詩經正變設考

金時俊 서울대학교 동아문화연구소 1979 東亞文化 Vol.16 No.-

It was written at the Mao Shi prefaces (毛詩序) that Shi Jing was divided into two groups; the Zheng Poem and the Bian Poem. According to this, many scholars published various assertions on how to distinguish the Zheng Poem from the Bian Poem in Shi Jing. Conseguently, these assertions were classified into four sorts. 1) Classification by the chronological order according to the political rise and fall 2) Distinction between eulogy and satire 3) Distinction the Poem which was accompanied by music from the poem which was not accompanied by it, 4) Classification by the style of the poem My study on each assertion leads to the following conclusion: 1) Although those scholars who made the first assertion defined that Shi Jing was published by the chronological order and they distinguished the Zheng Poem from the Bian poem by the table of contents, it is proved that Shi Jing was not published by the chronological order. 2) Those scholars who made the second assertion concluded that Shi-Jing was distinguished between eulogy and satiry at every prologue in Mao Shi and that the Zheng poem and the Bian Poem could be divided into eulogy or satire accordingly. But it is proved herein that the distinction eulogy from satire in Mao Shi prefaces was possible by the country and chronology without the definite standard even though the contents of the poem were the same. 3) Those scholars who made the third assertion divided Shi Jing into two parts. One that was accompanied by music was called the Zheng Poem and the other that was accompanied by music was called the Bian Poem. But it is proved that all of Shi Jing were accompanied by music 4) Those who made the fourth assertion distinguished between the Zheng Poem and the Bian Poem by the style of the Poem. But looking into the style, it is proved that the distinction between the Zheng Poem and the Bian Poem is the style itself. Thus, the above classifications seem to be unreasonable so far. Then, why did these assertions come to rise? These assertions were due to the Han scholars who regarded the poem as a remonstration. They attempted to classify the Zheng Poem as the poem of admonition and the Bian poem as that of warning. But they did not succeed in it.

Blocking of Cell Proliferation, Cytokines Production and Genes Expression Following Administration of Cordyceps Sinensis in the Bronchoalveolar Lavage Fluids Cells

Kuo, Yuh-Chi,Wu, Chia-Lin,Tasi, Wei-Jern,Wang, Jir-Yenn,Chang, Shi-Chung,Lin, Ching-Yuang,Shiao, Ming-Shi 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1

