A Research of Hwang ji-young’s work - “Without people and people” performance

Ji-Young Hwang,Sung-ok Choi 한국콘텐츠학회 2019 한국콘텐츠학회 ICCC 논문집 Vol.2019 No.12

A Multi-Center Educational Research Regarding Breastfeeding for Pediatrics Residents in Korea

Yong Sung Choi,정성훈,김은선,Eun Sun Kim,Eunhee Lee,Euiseok Jung,So-Yeon Lee,이우령,Hye Sun Yoon,Yong Joo Kim,Ji Kyoung Park,Son Moon Shin,Ellen Ai-Rhan Kim 대한신생아학회 2022 Neonatal medicine Vol.29 No.1

Purpose: Pediatricians have a significant responsibility to educate mothers about the importance of breastfeeding. However, there have been minimal efforts in the courses of resident training in Korea. The purpose of this study is to evaluate the change in knowledge and attitude before and after a 4-week breastfeeding educational intervention among multicenter residents. Methods: Prospective interventional educational research was designed for residents at eight training hospitals in Korea. Institutional reviews were obtained in each hospital. The education curriculum consisted of 14 courses regarding breastfeeding theory and practice. These materials were used to teach pediatric residents for 4 weeks. Knowledge-based tests were administered before the course, and re-tests were administered after the course using different test items of similar levels. Test scores and survey responses were compared before and after the intervention. Results: A total of 73 residents (1st year 20, 2nd year 23, 3rd year 16, and 4th year residents 14) from eight training hospitals completed the intervention. Their average age was 30.3±2.9 years, 17 (23.3%) were male, 22 (30.1%) were married, and eight had more than one child of their own. The mean pre-test score was 61.8±13.4 and the mean post-test score was 78.3±7.5 (P<0.001). The inter-grade difference in the score was significant in the pre-test (P=0.005), but not significant in the post-test (P=0.155). There were more responses of obtaining confidence after the intervention (P<0.001). Conclusion: In our study, pediatric residents showed improvement in their knowledge and confidence level after 4 weeks of the breastfeeding curriculum. This will provide a basis for future policymaking in the training of pediatric residents regarding breastfeedReceived: 6 January 2022 Revised: 15 February 2022 Accepted: 15 February 2022 Correspondence to: Ellen Ai-Rhan Kim, MD Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea Tel: +82-2-3010-3390 Fax: +82-2-3010-6978 E-mail: arkim@amc.seoul.kr A Multi-Center Educational Research Regarding Breastfeeding for Pediatrics Residents in Korea Yong-Sung Choi, MD,PhD1, Sung-Hoon Chung, MD, PhD2, Eun Sun Kim, MD, PhD3, Eun Hee Lee, MD4, Euiseok Jung, MD5, So Yeon Lee, MD, PhD5, Wooryoung Lee, MD6, Hye Sun Yoon, MD, PhD7, Yong Joo Kim, MD, PhD8, Ji Kyoung Park, MD, PhD9, Son Moon Shin, MD, PhD9, and Ellen Ai-Rhan Kim, MD, PhD5 1Department of Pediatrics, Kyung Hee University Hospital, Seoul, Korea 2Department of Pediatrics, Kyung Hee University Hospital at Gangdong, Seoul, Korea 3Department of Pediatrics, Kangwon National University Hospital, Chuncheon, Korea 4Department of Pediatrics, Korea University Anam Hospital, Seoul, Korea 5Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea 6Department of Pediatrics, Soonchunhyang University Seoul Hospital, Seoul, Korea 7Department of Pediatrics, Nowon Eulji Medical Center, Eulji University, Seoul, Korea 8Department of Pediatrics, Hanyang University Seoul Hospital, Seoul, Korea 9Department of Pediatrics, Inje University Busan Paik Hospital, Busan, Korea Neonatal Med 2022 February;29(1):28-35 https://doi.org/10.5385/nm.2022.29.1.28 pISSN 2287-9412 . eISSN 2287-9803 Copyright(c) 2022 By Korean Society of Neonatology This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:// creativecommons.org/licenses/by-nc/4.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Original Article 29 Neonatal Med 2022 February;29(1):28-35 https://doi.org/10.5385/nm.2022.29.1.28 ing in Korea.

