Optimal Pulse Sequence for Ferumoxides-Enhanced MR Imaging Used in the Detection of Hepatocellular Carcinoma: A Comparative Study Using Seven Pulse Sequences

SeungHoonKim,DongilChoi,JaeHoonLim,WonJaeLee,Hyun-JungJang,HyoKeunLim,SoonJinLee,JaeMinCho,SeungKwonKim,GabChulKim 대한영상의학회 2002 Korean Journal of Radiology Vol.3 No.2

Objective: To identify the optimal pulse sequence for ferumoxides-enhanced magnetic resonance (MR) imaging in the detection of hepatocelluar carcinomas (HCCs). Materials and Methods: Sixteen patients with 25 HCCs underwent MR imaging following intravenous infusion of ferumoxides. All MR studies were performed on a 1.5-T MR system, using a phased-array coil. Ferumoxides (Feridex IV) at a dose of 15 mol/Kg was slowly infused intravenously, and axial images of seven sequences were obtained 30 minutes after the end of infusion. The MR protocol included fast spin-echo (FSE) with two echo times (TR3333 8571/TE18 and 90-117), singleshot FSE (SSFSE) with two echo times (TR /TE39 and 98), T2*-weighted gradient-recalled acquisition in the steady state (GRASS) (TR216/TE20), T2*-weighted fast multiplanar GRASS (FMPGR) (TR130/TE8.4 9.5), and T2*-weighted fast multiplanar spoiled GRASS (FMPSPGR) (TR130/TE8.4 9.5). Contrast-to-noise ratios (CNRs) of HCCs determined during the imaging sequences formed the basis of quantitative analysis, and images were qualitatively assessed in terms of lesion conspicuity and image artifacts. The diagnostic accuracy of all sequences was assessed using receiver operating characteristic (ROC) analysis. Results: Quantitative analysis revealed that the CNRs of T2*-weighted FMPGR and T2*-weighted FMPSPGR were significantly higher than those of the other sequences, while qualitative analysis showed that image artifacts were prominent at T2*-weighted GRASS imaging. Lesion conspicuity was statistically significantly less clear at SSFSE imaging. In term of lesion detection, T2*-weighted FMPGR, T2*- weighted FMPSPGR, and proton density FSE imaging were statistically superior to the others. Conclusion: T2*-weighted FMPGR, T2*- weighted FMPSPGR, and proton density FSE appear to be the optimal pulse sequences for ferumoxidesenhanced MR imaging in the detection of HCCs.

The Korean Association of lnternal Medicine : Poster Session ; PS 1363 : Nephrology ; Polymorphic Ventricular Tachycardia and Painless Thyroiditis

( Seung Hoon Kim ),( Kyung Yoon Chang ),( Hyung Wook Kim ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Session A 61-year-old man presented with lower extremity paralysis and severe hypokalemia. His thyroid function test showed thyrotoxicosis. Despite attempts to correct his hypokalemia, he developed pulseless polymorphic ventricular tachycardia two hours later. He was successfully resuscitated after defi brillation. We performed continuous venovenous hemodiafi ltration for 10 days due to acute kidney injury and rhabdomyolysis. We observed life-threatening polymorphic ventricular tachycardia requiring urgent defi brillation, as well as rhabdomyolysis requiring dialysis during the transient thyrotoxic phase of painless thyroiditis. We should pay attention to the possibility of development of life-threatening ventricular tachycardia associated with hypokalemia in the setting of thyroiditis and thyrotoxic paralysis. In this case, severe hypokalemia during the transient thyrotoxic phase of painless thyroiditis caused life-threatening polymorphic ventricular tachycardia requiring urgent defibrillation, rhabdomyolysis requiring dialysis, and thyrotoxic paralysis. The patient`s renal function after acute kidney injury has not completely recovered. We should pay attention to the possibility of development of life-threatening ventricular tachycardia associated with hypokalemia in the setting of thyroiditis and thyrotoxic paralysis.

