http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Gait Variability Can Predict the Risk of Cognitive Decline in Cognitively Normal Older People
Byun, Seonjeong,Han, Ji Won,Kim, Tae Hui,Kim, Kayoung,Kim, Tae Hyun,Park, Jae Young,Suh, Seung Wan,Seo, Ji Young,So, Yoonseop,Lee, Kyoung Hwan,Lee, Ju Ri,Jeong, Hyeon,Jeong, Hyun-Ghang,Han, Kyuhee,Hon S. Karger AG 2018 DEMENTIA AND GERIATRIC COGNITIVE DISORDERS Vol.45 No.5
<P><B><I>Background:</I></B> The aim of this study was to investigate the association of gait speed and gait variability, an index of how much gait parameters, such as step time, fluctuate step-to-step, with risk of cognitive decline in cognitively normal elderly individuals. While high gait variability is emerging as an early indicator of dementing illnesses, there is little research on whether high gait variability predicts cognitive decline in cognitively normal elderly who have no evidence of cognitive impairment. <B><I>Methods:</I></B> In this 4-year prospective cohort study on 91 community-dwelling cognitively normal elderly individuals without cerebral ischemic burden or Parkinsonism, we evaluated gait speed and step time variability using a tri-axial accelerometer placed on the center of body mass, and diagnosed mild cognitive impairment (MCI) according to the International Working Group on MCI. We performed Kaplan-Meier analysis with consecutive log-rank testing for MCI-free survival by cohort-specific tertiles of gait speed; hazard ratios (HR) of incident MCI were estimated using Cox proportional hazards regression analysis adjusted for age, sex, education level, Cumulative Illness Rating Scale score, GDS score, and presence of the apolipoprotein E ε4 allele. <B><I>Results:</I></B> Out of the 91 participants in the baseline assessment, 87 completed one or more 2-year follow-up assessments, and the median duration of follow-up was 47.1 months. Kaplan-Meier curves of incident MCI show evident differences in risk by gait variability group (χ<SUP>2</SUP> = 9.64, <I>p</I> = 0.002, log-rank test). Mean MCI-free survival in the high variability group was 12% shorter than in the mid-to-low tertile group (47.4 ± 1.74 [SD] vs. 54.04 ± 0.52 months), while it was comparable between gait speed groups (51.59 ± 0.70 vs. 50.64 ± 1.77 months; χ<SUP>2</SUP> = 1.16, <I>p</I> = 0.281). In multivariate analysis, subjects with high gait variability showed about 12-fold higher risk of MCI (HR = 11.97, 95% CI = 1.29–111.37) than those with mid-to-low variability. However, those with slow gait speed showed comparable MCI risk to those with mid-to-high speed (HR = 5.04, 95% CI = 0.53–48.18). <B><I>Conclusions:</I></B> Gait variability may be a better predictor of cognitive decline than gait speed in cognitively normal elderly individuals without cerebral ischemic burden or Parkinsonism.</P>
Seonjeong Park,Seung A Ock,Yun Jeong Park,Yoo-Hyun Lee,Chan Yoon Park,Sunhye Shin 한국영양학회 2024 Journal of Nutrition and Health Vol.57 No.2
Purpose: Although activating thermogenic adipocytes is a promising strategy to reduce the risk of obesity and related metabolic disorders, emerging evidence suggests that it is difficult to induce adipocyte thermogenesis in obesity. Therefore, this study aimed to investigate the regulation of adipocyte thermogenesis in diet-induced obesity. Methods: Adipose progenitor cells were isolated from the white and brown adipose tissues of control diet (CD) or high-fat diet (HFD) fed mice, and fully differentiated white and brown adipocytes were treated with β-agonists or 18-carbon fatty acids for β-adrenergic activation or peroxisome proliferator-activated receptor (PPAR) activation. Results: Compared to the CD-fed mice, the expression of uncoupling protein 1 (Ucp1) was lower in the white adipose tissue of the HFD-fed mice; however, this was not observed in the brown adipose tissue. The expression of peroxisome proliferator-activated receptor gamma (Pparg) was lower in the brown adipose progenitor cells isolated from HFD-fed mice than in those isolated from the CD-fed mice. Norepinephrine (NE) treatment exerted lesser effect on peroxisome proliferator-activated receptor-γ coactivator (Pgc1a) upregulation in white adipocytes derived from HFD-fed mice than those derived from CD-fed mice. Regardless which 18-carbon fatty acids were treated, the expression levels of thermogenic genes including Ucp1, Pgc1a, and positive regulatory domain zinc finger region protein 16 (Prdm16) were higher in the white adipocytes derived from HFD-fed mice. Oleic acid (OLA) and γ-linolenic acid (GLA) upregulated Pgc1a expression in white adipocytes derived from HFDfed mice. Brown adipocytes derived from HFD-fed mice had higher expression levels of Pgc1a and Prdm16 compared to their counterparts. Conclusion: These results indicate that diet-induced obesity may downregulate brown adipogenesis and NE-induced thermogenesis in white adipocytes. Also, HFD feeding may induce thermogenic gene expression in white and brown primary adipocytes, and OLA and GLA could augment the expression levels.
