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Cardiovascular Fitness and Associated Comorbidities in An Executive Health Program
Otto A Sanchez(Otto A Sanchez ),Anton S. Hesse(Anton S. Hesse ),Morgan R. Betker(Morgan R. Betker ),Christopher J. Lundstrom(Christopher J. Lundstrom ),William E. Conroy(William E. Conroy ),Zan Gao(Za 사피엔시아 2022 Exercise Medicine Vol.6 No.-
Objectives: Low cardiorespiratory fitness, defined as a VO2 max below the 25th percentile for age and sex, is associated with greater body mass index (BMI), blood pressure, and plasma cholesterol values and is an independent risk factor for cardiovascular and metabolic diseases. Given that sedentarism has substantially increased in the U.S. population in the last 20 years and that office workers have the lowest cardiorespiratory fitness of the workforce, we aimed to assess the prevalence of low cardiorespiratory fitness in an corporate wellness program and determine its relationship with associated comorbidities. Methods: For this retrospective observational analysis demographics, height, weight, blood pressure at rest, plasma glucose, lipids, comorbidities, and VO2 max data was extracted from the medical records of 199 participants attending the Executive Health Program at M Health Fairview of the University of Minnesota. Participants were predominantly white, middle-aged men with near-optimal blood pressure values. Results: Participants with low cardiorespiratory fitness had a VO2 max [mean (range) of 28 (19.4 - 36.1) mL/kg/min], and was observed in 33% of all participants. Participants with low cardiorespiratory fitness were more likely to have higher BMI, dyslipidemia and hypertension than those in the excellent to superior category of cardiorespiratory fitness, VO2 max [mean (range) 45.6 (31.8 - 61.2) mL/kg/min]. Prevalence of obesity (17%) was lower than in the general U.S. population, and those who were obese were more likely to be of low cardiorespiratory fitness. Those with low cardiorespiratory fitness had a four fold relative risk of belonging to the group at high risk of cardiovascular and metabolic diseases when compared to those with a fair to superior cardiorespiratory fitness. Conclusions: Low cardiorespiratory fitness identified in a third of all participants, is a modifiable risk factor associated with risk for cardiovascular and metabolic disease, should be evaluated in executive health programs.
Guardo, Laura Alonso,Gala, Carlos Cano,Poveda, David Sanchez,Juan, Pablo Rueda,Sanchez Montero, Francisco Jose,Garzon Sanchez, Jose Carlos,Lamas, Juan Ignacio Santos,Sanchez Hernandez, Miguel Vicente The Korean Pain Society 2016 The Korean Journal of Pain Vol.29 No.1
Background: Sacral nerve stimulation is a therapeutic option with demonstrated efficacy for conditions presenting with perineal pain caused by different etiologies. We aimed to assess whether a sacral electrode ($Interstim^{(R)}$, Medtronic, Minneapolis, MN, USA) inserted through the caudal pathway is able to offer an acceptable level of sacral stimulation and rate of catheter migration. Methods: We present 12 patients with pelvic pain who received sacral neuromodulation via the sacral hiatus with the InterStim electrode. We evaluated patient satisfaction as well as migration and removal of the electrode, if necessary. Results: Our experience included 12 patients, 10 women and two men, with a mean age of 60 years. In eight of the 12 patients, the initial therapy was effective, and the final system implantation was performed. During subsequent follow-up, patient satisfaction was good. To date, there have been no cases of electrode displacement or migration. Conclusions: The caudal insertion of the InterStim electrode, with its own fixation system, and initially designed for transsacral insertion, appears in our experience to be a satisfactory option which can minimize electrode displacements, achieving similar results in therapeutic efficacy and causing no difficulties in removal.
Sanchez-Torrijos Jorge,Queral Cesar,Paris Carlos,Rebollo Maria Jose,Sanchez-Perea Miguel,Posada Jose Maria 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.12
The classical Probabilistic Safety Analysis (PSA) does not include any time dependence explicitly. However, the success criteria (SC) could evolve during the cycle for some initiating events. In that sense, there is a type of sequence in which this time-dependency is quite important, the family of Anticipated Transient without Scram (ATWS) sequences in Pressurized Water Reactors. Therefore, a new riskinformed approach is proposed in this paper, which makes it possible to obtain the time-dependent SC evolution of the safety functions affected by the Moderator Temperature Coefficient (MTC) value. Then, the evolution of the ATWS conditional core damage probability (CCDP) could be obtained using a PSA model. To quantify the CCDP, the average values of the time-dependent failure probabilities must be computed. Finally, the comparison between the CCDP obtained through the application of the classical PSA approach and the new one makes it possible to quantify the impact of time-dependence on the SC of the headers that this new risk-informed ATWS approach can provide.
