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Paraquat 유도 폐독성에 대한 Hydroxycinnamic Acid계 화합물의 독성 경감 효과 (Ⅲ)
최병기,오은정,정세영 한국환경독성학회 1999 환경독성보건학회지 Vol.14 No.3
The scavenging effects of two hyaroxycinnamic acids such as caffeic acid and chlorogenic acid on paraquat induced pulmonary toxicity were investigated. The results are summerized as follows: 1. In the 5-lipoxygenase assay, caffeic acid and chlorogenic acid inhibited the enzyme activities whose inhibition concentration (IC_(50)) were 4.1 and 9.6 μM respectively. 2. To evaluate the antiinflammatory effects on mediator related to the mechanism of inflammation, ADP-induced platelet aggregation assay and histamine degranulation assay were used. Caffeic acid and chlorogenic acid inhibited on ADP-induced platelet aggregation and histamine release at a concentration dependent manners. 3. Arachidonic acid--induced ear edema were inhibited by administration of caffeic acid and chlorogenic acid. 4. Cytologicad analysis of branchoalveolar lavage fluid (BALF) which was the useful tool for detection of an inflammatory response in the lungs of animals intoxicated with chemicals were used. Alveolar macrophages and neutrophils in BALF, as well as the protein content and the LDH activity in BALF supernatant increased by intoxication of paraquat, but decreased by administration of caffeic acid and chlorogenic acid. Therefore, two hydroxyeinnamic acids tested were the useful candidates for scavenger and antiinflammatory agents on paraquat induced pulmonary toxicity.
Effects on Sulfide Toxicity of Anaerobic Bacteria Degrading Volatile Fatty Acids(VFAs)
Oh, Sae-Eun 大田産業大學校 1999 한밭대학교 논문집 Vol.16 No.1
본 연구는 황화물의 농도 변화에 따른 메탄생성균과 아세트생성균의 활성을 평가하기 위하여 수행되었다. 메탄균의 활성은 황화물의 농도가 100mg/1 와 150mg/1에서 각각 15, 50%의 저해를 받았으며, 황화물의 농도가 200mg/1 이상에서는 메탄균의 활성이 거의 중단되었다. 유기물을 분해하는 다양한 종류의 혐기성은 황화물 농도에 따라 축적되거나 저해를 받는 것으로 보여지고 있다. 황화물에 따라 유기산의 분해능력을 평가한 길과 황화물의 농도가 증가함에 따라 반웅조내에 아세트산, 프로피온산, 브틸릭산 순서로 농도가 증가되었다. 이러한 현상은 반응조내에 활화물 농도가 증가하면 아세트산을 이용하여 메탄을 생성하는 메탄생성균이 프로피온산, 브틸릭산을 이용하여 아세트산을 생성하는 아세트 생성균 보다 황화물 독성에 훨씬 더잘 노출된다는 것을 보여주고 있다. 본 연구는 황화물의 농도 번화에 따른 메탄생성균과 아세트생성균의 활성을 평가하기 위하여 수행되었다. 메탄균의 활성은 황화물의 농도가 100mg/l 와 150mg/l 에서 각각 15, 50%의 저해를 받았으며, 황화물의 농도가 200mg/l 이상에서는 메탄균의 활성이 거의 중단되었다. 유기물을 분해하는 다양한 종류의 혐기성은 황화물 농도에 따라 축적되거나 저해를 받는 것으로 보여지고 있다. 황화물에 따라 유기산의 분해능력을 평가한 길과 황화물의 농도가 증가함에 따라 반응조내에 아세트산, 프로피온산, 브틸릭산 순서로 농도가 증가되었다. 이러한 현상은 반응조내에 황화물 농도가 증가하면 아세트산을 이용하여 메탄을 생성하는 메탄생성균이 프로피온산, 브틸릭산을 이용하여 아세트산을 생성하는 아세트 생성균 보다 황화물 독성에 훨씬 더잘 노출된다는 것을 보여주고 있다.
