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진균혈증의 진단에 있어서 혈청 (1→3)-β-D-glucan 측정의 유용성
최석훈,한상훈,진범식,박윤선,조병철,김희만,김윤재,이꽃실,장경희,송영구,김준명 대한감염학회 2003 감염과 화학요법 Vol.35 No.4
목적 : 진균혈증의 신속한 진단은 진균혈증 치료의 핵심이다. 그러나 진균혈증의 전통적인 진단법은 어렵기 때문에 진단을 지연시킬 수 있다. 진균혈증의 진단에서 β-glucan의 임상적 유용성을 알아보기 위하여 본 연구자들은 진균혈증 환자의 혈청 β-glucan의 농도를 측정하기 위하여 대조군으로써 균혈증 환자와 건강한 성인과 비교하였다. 방법 : 2001년 8월에서 2002년 10월까지 16명의 진균혈증 환자, 13명의 균혈증 환자, 그리고 18명의 정상 성인의 혈청 β-glucan 농도를 측정하였다. 본 연구자들은 β-glucan 농도를 β-Glucan Test(Wako Pure Chemical Industries, Ltd., Osaka, Japan)를 이용하여 측정하였다. 진균혈증 환자와 다른 환자들 사이의 혈청 β-glucan 농도 비교는 t-검정을 이용하였다. 결과 : 진균혈증 환자 중에서 남자는 10명(62.5%)이었고, 여자는 6명(37.5%)이었으며, 평균연령은 52.9±16.2세였다. 균혈증 환자 중에서 남자는 6명(46.2%)이었고, 여자는 7명(53.8%)였으며, 평균연령은 52.3±17.1세였다. 정상 성인 중에서 남자는 15명(83.3%)이었고, 여자는 3명(16.7%)였다. 평균연령은 23.8±2.1세였다. Cut-off value는 11 pg/mL이었다. 총 16명의 진균혈증 환자 중에서 13명의 혈청 β-glucan의 농도가 cut-off value 이상이었고(범위:11.5-863 pg/mL, 민감도:81.3%, 특이도:100%), 평균 농도는 217.8±273.8 pg/mL이었다. 총 13명의 균혈증 환자의 혈청 β-glucan 농도는 전부 cut-off 이하였고, 평균 혈청 β-glucan 농도는 0.1±0.3pg/mL이었다. 총 18명의 정상 성인의 혈청 β-glucan의 농도는 전부 cut-off value 이하였고, 평균 혈청 β-glucan 농도는 0 pg/mL이었다. 진균혈증 환자의 혈청 β-glucan의 농도는 통계학적으로 유의하게 대조군인 균혈증 환자와 건강한 성인의 농도보다 높았다(P-value : 0.006 및 0.006). 결론 : 결론적으로 진균혈증 환자의 진단에서 혈청 β-glucan의 농도 측정은 임상적으로 의미가 있다. 그러나 본 연구가 임상적으로 더욱 유용하기 위하여는 혈청 β-glucan 농도 측정을 통한 진균혈증의 조기진단이 진균혈증 환자의 예후에 미치는 영향과 혈청 β-glucan 농도와 진균혈증 환자의 항진균제에 대한 치료반응과의 연관을 밝히는 연구가 진행되어야 할 것이다(본 연구는 WAKO사의 β-glucan Test (Wako Pure Chemical Industries, Ltd., Osaka, Japan)의 제공으로 이루어졌음) Background : Early recognition of fungemia is essential for successful treatment. However, methods to culture fungus specimen taken from fungemia patients are difficult and time consuming. To assess the clincal usefulness of β-D-glucan in the detection of fungemia. we compared serum (1→3)-β-D-glucan concentrations in fungemia, bacteremia, and healthy persons. Methods : From August 2001 to October 2002, serum (1→3)-β-D-glucan concentrations were measured by turbidometric assay in 16 fungemia patients, 13 bacteremia patients and 18 healthy persons. Differences in (1→3-β-D-glucan concentrations between fungemia patients and other groups were compared by t-test. Results : Fungemia patients were composed of 10 male and 6 female patients, and mean age was 52.9±16.2 years. The cut-off value for a positive result was 11 pg/mL. thirteen out of 16 fungemia patients had concentrations above the cul-off value (range: 11.5-863 pg/mL, sensitivity: 81.3%, specificity: 100%), and mean concentration in fungemia was 217.8±273.8 pg/mL. Mean concentration in bacteremia was 0.1±0.3 pg/mL, and all the patients with bacteremia had the concentrations below the cut-off value. Mean concentration in the healthy persons was 0 pg/mL and all healthy persons had concentration below the cut-off value. The concentration in fungemia was statistically significantly higher than those of the other two groups(p-value: respectively 0.006, 0.006) Conclusion : We concluded that serum (1→3)-β-D-glucan is useful for the diagnosis of fungemia. Further study on the usefullness of serum (1→3)-β-D-glucan for early detection of fungemia and therapeutic monitoring is warranted.
