사매가 Ovalbumin감작으로 유발된 천식 생쥐 모델에서 기관지염증 억제에 미치는 영향

임중근,노성수,길기정,이영철,서영배 대한본초학회 2005 大韓本草學會誌 Vol.20 No.1

Asthma is a chronic inflammatory disease of the airways, characterized by airway eosinophilia, goblet cell hyperplasia with mucus hypersecretion, and hyper-responsiveness to both inhaled allergens and nonspecific stimuli. Eosinophil are important in the pathogenesis of asthma, with release of inflammatory mediators such as histamine, leukotrienes, cytokines, and IgE after exposure to allergen. Objectives : This research investigates the effect of the extract of Duchesnea chrysanta (EDC) on OVA-indued asthma murine model. Methods : After i.p of C57BL/6 mice, OVA sensitization (day 0) were challenged intratracheally with OVA on days 8 and 21. EDC administered weeks 8, blocked the airway inflammatory response to OVA assessed 24 h after the last OVA challenge on day 22. Results : The CC chemokine receptor 3 (CCR3) is expressed by eosinophils, mast cells, and Th2 cells. The role of CCR3 in a murine model of allergic skin inflammation induced by repeated epicutaneous sensitization with ovalbumin (OVA), and characterized by eosinophil skin infiltration, local expression of Th2 cytokines, and airway hyperresponsiveness (AHR) to inhaled antigen. The administration of EDC during OVA inhalation significantly reduced CCR3 plays an essential role in eosinophil recruitment to the skin and the lung and in the development of AHR.. EDC extract reduced total lung cells and eosinophils in bronchoalveolar lavage fluid, airway tissue eosinophilia, goblet cell hyperplasia, mucus secretion, and peribronchial edema. The inhibitory effect on airway eosinophilia and AHR was associated with reduced levels of IL-4, IL-5, and IL-13 in the bronchoalveolar lavage fluid as well as reduced serum levels of OVA-IgE. We show that OVA inhalation following OVA immunization increased airway responsiveness to induced IL-113, IL-4 and IL-5 mRNA expression in the lung tissue. The administration of EDC during OVA inhalation significantly reduced this increased airway hyperresponsiveness and also inhibited airway inflammation. Conclusions : These results support EDC as a therapeutic target in asthma and indicate that selective EDC inhibitors can reduce allergic airway inflammation.

LC 공진형 PWM 인버터를 이용한 X선 발생장치의 특성에 관한 연구

이성길,박수강,임홍우,조금배,백형래,임양수 조선대학교 에너지.자원신기술연구소 2002 에너지·자원신기술연구소 논문지 Vol.24 No.1

The conventional types of X-ray generators were bulky in physical size and heavy in weight, and the control accuracies of the output voltages were not always satisfactory. The high frequency switching inverter and converter technology on power conversion and control systems have been greatly closed up introducing power semiconductor devices. In this paper, the newly developed converter to take the balance of the output voltage versus the ground are also presented in detail to decreasing the volume and the weight of high voltage transformer and to stabilize ripple. This converter consists of the two independent L-C series resonant circuits using the two capacitances and the two primary windings of high voltage transformer.

