제조에 對한 文獻的 考察

안태규,최병렬,송기철,이용연,유화승,서상훈,최우진,조정효,이연월,손창규,조종관 대전대학교 한방병원 2001 惠和醫學 Vol.10 No.1

In the literatual study on Holotrichia, the results were obtained as follows ; 1. Holotrichia is larva of Holotrichia diomphalia Bates etc. powder or liquor of Holotrichia is used medically. 2. Appearance of Holotrichia is shape of kidney, yellowish color. 3. The oriental characters of Holotrichia is warm, toxicant, salty. 4. The significant efficancy of Holotrichia is breaking the stagnant blood. 5. Holotrichia can be applied to the diseases related to thrombosis, and recover the demage of liver. 6. Holotrichia avails Liver diseases such as Hepatitis, Liver cirrhosis, Hepatosplenomegaly, Hepatoma etc.

비만을 동반한 위암 환자에서 두 병을 같이 수술 치료한 경험(증례)

최경현,윤기영,문형환,신연명,서경원,안수미,송윤미,석정희,정경연,이은하 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.3

Obesity is growing problem in Korea. We had a case of bariatric surgery during gastric cancer operation. Patient was 29 year old Korean lady with early gastric cancer located in the lesser curvature side of the middle 1/3 of the stomach. Her body weight was 89 kg, height 163 cm, and thus body mass index was 33.5 kg/m2. Preoperative blood pressure was 130/90 mmHg, hemoglobin 12.9 g/dL, total lymphocyte count 3,280/mL, serum albumin 4.3 g/dL, CEA 1.1 ng/mL, CA 19-9 9.1 ng/mL, and alpha fetoprotein 2 ng/mL. Another associated disease was right thyroid follicular neoplasm. The chest X-ray was normal. After IM injection of 2,500 units of heparin 30 minutes before the induction of general anesthesia, she received curative subtotal gastrectomy and Roux en Y gastrojejunostomy when a malabsorption loop of 120 cm jejunum was incorporated between the Treitz ligament and the end to side jejuno-jejunostmy site at May 29th 2006. Her postoperative course was uneventful except a minor wound seroma and the elevations of serum amylase(up to 4 folds) and lipase(up to 2 folds). She lost her body weight 9 kg in 5th, 21 kg in 7th, and 27 kg in 10th postoperative months to became 61.5 kg. On follow up exams in July 2008, she gained 4 kg to overcome her weakness and fatigue. From the above result, the incorporation of a malabsorption loop during reconstruction phase of gastric cancer operation was a good option for obese gastric cancer patients especially in cases of early gastric cancer.

Safety and efficacy of nilotinib in adult patients with chronic myeloid leukemia: a post-marketing surveillance study in Korea

Seo-Yeon Ahn,Sang Kyun Son,Gyu Hyung Lee,Inho Kim,June-Won Cheong,Won Sik Lee,Byung Soo Kim,Deog-Yeon Jo,Chul Won Jung,Chu Myoung Seong,Jae Hoon Lee,Young Jin Yuh,Min Kyoung Kim,Hun-Mo Ryoo,Moo-Rim Pa 대한혈액학회 2022 Blood Research Vol.57 No.2

Background Nilotinib is a tyrosine kinase inhibitor approved by the Ministry of Food and Drug Safety for frontline and 2nd line treatment of Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML). This study aimed to confirm the safety and efficacy of nilotinib in routine clinical practice within South Korea. Methods An open-label, multicenter, single-arm, 12-week observational post-marketing surveillance (PMS) study was conducted on 669 Korean adult patients with Ph+ CML from December 24, 2010, to December 23, 2016. The patients received nilotinib treatment in routine clinical practice settings. Safety was evaluated by all types of adverse events (AEs) during the study period, and efficacy was evaluated by the complete hematological response (CHR) and cytogenetic response. Results During the study period, AEs occurred in 61.3% (410 patients, 973 events), adverse drug reactions (ADRs) in 40.5% (271/669 patients, 559 events), serious AEs in 4.5% (30 patients, 37 events), and serious ADRs in 0.7% (5 patients, 8 events). Furthermore, unexpected AEs occurred at a rate of 6.9% (46 patients, 55 events) and unexpected ADRs at 1.2% (8 patients, 8 events). As for the efficacy results, CHR was achieved in 89.5% (442/494 patients), and minor cytogenetic response or major cytogenetic response was achieved in 85.8% (139/162 patients). Conclusion This PMS study shows consistent results in terms of safety and efficacy compared with previous studies. Nilotinib was well tolerated and efficacious in adult Korean patients with Ph+ CML in routine clinical practice settings.