A Review on Care and Nursing in the Aging Society

Seung Hoon Kim 한국노인복지학회 2015 International Journal of Welfare for the Aged Vol.33 No.-

The study has been performed to literature review on care and nursing for the senile elderly at facility sites. In the study, the care worker is defined as the person who keeps working intimately at a senile elderly at home or nursing related places. Not just elderly care, child or baby care has a similar stream of paying attention to weak people. Family childcare workers work in their own homes. They may convert a portion of their living space into a dedicated space for the children. Nannies and babysitters usually work in their employers’ homes. As shown in a very primary and basic study in Korea, it is pessimistic that safety condition of care place is lower than our expectation, and we propose future basic step for the first place, keeping a safe place of the care place for the elderly. Conclusively, safety is the key point for the care place.

A Review on Elderly Leisure Place

Seung Hoon Kim 한국노인복지학회 2013 International Journal of Welfare for the Aged Vol.28 No.-

In this study, we review basic concepts and study results about the old citizens` leisure place.we analyzed various factors for attitudes about old people and aging. Number of generations as a living arrangement is a degree of solidarity among family members. Traditionally there is a strong norm in Koran society that older parents should live in extended families with children and grandchildren. Korean Institute of Gerontology(1993) reported that more than 70% of the Koreans aged 60 believe living with sons and grandchildren is the most comfortable and reputable life. As for satisfaction with societal environment, there were four items that showed significant differences by gender; availability of leisure & recreation facilities, availability of religious institutions, friendliness of neighborhood, and social relationship with community residents. Mean values of satisfaction score were 2.65 and 2.24(p<.01) for leisure & recreation facilities, 3.28 and 3.98(p<.05) for religious institutions, 3.73 and 3.98 (p<.01) for friendliness of neighborhood, and 3.80 and 4.05(p<.05) for social relationship with community residents, for male and females respectively. The leisure & recreation facilities showed significantly higher score for male, while other three items did so for females.

Clinical characteristics of smear/PCR-negative and culture positive pulmonary tuberculosis

( Seung Hoon Kim ),( Shin Young Kim ),( Sung Kyoung Kim ),( So Hyang Song ),( Chi Hong Kim ) 대한결핵 및 호흡기학회 2018 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.126 No.-

Background: Sputum AFB smear and PCR negativity in pulmonary tuberculosis (PTB) is a common clinical problem. Clinicians have difficulty in diagnosis smear and PCR-negative PTB without culture confirmation. It is very important to decide whether or not to treat a patient with smear and PCR-negative PTB when the culture results are pending. The aim of this study is to determine whether smear and PCR-negative PTB patients has significantly different clinical features compared to smear or PCR-positive. Methods: Among PTB patients who started treatment for past 12 months, patients with sputum culture positive PTB were enrolled. Results: In 87 patients with culture positive PTB, 39 (44.8%) were smear and PCR-negative and 48 (55.2%) were smear or PCR-positive. In univariate analysis, antibiotics usage within 2 weeks and taking immunosuppressants were significantly associated with smear and PCR-negative. Cavitary lesion, number of cavities, macro/micro-nodular lesion, number of micronodules, and multiple nodular lesions were significantly associated with smear or PCR-positive. Antibiotics usage with 2 weeks and taking immunosuppressants were significantly independent factors associated with smear and PCR-negative in multivariate analysis. On the other hand, micronodular lesion was significantly independent factors associated with smear or PCR-positive. Conclusions: Although there are typical radiological findings suspected of PTB, clinicians could need to consider that both smear and PCR may be negative in case of antibiotics usage within 2 weeks or taking immunosuppressants.

