한국인 열성 이영양형 수포성 표피박리증 환자의 임상 경과 및 장기 예후에 대한 후향적 단일기관 종단 연구

이승주 ( Seungju Lee ),이상균 ( Sang Gyun Lee ),김수찬 ( Soo-chan Kim ),이상은 ( Sang Eun Lee ) 대한피부과학회 2022 대한피부과학회지 Vol.60 No.1

Background: Recessive dystrophic epidermolysis bullosa (RDEB) manifests in various cutaneous and extracutaneous complications that lead to considerable morbidity and mortality, however, no precise incidence data are available. Objective: To investigate the prevalence of inherited epidermolysis bullosa (EB) stratified by subtypes, demographics, and clinical characteristics in Korean patients with EB, and major clinical events and outcomes in Korean RDEB patients. Methods: A total of 179 patients diagnosed with EB at a single tertiary hospital between January 2005 and January 2020 were retrospectively analyzed. Results: Among the 179 patients, 86 (48.0%) had EB simplex, 45 (25.1%) had dominant dystrophic EB, 38 (21.2%) had RDEB, and 10 (5.6%) had juncttional EB. Symptoms of the disease were present at age 1 year in 38 patients with RDEB (100%), 10 with junctional EB (100%), 41 with dominant dystrophic EB (91.1%), and 63 with EB simplex (73.3%). Among the 38 patients with RDEB, 20 (52.6%) had anemia, 21 (55.3%) had pseudosyndactyly, 9 (23.7%) had cardiac disorder (23.7%) (e.g., dilated cardiomyopathy), 9 (23.7%) had ophthalmic disorders, 11 (28.9%) had methicillin-resistant Staphylococcus aureus skin infection, 7 (18.4%) had esophageal stricture, and 4 (10.5%) developed squamous cell carcinoma at a mean age of 46.7 years. Seventeen subjects (44.7%) underwent hand/foot surgery at a mean age of 6.6 years. Six subjects (15.8%) underwent esophageal dilation at a mean age of 23 years. Five patients (13.2%) died. Conclusion: RDEB affects multiple organ systems and requires a multidisciplinary therapeutic approach. Understanding the incidence and outcomes of milestone clinical events is crucial for optimal management of RDEB patients. (Korean J Dermatol 2022;60(1):7∼15)

온실측고 인상기술 및 리모델링기술의 현장적용

이승주 ( Seungju Lee ),신동창 ( Dongchang Shin ),김태욱 ( Teawook Kim ),이종원 ( Jongwon Lee ),이현우 ( Hyunwoo Lee ),심상연 ( Sangyoun Sim ) 한국농공학회 2014 한국농공학회 학술대회초록집 Vol.2014 No.-

국내 측고인상기술이 주로 플라스틱온실을 대상으로 웜기어(전동방식)를 이용하여 일률적인 인상이 구현되기 어렵고 인상이 완료된 후에도 별도의 구조계산 없이 신규기둥을 보강하여 파이프가 휘거나 무게중심이 한쪽으로 쏠리는 문제들이 나타나고 있다. 따라서, 본 연구는 공압식을 이용하여 플라스틱온실과 유리온실 겸용으로 제작된 인상장치를 현장에 적용하고, 인상 후 개발한 리모델링 기술을 통해 구조적안전성을 확보 하고자 수행되었다. 장소는 전남 장흥군에 위치한 1-2W형 플라스틱온실(48mm원형/10,000㎡)에서 2014년 7월 부터 8월까지 실시되었으며, 4연동(1번온실, 2,500㎡),4연동(2번온실, 2,500㎡), 8연동(3번온실, 5,000㎡)으로 구역을 분리하여 인상장치를 4m~8m 간격으로 각각 119개, 79개, 111개 설치되었다. 인상도중 시설물 쓰러짐이나 붕괴 등의 피해를 최소화하기 위하여 전도방지장치를 추가로 설치하여 구조안전성을 확보하였다. 인상장치는 공압식으로 컴프레셔에서 9.0kgf/㎠ 의 토출압력을 주입하여 순차적으로 인상하였다. 인상 전 측고는 3,000(1번,2번온실)~3,300mm(3번온실)이었다. 현장적용 결과, 총 10,000㎡ 면적의 온실을 1,800mm 인상 완료하였으며, 허용변형량은 1회 기준 500mm이었고 인상속도는 별도의 에어노즐을 제작하여 1라인 15초 이내로 제어하여 일률적으로 인상하였다. 작업시간은 4연동(1번온실, 2번온실) 인상 시, 4시간~4시간 30분, 8연동(3번온실) 인상 시, 6시간 정도 소요되었다. 앞선 결과는 국내에서 기존에 온실을 수동으로 인상할 때 30일 소요되는 노동력을 절감 할 수 있을 것으로 생각하며 전도방지장치 설치로 인하여 온실이 좌우로 흔들리는 현상을 방지하는 것을 확인 할 수 있었다. 또한, 인상 후 신규기둥은 총 길이가 2,023mm으로 양쪽을 인발(115mm)하여 고정하였고, 방풍벽에 트러스 형태로 별도 제작하여 보강하였을 때, 안전한계풍속(m/s)은 기존온실 20m/s에 비해 개량하였을 때 26m/s으로 증가하였고 안전한계적설심(cm) 또한 기존온실 22cm에 비해 30cm로 증대되었다. 결과적으로, 시설의 노후화로 인해 온실높이(측고)가 낮은 국내온실을 구조적으로 안전하게 인상하고 리모델링을 추가로 적용함으로 인하여 작물의 생산성 향상에 기여할 것으로 생각한다.