Rey David Vargas-Sanchez,Felix Joel Ibarra-Arias,Brisa del Mar Torres-Martinez,Armida Sanchez-Escalante,Gaston Ramon Torrescano-Urrutia 아세아·태평양축산학회 2019 Animal Bioscience Vol.32 No.11
The present paper reviews the findings of different research studies on the effect of natural ingredients in the Japanese quail (Coturnix coturnix japonica) diet on carcass characteristics and meat quality. The results show a relationship between the type and concentration of ingredients used in diets and carcass characteristics and meat quality. The inclusion of medicinal herbs (thyme, black seed, and mint), plants (canola), seeds (chickpea), spices (cinnamon and coriander), worms (earthworms), bee products (propolis), phytochemicals (lycopene), and edible fungi (common mushrooms) in the diet improved carcass quality characteristics compared to the control diets (basal diets). The inclusion of medicinal herbs (spearmint and green tea), spices (cinnamon), vegetables (tomato), plants (verbena and canola), seeds (marijuana), and edible fungi (oyster mushrooms) improved meat quality. In conclusion, the use of ingredients of natural origin in the diet of Japanese quail improves carcass quality characteristics and meat quality.
Gene Expression of CYP1A1 and its Possible Clinical Application in Thyroid Cancer Cases
Gallegos-Vargas, JA,Sanchez-Roldan, J,Ronquillo-Sanchez, MD,Carmona-Aparicio, L,Floriano-Sanchez, E,Cardenas-Rodriguez, N Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.7
Background: Thyroid cancer is the most common endocrine malignancy, and exact causes remain unknown. The role of CYP450 1A1 (CYP1A1) in cancer initiation and progression has been investigated. The aim of this work was to analyze, for the first time, CYP1A1 gene expression and its relationship with several clinicopathological factors in Mexican patients diagnosed with thyroid cancer. Materials and Methods: Real-time PCR analysis was conducted on 32 sets of thyroid tumors and benign pathologies. Expression levels were tested for correlations with clinical and pathological data. All statistical analysis were performed using GraphPad Prism version 3.0 software. Results: We found that female gender was associated with thyroid cancer risk (P<0.05). A positive relationship was identified between CYP1A1 mRNA levels and the presence of chronic disease, alcohol use, tumor size, metastasis and an advanced clinical stage (P<0.05). Conclusions: The results suggest that CYP1A1 gene expression could be used as a marker for thyroid cancer.
( Laura Alonso Guardo ),( Carlos Cano Gala ),( David Sanchez Poveda ),( Pablo Rueda Juan ),( Francisco Jose Sanchez Montero ),( Jose Carlos Garzon Sanchez ),( Juan Ignacio Santos Lamas ),( Miguel Vice 대한통증학회 2016 The Korean Journal of Pain Vol.29 No.1
Background: Sacral nerve stimulation is a therapeutic option with demonstrated efficacy for conditions presenting with perineal pain caused by different etiologies. We aimed to assess whether a sacral electrode (InterStimⓡ, Medtronic, Minneapolis, MN, USA) inserted through the caudal pathway is able to offer an acceptable level of sacral stimulation and rate of catheter migration. Methods: We present 12 patients with pelvic pain who received sacral neuromodulation via the sacral hiatus with the InterStim electrode. We evaluated patient satisfaction as well as migration and removal of the electrode, if necessary. Results: Our experience included 12 patients, 10 women and two men, with a mean age of 60 years. In eight of the 12 patients, the initial therapy was effective, and the final system implantation was performed. During subsequent follow-up, patient satisfaction was good. To date, there have been no cases of electrode displacement or migration. Conclusions: The caudal insertion of the InterStim electrode, with its own fixation system, and initially designed for transsacral insertion, appears in our experience to be a satisfactory option which can minimize electrode displacements, achieving similar results in therapeutic efficacy and causing no difficulties in removal. (Korean J Pain 2016; 29: 23-28)
Sanchez-Fernandez, Elena,Magan-Fernandez, Antonio,O'Valle, Francisco,Bravo, Manuel,Mesa, Francisco Korean Academy of Periodontology 2020 Journal of Periodontal & Implant Science Vol.50 No.-
