정신분열증에서 공존하는 신체질환에 대하여

지익성,왕성근,신석철,이선우,황선희,신용재,김정란,배경도 충남대학교 의과대학 지역사회의학연구소 1999 충남의대잡지 Vol.26 No.1

In order to determine the frequency of physical illness in schizophrenia, 107 schizophrenics were assessed with physical exam and routine laboratoy test. The results were as follows 1) Among the total number of 107 schizophrenics, 31 had the physical illness(29%), and among the schizophrenics with physical illness, female outnumbered male at the rate of 17:14. 2) There was no difference between schizophrenics with physical illness and schizophrenics without physical illness in demographic characteristics. 3) Classification of physical illness were disease of skin 7 (22.6%), musculoskeletal system 5(16. 1%), ENT(ear nose throat) 3(9.7%), endocrine system 3(9.7%), circulatory system 2(6.5%), respiratory system 2(6.5%), digestive system 1(3.2%), genitourinary system 1(3.2%), infection 1(3. 2%), eye 1(3.2%) respectively Authors suggest that physical exam and routine laboratory test should be done for all hospitalized psychiatric patients

메카넘 바퀴 볼 로봇의 자세제어 및 주행

황승익(Seung-Ik Hwang),하휘명(Hwi-Myung Ha),이장명(Jang-Myung Lee) 제어로봇시스템학회 2015 제어·로봇·시스템학회 논문지 Vol.21 No.4

This paper proposes a balancing and driving control system for a Mecanum wheel ball robot which has a two axis structure and four motors. The inverted pendulum control method is adopted to maintain the balance of the ball robot while it is driving. For the balancing control, an anon-model-based controller has been designed to control the device simply without the need of a complex formula. All the gains of the controller are heuristically adjusted during the experiments. The tilt angle is measured by IMU sensors, which is used to generate the control input of the roll and pitch controller to make the tilt angle zero. For the driving control, the PID control algorithm has been adopted with angles of the wheels and the encoder data. The performance of the designed control system has been verified through the real experiments with the suggested ball robot.

Role of NADH: quinone oxidoreductase-1 in the tight junctions of colonic epithelial cells

( Seung Taek Nam ),( Jung Hwan Hwang ),( Dae Hong Kim ),( Mi Jung Park ),( Ik Hwan Lee ),( Hyo Jung Nam ),( Jin Ku Kang ),( Sung Kuk Kim ),( Jae Sam Hwang ),( Hyo Kyun Chung ),( Min Ho Shong ),( Chul 생화학분자생물학회(구 한국생화학분자생물학회) 2014 BMB Reports Vol.47 No.9

NADH: quinone oxidoreductase 1 (NQO1) is known to beinvolved in the regulation of energy synthesis and metabolism, and the functional studies of NQO1 have largely focused on metabolic disorders. Here, we show for the first time that compared to NQO1-WT mice, NQO1-KO mice exhibited amarked increase of permeability and spontaneous in flammationin the gut. In the DSS-induced colitis model, NQO1-KO miceshowed more severe inflammatory responses than NQO1-WTmice. Interestingly, the transcript levels of claudin andoccludin, the major tight junction molecules of gut epithelialcells, were significantly decreased in NQO1-KO mice. The colons of NQO1-KO mice also showed high levels of reactiveoxygen species (ROS) and histone deacetylase (HDAC) activity, which are known to affect transcriptional regulation. Takentogether, these novel findings indicate that NQO1 contributesto the barrier function of gut epithelial cells by regulating the transcription of tight junction molecules.

Reliability of Vascular Territory for a Circumflex Scapular Artery–Based Flap

Hwang, Jin Hee,Hwang, Kun,Bang, Sa Ik,Kim, Deog Im,Han, Seung Ho American Society of Plastic Surgeons 2009 Plastic and reconstructive surgery Vol.123 No.3

BACKGROUND:: The objective of this study was to evaluate the cutaneous vascular territories of the circumflex scapular artery and the areas supplied by perforators from neighboring anatomical vascular territories, and also to define the safety limits of circumflex scapular artery–based flaps by means of fresh cadaver injection studies. METHODS:: A total of 15 dorsal thoraxes from eight fresh cadavers were used in this study. After saline irrigation, contrast medium was injected into the subclavian artery of each specimen. Each full-thickness specimen of the posterior hemithorax was then radiographed to characterize vascular networks. RESULTS:: The primary zone of the circumflex scapular artery was calculated to be 93.8 ± 16.1 cm, which occupies a region smaller than that of the scapula. However, by capturing the secondary zone, which was composed of the territories supplied by adjacent perforators of the thoracodorsal artery, the dorsal intercostal artery, and the transverse cervical artery, potential flap survival dimensions extended beyond the scapular region. In fact, the potential zone was increased to 307.7 7 ± 55.3 cm, which extended beyond the scapular spine, the inferior angle of the scapula, the posterior axillary line, and close to the midline of the back. CONCLUSIONS:: The circumflex scapular artery is an appropriate source for harvesting a large fascial and fasciocutaneous flap based on a single perforating vessel. Surgeons should understand the limits of the circumflex scapular artery–based flap to make best use of it.