국내 정신과 의사의 항정신병 약물 장기 지속형 주사제 처방에 대한 인식조사

박한선,배승민,유재홍,김수인,임원정 大韓神經精神醫學會 2009 신경정신의학 Vol.48 No.3

Objectives Long acting injectable antipsychotic medication have the ability to sustain the drug effect for a long duration, thus enabling advances in the management of those psychiatric patients who have poor compliance or who have difficulty getting the oral form of their antipsychotic medications. Despite their benefits, previous studies have reported that depot antipsychotics have a much lower prescription ratein the treatment of schizophrenia or schizoaffective disorder. Psychiatrist's attitude toward depot antipsychotics clearly has an influence on the decision-making process regarding the selection of medications. Until now, there has been no data with respect to psychiatrists' attitudes regarding long-acting injectable antipsychotics in Korea. This Study examined these attitudes toward antipsychotic depot medications as well as the factors which could contribute to their choice of deports. Methods We questioned 347 psychiatrists, who had been attending a conference, about their attitudes toward depot antipsychotic treatment. Results The most important factor causing reluctance with respect to prescribing depot treatment (for both classes of antipsychotics) was a presumed sufficient level of compliance with available oral antipsychotic treatments. In addition, typical depots are not considered to be an appropriate treatment option for first-episode patients, and as a result, they are used sparingly. Lastly, atypical long-acting injectable drugs are avoided due to their strict criteria of insurance and high treatment costs. Conclusion Aversions to prescribe depot treatment are frequent among psychiatrists and appear to be unrelated to the antipsychotic class. The stated reasons for not choosing depots are generally not supported by the current literature. Further research is required to clarify the advantages using depot treatments.

Small Buyers Adoption of Reverse Aggregation Electronic Markets: A Case Study on the Korean Auto Repair Industry

Lim, Seong-Bae,Kim, Sung-Kwan,Mitchel, Robert B.,Hong, Soon-Goo Korea Association of Information Systems 2004 情報시스템硏究 Vol.13 No.2

The purpose of this study is to investigate factors which can lead small buyers to participate in a Reverse Aggregation Electronic Market (RAEM). Five factors including search, selection, price, delivery, and Internet literacy were selected as possible factors which are expected to influence small buyers' participation in a RAEM. This paper focused on a RAEM of the Korean automotive industry in which the third party aggregator formed a group of small automobile repair shops (ARS) and amassed buying power for them by building a buyer' oriented electronic market (EM). Survey data were collected from small ARS in South Korea. The results of the empirical analysis indicated that fast delivery and support for Internet illiteracy are potential incentives that could influence buyers' decisions to join a RAEM.

Small Buyers` Adoption of Reverse Aggregation Electronic Markets: A Case Study on the Korean Auto Repair Industry

Seong Bae Lim,Sung Kwan Kim,Robert B. Mitchel,Soon Goo Hong 한국정보시스템학회 2004 情報시스템硏究 Vol.13 No.2

Effect of temperature on mechanical properties and formability of coatings for pre-coated metal

Bae, Seong-Guk,Noh, Geon Ho,Hong, Seong Soo,Lim, Kwon Taek,Oh, Joong-Geul,Lee, Won-Ki Informa UK (TaylorFrancis) 2017 Molecular Crystals and Liquid Crystals Vol.659 No.1

미국과 유럽 구조기준에 따른 물류창고 Slab on Ground 설계 두께 비교 및 분석

임성배(Lim, Seong-Bae),최준호(Choi, Jun-ho),이창준(Lee, Chang-Joon) 대한건축학회 2022 대한건축학회 학술발표대회 논문집 Vol.42 No.2

A Study of Suppliers' Participation in Private Exchanges: Focusing on MRO Markets

임성배(Seong-bae Lim),김성관(Sung-kwan Kim),Robert B. Mitchell,홍순구(Soongoo Hong) 한국전자거래학회 2004 한국전자거래학회지 Vol.9 No.4