Early response-based intensification of primary therapy in newly diagnosed multiple myeloma patients who are eligible for autologous stem cell transplantation: phase II study

Ahn, Seo-Yeon,Jung, Sung-Hoon,Joo, Young Don,Lee, Won Sik,Lee, Sang Min,Choi, Chul Won,Kim, Seok Jin,Kim, Kihyun,Lee, Je-Jung Springer-Verlag 2014 Annals of hematology Vol.93 No.9

Prognostic Significance of Interim 11C-Methionine PET/CT in Primary Central Nervous System Lymphoma

Ahn, Seo-Yeon,Kwon, Seong Young,Jung, Sung-Hoon,Ahn, Jae-Sook,Yoo, Su Woong,Min, Jung-Joon,Bom, Hee-Seung,Ki, So Yeon,Kim, Hyeoung-Joon,Lee, Je-Jung,Song, Sang Yun,Yang, Deok-Hwan Lippincott 2018 Clinical nuclear medicine Vol.43 No.8

<P>Conclusions Response assessments based on interim C-11-MET PET/CT could predict the therapeutic outcome of PCNSL.</P>

Poster Session : PS 1400 ; Hemato-Oncology(Hematology) : The Impact of Oliguria in Patients with Multiple Mye-loma Presenting with Renal Impairment

( Seo Yeon Ahn ),( Sung Hoon Jung ),( Jae Sook Ahn ),( Deok Hwan Yang ),( Min Seok Cho ),( Yeo Kyeoung Kim ),( Hyeoung Joon Kim ),( Je Jung Lee ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Recently, change of urine output is valuable biomarker of acute kidney injury associated with mortality in critically ill patients. This study investigated the prognostic impact of oliguria for survival outcomes in patients with multiple myeloma (MM) presenting with renal impairment (RI). Methods: Retrospective data for 98 patients with MM and RI who were treated upfront with a novel agent containing regimen were analyzed. Oliguria was defined as a urine output that is less than 0.5ml/kg/hours. Results: Baseline median eGFR was 39.7 ml/min (range 5.1-59.8). Achievement of renal complete response (renalCR) was observed in 39.8% of patients. Nine patients (9.2%) presented with oliguria at initial diagnosis, and four initially required dialysis. Over follow-up for a median of 17.1 (range 1.7-100.0) months and median OS was 38.7 months (95% CI 25.0-52.5). On multivariate analysis, oliguria at diagnosis (hazard ratio [HR] 3628, 95% CI 1.366-9.849, P = 0.011) and thrombocytopenia < 100ⅹ 109/ L (HR 2.534, 95% CI 1.068-6.015, P = 0.035) at diagnosis were significantly associated with overall survival. Conclusions: Oliguria was significantly associated with high mortality in MM patients with RI. Therefore, close monitoring of urine output could be important in MM patients with RI.

국민기초생활보장제도 수급탈출 결정요인: 근로능력자 집단별 분석

안서연 ( Seo Yeon Ahn ),구인회 ( In Hoe Ku ),이원진 ( Won Jin Lee ) 한국사회복지정책학회 2011 사회복지정책 Vol.38 No.1