고속도로 IC 및 JCT 주변 유휴부지의 물류시설 활용가능성 분석 : 수도권 및 지방광역시를 중심으로

양현지(Yang, Hyun-Ji),최재성(Choi, Jae-Sung) 한국물류학회 2021 물류학회지 Vol.31 No.2

최근 코로나 19 등의 감염병으로 인한 비대면 활동 증가로 인터넷, 모바일 등을 통한 이커머스 택배 이용건수가 증가하며 택배업체 등의 물류시설 부지 확보 수요가 점점 증가하는 추세이다. 업체별로 필요한 부지를 연도별 임계치 수준에서 수급하며 적게는1천 평에서 많게는 1만 평 이상의 부지가 추가적으로 필요하므로 부족한 부지를 현재와 같이 부동산업체 등을 통해 사적영역에서확보하는 것은 지속가능성의 한계에 직면할 것으로 보인다. 본 연구에서는 수도권(서울, 인천, 경기도) 및 지방광역시(대전, 대구, 광주, 울산, 부산)를 중심으로 공공 부문의 도시계획시설 측면에서 가장 넓은 유휴부지의 확보가 가능한 고속도로 IC/JCT 교통광장 유휴부지의 부지현황⋅활용가능성을 분석하였다. 분석방법 및 내용으로 다음 카카오맵의 로드뷰, 스카이뷰 등을 활용해 연구대상지의 유휴부지를 전수조사 후 사업지 내 이면도로 등의 존재 유무에 따라 단기 및 중⋅장기적 사업 우선순위화 분류, 국가물류통합정보센터 내 물류단지 건립계획을 이용해 택배업체의 허브 및 서브터미널 건설 시 예상 사업비 분석, 한국은행의 산업연관표를 적용해 경제적 파급효과 등의 결과를 도출하였다. 도출된 유휴부지를 택배업체 등에서 활용하기 위해서는 IC/JCT 교통광장대부분의 지역이 현재 ｢국토계획법 시행령 제71조｣에 의해 생산⋅자연녹지 용도지역인 상황을 고려하면 ｢건축법 시행령 별표1｣ 의 ‘18.창고시설 중 물류터미널’을 추가하는 방안, ｢도로법｣내 교통광장의 설치 및 관리에 관한 규정을 신설하거나 박성중 의원등 10인이 제안하여 위원회 심사 중인 ｢도로공간의 입체개발에 관한 법률안｣의 본회의 통과를 통한 입법화를 완료해 법적 근거마련이 필요한 상황으로 보인다. 향후 법제도 개선을 통해 고속도로 IC/JCT의 유휴부지(총 183만평-수도권 140만평, 지방광역시43만평) 중 수도권은 약 12%, 지방광역시는 약 10% 정도만이라도 활용 가능하다면‘19년 한국통합물류협회의 18개 택배사업자가제시한 물류시설 구축을 위한 유휴부지 마련 수요를 충족시켜 부지확보의 어려움이 일정 부분 해소될 수 있을 것으로 추정한다. As contact-free activities have increased due to infectious diseases such as COVID-19, the number of delivery-related services has also increased through the rise of e-commerce. As such, the demand for securing sites for logistics facilities is rising as well. Each delivery company keeps supply and demand in balance at the annual threshold level, which means that they require additional land ranging from 3,300m2 (1,000 pyeong) to as much as 33,000m2 (10,000 pyeong). However, it is unreasonable to continuously secure land to meet demands from private areas through real estate companies, as is the current standard procedure done by delivery companies. This study analyzes the feasibility of securing unused land in its current state, focusing on unused sites in expressways IC/JCT, where the widest unused land, in terms of urban planning facilities can be found, mainly in the capital region (Seoul, Incheon, Gyeonggi-do) and provincial metropolitan cities (Daejeon, Daegu, Gwangju, Ulsan, Busan). Full-scale inspection of unused land near expressways is first conducted using Kakao Map’s Road View and Sky View, and the results, such as short-term or mid to long term business priorities, are derived depending on whether backside roads exist or not. Estimated business expenses are calculated using information of logistics center from the National Logistics Integrated Information Center, and economic effects of building hubs and sub-terminals for delivery companies in the unused land are also drawn, applying the Leontief input-output table from the Bank of Korea. Most unused land such as those surrounding roundabouts near expressways IC/JCT is considered as productive green areas and natural green areas in accordance with Article 71 of ｢Enforcement Decree of the National Land Planning and Utilization Act｣, so clause 18, which states “logistics terminal amongst storage facility field”, of schedule 1 in ｢Enforcement Decree of Building Act｣ should be added to the Article to loosen restriction on construction in areas surrounding roundabouts. Also, regulations on the installation and management of roundabouts in the ｢Road Act｣ should be established to allow delivery company to utilize the unused land derived through this analysis. Preparation of a legal basis is deemed necessary by passing legislation through the plenary session for ｢The Bill on the Development of Three-dimensional Road Space｣ under examination made by 10 lawmakers, including Park Sung-joong. If approximately 12% of the total unused land in expressways IC/JCT in the capital region and approximately 10% in provincial metropolitan cities are made available by improving the legal system in the future, demand of 18 delivery companies from Korea Logistics Association will be met. Through this, it is estimated that the difficulty of securing sites for logistics facility construction would be partially resolved.

