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Won, Kyung-Jong,Lee, Kang Pa,Kim, Dong-Ku,Jung, Seung Hyo,Lee, Chang-Kwon,Lee, Dong Hyen,Yu, Su Yeol,Park, Se Hyung,Lee, Hwan Myung,Kim, Bokyung S. Karger AG 2013 Journal of vascular research Vol.50 No.3
<P>Abstract</P><P><B><I>Background:</I></B> This study was attempted to identify new molecules expressed on the plasma membrane of human umbilical vein endothelial cells (HUVECs) using monoclonal antibody-based proteomics technology and to determine the effect of the identified antibody on vascular reactivity. <B><I>Methods:</I></B> Twenty-two antibodies were developed from rats inoculated with HUVECs, and their effects were determined by observing vascular reactivity. <B><I>Results: </I></B>Among the 22 antibodies, the C-7 antibody significantly inhibited endothelium-dependent vasorelaxation in response to acetylcholine (ACh) but not to histamine. Moreover, the C-7 antibody did not affect norepinephrine-induced contraction in either the endothelium-intact or -denuded aorta. A proteomics study involving immunoprecipitation of the C-7 antibody with biotinylated HUVECs showed that this antibody binds to plasma membrane proteins corresponding to immunoglobulin heavy chain (VHDJ region), chaperonin-containing T-complex polypeptide 1 and α-actinin 4. The muscarinic M3 ACh receptor and α-actinin 4 were colocalized on the plasma membrane of HUVECs, and the colocalization was found to increase in response to ACh and was inhibited by pretreatment with the C-7 antibody. <B><I>Conclusions: </I></B>These results demonstrate that monoclonal C-7 antibody exerts an inhibitory effect on endothelium-dependent vasorelaxation induced by ACh and that this response may at least partially result from the inhibition of α-actinin 4.</P><P>Copyright © 2013 S. Karger AG, Basel</P>
Molecular Diagnosis of <i>Taenia saginata</i> Tapeworm Infection in 2 Schoolchildren, Myanmar
Won, Eun Jeong,Jung, Bong-Kwang,Song, Hyemi,Kim, Mi-Seon,Kim, Hyun-Seung,Lee, Keon Hoon,Kim, Min-Jae,Shin, Myung Geun,Shin, Jong Hee,Suh, Soon-Pal,Hong, Sung-Jong,Sohn, Woon-Mok,Htoon, Thi Thi,Tin, Ht Centers for Disease Control and Prevention 2018 Emerging infectious diseases Vol.24 No.6
<P><I>Taenia saginata</I> is the most common human tapeworm worldwide but has been unknown in Myanmar. In 2017, fecal examination in Yangon, Myanmar, revealed eggs of <I>Taenia</I> species in 2 children from a monastic school. Several proglottids expelled after medication with praziquantel were morphologically and molecularly confirmed to be <I>T. saginata</I> tapeworms.</P>
The Processing of Specificity in the English Article System by Korean Learners of English
Seung Won Jung,Myung Kwan Park 현대문법학회 2013 현대문법연구 Vol.74 No.-
This paper investigated the role of specificity by Korean learners in processing the article choice parameter. To this end, Korean learners of EFL completed the online and the offline semantic acceptability-rating tasks. The online results indicated that the Korean learners of EFL at both the advanced and the intermediate level of the proficiency fluctuated between the specificity and definiteness parameter settings. Especially for the intermediate Korean learners of EFL, the response time of the [-definite, +specific] condition showed little difference from other conditions, implying that they adhered to the definiteness parameter setting. The offline results, in contrast, indicated that the Korean learners of EFL at both the advanced and the intermediate level of the proficiency adhered to the definiteness parameter setting. It seems that there is a possibility that the intermediate learners were adopting the definiteness parameter setting, which is different from the claims made in Ionin, Ko and Wexler’s (2004) specificity hypothesis.