First Record of Mycoplasma-like Organism in Pacific Oyster (Crassostrea gigas) in Korea
Choi Dong Lim,Choi Hee Jung,Lee Nam-Sil,Park Mi Seon The Korean Society of Fisheries and Aquatic Scienc 2003 Fisheries and Aquatic Sciences Vol.6 No.3
During routine survey of Pacific oyster (Crassostrea gigas) collected from Tongyoung area in southern coast of Korea, histological examination revealed that a intracellular microorganisms infected the digestive gland of the oyster. They infected hepatopancreatic cells extensively. The size of intracellular microorganism was of 45 to 86nm in diameter and 200nm to more thar 500nm in length. They were pleomorphic. The morphological characteristic of intracellular microorganisms lacked cell wall and was bounded by the plasma membrane. They contained typical prokaryotic ribosomes and fibrillar DNA-like strands. No additional internal structure has been observed. Based on the lack of cell wall and the cellular localization, the intracellular microorganism is considered as a Mycoplasma-like organism.
Helical tomotherapy for spine oligometastases from gastrointestinal malignancies
Choi, Yun-Seon,Kim, Jun-Won,Lee, Ik-Jae,Han, Hee-Ji,Baek, Jong-Geal,Seong, Jin-Sil The Korean Society for Radiation Oncology 2011 Radiation Oncology Journal Vol.29 No.4
Purpose: This study evaluated the treatment effectiveness and proper radiation dose of helical tomotherapy (HT) in spine oligometastases from gastrointestinal cancers. Materials and Methods: From 2006 to 2010, 20 gastrointestinal cancer patients were treated with HT for spine oligometastases (31 spine lesions). The gross tumor volume (GTV) was the tumor evident from magnetic resonance imaging images fused with simulation computed tomography images. Clinical target volume (CTV) encompassed involved vertebral bodies or dorsal elements. We assumed that the planning target volume was equal to the CTV. We assessed local control rate after HT for 31 spine metastases. Pain response was scored by using a numeric pain intensity scale (NPIS, from 0 to 10). Results: Spine metastatic lesions were treated with median dose of 40 Gy (range, 24 to 51 Gy) and median 5 Gy per fraction (range, 2.5 to 8 Gy) to GTV with median 8 fractions (range, 3 to 20 fraction). Median biologically equivalent dose (BED, ${\alpha}/{\beta}$ = 10 Gy) was 52 $Gy_{10}$ (range, 37.5 to 76.8 $Gy_{10}$) to GTV. Six month local control rate for spine metastasis was 90.3%. Overall infield failure rate was 15% and outfield failure rate was 75%. Most patients showed pain relief after HT (93.8%). Median local recurrence free survival was 3 months. BED over 57 $Gy_{10}$ and oligometastases were identified as prognostic factors associated with improved local progression free survival (p = 0.012, P = 0.041). Conclusion: HT was capable of delivering higher BED to metastatic lesions in close proximity of the spinal cord. Spine metastases from gastrointestinal tumors were sensitive to high dose radiation, and BED (${\alpha}/{\beta}$ = 10 Gy) higher than 57 $Gy_{10}$ could improve local control.