본 연구는 한국복지패널 1~4차년도 자료를 이용하여 국민기초생활보장제도 수급탈출의 결정요인을 분석하였다. 근로가능한 가구원이 있는 가구 중에서 가구별 대표근로능력자를 중고령자, 중장년남성, 중장년여성, 청년집단으로 분류하여 집단별 수급탈출 요인을 이산시간 해저드 모형(discrete-time hazard model)을 이용하여 분석하였다. 그리고 본 연구에서는 기존의 연구에서 간과되어왔던 수급자의 심리 정서적 요인을 분석에 포함하였다. 주요 분석 결과는 다음과 같다. 첫째, 집단별 수급탈출에 보편적으로 영향을 주는 변수는 근로인 것으로 밝혀졌다. 둘째, 근로능력자가 있는 수급가구에서 수급기간이 길어질수록 수급탈출확률이 낮아지는 현상이 관찰되었다. 마지막으로, 수급자의 심리·정서적 요인 중 자존감과 주관적 수급탈피 전망이 수급탈출에 일정한 영향을 미치는 것으로 나타났으며, 정신건강 변수의 영향은 집단에 따라 상이하였다. 이로서 기존의 합리적 선택모형 중심접근은 기대모형의 관점으로 보완될 필요가 있으며 수급자 집단에 대한 동일한 탈수급 경로를 가정하는 접근 역시 집단별 이질성을 고려하는 접근으로 보완되어야 한다. This study analyzes data from Korean Welfare Panel Study to examine the determinants of exit from National Basic Livelihood Security program. We classify able-bodied welfare recipients into four groups and estimate a discrete-time hazard model to identify the factors related to welfare exit of each group. Main findings are summarized as follows. First, we find that the work status of recipients is a strong predictor of welfare exit. This finding is robust across the groups. Second, the exit rates decline with time on welfare increases. Third, the psychological characteristics such as self-esteem and prospect of welfare exit are found to be associated with welfare exit. However, the effect of the psychological factors vary across the groups. Findings suggest that welfare reform approaches based on rational choice model need to be improved by emphasizing expectancy model. It is also suggested that a group-specific approach in helping self-sufficiency may be more effective, given the diversity of welfare population.

셀프카메라(Self-Camera)행위가 20대 여성들의 외모 존중감, 자기노출 욕구, 외모개선 욕구 및 사회적 자기효능감에 미치는 영향

안서연(Seo Yeon Ahn),김정현(Jung-Hyun Kim) 사이버커뮤니케이션학회 2016 사이버 커뮤니케이션 학보 Vol.33 No.2

스스로의 사진(셀프카메라, self-camera)을 핸드폰으로 촬영하고, SNS에 게재하는 행동을 뜻하는 셀피촬영(Selfie, 이하 셀피)이 세계에서 selfie 신드롬을 불러일으키며 새로운 자기표현의 수단으로 대두되었다. 그렇기 때문에 셀피를 통한 자기표현을 할 때 20대 여성들의 자신감으로 대변되는 자기노출, 외모존중감, 외모개선욕구, 사회적 자기효능감 등이 어떻게 나타나며 나르시시즘과 관련이 깊을 것으로 여겨지는 셀피 행위가 긍정적인 피드백을 받았을 때와 받지 않았을 때에 어떤 차이를 보이는지 아바타를 통해 진행되었던 실험인 프로 테우스효과를 새로운 자기표현인 셀카를 통해 보고자 했다. 외모 존중감, 외모관리 욕구, 자기노출 욕구, 사회적 자기효능감을 종속변인으로 설정하고 나르시시즘과 사진에 대한 긍정적인 댓글 유무를 독립변인으로 설정하여, 상호작용을 선형회귀분석으로 검증한 결과 나르시시즘과 긍정적인 댓글 유무의 상호작용은 외모 존중감, 자기노출 욕구, 사회적 자기효능감에서 통계적으로 유의미한 효과를 보이는 것으로 나타났고, 외모관리 욕구에는 유의미한 효과가 나타나지 않았다. 본 연구는 아바타로 진행되었던 프로테우스효과를 셀피를 통한 자기표현으로 까지 확장시켰으며 나르시시즘이 높은 사람들이 긍정적인 칭찬을 받았을 때 외모 존중감과 자기노출 욕구, 사회적 자기효능감이 높게 나타나는 것을 밝힘을 통해 셀피촬영 후 자신감이 높아지는 데에는 긍정적인 피드백과 나르시시즘의 상호작용효과가 나타난다는 것을 밝혔다. Self-Camera(selfie) which is a habit taking photos of oneself using a smart- phone and uploading on social network sites is making world-wide syndrome nowadays. Selfie represents as a way of self-presentation online widely. Particularly, recent self-presentation online via selfie to some extent reflects one’s identity in reality. Therefore, this paper tried to focus on the recent phenomenon of self-presentation online via selfie, the influence of selfie on 20s women’s confidence like self-disclosure, body-esteem, appearance management and social self-efficacy and also tried to figure out the difference between groups who got the positive reply or no reply at all. As a result, a significant interaction effect between narcissism and positive reply appeared to exist in self-disclosure, body-esteem, and social self-efficacy except appearance management. This study has a significant meaning in that it identified the relationship between selfie, narcissism and the desire for social support. Further discussion on the results in detail and implications are suggested.

