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Can proximal Gastrectomy Be Justified for Advanced Adenocarcinoma of the Esophagogastric Junction?
Sato, Yuya,Katai, Hitoshi,Ito, Maiko,Yura, Masahiro,Otsuki, Sho,Yamagata, Yukinori,Morita, Shinji The Korean Gastric Cancer Association 2018 Journal of gastric cancer Vol.18 No.4
Purpose: To evaluate the status of number 3b lymph node (LN) station in patients with adenocarcinoma of the esophagogastric junction (AEG) and to investigate the optimal indications for radical proximal gastrectomy (PG) for AEG. Materials and Methods: Data of 51 patients with clinically advanced Siewert types II and III AEG who underwent total gastrectomy (TG) between April 2010 and July 2017 were reviewed. The proportion of metastatic LNs at each LN station was examined. Number 3 LN station was separately classified into number 3a and number 3b. The risk factors for number 3b LN metastasis and the clinicopathological features of number 3b-positive AEG patients were investigated. Results: The incidences of LN metastasis were the highest in number 1 (47.1%), followed by number 2 (23.5%), number 3a (39.2%), and number 7 (23.5%) LN stations. LN metastasis in number 3b LN station was detected in 4 patients (7.8%). A gastric invasion length of more than 40 mm was a significant risk factor for number 3b LN metastasis. All 4 patients with number 3b-positive AEG had advanced cancer with a gastric invasion length of more than 40 mm. The 5-year survival rate of patients with a gastric invasion length of more than 40 mm was 50.0%. Conclusions: Radical PG may be indicated for patients with AEG with gastric invasion length of less than 40 mm.
Can proximal Gastrectomy Be Justified for Advanced Adenocarcinoma of the Esophagogastric Junction?
Yuya Sato,Hitoshi Katai,Maiko Ito,Masahiro Yura,Sho Otsuki,Yukinori Yamagata,Shinji Morita 대한위암학회 2018 Journal of gastric cancer Vol.18 No.4
Purpose: To evaluate the status of number 3b lymph node (LN) station in patients with adenocarcinoma of the esophagogastric junction (AEG) and to investigate the optimal indications for radical proximal gastrectomy (PG) for AEG. Materials and Methods: Data of 51 patients with clinically advanced Siewert types II and III AEG who underwent total gastrectomy (TG) between April 2010 and July 2017 were reviewed. The proportion of metastatic LNs at each LN station was examined. Number 3 LN station was separately classified into number 3a and number 3b. The risk factors for number 3b LN metastasis and the clinicopathological features of number 3b-positive AEG patients were investigated. Results: The incidences of LN metastasis were the highest in number 1 (47.1%), followed by number 2 (23.5%), number 3a (39.2%), and number 7 (23.5%) LN stations. LN metastasis in number 3b LN station was detected in 4 patients (7.8%). A gastric invasion length of more than 40 mm was a significant risk factor for number 3b LN metastasis. All 4 patients with number 3b-positive AEG had advanced cancer with a gastric invasion length of more than 40 mm. The 5-year survival rate of patients with a gastric invasion length of more than 40 mm was 50.0%. Conclusions: Radical PG may be indicated for patients with AEG with gastric invasion length of less than 40 mm.
Yuji Ikeda,Sho Sato,Akira Yabuno,Daisuke Shintani,Aiko Ogasawara,Maiko Miwa,Makda Zewde,Takashi Miyamoto,Keiichi Fujiwara,Yusuke Nakamura,Kosei Hasegawa 대한부인종양학회 2020 Journal of Gynecologic Oncology Vol.31 No.6
Objective: Maternal embryonic leucine zipper kinase (MELK) is receiving an attentionas a therapeutic target in various types of cancers. In this study, we aimed to evaluate theprognostic significance of MELK expression in ovarian cancer using clinical samples, andassessed the efficacy of a small molecule MELK inhibitor, OTS167, using patient-derivedovarian cancer cells as well as cell lines. Methods: Expression levels of MELK in 11 ovarian cancer cell lines were confirmed bywestern blotting. Inhibitory concentration of OTS167 was determined by colorimetric assay. MELK messenger RNA (mRNA) expression was evaluated in 228 ovarian cancer patients byquantitative polymerase chain reaction. Growth inhibition of OTS167 was also evaluatedusing freshly-isolated primary ovarian cancer cells including spheroid formation condition. Results: MELK mRNA expression was significantly higher in ovarian cancer than in normalovaries (p<0.001), and high MELK mRNA expression was observed in patients with advancedstage, positive ascites cytology and residual tumor size. Patients with high MELK mRNAexpression showed shorter progression-free survival (p=0.001). Expression of MELK wasalso confirmed in 10 of 11 ovarian cancer cell lines tested, and the half maximal inhibitoryconcentration of MELK inhibitor, OTS167, ranged from 9.3 to 60 nM. Additionally, OTS167showed significant growth inhibitory effect against patient-derived ovarian cancer cells,regardless of their tumor locations, histologic subtypes and stages. Conclusions: We demonstrated MELK as both a prognostic marker and a therapeutic targetfor ovarian cancer using clinical ovarian cancer samples. MELK inhibition by OTS167 may bean effective approach to treat ovarian cancer patients.
Cavity Propagation Caused by Surface Discharge in Silicone Gel
Shin Nakamura,Masahiro Sato,Akiko Kumada,Kunihiko Hidaka,Sho Takano,Yuji Hayase,Keisuke Yamashiro,Tetsumi Takano 대한전기학회 2021 대한전기학회 학술대회 논문집 Vol.2021 No.10
Silicone gel is widely used to encapsulate power modules. The weakness of the insulation system is surface discharges propagating along with the interface between the silicone gel and substrate, which causes electrical degradation called a cavity. To realize more reliable power modules, there are high demands to clarify what mechanism the cavity propagates and what affects final cavity propagation length. This paper introduces our studies about the cavity phenomenon.
