장벽경색이 선행한 Henoch-Schonlein 자반증 1례

한헌석,하태선,송형근,이상전,안묘순,박범수 충북대학교 의과대학 충북대학교 의학연구소 1993 忠北醫大學術誌 Vol.3 No.1

Henoch-Schonlein 자반증은 피부, 위장관, 관절, 신장 등을 주로 침범하며 소혈관염을 기본 병리 소견으로하는 전신성 혈관 장애 질환이다. 위장관계 증상으로는 복통, 오심 및 구토, 잠혈, 토혈, 흑색변 등이 있을 수 있고, 이러한 증상은 합병증 없이 회복되는 것이 보통이나 드물게는 장중첩증, 장벽경색 및 괴사, 장천공 등의 심한 합병증을 동반할 수도 있다. 이러한 위장관계 증상들은 특징적인 피부 소견에 선행하여 나타날 수도 있으며, 이때는 급성복증에 대한 감별진단이 중요하다. 저자들은 장벽경색이 선행하여 감별진단에 어려움을 겪고 시험적개복술을 시행한 이후에 특징적인 피부 자반이 발현되어 Henoch-Schonlein 자반증으로 진단할 수 있었던 증례를 경험하였기에 이를 보고하고자 한다. 본 증례는 입원 1일전부터 시작된 복통을 주소로 입원한 5세 남아가 배꼽 주위에 심한 경련성 복통을 지속적으로 호소하였고 이학적 소견상 배꼽주위의 압통, 장음의 감소, 흑색변 등이 있었으며 소장조영술상 공장 부위에 미만성의 불규칙한 점막비후 소견을 보여 제 8병일에 시험적개복술을 시행한 결과 근위 공장에 국한된 장괴사의 소견이 발견되어 절제 및 문합술을 실시 하였다. 병리학적 검사에서는 장벽경색의 소견을 보였다. 수술후에 복통은 완화되었으나 경미하게 지속되었고, 제 13병일경에 급성 부고환염이 병발되었다가 회복되었고 제 15병일경에는 하지에서부터 발현된 자반이 3일간 지속되었다. 결구 Henoch-Schonlein 자반증과 이의 합병증으로 발생한 근위 공장의 장벽경색으로 진단하였다. Colicky abdominal pain as symptom of Henoch-Schonlein purpura occurs in up to 70% of patients, and results from submucosal edema and hemorrhage. Abdominal pain and other GI symptoms such as nausea, vomiting, melena and hematemesis resolve mostly without any complications. But rarely life-threatening GI complications such as intussusception, intestinal mural infarction and necrosis, and massive hemorrhage may develope. In 14% of patients, abdominal pain may precede other symptoms, and creats diagnostic difficulties. We reports a case of the Henoch-Schonlein purpura presented with colicky abdominal pain which resulted from intestinal mural infarction and preceded characteristic purpuric skin lesion by several weeks. This 5 year old male patient complained of colicky abdominal pain, nausea and melena. Exploratory laparatomy was done and revealed intestinal mural infarction in proximal jejunum. One week later operation, purpuric skin lesion develiped in both leg and feet, and then, Henoch-Schonlein purpura was diagnosed.

精密測定 計器用 Stainless Steel의 諸性質에 미치는 熱處理의 影響

金善泰,安幸根,韓泰鍾 Natural Science Research Institute JEONJU UNIVERSI 1987 전주대학교 자연과학연구소 학술논문집 Vol.2 No.2

The changes of microstructure and hardness with the various heat treatments on the properties of Fe-13.36% Cr-0.37%C stainless steel for precision measuring gauge have been investigated. Type 420 stainless steel has the self-hardenability, because the nose of isothermal transformation diagram located greatly to the right. The highest hradness in the martensite martrix with undissolved carbide is obtained by oil and air cooling treatment after austenizing at 1000-1050℃, for 1/6-1/3hr. In case of low temperature tempering, internal stress is reduced without dissolution of martensite matrix, and hardness reduced slightly. In case of high temperature tempering, hardness is reduced greatly, because the martensite matrix is dissolved into a ferrite and carbide.

만성정신질환자의 직업재활 사례

황태연,한은선,이영문,강순정,정경선 용인정신의학연구소 1995 용인정신의학보 Vol.2 No.1

미혼 여성근로자의 건강행태와 자각적 건강상태와의 관련요인 분석

김현지,한성현,이태용,김정선 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

This study was peroformed to identify health behaviors and health problems, and the relations between health behaviors and health problems of unmarried female workers. The Cornell Medical Index Health Questionnaire(CMI) was used to measure their health problems. Survey was conducted with 973 unmarried female workers from October 2001 to March 2002. The main reason of health problems is the stress commonly in both white color workers and blue color workers. Among white color workers, smoking and stress is significantly related with respiratory system, musculoskelectal system. Stress is significantly related with digestive system, neurological system. Drinking and stress is significantly related with fatigability(p<0.05). Among blue color workers, smoking, drinking, strees is significantly related with respiratory system. Stress, smoking, eating habit is significantly related with digestive system. Stress, smoking, eating habit, hours of sleep is significantly related with musculoskeletal system. Stress, smoking is significantly related with fatigability(p<0.05).