Yuh-Chi Kuo¹,Chia-Lin Wn¹,Wei-jern Tasi¹,Jir-Yenn Wang²,Shi-Chung Chang₃,Ching-Yung Lin⁴,and Ming-Shi Shiao⁴¹National Research Institute of Chinese Medicine, ²Department of Biology,Fu Jen University, ³Department of Chest, ⁴Department of Pediatrics, □De[art,amt of Medical Research and Education. Taipei Veterans General Hospital, Taipei, Taiwan Yuh-Chi Kuo¹,Chia-Lin Wn¹,Wei-jern Tasi¹,Jir-Yenn Wang²,Shi-Chung Chang²,Ching-Yung Lin³,and Ming-Shi Shiao⁴.¹National Research Institute of Chinese Medicine, ²Department of Biology,Fu Jen University, ³Department of Chest, ⁴Department of Pediatrics, □De[art,amt of Medical Research and Education. Taipei Veterans General Hospital, Taipei, Taiwan. Blocking of Cell Proliferation, Cytokines Production and Genes Expression Following Administration of Cordyceps sinensis in the Bronchoalveolar Lavage Fluids Cells. Proceedings of international Symposium on East-West Medicine, Seoul. 44-64, 1999.-Cordyceps sinensis is a major parasitic fungus on larva of Lepidoptera. It is one of the well know fungi used in traditional Chinese medicine for treatment asthma, lung and kideney diseases. Many fungi belonging to the genus Cordyceps have been demonstrated to produce natural products with various biological activities. Reported biological activities of genus cordyceps include:(a)inhibition of DNA and RNA synthesis;(b)enhancement of cell differentiation;(c)restruction of cytoskeleton;(d)inhibition of protein kinase activity;(e)antitumor activity on bladder, colon, lung carcinoma as well as fibroblastoma;(f)inhibition of the infection and revers transciptase activity of human immunodeficiency virus type 1; and(g) inhibition of methylation of nucleic acid. Thus, it is suggested that the extracts of Cordyceps sp. Contain antitumor, antiviral, and many other biological activities. In our previous studies, we proved that C. sinensis contains the antitumor and immunomodulatory agents. In the present studies, effects of C. sinensis on bronchoalveolar lavage fluids(BAL)cells were demonstrated. The crude methanolic extracts of C. sinensis were fractionated into 15 fractions by silica gel column chromatography. Effects of various fraction on BAL cells proliferation and lipopolysaccharide(LPS) stimulated interleukin-1β(IL-8),platelet activating factor(PAF), interleukin-6(IL-6), tumor necrosis factor-α(TNF-α),and interleukin-8(IL-8) production on BAL cells were determined. The result indicated that the CS-19-22 fraction suppressed BAL cells proliferation activated by LPS. The median inhibitory concentration(IC50) was 6㎍/ml. The CS-19-22 fraction also decreased IL-1β,PAF,IL-6, TNF-αand IL-8 production.The results of revers transcription-polymerase chain reaction(RT-PCR) demonstrated that the CS-19-22 fraction did not affect IL-1β,PAF,IL-6, TNF-α,and IL-8 mRNAs expression in BAL cells activated by LPS. By contrast, it inhibited the IL-10 mRNA expression but enhanced IFN-γand IL-12 mRNAs expression in activated BAL cells. Moreover, the CS-19-22 fraction blocked PAF-induced platelet aggregation. It is unlikely that cytotoxicity was involved. Because no cell deths were observable. We hypothesize that inhibitory mechanisms of CS-19-22 on BAL cells proliferation may be related to the impairments of gene expression and production of cytokines in BAL cells. The explanation of C. sinensis antiasthma function may involved the following(1)C.sinenesis contained immunomodulatory agents that stimulated IFN-γand IL-12 expression in TH1cells.(2)Enhanced secretion of IFN-γand IL-12 will inhibit the Tγcells immune responses Ex. Decreasing of IL-6 and IL-10 production.(3) The impairments of cytokines production in TH2 cells suppressed th BAL cells proliferation then more cytokines production Ex.IL-1β,PAF,IL-6,TNF-αand IL-8 in activated BAL cells were decreased. (4)The suppression of TH2cells immune responses will inhibit the growth and differentiation of B cells then IgE production will be decreased. (5)Reduced production of IgE will decreased asthma attack occurring in individuals. However, the results of the present study suggested that C. sinensis may also have acted to treat asthma in part by inhibiting BAL cells proliferation and cytokine gene expression and production. Future, experiments with treatment of animals with asthma with C. sinensis will be necessary to defined whether C. sinensis can reduce asthma injury. Plans are underway for the isolation of pure principal growth inhibitors and their mechanisms of action are subjected for further study.

Hot Deformation Characteristics and Processing Map Analysis of Pre-Forged AZ80 Magnesium Alloy

Shi‑quan Huang,Ming Lu,Sheng‑lan Luo,Hai‑lin He,You‑ping Yi 대한금속·재료학회 2021 METALS AND MATERIALS International Vol.27 No.5

The hot deformation behavior of pre-forged AZ80 magnesium alloy is investigated by the isothermal compression tests attemperatures of 523–683 K and strain rates of 0.0001–0.1 s−1, and analyzed by the processing maps for guiding isothermaldie forging. Flow localization and even cracking occurs at low temperatures and high strain rates, where shear deformationdegree shows a positive correlation with the ��( ̇�� ) value. Two stability regions with high efficiency is found out by theprocessing maps. At common stability region with high temperatures and low strain rates, peak power dissipation efficiencydoes not represent optimum deformation condition as reported in other materials. A Z parameter criterion is introduced forparameters optimization. javascript:void(0); a new stability domain of 523–590 K and 0.0001–0.01 s−1 is observed, which istypical for fine microstructure composed of equiaxed clean α-Mg grains and big particles both about 1 μm (573 K/0.01 s−1).Super plasticity is speculated to occur at that condition.

