Session 9 Distribution Science(Student-Myongii University)-VIII : Graduate School of Distribution

Ahn,Sung-Woo,Kim,Dae-yun,Kim,Mi-Song,Kim,Han-Sung,Jung,Je-Woo,Song,Ha-Su,Eom,Heung-Jun 한국유통과학회 2008 한국유통과학회 학술대회 논문집 Vol.2008 No.-

일반논문 : 판소리 수궁가 의학기사(醫學記事)에 내포된 역사성과 조선후기 민중 의학지식의 보급 -김연수 창본 수궁가의 사설을 대상으로-

인상우 ( Sang Woo Ahn ) 전남대학교 호남학연구원 2010 호남학 Vol.0 No.47

<수궁가>는 구토설화에서 파생된 판소리 창본으로 내용 중 醫學記事가 자주 등장한다. 醫學記事는 신재효의 창본정리 과정에서 <수궁가> 전반에 삽입된 것으로 보이는데, 지방관청에 소속된 官藥房을 했던 부친의 영향으로 『東醫寶鑑』과 여러 의서들, 藥器를 쉽게 접할 수 있었던 까닭에 <수궁가> 내에 그 내용을 충분히 실어 넣은 것으로 보인다. 본고에서 진행한 <수궁가>의 의학적 분석을 통한 연구는 <수궁가>에서 절반 가까이 차지하는 藥性歌 및 醫學記事의 많은 부분이 한의학 지식과 매우 일치하며, 내용전반에 민간에서 쓸 수 있는 한의학 지식을 바탕에 깔고 있음을 확인할 수 있었다. 특히 『東醫寶鑑』이 점차 보편화되면서 <수궁가> 속의 醫學記事도 전문성을 더해갔다. <수궁가>에서 도가적 양생사상의 신선술과 주술에 의거한 치료형태를 풍자하고 희화시켰던 양상은, 동시기에 『東醫寶鑑』이 여러 의서를 종합하면서 도가적인 주술이나 미신적인 요소를 배제하고, 체계적이고 임상의학적으로 재정비했다는 점과 맥을 같이한다. 18세기중반 이후로 19~20세기 양반지식층의 애호참여로 유교사상을 재정비하면서 醫學記事가 전문지식의 과시수단으로 사용되기도 하였으나, 한편으로는 전문성있는 의학지식을 판소리내에 삽입함으로써 판소리에 사실성을 부여하고, 청자들로 하여금 판소리의 현실감을 극대화하는 역할로 작용하였다. 그로인해 <수궁가>내에서 더욱 전문화된 醫藥記事들은 이후 판소리, 국문한문소설로 변화되어 보급되었고, 19세기부터는 라디오매체와 음반사의 판소리 취입으로 더욱 보편화되면서 서민들의 입과 귀로 널리 전해졌다. 비록 醫學記事가 서민들에게 의학지식의 보급을 목적으로 작성된 것은 아니었다 하더라도, 의료정책이 미비했던 당시 『東醫寶鑑』을 바탕으로 보완되었던 <수궁가>의 보급은 원래의 목적이상으로 민중들에게 민간의학지식을 파급시키는 역할을 수행했다. Sugungga is a Pansori[recite a dramatic song] story derived from a tale about a terrapin and a rabbit, and Yakseongga appears in its first part. Sugungga has been handed down through a lineage of singers: Song Heung-Rok, Song Gwang-Rok, Song Woo-Ryong, Ryu Seong-Jun, and Kim, Yeon-Su. Yakseongga completely settled in Sugungga thanks to adaptation of Shin Jae-Hyo, whose medicinal knowledge was mostly from his father, Shin Gwang-Heup, an official pharmacist in a local government office. Between the 17th century and the mid-18th century, Sugungga was evolved from ancient taoistic idea of health to Confucianistic rational subject. This was similar in nature that Korean medicine was overhauled to a more scientific and clinical practice in the same period by putting together diverse medicinal books such as DongeuiBogam, Huangdi Neijing, Hyang-yak Jipseongbang, Euibang Ryuchwi, and Euibang Chalyo, while eliminating elements of taoistic charms or superstitions. This study confirmed that from the study of oriental medicine, Yakseongga in Sugungga was based on oriental medicinal knowledge, not simple humor. It seems that Yakseongga was heavily influenced by oriental medicinal books such as Huangdi Neijing, Hyang-yak Jipseongbang, Dongeui Bogam, and Jejung Sinpyeon. After the mid-18th century, deconfucianistic Sugungga was modified again. Participation of aristocratic intellectuals from the 19th and 20th Century tarnished lively popularity of Sugungga, while Confucianism was reintroduced and “ostentation of expertise” became more noticeable in Yakseongga. Such trends of pansori became more popular following the introduction of modern novels as well as radios and phonograph records. Although Yakseongga was not made to teach medicinal knowledge, it performed a role of distributing folk remedies to the public far beyond its original intention when it had been compiled based on Dongeui Bogam and Jejung Sinpyeon.