Irbesartan과 Lercanidipine의 병용요법이 고혈압 및 혈관재형성에 미치는 효과

이도형, 임태완, 조은지, 박현수, 정상혁, 한주희, 병창선 충남대학교 약학대학 의약품개발연구소 2017 藥學論文集 Vol.32 No.-

Hypertension is one of the major risk factor for cardiovascular disease and can lead to or make worse many complications, heart disease, atherosclerosis and diabetes. Thus, managing blood pressure effec tively using therapeutic drugs such as angiotensin II receptor blocker (ARB) and Ca2+ channel blocker (CCB) can be prevent other complications. Therefore, we investigated the synergistic effect of these two drugs, ir besartan and lercanidipine, for antihypertension, cardioprotection and antidiabetes. Irbesartan (28.74 mg/kg, 14.37 mg/kg) or lercanidipine (1.92 mg/kg, 0.96 mg/kg) alone or combination was administered to sponta-neously hypertensive rats (SHRs) and C57BL/6 mice. A two-week treatment of combination with irbesartan and lercanidipine significantly attenuated systolic blood pressure (SBP) and mean arterial pressure (MAP) compared with monotherapy. Futhermore. the combination therapy protected myocardial ischemia reperfusion injury more effectively than monotherapy. In vascular remodeling, combination therapy significantly diminished cuff -induced neointima formation and reduced serum -indllced vascular smooth muscle cells (VSMCs) pro-liferation compared with monotherapy. However, combination therapy had no significant synergistic effect of blood glucose regulation. Taken together, present study suggest that the combination therapy of irbesartan and lercanidipine may be more effective therapeutic strategy for the treatment of hypertension and related complications, myocardial infarction and arterial restenosis than monotherapy

사람폐암세포주 (PC-14)에서 Cyclosporin A에 의한 Adriamycin 내성의 극복

김영환,홍원선,송재관,강윤구,이진오,강태웅,김건열,한용철 대한내과학회 1990 대한내과학회지 Vol.38 No.3

Cyclosporin A and verapamil were tested using MTT assay to evalute the modification effect on the resistance to adriamycin in a human lung cancer cell line(PC-14) and its resistant subline(PC-14/A). PC-14/A was derived by the continuous exposure of PC-14 to incremental concentrations of adriamycin. PC-14/A was 2.5 times more resistant to adriamycin in terms of ICso than PC-14. Cyclosporin A alone, at a concentration of 2.5㎍/㎖, inhibited the growth of PC-14 to 68.3%. 2.5㎍/ ㎖ and 5.0㎍/㎖ of cyclosporin A showed an increase in the cytotoxicity of adriamycin (p<0.01) with 5.0㎍/㎖ being greater than 2.5㎍/㎖(p<0.01). Excluding the direct cytotoxic effect, however, cyclosporin A did not increase in the sensitivity of PC-14 to adriamycin but only showed an additional cytotoxic effect with adriamycin. Verapamil (up to 6.0㎍/㎖) did not inhibit the growth of PC-14. 3.0㎍/㎖ of verapamil did not increase the cytotoxic effect of adriamycin. The combination of cyclosporin A and verapamil with adriamycin enhanced the cytotoxicity of adriamycin, but the result was similar to that of cyclosporin A with adriamycin. 5.0㎍/㎖ of cyclosporin A modified the adriamycin resistance of PC-14/A(SR, 3.2). However, 3.0㎍/㎖ of verapamil did not significantly reverse the adriamycin resistance of PC-14/A. The modified effect of the combination of 5.0㎍/㎖ of cyclosporin A and 3.0㎍/㎖ of verapamil was similar to that of 5.0㎍/㎖ of cyclosporin A alone in PC-14/A. These results demonstrate that cyclosporin A has an additional cytotoxic effect with adriamycin in PC-14 and PC-14/A and has overcome the acquired resistance to adriamycin in PC-14/A. They also suggest that cyclospoin A may have the therapeutic potential in the treatment of human lung cancer.

