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Sung Yong Park,Dae Hee Kim,Han Bum Joe,Ji Young Yoo,Jin Soo Kim,Min Kang,Yong Woo Hong 대한마취통증의학회 2012 Korean Journal of Anesthesiology Vol.62 No.5
Background: During beating heart surgery, the accuracy of cardiac output (CO) measurement techniques may be influenced by several factors. This study was conducted to analyze the clinical agreement among stat CO mode (SCO), continuous CO mode (CCO), arterial pressure waveform-based CO estimation (APCO), and transesophageal Doppler ultrasound technique (UCCO) according to the vessel anastomosis sites. Methods: This study was prospectively performed in 25 patients who would be undergoing elective OPCAB. Hemodynamic variables were recorded at the following time points: during left anterior descending (LAD) anastomosis at 1 min and 5 min; during obtuse marginal (OM) anastomosis at 1 min and 5 min: and during right coronary artery (RCA) anastomosis at 1 min and 5 min. The variables measured including the SCO, CCO, APCO, and UCCO. Results: CO measurement techniques showed different correlations according to vessel anastomosis site. However, the percent error observed was higher than the value of 30% postulated by the criteria of Critchley and Critchley during all study periods for all CO measurement techniques. Conclusions: In the beating heart procedure, SCO, CCO and APCO showed different correlations according to the vessel anastomosis sites and did not agree with UCCO. CO values from the various measurement techniques should be interpreted with caution during OPCAB. Background: During beating heart surgery, the accuracy of cardiac output (CO) measurement techniques may be influenced by several factors. This study was conducted to analyze the clinical agreement among stat CO mode (SCO), continuous CO mode (CCO), arterial pressure waveform-based CO estimation (APCO), and transesophageal Doppler ultrasound technique (UCCO) according to the vessel anastomosis sites. Methods: This study was prospectively performed in 25 patients who would be undergoing elective OPCAB. Hemodynamic variables were recorded at the following time points: during left anterior descending (LAD) anastomosis at 1 min and 5 min; during obtuse marginal (OM) anastomosis at 1 min and 5 min: and during right coronary artery (RCA) anastomosis at 1 min and 5 min. The variables measured including the SCO, CCO, APCO, and UCCO. Results: CO measurement techniques showed different correlations according to vessel anastomosis site. However, the percent error observed was higher than the value of 30% postulated by the criteria of Critchley and Critchley during all study periods for all CO measurement techniques. Conclusions: In the beating heart procedure, SCO, CCO and APCO showed different correlations according to the vessel anastomosis sites and did not agree with UCCO. CO values from the various measurement techniques should be interpreted with caution during OPCAB.
( Sung Hyub Han ),( Ji Won Byun ),( Won Soo Lee ),( Hoon Kang ),( Yong Chul Kye ),( Ki Ho Kim ),( Do Won Kim ),( Moon Bum Kim ),( Seong Jin Kim ),( Hyung Ok Kim ),( Woo Young Sim ),( Tae Young Yoon ) 대한피부과학회 2012 Annals of Dermatology Vol.24 No.3
Background: Androgenetic alopecia (AGA) is a common hair loss disease with genetic predisposition among men and women, and it may commence at any age after puberty. It may significantly affect a variety of psychological and social aspects of one`s life and the individual`s overall quality of life (QoL). Objective: This study aimed to investigate the QoL of AGA patients and discover the factors that can influence the QoL of AGA patients, including previous experience in non-medical hair care, reasons for hospital visits, age, duration, and the severity of AGA. Methods: A total of 998 male patients with AGA were interviewed, using the Hair Specific Skindex-29 to evaluate the QoL of AGA patients. Results: The results of the Hair Specific Skindex-29 on patients with AGA were as follows: symptom scale: 26.3±19.5, function scale: 24.0±20.1, emotion scale: 32.1±21.8, and global score: 27.3±19.1. According to this assessment, QoL was more damaged if the patient had severe alopecia, a longer duration of AGA, younger age, had received previous non-medical hair care, and visited the hospital for AGA treatment. Conclusion: This study showed that AGA could harmfully affect the patients` QoL. These findings indicate that dermatologists should address these QoL issues when treating patients with alopecia.