8.3~10.6㎓-Band New LC Oscillator with Low Phase-Noise and Wide Tuning Range for SONET Communication Applications

Seung-Hoon Kim,Hyo-Moon Cho,Sang-Bock Cho 대한전자공학회 2008 ICEIC:International Conference on Electronics, Inf Vol.1 No.1

This paper presents a new inductancecapacitance (LC) oscillator topology. 8.3~10.6-㎓-Band New LC Oscillator has been designed and fabricated using commercial 0.18-)m CMOS technology. The complementary cross-coupled differential topology is adopted in the design. The fabricated LC Oscillator has a wide tuning range of 23% from 8.3 ㎓ to 10.6 ㎓ with a power dissipation of 6.48㎽. The measured phase noise is - 114㏈c/㎐ at 1-MHz offset, respectively. FOM of the new LC VCO could get to -185.9㏈c/㎐ at a 1-㎒ offset from a 10㎓ center frequency. New LC VCO topology consists of the on-chip spiral inductor, the varactor and the crosscoupled N and P-MOSFETs as negative conductance. The new LC VCO has exhibited wide tuning range without critical degradation of phase noise This design is very useful for the 10Gb/s clock and data recovery integrated circuit (IC) and SONET communication applications.

Leading Combination of Optimizing Lysis Buffer Reagents for Solubilization and Preservation of Proteins from Cells and Tissues

Seung Hoon KIM,Byeong Hee HWANG 한국생물공학회 2016 한국생물공학회 학술대회 Vol.2016 No.10

Analysis of Long-Term Medical Expenses in Vertebral Fracture Patients

Seung Hoon Kim,Suk-Yong Jang,Kyeongdong Nam,Yonghan Cha 대한정형외과학회 2023 Clinics in Orthopedic Surgery Vol.15 No.6

Background: The objective of this study was to analyze the direct medical expenses of a vertebral fracture cohort (VC) and a matched cohort (MC) over 5 years preceding and following the fracture, analyze the duration of the rise in medical expenses due to the fracture, and examine whether the expenses vary with age group, utilizing a national claims database. Methods: Subjects with vertebral fractures and matched subjects were chosen from the National Health Insurance Service Sample cohort (NHIS-Sample) of South Korea. Patients with vertebral fractures were either primarily admitted to acute care hospitals (index admissions) or those who received kyphoplasty or vertebroplasty during the follow-up period (2002–2015). A risk-set matching was performed using 1 : 5 random sampling to simulate a real-world situation. Individual-level direct medical expenses per quarter were calculated for 5 years prior and subsequent to the vertebral fracture. In this analysis using a comparative interrupted time series design, we examined the direct medical expenses of a VC and an MC. Results: A total of 3,923 incident vertebral fracture patients and 19,615 matched subjects were included in this study. The mean age was 75.5 ± 7.4 years, and 69.5% were women. The mean difference in medical expenses between the two groups increased steadily before the fracture. The medical expenses of the VC peaked in the first quarter following the fracture. The cost changes were 1.82 times higher for the VC than for the MC (95% confidence interval, 1.62–2.04; p < 0.001) in the first year. Subsequently, there were no differential changes in medical expenses between the two groups (p > 0.05). In the < 70-year subgroup, there were no differential changes in medical expenses between the two groups (p > 0.05). However, in the ≥ 80-year subgroup, the cost changes for the VC were higher than those for the MC up to 5 years after time zero. Conclusions: Based on our study results, we suggest that health and medical policies for vertebral fractures should be designed to last up to approximately 1 year after the fracture. Health policies should be differentiated according to age group.

Clinical Characteristics of Patients with Smear-negative Pulmonary Tuberculosis

( Seung Hoon Kim ),( Ju Sang Kim ),( Hyung Woo Kim ),( Yong Hyun Kim ),( Sung Soo Jeong ),( Jee Youn Oh ),( Jin Woo Kim ),( Sang Haak Lee ),( Sung Kyoung Kim ),( Sun-hyung Kim ),( Jinsoo Min ) 대한결핵 및 호흡기학회 2023 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.136 No.0

Immune Stimulating Activity of Chitosan Nanoparticles

Seung Hoon KIM,Byeong Hee HWANG 한국생물공학회 2018 한국생물공학회 학술대회 Vol.2018 No.4