Brain energy metabolism and multiple sclerosis: progress and prospects

Sung Jean Park,Ji Woong Choi 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.10

Multiple sclerosis (MS) is an autoimmune diseaseaccompanied with nerve pain and paralysis. Althoughvarious pathogenic causes of MS have been suggested,including genetic and environmental factors, how MS occursremains unclear. Moreover, MS should be diagnosed basedon clinical experiences because of no disease-specific biomarkerand currently available treatments for MS just canreduce relapsing frequency or severity with little effectson disease disability. Therefore, more efforts are requiredto identify pathophysiology of MS and diagnosis markers. Recent evidence indicates another aspect of MS pathogenesis,energy failure in the central nervous system (CNS). Forinstance, inflammation that is a characteristic MS symptomand occurs frequently in the CNS of MS patients can resultinto energy failure in mitochondria and cytosol. Indeed,metabolomics studies for MS have reported energy failurein oxidative phosphorylation and alteration of aerobic glycolysis. Therefore, studies on the metabolism in the CNS mayprovide another insight for understanding complexity of MSand pathogenesis, which would facilitate the discovery ofpromising strategies for developing therapeutics to treat MS. This review will provide an overview on recent progress ofmetabolomic studies for MS, with a focus on the fluctuationof energy metabolism in MS.

Columbianadin Inhibits Cell Proliferation by Inducing Apoptosis and Necroptosis in HCT116 Colon Cancer Cells

( Ji In Kang ),( Ji Young Hong ),( Jae Sue Choi ),( Sang Kook Lee ) 한국응용약물학회 2016 Biomolecules & Therapeutics(구 응용약물학회지) Vol.24 No.3

Columbianadin (CBN), a natural coumarin from Angelica decursiva (Umbelliferae), is known to have various biological activities including anti-inflammatory and anti-cancer effects. In this study, the anti-proliferative mechanism of actions mediated by CBN was investigated in HCT-116 human colon cancer cells. CBN effectively suppressed the growth of colon cancer cells. Low concentration (up to 25 mM) of CBN induced apoptosis, and high concentration (50 mM) of CBN induced necroptosis. The induction of apoptosis by CBN was correlated with the modulation of caspase-9, caspase-3, Bax, Bcl-2, Bim and Bid, and the induction of necroptosis was related with RIP-3, and caspase-8. In addition, CBN induced the accumulation of ROS and imbalance in the intracellular antioxidant enzymes such as SOD-1, SOD-2, catalase and GPx-1. These findings demonstrate that CBN has the potential to be a candidate in the development of anti-cancer agent derived from natural products.

Ecological Attributes by Forest Types in the Natural Forest of Mt. Odae

Choi, Yeong Hwa,Kim, Ji Hong,Chung, Sang Hoon Institute of Forest Science 2017 Journal of Forest Science Vol.33 No.1

This study was conducted to evaluate the ecological attributes of forest types which were classified by cluster analysis in the natural forest of Mt. Odae on the basis of the vegetation data (232 sampling points) from the point-quarter sampling methods. For the classified types, the species composition was expressed by importance value to describe the stand structure and the species diversity was quantified using the Shannon's diversity index. Recognized forest types were 1) Quercus mongolica-Pinus densiflora-Betula ermanii forest type, 2) Mixed mesophytic forest type, 3) Q. mongolica forest type, 4) B. ermanii forest type. Species diversity indices of total and overstory were highest in the Mixed mesophytic forest type (3.465 and 2.942), and lowest in the B. ermanii forest type (0.118 and 0.832). In addition to that, Q. mongolica-P. densiflora-B. ermanii forest type was calculated as 3.226 and 2.565, and Q. mongolica forest type was calculated as 2.776 and 1.218 in total and overstory, respectively. It was considered that after the P. densiflora and B. ermanii first invaded and site condition became good, Q. mongolica-P. densiflora-B. ermanii forest type was dominated by Q. mongolica. Mixed mesophytic forest type showed the most stable stand structure with various species distributed uniformly. Q. mongolica forest type would preserve the present stand status for a while, and the B. ermanii in B. ermanii forest type would be pressed by other species over time.