Kang, Ji-Hoon,Chun, Ho-Hyun,Song, Nak-Bum,Kim, Min-Sung,Park, Jiyong,Oh, Deog-Hwan,Song, Kyung Bin The Korean Society for Applied Biological Chemistr 2013 Applied Biological Chemistry (Appl Biol Chem) Vol.56 No.3
Effects of ultraviolet-C (UV-C) and electron beam irradiation on the quality and microbial populations of leafy vegetables were compared as a microbial decontamination method. Tatsoi and red chard leaves were treated with UV-C at a dose of $5kJ/m^2$ or by electron beam irradiation at doses of 0.5, 1, and 3 kGy. After UV-C or electron beam irradiation treatment, the samples were stored at $4{\pm}1^{\circ}C$ for 11 days. Populations of total aerobic bacteria in leafy vegetables decreased by 0.8-1.1 log CFU/g after treatment with UV-C irradiation, and those of yeast and molds decreased by 1.0-1.8 log CFU/g. On the contrary, electron beam irradiation at 0.5 or 1 kGy reduced the microbial populations by 2.0-2.5 log CFU/g. Electron beam irradiation at 3 kGy eliminated the microorganisms in the samples. These results suggest that electron beam irradiation at low dose below 3 kGy can be more effective than UV-C treatment for the inactivation of microorganisms in Tatsoi and red chard leaves.
Prevalence of Reflux Esophagitis During 12 Years in Daegu and Gyeongbuk Provinces
( Sung Jae Kim ),( Seok Keun Lee ),( Kang Wook Chung ),( Eun Soo Kim ),( Byoung Kuk Jang ),( Woo Jin Chung ),( Kwang Bum Cho ),( Jae Seok Hwang ),( Kyung Sik Park ) 대한소화기기능성질환·운동학회 2009 Journal of Neurogastroenterology and Motility (JNM Vol.15 No.2
Background/Aims: The prevalence of reflux esophagitis (RE) has been reported up to 12% in Korea, and seems being increased. However, epidemiological data for long-term trend are scarce. Moreover, there is no published report about the prevalence of RE in Daegu and Gyeongbuk provinces. Therefore, we analyzed the prevalence of RE during the recent 12 years in Daegu and Gyeongbuk provinces and also analyzed associated risk factors. Methods: We retrospectively reviewed 8,446 age and gender adjusted subjects who had visited a health promotion center for health check-up including esophagogastroduodenoscopy. Results: The mean age was 43.3±13.4 years. The overall prevalence of RE was 2.8%. The prevalences of RE in health check up subject from 1997 to 1999, from 2000 to 2002, from 2003 to 2005, and from 2006 to 2008 were 0.3%, 1.2%, 2.8%, and 6.8%, respectively. On the univariate analysis, male gender, high body mass index (BMI), obesity (BMI≥25 kg/m2), and hypertriglyceridemia were significantly related with presence of RE. On the multivariate analysis, male gender and obesity were independent risk factors of RE. Conclusion: The prevalence of RE is increasing recently in Daegu and Gyeongbuk provinces and male gender and obesity are independent risk factors of this disease.(Korean J Neurogastroenterol Motil 2009;15:124-129)
S-15 The Association of Gallstone & Cholecystectomy with Metabolic changes or Intestinal bacteria
( Sang Hoon Lee ),( Dae Bum Kim ),( Chang Nyol Paik ),( Yeon Ji Kim ),( Keun Joong Yun ),( Ji Min Lee ),( Woo Chul Chung ),( Kang-moon Lee ),( Jin Mo Yang ) 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1
Objectives: Gallbladder (GB) diseases including the status of gallstone or cholecystectomy could be associated with metabolic diseases or intestinal bacteria. However, their role has not been clarified. We investigate the relationship of GB diseases with fatty liver, hypertension, diabetes, metabolic syndrome, and small intestinal bacterial overgrowth (SIBO). Methods: We prospectively evaluated the consecutive outpatients with GB diseases attending a gastrointestinal clinic, who underwent demographic investigation, blood test for metabolic diseases, abdominal ultrasonography, glucose