요소수의 분무 특성과 관내 분무 거동에 관한 실험적 연구

이정구 ( Jungkoo Lee ),이창기 ( Changki Lee ),우승철 ( Seungchul Woo ),백승주 ( Seungju Beak ),이수홍 ( Soohong Lee ),박성훈 ( Sunghoon Park ),이기형 ( Kihyung Lee ) 한국액체미립화학회 2018 한국액체미립화학회 학술강연회 논문집 Vol.2018 No.-

As a method of reducing NOx in a diesel vehicle, lean NOx trap (LNT) and selective catalytic reduction (SCR) are mainly used. The Urea-SCR system has been evaluated as the best method of reducing NOx. In the Urea-SCR system, the urea water solution is injected at the upstream of the SCR catalyst. At this time, the urea water solution is hydrolyzed and decomposed into ammonia gas. The ammonia gas reacts with NOx in the SCR catalyst and NOx is converted to water and nitrogen. In order to improve the reduction efficiency, the SCR system should be optimized so that the urea water solution is completely converted to ammonia gas and has a high uniformity distribution. In this study, spray characteristics of urea water solution were analyzed through visualization using high speed camera under various test conditions. In addition, urea water solution was sprayed into a transparent exhaust pipe made with Pyrex tube to analyze spray behavior and wall-wetting phenomenon. In order to observe the influence of the exhaust pipe and the mixer shape, three types of transparent exhaust pipes and two types of SCR mixers were used.

Is bone mineral density a prognostic factor in postmenopausal women with luminal A breast cancer?

Lee Seungju,Kim Hyun Yul,Jung Youn Joo,Kang Seok-Kyung,Kim Jee Yeon,Yun Mi Sook 대한종양외과학회 2023 Korean Journal of Clinical Oncology Vol.19 No.1

Purpose: Several studies are concerned about the association between bone mineral density (BMD) and the risk of breast cancer in postmenopausal women, but it is controversial. Therefore, we evaluated whether BMD might be a risk factor for recurrences, or metastases in menopausal luminal A breast cancer patients.Methods: In this retrospective study, data of 348 patients with luminal A breast cancer who received treatment at Pusan National University Yangsan Hospital between 2012 and 2016 were analyzed. Patients were divided into two groups: normal BMD and low BMD including osteopenia or osteoporosis in preoperative examination. Patients were also divided into three groups according to BMD changes: no change in BMD; improvement in BMD, and deterioration in BMD. Events were defined as recurrence, occurrence of contralateral breast cancer, and metastasis to any other organ.Results: Preoperative examination revealed normal BMD in 129 of 348 patients and low BMD in 219 patients. During a median follow-up period of 78 months, only 14 patients (4.0%) experienced recurrences, distant metastases, or occurrences of contralateral breast cancer. Five-year disease-free survival rate was 98.2% for 219 patients with low BMD and 95.0% for 129 patients with normal BMD (P=0.33). Disease-free survival at 5 years was 97.0% for the no change in the BMD group, 94.6% for the BMD improvement group, and 98.4% for the BMD deterioration group (P=0.79).Conclusion: In this study, BMD had no statistically significant associations on recurrences, metastases, or incidences of contralateral breast cancer in postmenopausal patients with luminal A breast cancer.

Are the Outcomes of Breast Conservation Surgery Inferior to Those of Mastectomy in Patients with Stage II-IIIA Triple-Negative Breast Cancer?

Seungju Lee,김현열,Youn Joo Jung,Hyun-June Paik,Dong Il Kim,Chang Shin Jung,Seok-Kyung Kang,김지연,이석원,Youngtae Bae 한국유방암학회 2021 Journal of Breast Disease Vol.9 No.2