Mountain ginseng extract exhibits anti-lung cancer activity by inhibiting the nuclear translocation of NF-관B.

Hwang, Jeong Won,Oh, Jung Han,Yoo, Hwa-Seung,Lee, Yeon-Weol,Cho, Chong-Kwan,Kwon, Ki-Rok,Yoon, Jung-Ho,Park, Junsoo,Her, Song,Lee, Zee-Won,Jang, Ik-Soon,Choi, Jong-Soon Institute for Advanced Research in Asian Science a 2012 The American journal of Chinese medicine Vol.40 No.1

<P>Administration of mountain ginseng (MG) extract can restore advanced cancer to a normal state. To elucidate the mechanism by which MG extract prevents the progression of lung cancer, the processes of proliferation and death of lung cancer cells (A549) were examined after treatment with MG extract. Butanol-extracted MG (BX-MG) showed a high inhibitory effect (IC(50) = 2 mg/ml) by attenuating proliferation and inducing apoptosis in lung cancer cells. By HPLC-UV analysis of BX-MG, ginsenosides, Rb1 was identified as the most abundant ginsenoside, followed by Rg1, Re, Rc and Rb2. BX-MG induced caspase-3 dependent apoptosis by inhibiting NF-관B. In addition, BX-MG activated p53 and p21, resulting in the attenuated proliferation of A549 cells. Reduced activity of the NF-관B promoter and increased activity of the p53 promoter indicate that BX-MG regulates apoptosis at the level of transcription in lung cancer cells. Furthermore, BX-MG blocked the nuclear translocation of RelA and the associated reduction in surviving. These results suggest that BX-MG inhibits lung cancer cell growth by activating tumor suppressors and inhibiting nuclear translocation of NF-관B.</P>

Pixel Architecture for Low-Power Liquid Crystal Display Comprising Oxide and Ferroelectric Memory Thin Film Transistors

Seung-Hyuck Lee,Jongbin Kim,Seong Ho Yoon,Kyeong-Ah Kim,Sung-Min Yoon,Chunwon Byun,Chi-Sun Hwang,Gi Heon Kim,Kyoung-Ik Cho,Seung-Woo Lee IEEE 2015 IEEE electron device letters Vol.36 No.6

<P>A new pixel architecture and driving scheme for a low-power liquid crystal display (LCD) with a low refresh-rate is proposed. The proposed pixel architecture comprises two oxide thin-film transistors (Ox-TFTs), two ferroelectric memory TFTs (Fe-MTFTs), and two capacitors. Both TFTs have the same indium gallium zinc oxide film as an active layer. The Fe-MTFT exhibits a hysteresis property owing to the ferroelectric gate insulator that enables it to operate as a memory. A prototype LCD with 6 × 5 pixels is fabricated in this letter. The fieldeffect mobility of Ox-TFTs is 11 cm<SUP>2</SUP>V<SUP>-1</SUP>s<SUP>-1</SUP>. The memory window of Fe-MTFT is 5 V with a gate-voltage sweep from -20 to 20 V. After programming the Fe-MTFTs, the fabricated LCD successfully operates at a 0.5-Hz refresh-rate.</P>

Automatic Moving Object Segmentation and Tracking Using Object Region Finding Algorithm

Seung-Ik Lee,Hee-Chul Hwang,Kwang-Ho Lee,Duk-Gyoo Kim 대한전자공학회 2003 ITC-CSCC :International Technical Conference on Ci Vol.2003 No.7

Tetraspanin-2 promotes glucotoxic apoptosis by regulating the JNK/β-catenin signaling pathway in human pancreatic β cells

Hwang, In-Hu,Park, Junsoo,Kim, Jung Min,Kim, Seung Il,Choi, Jong-Soon,Lee, Kyung-Bok,Yun, Sung Ho,Lee, Min-Goo,Park, Soo Jung,Jang, Ik-Soon Federation of American Societies for Experimental 2016 The FASEB Journal Vol.30 No.9