성장 잠재력에도 불구하고 많은 B2B 시장은 참여업체 수의 부족으로 운영의 어려움을 겪고 있다. 따라서 어떠한 방법을 통해 충분한 숫자의 기업들을 시장에 참여하도록 유도할 것인가가 B2B 시장의 성공을 위한 주요 요인 중의 하나로 인식되고 있다. 본 논문은 MRO 시장을 대상으로 공급업체들을 구매자 중심의 전용시장(Private Exchanges)에 참여하게 만드는 요인들이 어떤 것인지를 규명해 보는 것을 주요 목적으로 하고 있다. 이를 위해 EDI 채택에 관한 선행연구와 실무자들과의 면접에 기초하여 실험대상 요인들을 추출하였다. 불완전한 계약 이론(Incomplete contract theory)에 기초하여 가설의 설정과 검증을 하였으며, 분석 결과 시장에 참여할 것으로 기대되는 공급업자들의 수와 시장 참여의 대가로 주어질 보상의 유무가 B2B시장의 참여에 긍정적인 영향을 주는 요인으로 나타났다. 한편 구매업자에 대한 신뢰는 유의한 요인으로 드러나지 않아 공급업자들은 기존의 구매업자와의 신뢰관계가 B2B 시장에서는 중요하지 않는 것으로 조사되었다. Many B2B electronic markets (EMs) are struggling to survive because they failed to attract enough participants. Thus reaching critical mass of participants is one of the key success factors for various types of EMs. The main purpose of this study is to investigate factors that lead MRO (maintenance, repair, and operating) suppliers to participate in private exchanges (PE), the buy-side EM. This paper introduces the characteristics of the PE according to the classification schemes introduced in previous studies about EM types. Literature is reviewed on suppliers’ adoption of inter-organizational information systems focusing on EDI adoptions issues. Data analysis based on incomplete contract theory and the social exchange theory is then presented. The results of this study show that the number of suppliers and subsidy are factors that influence suppliers' participation in PEs. Nonsignificant results relating to trust imply that suppliers who are invited to participate in a PE do not expect their off-line relationships with the buyer to be transferred to the PE.

창호일체형 태양열 집열기

박성배(Park seong-bae),임성환(Lim seong-whan),박만귀(Park Mann-kwi) 한국태양에너지학회 2009 한국태양에너지학회 학술대회논문집 Vol.- No.-

Window integrated solar collector is to simply install inside of the existing double glass window frame. Double glass window frame is consist of inner glass of Low-E coating and Silver coating, and outer glass of low iron reinforced glass. In order to secure natural lighting in a room, only 50% of window frame is covered with solar collectors. Solar absorption or transmission rate varies seasonally depending on sun angles. Part of inner glass where right behind of the solar plate is covered with silver coating to increse absorption rate of solar plate. The collector is made of a copper serpentine where aluminum fins are soldering. To improve the effect of insulation of inside of the window frame is recommend vacuum. As a result, we are making the 3th sample and will archieve below FRUL=7.5W/㎡℃ that is the account of heat lossed, and above FR(Tα)= 0.45.

복합재료 블레이드 단면 해석 프로그램(Ksec2d-AE)의 신뢰성 검증

배재성(Jae-Seong Bae),김현식(Hyun-Sik Kim),배진규(Jin-Kyu Bae),임태현(Tae-Hyun Lim),황재민(Jae-Min Hwang),정성남(Sung Nam Jung) 한국항공우주학회 2018 韓國航空宇宙學會誌 Vol.46 No.4

본 연구에서는 유한요소법 기반의 단면 특성치 해석 프로그램인 Ksec2d-AE의 정확성을 검증함으로써, 학부 수준의 비행체 구조해석 및 설계 시 활용가능성을 제시하고자 한다. 이를 위해 다양한 요소를 적용하여 Ksec2d-AE 로부터 계산된 단면강성계수 결과에 대한 유한요소의 수렴성을 확인하였다. 또한 Ksec2d-AE로부터 구한 단면강성계수를 상용 구조해석 프로그램인 MSC NASTRAN 으로부터 구한 강성계수와 비교하고, 주요 공학적 중심치(인장 중심, 전단 중심, 주 굽힘축)의 특성에 부합하게 구조물이 거동하는지 확인함으로써 Ksec2d-AE의 단면강성계수 및 중심치 결과를 검증하였다. 본 연구를 통하여 Ksec2d-AE 프로그램의 유용성을 확인하였다. In this study, the accuracy and efficiency of a composite rotor blade cross-section analysis program, Ksec2d-AE, which is available at an educational web-based platform called EDISON-CSD, are assessed for possible use in undergraduate structural analysis projects. To this purpose, the convergence of cross-sectional constants by varying the number of finite elements in the cross-section of a wind turbine blade is investigated. The stiffness constants along with the cross-sectional engineering offsets obtained using Ksec2d-AE are validated against a 3D finite element analysis program MSC NASTRAN.