Quantitative Analysis of Microstructures and Reaction Interfaces on Composite Cathodes in All-Solid-State Batteries Using a Three-Dimensional Reconstruction Technique

Choi, Sungjun,Jeon, Minjae,Ahn, Junsung,Jung, Wo Dum,Choi, Sung Min,Kim, Ji-Su,Lim, Jaemin,Jang, Yong-Jun,Jung, Hun-Gi,Lee, Jong-Ho,Sang, Byoung-In,Kim, Hyoungchul American Chemical Society 2018 ACS APPLIED MATERIALS & INTERFACES Vol.10 No.28

<P>The composite cathode of an all-solid-state battery composed of various solid-state components requires a dense microstructure and a highly percolated solid-state interface different from that of a conventional liquid-electrolyte-based Li-ion battery. Indeed, the preparation of such a system is particularly challenging. In this study, quantitative analyses of composite cathodes by three-dimensional reconstruction analysis were performed beyond the existing qualitative analysis, and their microstructures and reaction interfaces were successfully analyzed. Interestingly, various quantitative values of structure properties (such as the volume ratio, connectivity, tortuosity, and pore formation) associated with material optimization and process development were predicted, and they were found to result in limited electrochemical charge/discharge performances. We also verified that the effective two-phase boundaries were significantly suppressed to ∼23% of the total volume because of component dispersion and packing issues.</P> [FIG OMISSION]</BR>

Mori Folium regulates DSS-induced ulcerative colitis in mice and cytokine production in mast cells

Choi, In-Young,Kim, You-Jeong,Kee, Ji-Ye,Kim, Min-Chol,Lee, Dong-Jin,Cho, Sung-One,Ko, Jang-Ho,Kim, Dae-Seung,Jeon, Yong-Deok,Yoon, Cheol-Hee,Park, Yun-Jum,Um, Jae-Young,Hong, Seung-Heon 경희한의학연구센터 2012 Oriental Pharmacy and Experimental Medicine Vol.12 No.2

Inflammatory bowel disease (IBD) is characterized by detrimental immune reactivity in the gut, and the imbalance between proinflammatory and anti-inflammatory reactivity. The incidence and prevalence rates of IBD in Korea have been increasing rapidly during the past decades. In this study, we investigated regulatory effect of leaf of a mulberry tree (Moraceae) called Gwasang-No.2 in Korea. Leaf of Gwasang-No.2 (Gwa.L) inhibited the inflammatory responses on dextran sulfate sodium induced ulcerative colitis in mice and the production of nitrite oxide from lipopolysaccharide and interferon-gamma stimulated mouse peritoneal macrophages. Gwa.L inhibited IL-6 and IL-8 production from HMC-1 cells without cytotoxic effects on cell viability. These results may be relevant for future pharmacological or dietary interventions in patients with ulcerative colitis.

Biofunctional activities of the enzymatic collagen hydrolysate

Ji Hoon Choi,Sang Moo Kim 한국식품영양과학회 2015 한국식품영양과학회 학술대회발표집 Vol.2015 No.8

Development of vitiligo during treatment with adalimumab: a plausible or paradoxical response?

( Ji Hyun Lee ),( Joon Min Jung ),( Ye Jin Lee ),( Chong Hyun Won ),( Sung Eun Chang ),( Mi Woo Lee ),( Jee Ho Choi ),( Kee Chan Moon ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1

Adalimumab is a fully human monoclonal anti-tumor necrosis factor-α(anti-TNFα) agent which is generally well tolerated. With increasing use of adalimumab and other anti-TNFα therapies, several cutaneous adverse events have been reported during the therapy, including immune mediated skin lesions. A 39-year-old woman with a 11-year history of Crohn’s disease who had been treated with adalimumab at a dose of 40 mg administered subcutaneously every other week visited our clinic with multiple achromic macules and patches located on the extremities. The lesions developed abruptly about 12 months after initiation of adalimumab therapy. The diagnosis of vitiligo was made after the patient’s skin turned into blue under the Wood’s lamp. The patient has been treated with combination therapy of excimer laser and topical tacrolimus without stopping adalimumab therapy. Anti-TNFα agents including adalimumab can develop vitiligo and dermatologist should aware of that for earlier detection and treatment of vitiligo in the patients receiving anti-TNFα therapy.