Competition Between SRB and MPB in an Thermophilic UASB Reactor
Oh,Sae Eun,Park,Eun Hwa,Paik,Byeong Cheon 여수대학교 1997 論文集 Vol.11 No.2
고농도의 환산염이 포함된 폐수의 고온혐기성소화를 위해 메탄생성균의 활성을 향상시킬 목적으로 고온 UASB 반응조를 운전하였다. 반응온도를 35℃에서 55℃로 상승시켰을 때 메탄생성균은 황환원균보다 온도에 민감하게 반응하여 활성이 급격히 감소하였으나, 시간이 지남에 따라 활성이 점진적으로 회복되고 고온에서 높은 활성을 보였다. 반면에 황환원균은 메탄생성균보다 온도변화에 덜 민감하였다. 그러나, 황환원균에 의해 35℃에서 제거된 35~44%의 COD제거율은 반응온도를 55℃의 고온으로 상승시켰을 때 초기에는 80%의 COD를 제거하였으나 시간이 지남에 따라 37%로 급격히 감소한 바, 고온에서는 황환원균보다 메탄생성균의 성장이 우세한 것으로 나타났다. 입상슬러지는 초기 회색에서 입상슬러지에 황화철의 침전에 의해 검은색으로 변화하였다. Thermophilic anaerobic digestion of wastewater with high sulfate was tried for the purpose of enhancing the methane producing bacteria (MPB) by using an thermophilic UASB (upflow anaerobic sludge blanket) reactor. Methanogensis was more sensitive than sulfate reduction initially when the temperature changed from 35 to 55℃, mainly because of the lower growth rate of MPB. However, sulfate reducing bacteria(SRB) are much less sensitive towards temperature shocks than MPB. It was estimated that the portion of electron flow used by SRB increased from 35% to 44% at 35℃, while COD used by SRB was rapidly decreased from 80% to 37% at 55℃. Presumably, thermophilic MPB was more prevalent than thermophilic SRB. In addition, the color of granules was changed from gray at the inital stage to dark at the end of experiment. This may be indicated that the complex formed by iron with sulfide is accumulated into the granules as sulfide precipitates.
Oh, Keunhee,Kim, Sae Rom,Kim, Dae-Kyum,Seo, Myung Won,Lee, Changjin,Lee, Hak Mo,Oh, Ju-Eun,Choi, Eun Young,Lee, Dong-Sup,Gho, Yong Song,Park, Kyong Soo American Chemical Society 2015 ACS NANO Vol.9 No.12
<P>The current diabetes mellitus pandemic constitutes an important global health problem. Reductions in the mass and function of β-cells contribute to most of the pathophysiology underlying diabetes. Thus, physiological control of blood glucose levels can be adequately restored by replacing functioning β-cell mass. Sources of functional islets for transplantation are limited, resulting in great interest in the development of alternate sources, and recent progress regarding cell fate change <I>via</I> utilization of extracellular vesicles, also known as exosomes and microvesicles, is notable. Thus, this study investigated the therapeutic capacity of extracellular vesicle-mimetic nanovesicles (NVs) derived from a murine pancreatic β-cell line. To differentiate insulin-producing cells effectively, a three-dimensional <I>in vivo</I> microenvironment was constructed in which extracellular vesicle-mimetic NVs were applied to subcutaneous Matrigel platforms containing bone marrow (BM) cells in diabetic immunocompromised mice. Long-term control of glucose levels was achieved over 60 days, and differentiation of donor BM cells into insulin-producing cells in the subcutaneous Matrigel platforms, which were composed of islet-like cell clusters with extensive capillary networks, was confirmed along with the expression of key pancreatic β-cell markers. The resectioning of the subcutaneous Matrigel platforms caused a rebound in blood glucose levels and confirmed the source of functioning β-cells. Thus, efficient differentiation of therapeutic insulin-producing cells was attained <I>in vivo</I> through the use of extracellular vesicle-mimetic NVs, which maintained physiological glucose levels.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2015/ancac3.2015.9.issue-12/acsnano.5b02997/production/images/medium/nn-2015-02997m_0008.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn5b02997'>ACS Electronic Supporting Info</A></P>