Purpose: Breast conserving surgery (BCS) is generally not considered for breast cancer because of concerns about the poor prognosis of triple negative breast cancer (TNBC). We assessed the outcomes of BCS and mastectomy for patients with stage II-IIIA TNBC. Methods: The data of 172 breast cancer patients diagnosed with stage II-IIIA TNBC who underwent treatment at Pusan National University Hospital and Pusan National University Yangsan Hospital from 2010 to 2014 were retrospectively analyzed. The patients were divided into the following two groups: patients who underwent BCS (n=101) and those who underwent mastectomy (n=71). The Cox regression model was used to examine the outcomes of both treatments. The median follow-up period was 71 months in the BCS group, and 67 months in the mastectomy group. Results: The median age of the 172 patients was 51 years (range, 22-82 years). In the BCS group, radiation therapy and chemotherapy (p<0.001 and p=0.007, respectively) were performed more frequently. The BCS group had more patients with a high Ki-67 index (p=0.006), while the mastectomy group included more patients with a higher pathologic T (pT) stage (p=0.005). The 5-year loco-regional recurrence-free, disease-free, and overall survival rates of the BCS group versus the mastectomy group were 93.8% versus 95.3%, 89.8% versus 90.7%, and 90.8% versus 86.3%, respectively, but the differences were not statistically significant. Lymphovascular invasion was a risk factor for disease-free survival and advanced stage was an important risk factor for overall survival. Conclusion: In stage II-IIIA TNBC, BCS was not inferior to mastectomy in locoregional recurrence rates, disease-free survival rates, or overall survival rates.

Get Opportunities from the middle of difficulty: The effect of incumbents’ problems on market entry of entrepreneurial firms

Seungju Lee(이승주),Seungho Choi(최승호),Sang-Joon Kim(김상준) 한국경영학회 2021 한국경영학회 통합학술발표논문집 Vol.2021 No.8

Building on literature in entrepreneurship and organizational theory, This study examines the effect of market problems of incumbents on entrepreneurial firms’ market entry. Through 20 U.S. domestic direct flight routes during 1995 - 2019, this study examines the likelihood of entrepreneurial airlines’ route entry under greater incumbents’ market problems. We find that the likelihood of entrepreneurial firms’ market entry increases when a market has greater incumbents’ problems. Simultaneously, we find that higher market concentration strengthens the relationship between incumbents’ market problems and entrepreneurial firms’ market entry. These findings show that existing market problems could be a catalyst for entrepreneurial firms’ market entry. Additionally, our finding provides a new perspective for resource partitioning theory by suggesting entrepreneurial firms’ market entry to a problematic mainstream market, not the periphery.

Adeno-associated virus surface engineering for targeting pancreatic cancer cells via fucosylation

Seungju YOO,Byunguk KANG,Mira CHO,Seung-Hyun KIM,Yoojin KIM,Seokmin OH,Heehyung LEE,Nara LEE,Ginah HAN,Jae-Hyung JANG 한국생물공학회 2018 한국생물공학회 학술대회 Vol.2018 No.4

Thermographic Inspection of CLP Defects on the Subsurface Based on Binary Image

Seungju Lee,Yoonjae Chung,Chunyoung Kim,Ranjit Shrestha,Wontae Kim 한국정밀공학회 2022 International Journal of Precision Engineering and Vol.23 No.3

This study performed an experimental investigation on LIT to detect thinning defects of steel plates that is the protective wall of the structure of a nuclear power plant in Korea. IRT has proven to be an important technique in NDT because it can quickly inspect a large area in real time. However, the most important problem in the analysis of infrared thermography technology is the acquisition of quantitative data. In this study, we present a quantitative detectability analysis of thinning defects on the subsurface of CLP. The optimum excitation frequency and cycle of amplitude and phase was analyzed through a LIT to which to total 4 cycles were applied, and PCA signal processing was performed based on the amplitude and phase images. The SNR of the image applied the four filtering (mean, median, NLmeans and Gaussian) at 0.02 Hz was analyzed. In addition, the binary image processing classified based on the threshold value was performed using the Otsu algorithm. Then, RMSE was calculated by fusion with the raw image and comparative analysis was performed to analyze the detectability of each image. This proved the potential of quantification of defects by calculating RMSE.

Are the Outcomes of Breast Conservation Surgery Inferior to Mastectomy in Patients with Stage II-IIIA Triple-negative Breast Cancer?

Seungju Lee 대한외과학회 2020 대한외과학회 학술대회 초록집 Vol.2020 No.11

Health-enhancing Effects of feed supplemented with mealworm(Tenebrio molitor) on dog

Jingu Lee,Seung-Hwan Yun,Gab June Lim,Jae Eun Jang,Jieun Hwang,Seungju Lee,Sung Mo Yoon 한국응용곤충학회 2019 한국응용곤충학회 학술대회논문집 Vol.2019 No.04

Mealworm(Tenebrio molitor) was added to the feed to improve the health of dogs. As the amount of mealworm powder added to dog feed increased from 2.5 to 7.5%, the contents of crude protein, crude fat, crude fiber and crude ash increased. In the old dogs, creatinine and BUN related to nephropathy, triglyceride related to hypertension, calcium related to osteoporosis, globulin related to immunity, and ALT related to hepatic function were in the normal range. Particularly, ALT showed a tendency to increase overall, but the numerical increase tended to decrease as the amount of mealworm powder added. In the young dogs, all investigative items such as BUN and creatine were in the normal range and ALT tended to decrease at 2.5~5.0% treatment of mealworm. As a result, it was shown that adding 2.5~5.0% of mealworm powder to feed effectively improved the hepatic function of old and young dogs.