사업장 소음 폭로에 의한 일과성 역치 상승과 회복

조수헌,하미나,한상환,주영수,성주헌,강종원,윤덕로,송동빈,이명학,김선태 大韓産業醫學會 1996 대한직업환경의학회지 Vol.8 No.2

To determine the recovery time from noise-induced temporary threshold shift(TTS), a prospective field study was conducted at three worksites where workers are known to be exposed high level of noise. Subjects were selected according to answers on a questionnaire which inquired about otological history and previous noise exposure, including avocational, military and occupational exposures. After excluding employee with past otologic problems, recent exposure to high level noise, and under medications, total 92 employees participated in the study. Among 92 participants, complete consecutive audiometric examinations were carried out at 0∼2 hours, 5∼7 hours, 14∼16 hours after worktime noise exposure on 26 participants wearing hearing protectors and 22 participants wearing no protective devices. The difference between the hearing level 0∼2 hours after noise exposure and 5∼7 hours is statistically significant by paired t-test(p<0.01). The median recovery times calculated from the data of 22 participants wearing no protective hearing devices are 15.6 hours at 4000Hz, and 7.7 hours, 10.3 hours, 8.4 hours at 1000Hz, 2000Hz and 8000Hz respectively. These data suggest that when measuring the pure tone audiometry for noise exposed workers, at least 16 hours noise-free interval is required.

Observational Study in Real Time Navigational Surgery with Near-Infrared Camera in Laparoscopic Gastric Cancer Surgery

Tae Han Kim,Yun Suk Choi,Yun-Suhk Suh,Seon Ho Kong,Hyuk Joon Lee,Han Kwang Yang 대한종양외과학회 2016 대한임상종양학회 학술대회지 Vol.2016 No.2

Comparative analysis of chloroplast genomes and 45S nuclear ribosomal DNAs within 9 perilla species

Seon-Hwa Bae,In-Seon Jeong,Ye-Ji Lee,Myoung-Hee Lee,Jeong-Hee Lee,Ung-Han Yoon,Jang-Ho Hahn,Tae-Ho Kim 한국육종학회 2015 한국육종학회 심포지엄 Vol.2015 No.07

Perilla is a annual herb plant of the mint family, Laminaceae and mainly cultivated in eastern Asia, i.e. Korea, China and Japan. In response to an increased interest for healthy supplement food from the public, people are focusing on the properties of perilla. The applicable parts of perilla plants are the leaves and seeds. Perilla has been cultivated as a source of unsaturated fatty acid oil. But in spite of advantage of the important nutritional traits the genome or molecular studies on perilla remains largely unknown. Sequence comparisons of chloroplast (cp) genomes or nuclear ribosomal DNA (nrDNA) are of great important to provide a evidence for taxonomic studies or species identification or understanding mechanisms that underlie the evolution of perilla species. So, we tried to study a structural analysis of perilla genome and 45s nrDNA using 9 species (3 Diploid; Perilla B-17, P. hirtella, P. setoyensis / 6 Tetraploid; YCPL 285, YCPL 170, YCPL 205-1, YCPL 181-1, YCPL 177-1, YCPL 207-1). The complete cp genome and nrDNA of 9 perilla species were determined using Illumina sequencing technology and analyzed on the variance in base level between perilla B-17 and salvia miltiorrhiza. Total chloroplast genome size of perilla B-17 as a reference was 152,589 bp in length. We also identified an slightly overlapped intergenic regions between salvia miltiorrhiza and B-17. The results above will contribute to growing of molecular or genome structure and functional genomics of perilla available in studying perilla biology. For further study, we will look for genetic diversity of perilla species.

Effects of Artificial UV-B and Solar Radiation on Four Species of Antarctic Rhodophytes

Han, Tae-Jun,Park, Seon-Joo,Lee, Min-Soo,Han, Young-Seok,Kang, Sung-Ho,Chung, Ho-Sung,Lee, Sang-Hoon Korea Institute of Ocean Science Technology 2001 Ocean and Polar Research Vol.23 No.4

During austral summer 1998 we examined the impacts of artificial UV-B and solar radiation on chlorophyll a content and fresh weight of four species of Antarctic red algae namely, Georgiella confluens, Iridaea cordata, Pantoneura plocamioides and Porphyra endiviifolium. These subject species were taken in consideration of clear demarcations of their vertical distribution and classified as shallow water group (Iridaea and Porphyra) and deep water group (Georgiella and Pantoneura). When irradiated with artificial UV-B at the irradiance of $2.0Wm^{-2}$ the shallow water inhabitants were much more resistant than the algae from deep water the fresh weight of which was reduced by 40-50% relative to control apart from loss of pigmentation. Direct solar radiation was lethal to the deep water group with a sign of complete bleaching whereas the shallow water group did not show any change in the physiological parameters. We were unable to discriminate difference in the algal sensitivity between UV-filtered and UV-transparent treatments since samples tested were either all unaffected or dead. Spectrophotometric measurements of methanolic extracts revealed a strong absorption peak in the UV range in the shallow water group of algae, Iridaea and Porphyra, but not in the deep water counterparts. Species difference in sensitivity to artificial UV-B and solar radiation is discussed in relation to biochemical and morphological characteristics and the role of the radiation in the algal vertical distribution is suggested from ecological perspective.