한국막학회 1991 멤브레인 Vol.1 No.1
Since the discovery of the Loeb-Sourirajan reverse osmosis membrane, thirty years have passed and many membrane technologies and new membranes for applications have been developed in the world. In the early stage of these developments Japan has not contributed much, but from the middle of 70ties Japan has started its own R&D projects starting from the desalination technology, and now various private industries and government ministries are actively engaging in R & D of membrane technologies in Japan. In Table 1 the chronological developments of important events of developments and projects relating membrane technologies inside and outside of Japan are introduced and their details will be explained. The first membrane technology applied in the Japanese industry was a electrodialysis(ED) process using ion-exchange membranes. These membranes were first developed in early 50ties and the Japanese government decided to use this method for concentration of sea-water to produce salt, which was then produced by solar evaporation. This development program started from 1960 by the Japan Monopoly Corp.(at that time). To apply ED process for sea-water concentration it was necessary to develop ion-exchange membranes having very low electric resistance to avoid energy loss due to Joule heat, and those having selectivity to permeate single valent ions only to avoid scale formation in the ED stacks. Three Japanese companies, Asahi Glass, Asahi Chemical and Tokuyama Soda, have succeeded to develop such membranes, and until 1971 all of the seven salt manufacturing companies had adopted ED for production of food salt.
Shoji Seki,Hayato Mine,Yoshiharu Kawaguchi,Hiroto Makino,Tomoatsu Kimura 대한척추외과학회 2015 Asian Spine Journal Vol.9 No.4
Thoracic and thoracolumbar ossification of the posterior longitudinal ligament (OPLL) can be difficult to treat due to the anatomical position. The purpose of this study was to report the significance of a novel surgical technique that represented two cases of thoracic or thoracolumbar OPLL. The first patient was a 72-year-old woman who had a beak-type OPLL at the T11/12. The second was a 45-yearold woman who had a beak-type OPLL at the T12/L1. We performed circumferential spinal cord decompression through a single posterior approach with microendoscopy in both cases. The postoperative computed tomography revealed the complete removal of the OPLL, and the magnetic resonance imaging confirmed adequate decompression of the spinal cord. Preoperative symptoms were substantially improved in both patients. To date, we have used this novel technique to treat five patients with thoracic or thoracolumbar OPLL. This new surgical technique is likely to be useful in patients with a beak-type OPLL of the thoracic or thoracolumbar spine.