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Yuji Ikeda,Akiko Furusawa,Ryo Kitagawa,Aya Tokinaga,Fuminori Ito,Masayo Ukita,Hidetaka Nomura,Wataru Yamagami,Hiroshi Tanabe,Mikio Mikami,Nobuhiro Takeshima,Nobuo Yaegashi 대한부인종양학회 2016 Journal of Gynecologic Oncology Vol.27 No.3
Objective: Although radiation therapy (RT) and concurrent chemoradiotherapy (CCRT)are the global standards for adjuvant therapy treatment in cervical cancer, many Japaneseinstitutions choose chemotherapy (CT) because of the low frequency of irreversible adverseevents. In this study, we aimed to clarify the trends of adjuvant therapy for intermediate/highriskcervical cancer after radical surgery in Japan. Methods: A questionnaire survey was conducted by the Japanese Gynecologic OncologyGroup to 186 authorized institutions active in the treatment of gynecologic cancer. Results: Responses were obtained from 129 facilities. Adjuvant RT/CCRT and intensitymodulatedRT were performed in 98 (76%) and 23 (18%) institutions, respectively. On theother hand, CT was chosen as an alternative in 93 institutions (72%). The most commonregimen of CT, which was used in 66 institutions (51%), was a combination of cisplatin/carboplatin with paclitaxel. CT was considered an appropriate alternative option to RT/CCRTin patients with risk factors such as bulky tumors, lymph node metastasis, lymphovascularinvasion, parametrial invasion, and stromal invasion. The risk of severe adverse events wasconsidered to be lower for CT than for RT/CCRT in 109 institutions (84%). Conclusion: This survey revealed a variety of policies regarding adjuvant therapy amonginstitutions. A clinical study to assess the efficacy or non-inferiority of adjuvant CT iswarranted.
Three-Dimensional Characterization of Strong Recirculating Flow by Stereoscopic PIV
Ikeda, Yuji,Palero, Virginia,Sato, Kei,Nakajima, Tsuyoshi The Korean Society of Combustion 2002 한국연소학회지 Vol.7 No.1
Spray characteristics in the swirling flow were investigated by Stereoscopic PIV. Spatial spray structures were measured by PIV as well as PDA in order to understand stable flame stabilization. The feasibility study of Stereoscopic PIV in spray flame was also demonstrated. The size and location of recirculation flow were measured. The stereoscopic PIV could provide 3-D flow fluctuation that cannot be measured by convectional measurement systems.
Yuji Ikeda,Sho Sato,Akira Yabuno,Daisuke Shintani,Aiko Ogasawara,Maiko Miwa,Makda Zewde,Takashi Miyamoto,Keiichi Fujiwara,Yusuke Nakamura,Kosei Hasegawa 대한부인종양학회 2020 Journal of Gynecologic Oncology Vol.31 No.6
Objective: Maternal embryonic leucine zipper kinase (MELK) is receiving an attentionas a therapeutic target in various types of cancers. In this study, we aimed to evaluate theprognostic significance of MELK expression in ovarian cancer using clinical samples, andassessed the efficacy of a small molecule MELK inhibitor, OTS167, using patient-derivedovarian cancer cells as well as cell lines. Methods: Expression levels of MELK in 11 ovarian cancer cell lines were confirmed bywestern blotting. Inhibitory concentration of OTS167 was determined by colorimetric assay. MELK messenger RNA (mRNA) expression was evaluated in 228 ovarian cancer patients byquantitative polymerase chain reaction. Growth inhibition of OTS167 was also evaluatedusing freshly-isolated primary ovarian cancer cells including spheroid formation condition. Results: MELK mRNA expression was significantly higher in ovarian cancer than in normalovaries (p<0.001), and high MELK mRNA expression was observed in patients with advancedstage, positive ascites cytology and residual tumor size. Patients with high MELK mRNAexpression showed shorter progression-free survival (p=0.001). Expression of MELK wasalso confirmed in 10 of 11 ovarian cancer cell lines tested, and the half maximal inhibitoryconcentration of MELK inhibitor, OTS167, ranged from 9.3 to 60 nM. Additionally, OTS167showed significant growth inhibitory effect against patient-derived ovarian cancer cells,regardless of their tumor locations, histologic subtypes and stages. Conclusions: We demonstrated MELK as both a prognostic marker and a therapeutic targetfor ovarian cancer using clinical ovarian cancer samples. MELK inhibition by OTS167 may bean effective approach to treat ovarian cancer patients.