Study on Marketing Policy of Beijing’s Incentive Tourism Promotion

Shi,Mei-Yu 동북아관광학회 2011 동북아관광연구 Vol.7 No.2

등속성 근력 측정기를 이용한슬관절 우력 곡선의 분석

이시욱,한태륜,방문석 大韓再活醫學會 2000 Annals of Rehabilitation Medicine Vol.24 No.5

소아 중증 두뇌손상환자에 대한 임상적 고찰

송시헌 충남대학교 의과대학 지역사회의학연구소 1994 충남의대잡지 Vol.21 No.2

The purpose of this study is to report the outcomes of 73 children, 15 years of age or younger, who were consecutively admitted to Chungnam National University Hospital over a 5-year period with nonpenetrating severe brain injury and to compare these results with reports from other centers in a community with well trained paramedic care and an excellent transfer system. In addition, clinical analysis of the relationship between age, initial GCS score, coma duration, clinical findings, intracranial lesions and outcome have been studied. The results were as follows : 1. The average age was 8.7 years and occured predominantly in males(2.3 : 1 ratio). 2. The most common cause of brain injury was motor vehicle accident (84.9%). 3. The number of patients with intracranial hematoma was 25(34.2%) and patients with acute subdural hematoma showed the poorest outcome. 4. Seventeen patients(23.3%) died, fourty-six patients(63%) recovered functionally and ten patients (13.7%) showed a nonfunctional outcome. 5. A significant relationship was found between outcome, initial GCS score and bilateral pupillary abnormalities. However, the age, duration of coma, other clinical findings and intracranial lesions, except acute subdural hematoma, did not relate to the outcome.

강직성 뇌성마비 환아를 위한 선택적 척수 후신경근 절단술

송시헌 충남대학교 의과대학 지역사회의학연구소 1996 충남의대잡지 Vol.23 No.2

Cerebral palsy is a multifaceted disorder of which spasticity is only one aspect. Selective posterior rhizotomy(SPR) is a well-established treatment for spasticity associated with cerebral palsy and favorable results have been reported from a number of different centers. However, the techniques used in performing SPR to treat spastic cerebral palsy remains controversial. A review of the personal experience of the SPR performed at Chungnam National University Hospital(CNUH) for reduction of spasticity in children with cerebral palsy is presented. The SPR procedure performing in CNUH involves an L1 and L2 laminectomy, followed by the about 60.9% selective section of certain lumbosacral posterior spinal nerve rootlets(Ll-S1 or S2), based on the electromyographic responses to their electrical stimulation. All patients showed markedly relieved or disappeared spasticity on post-rhizotomy neurologic examination. Postoperative physical and occupational therapy are felt to be essential for regaining strength and improving motor function following the SPR.

한국기업의 경영혁신전략과 추진과정모델

고시천 建國大學校 經濟經營硏究所 1998 商經硏究 Vol.23 No.2

In the era of globalization and information revolution, Korean Firms are facing with new challenges and crises from the hyperturbulent and chaotic environments. Therefore, They must search for new management paradigms and management Innovation strategy for surviving and overcoming the urgent and tremendously cataclysmal threats. The purpose of this paper of this paper reviews the concepts, approaches, and obstacles of management innovation and also to describe the management innovation strategy and it's implementation process model for the Korean Firms.

소아 두개저 골절의 임상적 고찰

송시헌 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.2

The purpose of this study is to analyze clinical features of 51 patients, who have admitted Chungnam National University Hospital, from January 1, 1992, to, June 30, 1997, with basal skull fracture in children. The results were as follows: 1. The peak age was 3-12 year-old and occured predominantly in male(1.7:1 ratio). 2. The most common cause of trauma was traffic accident(80.4%). 3. The frequent clinical features, in decreasing order of frequency, were pneumocephalus(72.5%), CSF otorrnea(33.3%), raccoon eye(23.5%), CSF rhinorrhea(21.6%), and facial palsy(15.7%). 4. The basal skull fracture line was detected in only 49% of cases by skull X-ray film. 5. The degree of development of paranasal sinus were poor in 68.2%. 6. CSF leak was noted in 66.75 of cases and among them 79.5% of cases were stopped spontaneously.

효소 중합반응에 의한 인공 cDNA 클론의 형성

유시현,권무식 成均館大學校 科學技術硏究所 1992 論文集 Vol.43 No.2

The sequence-specific DNA binding protein, PU.1 common to macrophage and B cell in mammals, is one of the transcription activators. Its DNA binding activity seems to correlate with the phosphorylation of specific serine residue(s). It is, however, not clear that which serine(s) could be phosphorylated for the activation of PU.1. To understand the phosphorylation mechanism of the transcription factor, the first nucleotide coding the 11th amino acid [TCC] of PU.1, "Thymidine", was substituted with "Guanidine" by site-directded mutagenesis. The mutant PU.1 cDNA restricted by Xba I and Hind III, was ligated into Xbal-HindIII cut pBluescript KS+, and then transformed into E.coli JM109 to generate a new mutant clone of PU.1. The mutant will be instrumental in evaluating a plausible phosphorylation site of PU.1.