국내 한의학 학술지에 발표된 동의보감 연구 현황 조사

한창현(Chang-hyun Han),박상영(Sang-young Park),권오민(Oh-min Kwon),안상영(Sang-young Ahn),안상우(Sang-woo Ahn) 한국의사학회 2009 한국의사학회지 Vol.22 No.2

Background : To understand Korean medicine it is crucial to first understand medical aspect of ‘DongUiBoGam’. It is also meaningful that it became one of the influential book even to posterity. Also based on the apprehension, we can take a view of development of Korean medicine led by ‘DongUiBoGam’. Objectives : This study aims to review the status, study field, specialist of DongUiBoGam. In the process, this review will grasp trends in this field of studies and will direct further researches into the right direction. Method : The computerized Korean databases were searched from their respective inceptions up to December 2008. The search terms used were ‘DongUiBoGam’ and random or Korean language terms related to DongUiBoGam. Several specialized journals were also manually searched for relevant articles. Result : Since the 2000s, DongUiBoGam papers in the Korean Literature is increased. Published 58 papers on The Korean Journal of Oriental Medical Prescription were more than the other journals. 58 papers published in The Korean Journal of Oriental Medical Prescription are the best in many areas related to Korean medicine. Most people have submitted papers related to DongUiBoGam was Woo-yeal Jeong. Conclusions : ‘DongUiBoGam’ research is conducted and current tendency and outlook for ‘DongUiBoGam’ is carried out focusing on several associations.

Effect of morphology of electrodeposited Ni catalysts on the behavior of bubbles generated during the oxygen evolution reaction in alkaline water electrolysis

Ahn, Sang Hyun,Choi, Insoo,Park, Hee-Young,Hwang, Seung Jun,Yoo, Sung Jong,Cho, EunAe,Kim, Hyoung-Juhn,Henkensmeier, Dirk,Nam, Suk Woo,Kim, Soo-Kil,Jang, Jong Hyun The Royal Society of Chemistry 2013 Chemical communications Vol.49 No.81

<P>We have investigated the release of active sites blocked by bubbles attached on the surface of catalysts during the oxygen evolution reaction (OER) in alkaline water electrolysis, <I>via</I> the modulation of the wetting properties of the four different morphologies of a nickel catalyst.</P> <P>Graphic Abstract</P><P>Ni catalyst with hierarchical morphology provided high OER activity with easy release of generated bubbles. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c3cc44891f'> </P>

Characteristic molecular signature of pericardial effusion identifies malignant cancer in pericardial disorder patients

Sang Yean Kim,Jung Woo Eun,Hyung Seok Kim,Hee Doo Yang,Min Jeong Na,Young Min Ahn,Hae Ok Jung,Suk Woo Nam 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.3

Background Pericardial effusion (PE) can develop in patients with virtually any condition that affects the pericardium, including acute pericarditis and a variety of systemic disorders. Thus, definite differentiation of malignant pericardial effusion and rapid diagnosis are known to have therapeutic and prognostic importance. Objective The aim of this study was to identify novel molecular markers for the detection of cancer in patients with pericardial disorder. Results We performed one-way ANOVA analysis of whole transcriptome scans of 18 PEs from the patients with pericardial disorder including cancer. It resulted in 4385 outlier genes. Hierarchical clustering analysis showed two distinct clusters [cancer patient’s PEs (G1 + G2) vs. non-cancer PEs (G3)] within the dendrogram. To identify cancer-specific molecular signature, Welch’s t test of G1 and G3 was performed and 1639 gene elements were suggested as stringent classifiers between cancer PE and non-cancer PE. Gene set enrichment analysis of PE signature suggested that CD24, SDC1, and ST14 were strong molecular markers for identifying cancer patients among patients with pericardial disorder. Conclusion Our results suggest that etiology-specific molecular signatures can discriminate cancer patients within pericardial disorder patients. CD24, SDC1, and ST14 are strong molecular markers for such discrimination.