<P>Diabetes mellitus is a complex and heterogeneous disease, which has β-cell dysfunction at its core. Glucotoxicity affects pancreatic islets, causing β-cell apoptosis. However, the role of JNK/β-catenin signaling in glucotoxic β-cell apoptosis is not well understood. Recently, we identified tetraspanin-2 (TSPAN2) protein as a proapoptotic β-cell factor induced by glucose, suggesting that TSPAN2 might contribute to pancreatic β-cell glucotoxicity. To investigate the effects of glucose concentration on TSPAN2 expression and apoptosis, we used reverted immortalized RNAKT-15 human pancreatic β cells. High TSPAN2 levels up-regulated phosphorylated (p) JNK and induced apoptosis. p-JNK enhanced the phosphorylation of β-catenin and Dickkopf-1 (Dkk1). Dkk1 knockdown by small interfering (si)RNA up-regulated nuclear β-catenin, suggesting that it is a JNK/β-catenin-dependent pathway. siRNA-mediated TSPAN2 depletion in RNAKT-15 cells increased nuclear β-catenin. This decreased BCL2-associated X protein (Bax) activation, leading to marked protection against high glucose–induced apoptosis. Bax subfamily proteins induced apoptosis through caspase-3. Thus, TSPAN2 might have induced Bax translocation and caspase-3 activation in pancreatic β cells, thereby promoting the apoptosis of RNAKT-15 cells by regulating the JNK/β-catenin pathway in response to high glucose concentrations. Targeting TSPAN2 could be a potential therapeutic strategy to treat glucose toxicity-induced β-cell failure.—Hwang, I.-H., Park, J., Kim, J. M., Kim, S. I., Choi, J.-S., Lee, K.-B., Yun, S. H., Lee, M.-G., Park, S. J., Jang, I.-S. Tetraspanin-2 promotes glucotoxic apoptosis by regulating the JNK/β-catenin signaling pathway in human pancreatic β cells.</P>

개에서 염산정주로 유발한 대사성산증이 심폐혈관반응에 미치는 영향

황재현,승익상 한양대학교 의과대학 1993 한양의대 학술지 Vol.13 No.1

Hypoxic pulmonary vasoconstriction (HPV) is an intrapulmonary adaptation mechanism that diverts blood away from hypoxic regions of the lung There are controversial reports regarding the effects of metabolic acidosis on HPV. Metabolic acidosis induced by acid infusion has been observed either not to affect, to increase, or to decrease hypoxia-induced increases in pulmonary arterial pressure (PAP) or pulmonary vascular resistance PVR). But some have suggested that hypoxia and acidosis are major determinants, and that, although they may function as in dependent stimuli, they also manifest a complex interdependence. Experiments were designed to measure cardiopulmonary hemodynamic parameter during normal oxygenation by controlled mechanical respiration and exposures to metabolic acidosis around of arterial pH up to 7.19 unit by intravenous infusion of 2M HCL in the rate of 2mmol/kg/min The authors conducted experiments in intact dogs to reevaluate the effects of metabolic acidosis by infusion of HCL on HPV with normoxemia. Cardiopulmonary vascular parameters were measured at several pH levels (range of 7.38±7.19). The results were as follow : 1. Arterial pH was changed from 7.38±0.01 unit to 7.30±0.02 unit and 7.19±0.04 unit at 30 and 60minutes respectively, after intravenous infusion of HCL. 2. At 10 and 60 minutes after intravenous infusion of HCL, mean PAP was significantly increased 96.43±15.93% and 109.57±12.00% (P=0.0000) respectively, from basic value of 13.14 ±0.74 mmHg. 3. Mean PVR was also significantly increased 156.14±19.56% and 215.00±33.91% at 30 and 60 minutes respectively (p=0.0000), after intravenous infusion of HCL from basic value of 361.78±23.94 dyne. sec. cm. 4. Cardiac output had slowly decreased from 1.83±0.07 to 1.53±0.18 L/min(up to about 16.4% after 60 minutes)after intravenous infusion of HCL(P<0.05). 5. There were on significant changes of central venous pressure, pulmonary capillary wedge pressure, mean arterial blood pressure, and heart rate throughout the experiment. With above results the author concluded that metabolic acidosis by infusion of HCI increased PAP and PVR markedly, but decreased cardiac output slowly. This suggested that metabolic acidosis was one of major determinants to increase HPV.

DC Microgrid Operational Method for Enhanced Service Reliability Using DC Bus Signaling

Hwang, Pyeong-Ik,Jang, Gilsoo,Pyo, Gi-Chan,Han, Byung-Moon,Moon, Seung-Il,Ahn, Seon-Ju The Korean Institute of Electrical Engineers 2015 Journal of Electrical Engineering & Technology Vol.10 No.2

This paper proposes a DC microgrid operational strategy and control method for improved service reliability. The objective is to supply power to as many non-critical loads as possible, while providing an uninterrupted power supply to critical loads. The DC bus signaling method, in which DC voltage is an information carrier, is employed to implement the operational strategy in a decentralized manner. During grid-connected operation, a grid-tied converter balances the power of the microgrid by controlling the DC voltage. All loads are connected to the microgrid, and operate normally. During islanded operation, distributed generators (DGs), a backup generator, or an energy storage system balances the power. However, some non-critical loads may be disconnected from the microgrid to ensure the uninterrupted power supply to critical loads. For enhanced service reliability, disconnected loads can be automatically reconnected if certain conditions are satisfied. Control rules are proposed for all devices, and detailed microgrid operational modes and transition conditions are then discussed. Additionally, methods to determine control parameter settings are proposed. PSCAD/EMTDC simulation results demonstrate the performance and effectiveness of the proposed operational strategy and control method.