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z-방향으로 비등방적인 원통형 결함을 가진 YBCO 단결정의 자속운동
심성엽,황태종,김동호 嶺南大學校 基礎科學 硏究所 1998 基礎科學硏究 Vol.18 No.-
We have made a comparison of the magnetic properties between columnar defect introduced YBCO single crystal(S#1) and partially introduced crystal(S#2).Magnetization vs. applied field curves of S#1 had larger width than S#2 by SQUID magnetometer measurement. But if we considered the volume of partially introduce columnar defect in S#2, the curves of magntization of S#1 and S#2 showed nearly same magnitude. Moreover, S#1 and S#2 showed same normalized relaxation rate thus we may concluded that only the part of columnar defect contrubute the flux pinning in S#2. Irreversibility line(IRL)was obtained from AC susceptibility measurement. IRL of S#2 showed downward shift relative to the case of S31. Below the Bcr, exponent αwas 1.85 and 1.68 in the S#2, respectively. Bose-glass phase was even showed in the case of S#2 defect structure.
Kim, S Y,S Hong, Y,K Shim, E,Kong, S-Y,Shin, A,Baek, J Y,Jung, K H Nature Publishing Group 2013 The British journal of cancer Vol.109 No.6
<P><B>Background:</B></P><P>S-1 is an oral fluoropyrimidine that mimics infusional 5-fluorouracil. The aim of this phase II trial was to explore the clinical efficacy of the triplet regimen TIROX, which consists of S-1, irinotecan and oxaliplatin.</P><P><B>Methods:</B></P><P>Forty-two chemo-naive patients with metastatic colorectal cancer (mCRC) were planned to be enrolled and be treated with irinotecan 150 mg m<SUP>−2</SUP> followed by oxaliplatin 85 mg m<SUP>−2</SUP> on day 1 and S-1 80 mg m<SUP>−2</SUP> per day from day 1 to 14 every 3 weeks. Polymorphisms in the <I>UGT1A1</I>, <I>UGT1A6</I>, <I>UGT1A7</I> and <I>CYP2A6</I> genes were analysed.</P><P><B>Results:</B></P><P>Between July 2007 and February 2008, 43 patients were enrolled. An objective response was noted in 29 patients (67.4%, 95% confidence interval: 53.4–81.4), of which 2 achieved durable complete responses. The median progression-free survival was 10.0 months and the median overall survival was 19.2 months. Significant grade 3 or 4 adverse events were neutropenia (45.2%), febrile neutropenia (9.5%), diarrhoea (7.1%) and vomiting (9.5%). Increased gastrointestinal toxicities were associated with the presence of <I>UGT1A6*2</I> or <I>UGT1A7*3</I> and an improved tumour response was noted in those without variant alleles of <I>CYP2A6</I> or <I>UGT1A1*60</I>.</P><P><B>Conclusion:</B></P><P>The combination of S-1, irinotecan and oxaliplatin showed favourable efficacy and tolerability in untreated patients with mCRC.</P>
Yoon, I.S.,Chung, C.W.,Sung, J.H.,Cho, H.J.,Kim, J.S.,Shim, W.S.,Shim, C.K.,Chung, S.J.,Kim, D.D. Society for Bioscience and Bioengineering, Japan ; 2011 Journal of bioscience and bioengineering Vol.112 No.4
Human adipose-derived mesenchymal stem cells (AD-MSCs) attracted much interest as a promising alternative to autologous chondrocytes and bone marrow-derived mesenchymal stem cells for cartilage regeneration. Developing a suitable culture technique to direct AD-MSCs into the chondrogenic lineage could be a crucial prerequisite for the cartilage defect repair application of AD-MSCs. Herein, we prepared the PEGDG-crosslinked porous three-dimensional (3D) hyaluronic acid (HA) scaffold and evaluated for its feasibility to induce proliferation and chondrogenic differentiation of the AD-MSCs. In addition, the effect of bone-morphogenetic protein-2 (BMP-2) and platelet-derived growth factor (PDGF) on chondrogenic differentiation was further investigated. Proliferation and chondrogenic differentiation were evaluated by cell morphology, DNA contents, s-GAG contents, and level of mRNA expression of relevant marker genes. When cultured with reference chondrogenic medium (RCM; serum-free DMEM-HG supplemented with 10ng/mL of transforming growth factor-β1 (TGF-β1), 50nM ascorbate, 100nM dexamethasone, and 5μg/mL of ITS), better proliferation and chondrogenic differentiation of AD-MSCs were obtained in the 3D HA scaffold culture as compared to the micromass culture, a standard 3D culture system. Moreover, the level of chondrogenic differentiation of AD-MSCs in the HA scaffold-RCM culture system was further increased by BMP-2, and decreased by PDGF. These results suggested that the HA scaffold with RCM was a promising chondrogenic culture system of AD-MSCs, and that BMP-2 could potentially serve as a chondrogenic supplement for AD-MSCs. However, PDGF was determined to be an inappropriate supplement based on its inhibition of the chondrogenic differentiation of AD-MSCs.
Fentanyl Transdermal System의 약물사용평가
심릿다,윤혜영,오지영,강진숙,김옥녀 한국병원약사회 1997 병원약사회지 Vol.14 No.1
DUROESIC^(R) is a transdermal patch providing continuous systemic delivery of fentanyl, a potent opioid analgesic for 72 hours. A retrospective Drug Use (DUE) study on fentanyl Transdermal Therapeutic System(TTS) was conducted. The charts of 50 patients, hospitalized at St. Mary's Hospital from March 1. 1996 to May 31. 1996 and applied fentanyl TTS, were reviewed. The procedure collaborated DUS criteria for fentanyl TTS established by American Journal of health-system pharmacists(AJHP) and manufacturer's guideline. The following information was gathered for patient; indication for use, initial dosage, and dosage interval. As a result, 46 patients(96%) met the criteria for indication of use, 30 patients met the criteria for initial dosage conforms, and 42 patients met criteria for dosage interval. Adverse effects, constipation(44%), nausea/vomiting(23%), respiratory depression (13%), etc, were observed. This study suggests the education for TTS dosage form needs to be provided to medical team.
HMM을 이용한 연속 음성인식 시스템의 화자적응화에 관한 연구
심장엽,김상범,김주성,김수훈,이영재,이종진,허강인 동아대학교 공과대학 부설 한국자원개발연구소 1995 硏究報告 Vol.19 No.2
It is hard to collect sufficient speech data for training a speaker-dependent (SD) model from the same speaker. In contrast, to trains a speaker-independent (SI) model need not collect a large amount of speech data per speaker but from many speakers. Speaker-adaptation (SA) is an additional training technique from SI model by a small amount of adaptation speech. It has proved to be a powerful tool for achieving good recognition performance without the high cost of SD training. In this study, a speaker adaptation algorithm (MAPE) which trains it by every utterance sequentially without hand-labelling is introduces. The hand-labelling is performed automatically by Concatenation training and Viterbi-segmentation. The secuential-training is performed by MAPE(Maximum A Posteriori probability Estimation). We can train it using any small amount of adaptation speech data. For newspaper editorial continuous speech, the recognition rates of adaptation of HMM was 62.5% respectively which is approximately 32.5% improvement over that of unadapated HMM.