Role of prophylactic antibiotics in elective laparoscopic cholecystectomy

Sang Hoon Kim,Hee Chul Yu,Jae Do Yang,Sung Woo Ahn,Hong Pil Hwang 한국간담췌외과학회 2018 Annals of hepato-biliary-pancreatic surgery Vol.22 No.3

Backgrounds/Aims: The role of prophylactic antibiotics for laparoscopic cholecystectomy in low-risk patients is still unclear. This study aimed to verify the conclusion of previous meta-analyses concerning the effectiveness of antibiotic prophylaxis for elective laparoscopic cholecystectomy in low-risk patients. Methods: Comprehensive literature searches were performed on electric databases and manual searches. Randomized controlled trials (RCTs), prospective studies, and retrospective studies comparing antibiotic prophylaxis to placebo or no antibiotics in low-risk elective laparoscopic cholecystectomy were included. Results: This study included 28 RCTs, three prospective studies, and three retrospective studies. In RCTs, prophylactic antibiotics did not prevent deep surgical site infections (SSI) (RR 1.10, 95% confidence interval [CI] [0.45-2.69], p=0.84) but reduced SSI (RR 0.70, 95% CI [0.53-0.94], p=0.02), and superficial SSI (RR 0.58, 95% CI [0.42-0.82], p=0.01). Prospective studies showed prophylactic antibiotics did not reduce superficial SSI (RR 0.35, 95% CI [0.01-8.40], p=0.52) but reduced SSI (RR 0.12, 95% CI [0.04-0.35], p=0.0001). In retrospective studies, antibiotic prophylaxis did not reduce SSI (RR 1.59, 95% CI [0.30-8.32], p=0.58). The pooled data (12121 patients) including RCTs and prospective and retrospective studies showed that prophylactic antibiotics were not effective in preventing deep SSI (RR 1.01 95% CI [0.46-2.21], p=0.98) but effective in reducing SSI (RR 0.67, 95% CI [0.51-0.88], p=0.003) and superficial SSI (RR 0.61, 95% CI [0.45-0.83], p=0.002). Conclusions: The use of prophylactic antibiotics is effective for reducing the incidence of SSI and superficial SSI but is not effective for preventing deep SSI in low-risk patients who underwent elective laparoscopic cholecystectomy.

Anti-tumor Activity of Novel Indirubin Derivatives in Rat Tumor Model

Sang Gun Ahn,Soo A Kim,Hyun Woo Kim,Young Ho Woo,Jung Hoon Yoon 대한구강악안면병리학회 2005 대한구강악안면병리학회지 Vol.29 No.5

lndil‘ ubin is the active ingredient of Danggui Longhui Wan‘ a mixture of herbal medici l1e t hat is used to treat chronic myelocytic leukemia in tradi t ional Chinese medicine‘ He re, we show that new indirubin deri vatives 5' -ni tro-indirubinoxime, 5' -f1 uoro-indiru binoxime and 5’ -tri rnethylacetamino-i nd i 1'1.1 bi noxi me‘ have potent a n ti- proliferative activity on various human cancer cells and oncogenic RK3E-ras rat kidney cells with lC50 con centration ranging from 1-25 μ M, When the RK3E-ras cells were treated with indirubin derivatives for 24 h, the activity of caspase-3 and caspasc-7 was induccd followed by apoptosis , 011 the other hand, the activity of SAPK/JNK was inhi bited over the same period , lndirubin deri vatives a lso s howed strong ant i-tumor activity in rat s이 id and oral tumor models The inhibition of tlUl10r g:rowth was observed in animals beaJ‘ing RK3E-ras-induced turnor given subcutaneous dose of 100 mg/kg every other day for 10 days, Histologically, μeatment of indirubin derivatives caused significant inhibition of tumor formation associated wi th increased apoptosis and decreased proliferation of tumor cell s , These findings provide the potential value of indirubin derivatives as a novel candi date fOl 없l tJ -cancer agents ,

Chronic administration of phosphodiesterase 5 inhibitor improves erectile and endothelial function in a rat model of diabetes

AHN, GOOK JUN,YU, JAE YOUNG,CHOI, SEUL MIN,KANG, KYUNG KOO,AHN, BYOUNG OK,KWON, JONG WON,KANG, SUNG KEUN,LEE, BYEONG CHUN,HWANG, WOO SUK Blackwell Science Ltd 2005 International journal of andrology Vol.28 No.5