히알루론산 기반 비타민 D 함유 구강용해필름의 제조 및 특성평가

강서연(Seo-Yeon Kang),안다연(Da-Yeon Ahn),한정아(Jung-Ah Han) 한국식품과학회 2022 한국식품과학회지 Vol.54 No.3

칼슘과 함께 뼈 건강에 필수적이나, 그 섭취량이 부족하여 문제가 되고 있는 비타민 D를 쉽게 보충할 수 있는 새로운 제형으로 천연 고분자 물질인 히알루론산을 기반으로 한 비타민 D함유 구강용해필름(orally disintegrating film, ODF)을 개발하고 비타민 D 함량에 따른 필름의 특성을 분석하였다. 첨가량은 2020 한국인 영양소섭취기준의 비타민 D 하루 충분섭취량(400IU: 10μg)을 기준으로 4, 7배, 그리고 상한섭취량인 10배로 설정하였다. 제조한 필름의 두께는 기반물질의 농도가 가장 높은 대조군이 가장 두꺼웠고, 비타민 D 첨가량에 따른 유의적 차이는 없었다(p<0.05). 비타민 D 첨가군간 필름의 수분함량의 차이는 없었으며, 첨가량이 많아질수록 투습도는 다소 감소하는 경향을 보여 소수성 물질인 비타민 D가 영향을 미친 것으로 보인다. 비타민 D의 함량이 높아질수록 필름의 명도는 10AI만 유의적으로 높았으며, 적색도는 감소하고 황색도는 증가하였다(p<0.05). 이와 같은 색도특성은 첨가한 비타민 D 시료 자체 색의 영향을 받은 것으로 보인다. 대조군과 비교하였을 때 비타민 D의 증가는 불투명도를 유의적으로 증가시켰으며(p<0.05), 7AI와 10AI에서 가장 높은 불투명도를 보였다. 다른 친수성 고분자 필름과 달리 본 연구에서 제조된 히알루론산 기반 필름은 가소제의 첨가 없이도 타연구의 필름에 비교하여 높은 인장강도(84.40-106.6MPa)(p<0.05)와, 비슷한 수준의 연신율(4.71-9.43%)(p>0.05)을 갖는 질감 특성을 보였다. HPLC/MS 분석을 통해 필름 내의 실제 비타민 D 함량을 분석한 결과, 제조 과정 중 비타민 D의 손실이 발견되었으며 이로 인해 목표섭취량(2020 한국인 영양소섭취기준 비타민 D 충분섭취량)을 충족하기 위해서는 제조 기준의 1.5-2배를 섭취하는 것이 적절할 것으로 보인다. 본 연구에서는 생체물질인 히알루론산을 기반으로 비타민 D를 쉽게 섭취할 수 있는 새로운 제형을 개발하였으며, 비타민 D 첨가로 인한 필름의 특성이 향상되는 결과를 이용하여 구강용해용 뿐 아니라 가식성 포장재 등 다양한 활용이 가능할 것으로 제안하는 바이다. An orally disintegrating film (ODF) based on hyaluronic acid (HA) containing vitamin D was developed. The vitamin D content in the ODF was set based on the adequate intake (AI) of vitamin D from 0 to 10 AI (0, 1, 4, 7, and 10AI). The control (0AI) had the highest thickness and showed the longest disintegration time among the samples. The moisture content of the ODFs was significantly lower in those with vitamin D compared to the control. As the amount of vitamin D increased, the water vapor permeability (WVP) of the ODFs decreased, and the opacity significantly increased. The tensile strength was higher in the films containing vitamin D compared to the control films. However, the elongation at the break showed no significant difference among the films. The vitamin D content in the film was reduced by 25.7-44.2% during processing compared to the amount that was originally added. Based on the above results, a new and convenient vitamin D delivery system, an ODF, could be successfully produced.

자활직업훈련 사업의 임금 효과 분석 -Propensity Score Matching 방법으로-

안서연 ( Seo Yeon Ahn ) 한국사회복지연구회 2008 사회복지연구 Vol.37 No.-