Miyoung Jeong,Hyejo Hailey Shin,Seonjeong Ally Lee,Minwoo Lee 글로벌지식마케팅경영학회 2023 Global Marketing Conference Vol.2023 No.07
As digital technology becomes more prevalent in today’s business environment and interest in digital trust rises, restaurants need to identify whether and how their mobile apps enhance the customer experience, and what features of the apps can strengthen customers’ attachment to them. However, few studies have examined the role of restaurant mobile apps as a catalyst for building customer loyalty. Considering restaurant mobile apps as a means to build a trustworthy relationship between customers and restaurants, this study develops and validates a research framework to measure digital trust between restaurants and customers through restaurant mobile apps. Specifically, due to the lack of measurement constructs for digital trust, a reliable and valid set of measurements that can explain digital trust in relation to restaurant mobile apps is developed and the effects of mobile apps’ digital trust on customers’ trust in a restaurant brand, overall experience, and their continued use intention are assessed.
Jun Gyo Gwon,Seonjeong Jeong,Hana Jin,Gi-Young Ko,Yong-Pil Cho,Tae-Won Kwon 대한외과학회 2022 Annals of Surgical Treatment and Research(ASRT) Vol.103 No.6
Purpose: Endovascular aneurysm repair (EVAR) has lower perioperative mortality and morbidity rates and shorter hospital stays when compared to open surgical repair (OSR) in octogenarian patients. However, its long-term results remain unclear. Hence, we aimed to analyze and compare the long-term outcomes of OSR and EVAR in this aging population. Methods: This single-center, retrospective, observational study analyzed the data of patients older than 80 years who underwent primary repair of an abdominal aortic aneurysm (AAA) between 2011 and 2016 in our hospital. The primary outcomes were in-hospital complications and 30-day mortality, while the secondary outcomes included all-cause mortality and reintervention rate. Results: Among the 48 patients with elective AAA repair, 13 underwent OSR and 35 underwent EVAR. In-hospital complications occurred in 10 patients (20.8%), 5 for OSR (38.5%) and 5 for EVAR (14.3%) with no significant difference between the groups (P = 0.067). In the OSR group, pulmonary complications were the most common events; in the EVAR group, 2 patients had ischemic colitis diagnosed with sigmoidoscopy and recovered by conservative treatment. The 1- and 5-year survival rates were 77.8% and 55.6% in the OSR group, and 66.0% and 54.9% in the EVAR group, respectively. The reintervention rate was 8.6% for the EVAR group; none of the OSR group were readmitted. Conclusion: The difference in procedures did not affect patient survival. Therefore, OSR does not necessarily have a worse prognosis than EVAR. Individual risk stratification must be preceded before the selection of an appropriate treatment method.
정신건강의학과 개방병동 입원 환자의 진단군별 약물 처방 경향 변화 : 경기도 소재 일 대학병원에서의 11년 비교 연구
변선정,김의태,유희정,하태현,윤인영,김기웅,Byun, Seonjeong,Kim, Euitae,Yoo, Hee Jeong,Ha, Tae Hyon,Yoon, In-Young,Kim, Ki Woong 대한생물정신의학회 2015 생물정신의학 Vol.22 No.4
Objectives This study investigated the patterns of psychotropic medications prescribed to patients admitted to an open psychiatric ward. Methods We reviewed 4282 medical records of patients who were discharged from an open psychiatric ward from May 2003 through April 2014. Data were collected on each patient's age, sex, length of hospital stay, number of past admissions, discharge diagnosis, and kinds and dosages of psychotropic medications at discharge. Results Among the 1384 male and 2898 female patients, 3.56 psychotropic medications were prescribed on average, with the number increasing across years, from 3.30 in 2003-2008 to 3.76 in 2009-2014. Prescription rates of antipsychotics, anxiolytics, and hypnotics significantly increased in patients with depressive disorders, bipolar disorders, anxiety disorders, delirium, dementia, and amnestic and other cognitive disorders. Only lithium prescription rates decreased significantly. Prescriptions for two or more anxiolytics and antipsychotics increased during the survey years, while antidepressant polypharmacy rates decreased. Conclusions Recently, there has been a significant increase in the number of psychotropic medications prescribed, including antipsychotics, anxiolytics, and hypnotics. Caution should be exercised when prescribing medications to avoid cost increases and the risk of side effects, with uncertain gains in the quality of care.
Tree Ring Growth of Clones in a Seed Orchard of A. nephrolepis during Drought Periods
Hye-Jin Lee,Sang-Jin Yoon,Seonjeong Kim,Sun-Cheon Hong,Dayoung Lee,Tae-Lim Yeo,Yoonji Hahn,Gye-Hong Cho,Yang-Gil Kim,Kwang Hyun Nam,Hyunjoong Sung,En-Bi Choi,Jun-Hui Park,Jeong-Wook Seo,Kyu-Suk Kang 한국육종학회 2023 한국육종학회 공동학술발표집 Vol.2023 No.-