( Yuji Maehata ),( Shotaro Nakamura ),( Motohiro Esaki ),( Fumie Ikeda ),( Tomohiko Moriyama ),( Risa Hida ),( Ema Washio ),( Junji Umeno ),( Minako Hirahashi ),( Takanari Kitazono ),( Takayuki Matsum 대한간학회 2017 Gut and Liver Vol.11 No.5
Background/Aims: Gastric cancers develop even after suc-cessful Helicobacter pylori eradication. We aimed to clarify the characteristics of early gastric cancers discovered after H. pylori eradication. Methods: A total of 1,053 patients with early gastric cancer treated by endoscopic submucosal dis-section were included. After matching the propensity score, we retrospectively investigated the clinicopathological fea-tures of 192 patients, including 96 patients who had under-gone successful H. pylori eradication (Hp-eradicated group) and 96 patients who had active H. pylori infection (Hp-positive group). Results: In the Hp-eradicated group, early gastric cancers were discovered 1 to 15 years (median, 4.1 years) after H. pylori eradication. Compared with Hp-positive pa-tients, Hp-eradicated patients showed a more frequently de-pressed configuration (81% vs 53%, respectively, p<0.0001) and a higher trend toward submucosal invasion (18% vs 8%, respectively, p=0.051). A multivariable analysis revealed the macroscopic depressed type to be characteristics of early gastric cancers after H. pylori eradication. Among patients in the Hp-eradicated group, metachronous cancers showed less frequent depressed lesions (68% vs 84%, respectively, p=0.049) and smaller tumor sizes (median, 11 mm vs 14 mm, respectively, p=0.014) than primary cancers. Conclu-sions: Early gastric cancers after H. pylori eradication are characterized by a depressed configuration. Careful follow- up endoscopies are necessary after H. pylori eradication. (Gut Liver 2017;11:628-634)
Yuji Kasashima,Tatsuo Tabaru,Takashi Ikeda 대한전자공학회 2023 Journal of semiconductor technology and science Vol.23 No.1
In plasma etching process at LSI mass-production line, the particles cause the decrease in the production yield and the overall equipment effectiveness (OEE). In this study, the particles, which originate from etching reaction product, are investigated under the condition that a gas shower type electrode made from the developed MgO-based ceramics is used and a Si wafer is etched by using SF6 gas. We have demonstrated that plasma impedance monitoring method can monitor the tendency of particle generation caused by the flaking off of the film deposited on chamber inner walls. This non-invasive measurement method can be easily applied to the process equipment at mass-production line therefore the results can contribute to improvement of the production yield and the OEE.
Keisuke Nishimura,Takashi Ikeda,Yuji Harata 대한기계학회 2015 대한기계학회 춘추학술대회 Vol.춘계 No.-
The behavior of dual centrifugal pendulum vibration absorbers (CPVAs) are investigated when they are attached to a rotor in order to suppress torsional vibrations of a horizontally rotating shaft. The frequency response curves are theoretically determined using van der Pol’s method in the two cases where CPVAs are attached at point-symmetrical positions and identical positions. In the former case, Hopf bifurcations occur and combination resonances appear at comparatively higher rotational seeds than a Hopf bifurcation point. In the latter case, two types of localization phenomena may occur depending on the stiffnesses of torsion springs installed at the supporting points of the CPVAs. These phenomena are confirmed by calculating time histories and their frequencies. It is concluded that the optimal positions of the two pendula may exist to suppress the torsional vibrations of the rotor.
Jeong, Haeyoung,Lee, Kihyung,Ikeda, Yuji IOP Pub 2007 Measurement Science and Technology Vol.18 No.5
<P>There are many ways to reduce diesel engine exhaust emissions. However, NO<SUB><I>x</I></SUB> emission is difficult to reduce because the hydrocarbon (HC) concentration in a diesel engine is not sufficient for NO<SUB><I>x</I></SUB> conversion. Therefore, in order to create stoichiometric conditions in the De-NO<SUB><I>x</I></SUB> catalyst, a secondary injection system is designed to inject liquid HC into the exhaust pipe. The atomization and distribution characteristics of the HC injected from a secondary injector are key technologies to obtain a high NO<SUB><I>x</I></SUB> conversion because inhomogeneous droplets of injected HC cause not only high fuel consumption but also deterioration of NO<SUB><I>x</I></SUB> emission. This paper describes the spray characteristics of a secondary injector including the spray angle, penetration length and breakup behaviour of the spray to optimize the reduction rate of the NO<SUB><I>x</I></SUB> catalyst. In this study, various optical diagnostics were applied to investigate these spray characteristics, the atomization mechanism and spray developing process. The visualization and image processing method for the spray pulsation were developed by high speed photography. The influence of the fuel supply pressure on the spray behaviour and a more detailed spray developing process have been analysed experimentally using image processing. Finally, the experimental results were used to correlate the spray structure to the injection system performance and to provide a design guide for a secondary injector nozzle.</P>