Purpose: This study investigated the effects of hyaluronic acid (HA) on peri-implant clinical variables and crevicular concentrations of the proinflammatory biomarkers interleukin (IL)-1β and tumor necrosis factor (TNF)-α in patients with peri-implantitis. Methods: A randomized controlled trial was conducted in peri-implantitis patients. Patients were randomized to receive a 0.8% HA gel (test group), an excipient-based gel (control group 1), or no gel (control group 2). Clinical periodontal variables and marginal bone loss after 0, 45, and 90 days of treatment were assessed. IL-1β and TNF-α levels in crevicular fluid were measured by enzyme-linked immunosorbent assays at baseline and after 45 days of treatment. Clustering analysis was performed, considering the possibility of multiple implants in a single patient. Results: Sixty-one patients with 100 dental implants were assigned to the test group, control group 1, or control group 2. Probing pocket depth (PPD) was significantly lower in the test group than in both control groups at 45 days (control 1: 95% CI, -1.66, -0.40 mm; control 2: 95% CI, -1.07, -0.01 mm) and 90 days (control 1: 95% CI, -1.72, -0.54 mm; control 2: 95% CI, -1.13, -0.15 mm). There was a trend towards less bleeding on probing in the test group than in control group 2 at 90 days (P=0.07). Implants with a PPD ≥5 mm showed higher levels of IL-1β in the control group 2 at 45 days than in the test group (P=0.04). Conclusions: This study demonstrates for the first time that the topical application of a HA gel in the peri-implant pocket and around implants with peri-implantitis may reduce inflammation and crevicular fluid IL-1β levels.
Sanchez Barea Joel,Kang Dong‐Ku 대한화학회 2021 Bulletin of the Korean Chemical Society Vol.42 No.6
Identification and monitoring cancer-related genetic mutation become a powerful tool for targeted therapy in recent decades and KRAS is one of the most frequently mutated oncogenes in many types of cancers. Polymerase chain reaction (PCR) is one of the most powerful diagnostic tools and it is widely used for monitoring infectious diseases and tumor-related mutations. However, there are still limitations for monitoring rare mutations in complex biological samples and also for monitoring various mutations in a multiplexed manner from a single set assay. In this study, we present an integration of surface-enhanced Raman scattering (SERS) with PCR that can be used for monitoring KRAS G12D mutation and also can distinguish from similar mutations such as KRAS G13D, G12S, and G12V. With this approach, various KRAS mutations can be detected from a single set of experiment without complex procedures or microdevices.
Oncogenic Signaling Pathways in The Cancer Genome Atlas
Sanchez-Vega, Francisco,Mina, Marco,Armenia, Joshua,Chatila, Walid K.,Luna, Augustin,La, Konnor C.,Dimitriadoy, Sofia,Liu, David L.,Kantheti, Havish S.,Saghafinia, Sadegh,Chakravarty, Debyani,Daian, F Elsevier 2018 Cell Vol.173 No.2
<P><B>Summary</B></P> <P>Genetic alterations in signaling pathways that control cell-cycle progression, apoptosis, and cell growth are common hallmarks of cancer, but the extent, mechanisms, and co-occurrence of alterations in these pathways differ between individual tumors and tumor types. Using mutations, copy-number changes, mRNA expression, gene fusions and DNA methylation in 9,125 tumors profiled by The Cancer Genome Atlas (TCGA), we analyzed the mechanisms and patterns of somatic alterations in ten canonical pathways: cell cycle, Hippo, Myc, Notch, Nrf2, PI-3-Kinase/Akt, RTK-RAS, TGFβ signaling, p53 and β-catenin/Wnt. We charted the detailed landscape of pathway alterations in 33 cancer types, stratified into 64 subtypes, and identified patterns of co-occurrence and mutual exclusivity. Eighty-nine percent of tumors had at least one driver alteration in these pathways, and 57% percent of tumors had at least one alteration potentially targetable by currently available drugs. Thirty percent of tumors had multiple targetable alterations, indicating opportunities for combination therapy.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Alteration map of 10 signaling pathways across 9,125 samples from 33 cancer types </LI> <LI> Reusable, curated pathway templates that include a catalogue of driver genes </LI> <LI> 57% of tumors have at least one potentially actionable alteration in these pathways </LI> <LI> Co-occurrence of actionable alterations suggests combination therapy opportunities </LI> </UL> </P> <P><B>Graphical Abstract</B></P> <P>[DISPLAY OMISSION]</P>