Katsuki Yaguchi,Reiko Kunisaki,Sho Sato,Kaori Hirai,Misato Izumi,Yoshimi Fukuno,Mami Tanaka,Mai Okazaki,Rongrong Wu,Yurika Nishikawa,Yusuke Matsune,Shunsuke Shibui,Yoshinori Nakamori,Masafumi Nishio,M 대한장연구학회 2024 Intestinal Research Vol.22 No.3
Background/Aims: Intestinal Behçet disease is typically associated with ileocecal punched-out ulcers and significant morbidity and mortality. Intestinal ultrasound is a noninvasive imaging technique for disease monitoring. However, no previous reports have compared intestinal ultrasound with endoscopic ulcer activity or histopathological findings for intestinal Behçet disease. We evaluated the usefulness of intestinal ultrasound for assessing the activity of ileocecal ulcers in intestinal Behçet disease.Methods: We retrospectively compared intestinal ultrasound findings with 73 corresponding endoscopic images and 6 resected specimens. The intestinal ultrasound findings were assessed for 7 parameters (bowel wall thickness, vascularity [evaluated using the modified Limberg score with color Doppler], bowel wall stratification, white-plaque sign [strong hyperechogenic lines or spots], mesenteric lymphadenopathy, extramural phlegmons, and fistulas), and endoscopic ulcer activity was classified into active, healing, and scar stages. Histopathological findings were evaluated by consensus among experienced pathologists. Results: Bowel wall thickness (P< 0.001), vascularity (P< 0.001), loss of bowel wall stratification (P= 0.015), and white-plague sign (P= 0.013) were significantly exacerbated in the endoscopic active ulcer stage. Receiver operating characteristic curve analysis revealed that a bowel wall thickness of > 5.5 mm (sensitivity 89.7%, specificity 85.3%) was potentially useful for detecting active lesions. When compared with histopathological findings, an increase in bowel wall thickness reflected the ulcer marginal ridge, and the white-plaque sign reflected the ulcer bottom. Conclusions: Intestinal ultrasound is useful for monitoring intestinal ulcer activity in intestinal Behçet disease.
Yamada, Yoichi,Kuklin, Artem V.,Sato, Sho,Esaka, Fumitaka,Sumi, Naoto,Zhang, Chunyang,Sasaki, Masahiro,Kwon, Eunsung,Kasama, Yukihiko,Avramov, Pavel V.,Sakai, Seiji Elsevier 2018 Carbon Vol.133 No.-
<P><B>Abstract</B></P> <P>We report the scanning tunneling microscope (STM) observation of the Li<SUP>+</SUP> ion endohedral C<SUB>60</SUB> on Cu(111), prepared by means of evaporation of a high-purity Li<SUP>+</SUP>@C<SUB>60</SUB>[PF<SUB>6</SUB> <SUP>−</SUP>] salt. The electronic state of Li<SUP>+</SUP>@C<SUB>60</SUB> in the Li<SUP>+</SUP>@C<SUB>60</SUB>[PF<SUB>6</SUB> <SUP>−</SUP>] salt was also determined using photoemission and X-ray absorption spectroscopy, along with the density functional theory (DFT) calculations. In the salt, Li and PF<SUB>6</SUB> had nearly single positive and negative charge, respectively; thus the C<SUB>60</SUB> cage was practically neutral. The salt decomposed under ultra-high vacuum while heating at 400 °C. This allowed the selective deposition of Li<SUP>+</SUP>@C<SUB>60</SUB> on Cu(111). Although secondary-ion mass spectroscopy of the deposited Li<SUP>+</SUP>@C<SUB>60</SUB> film showed a decrease in the Li-content during evaporation, Li<SUP>+</SUP>@C<SUB>60</SUB> was successfully identified using STM. The DFT calculations of Li<SUP>+</SUP>@C<SUB>60</SUB> on Cu(111) suggested that the Li<SUP>+</SUP> ion was singly charged and the location of the Li<SUP>+</SUP> ion was displaced in an upward direction, which altered the local density of states in an upper section of C<SUB>60</SUB>, especially for LUMO+2. The calculated results were mostly in agreement with the bias-dependent STM and dI/dV images. However, an inconsistency was observed between the calculation and experiments in case of empty state imaging where tip-induced displacement of the Li<SUP>+</SUP> ion may occur.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Sb NQR Study of the Filled Skutterudite CeFe4Sb12 Synthesized under High Pressure
Ko-ichi Magishi,,Masahiro Takahashi,Takahito Saito,Kuniyuki Koyama,Hitoshi Sugawara,Takashi Saito,Sho Tatsuoka,Kenya Tanaka,Hideyuki Sato 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.63 No.3
We report the results of Sb nuclear quadrupole resonance (NQR) measurements on the filledskutterudite CeFe4Sb12 synthesized under high pressure (HP) and compare them with those forthe sample synthesized under ambient pressure (AP) to understand the influence of the Ce-sitefilling fraction. The NQR spectra for the HP sample are much sharper than those for the APsample, suggesting that the Ce filling fraction is higher. Also, the nuclear spin-lattice relaxationrate 1/T1 follows an exponential decrease 1/T1 ∝ exp(−Δ/kBT), with the gap being Δ/kB = 270K at temperatures above 100 K, which is larger than that for the AP sample. This result suggeststhat the c-f hybridization is enhanced by increasing the Ce-site filling fraction.