<P>Summary</P><P>This study was conducted to determine if the long-term administration of the phosphodiesterase type 5 (PDE 5) inhibitor, DA-8159, to diabetic rats can ameliorate the development of erectile dysfunction (ED) and endothelial dysfunction. After inducing diabetes with streptozotocin, DA-8159 was orally administered at a dose of 3 mg/kg or 10 mg/kg for 8 weeks. To examine the effect on erectile response, electrostimulation of the cavernous nerve with the parameters of 3 V, 5 ms, 5 Hz or 10 Hz, was performed to measure the intracavernous pressure (ICP) and mean arterial pressure (MAP). Thoracic aorta relaxation <I>in vitro</I> was evaluated by adding acetycholine (Ach) cumulatively to the bathing medium. In addition, the plasma endothelin-1 (ET-1) levels were measured in order to investigate the effect of DA-8159 on endothelial dysfunction. The area under the curve (AUC) from the ICP/MAP ratio in the 10 Hz stimulation showed a significantly increased AUC after the 10 mg/kg treatment compared with the diabetic group (8891 ± 619 vs. 6316 ± 1016, respectively, <I>p</I> < 0.05). At the 5 Hz frequency, DA-8159 10 mg/kg also induced a significant increase in the AUC compared with the diabetic control. The maximum ICP/MAP ratio (%) of the 10 mg/kg treatment group was significantly higher in both the 10 Hz and 5 Hz frequency groups (<I>p</I> < 0.05). A treatment of 3 mg/kg tended to increase the AUC and peak ICP/MAP but was not statistically significant. The Ach EC<SUB>50</SUB> value of the diabetic group was significantly higher than in the normal control (120.50 ± 22.90 n<SMALL>M</SMALL> vs. 86.80 ± 9.30 n<SMALL>M</SMALL>, respectively), and 10 mg/kg treatment group showed a significantly lower EC<SUB>50</SUB> value (88.38 ± 19.7 n<SMALL>M</SMALL>). The ET-1 level was lower in groups treated with DA-8159, 3 mg/kg and 10 mg/kg treatment induced a statistical difference compared with the diabetic control (1.15 ± 0.34 fmol/mL vs. 2.51 ± 0.55 fmol/mL, respectively, <I>p</I> < 0.05). These results demonstrate that chronic administration of DA-8159 could attenuate the development of the ED in diabetes and its effect is associated with an improvement in the endothelial function.</P>

Evaluation of body composition using computed tomography in patients with anti-neutrophil cytoplasmic antibody-associated vasculitis

( Sung Soo Ahn ),( Byung-woo Yoo ),( Hyeok Chan Kwon ),( Juyoung Yoo ),( Seung Min Jung ),( Jason Jungsik Song ),( Yong-beom Park ),( Sang-won Lee ) 대한내과학회 2021 The Korean Journal of Internal Medicine Vol.36 No.5

Background/Aims: Measures of body composition, including visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and skeletal muscle area (SMA), are considered important prognostic factors in chronic diseases. The association of these measures with auto-inflammatory disorders, such as anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV), remains unclear. We investigated the clinical significance of VAT, SAT, and SMA in patients with AAV. Methods: Patients with AAV subjected to chest computed tomography (CT), abdominal CT, or positron emission tomography-CT on diagnosis of AAV were evaluated. Quantitative assessment of VAT, SAT, and SMA was performed at the third lumbar vertebral level and computed by summing the pixel attenuation for tissue-specific Hounsfield units in the corresponding region. Associations of VAT, SAT, and SMA with clinical and laboratory data and clinical outcome measures were evaluated. Results: Of the 117 patients, 61 (52.1%) were classified as having microscopic polyangiitis, 28 (23.9%) as granulomatosis with polyangiitis, and 28 (23.9%) as eosinophilic granulomatosis with polyangiitis. VAT significantly correlated with age, weight, body mass index (BMI), and Birmingham Vasculitis Activity Score, whereas SAT correlated with weight, BMI, and creatinine levels. A significant association was found between SMA and age, height, weight, BMI, and the Five-Factor Score. Cox proportional hazards analysis showed that creatinine levels (odds ratio [OR], 1.346; 95% confidence interval [CI], 1.034 to 1.753; p = 0.027) and high VAT (OR, 7.137; 95% CI, 1.343-37.946; p = 0.021) were independently associated with all-cause mortality during follow-up. Conclusions: Evaluation of VAT using CT is useful for estimating disease activity and all-cause mortality in patients with AAV.

Comparison of drug-eluting stents with bare metal stents in patients with Large(≥3.5 mm) coronary arteries (초)

Woo Jong Kim,Jang Yeon Jo,Jong Heok Jung,Ming Eun Lee,Jae Sung Yoon,Yong Soo Ahn,Young Jun Hwang,Hong Myeong Jung,Su Heon Kim,Jung Young Kim 대한내과학회 2009 대한내과학회지 Vol.77 No.4S