breath test (GBT). The 26 Controls without any abdominal symptoms were also enrolled. Results: 178 patients with GB diseases (131 GB stone, 47 cholecystectomy) were finally enrolled. The mean age of the patients were 55.4 years (range: 19-80) and 37.6% were male. The prevalence of fatty liver (46.1%), dyslipidemia (41.0%), hypertension (33.7%), metabolic syndrome (29.8%), SIBO (35.4%) and serum alanine aminotransferase (ALT) were significantly higher or higher tendency in patients with GB disease than in controls. Multivariate logistic regression analysis showed that dyslipidemia (OR=3.12, 95% confidence interval (CI): 1.02-9.73), hypertension (OR=4.62, 95% confidence interval (CI): 1.24-17.26), fatty liver (OR=3.42, 95% confidence interval (CI): 1.07-10.90) and metabolic syndrome (OR=10.39, 95% confidence interval (CI): 1.28-84.06) were independent factors associated with GB diseases. In subgroups with GB stones, dyslipidemia, hypertension, metabolic syndrome, and SIBO were independent factors. Whereas in subgroups with cholecystectomy, metabolic syndrome, fatty liver, and severity fatty liver were independent factors. Conclusions: The metabolic status with dyslipidemia, hypertension, metabolic syndrome is common risk factors related with both GB stone and cholecystectomy. Cholecystectomy is associated with the progression of fatty liver; whether GB stone is independently related with risk of intestinal bacteria
A Simple Method for the Detection and Identification of Korean Brown Cattle(Hanwoo) using DHPLC
Kang. Won,Park. Sane-Bum,Nam. Youn-Hyoung,An. Young-Chang,Lee. Sang-Hyun,Park. Jin-Keun,Lee. Jae-Sik,Jang. On-Cheoul,Park. Su-Min,Park. Yong-Hyun,Ko. Kyung-Hee,Moon. Sung-Sil 한국축산식품학회 2006 심포지움 및 학술발표회 Vol.- No.37
Denaturing high-performance liquid chromatography(DHPLC) is used in a wide variety of genetic applications and is an efficient method for detection of mutations involving one or a few nucleotides. We developed a high-throughput DHPLC method for identifying polymorphisms in the MC1R gene that are characteristic of Hanwoo cattle. We compared 10 tissue samples from Hanwoo cattle, 10 samples from Holstein cattle and 10 samples from Hanwoox Holstein crossbred cattle to determine whether DHPLC analysis can be used to distinguish between these genotypes. Samples obtained from Hanwoo cattle had a unique profile of peaks that could be used as a molecular fingerprint for this breed. We also analyzed two hundred samples in a trial in which we were blinded to the genotype of the samples and correctly identified the breed-of-origin of 594 out of 600 sequence variations(99%).
Kang Kyoung-Ah,Lee Kyoung-Hwa,Chae Sung-Wook,Kim Jeong-Ki,Seo Jung-Yeon,Ham Yong-Ho,Lee Kee-Ho,Kim Bum-Joon,Kim Hee-Sun,Kim Dong-Hyun,Hyun Jin Won The Korean Society for Biotechnology and Bioengine 2006 Biotechnology and Bioprocess Engineering Vol.11 No.1
Telomerase activation is detected in most cancerous cells; hence, telomerase is a highly selective target for cancer therapy, which plays an important role in the apoptotic process. We have previously reported that the ginseng saponin metabolite, Compound K (20-O-D-glucopyranosyl-20(S)-protopanaxadiol, IH901), inhibits cell proliferation by inducing apoptosis and cell cycle arrest at the $G_1$ phase. The present study investigated the regulation of telomerase activity in Compound K treated U937 cells. Compound K treatment caused a reduction in telomerase activity and down-regulated the human telomerase reverse transcriptase (hTERT) gene, resulting in the decreased expressions of its protein, and of the c-Myc and Spl proteins (transcription factors of hTERT). These results indicate that the anticancer activity of Compound K could be mediated by inhibition of the telomerase activity.