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Seo, Ji-Hyun,Koo, Sang-Il,Youn, Hee-Shang,Jun, Jin-Su,Lim, Jae-Young,Park, Chan-Hoo,Woo, Hyang-Ok,Kang, Hyung-Lyun,Baik, Seung-Chul,Lee, Woo-Kon,Cho, Myung-Je,Rhee, Kwang-Ho The Korean Society for Microbiology 2012 Journal of Bacteriology and Virology Vol.42 No.4
The aims of this study were to investigate the changing pattern of Helicobacter pylori antibiotic resistance in Jinju over a 15-year period. H. pylori strains were isolated from 170 adults living in Jinju from 1985-1989, 1990-1994 and 1995-1999, and from 23 adults living in Cheongju from 1995 to 1999. Susceptibility to erythromycin, clarithromycin, azithromycin, amoxicillin, tetracycline, metronidazole, furazolidone, levofloxacin, ciprofloxacin, moxifloxacin, and rifabutin was tested using the serial two-fold agar dilution method. Moxifloxacin resistance significantly increased in Jinju from 1985-1989 (0%) to 1995-1999 (14.9%) (p < 0.0001). Resistance to amoxicillin was increasesed trend to decreased trend from 1985 to 1999 (p = 0.033), whereas metronidazole resistance decreased from 37.5% to 21.3%. Resistance to furazolidone was greater from 1985-1989 (9.4%) than in 1995-1999 (2.1%). In comparing Jinju and Cheongju, minimal inhibitory concentrations (MICs) of tetracycline and levofloxacin among H. pylori isolated from Jinju were lower than for isolates from Cheonju (p < 0.05). The levofloxacin resistance rate was higher in Cheongju than in Jinju (p = 0.02). No macrolide resistance was observed in Cheongju. Overall, we did not observe any remarkable antimicrobial resistance increase of H. pylori strains isolated from Jinju over 15 years. The MIC distributions of antimicrobials and antimicrobial resistant rates were time- and region-specific among different strains. Future anti-H. pylori eradication regimens should be designed based on the changing patterns of antimicrobial resistance according to the resident area.
Seo, Kyung Hye,Zhuang, Ningning,Chen, Cong,Song, Jae-Young,Kang, Hyung-Lyun,Rhee, Kwang-Ho,Lee, Kon Ho Elsevier 2012 FEBS letters Vol.586 No.4
<P><B>Highlights</B></P><P>► The binary structure of HpCAD complex NADP(H) is solved at 2.18Å. ► An unusual conformation of the 2′phosphate group of the NADPH, not seen in other CAD structures, was found. ► Docking calculations showed that the substrate is stacked between the aromatic side chains of Tyr116 and Phe114.</P> <P><B>Abstract</B></P><P>Cinnamyl alcohol dehydrogenase is a zinc- and NADPH-dependent dehydrogenase catalyzing the reversible conversion of <I>p</I>-hydroxycinnamaldehydes to their corresponding hydroxycinnamyl alcohols. A CAD homolog from <I>Helicobacter pylori</I> (HpCAD) possesses broad substrate specificities like the plant CADs and additionally a dismutation activity converting benzaldehyde to benzyl alcohol and benzoic acid. We have determined the crystal structure of HpCAD complexed with NADP(H) at 2.18Å resolution to get a better understanding of this class of CAD outside of plants. The structure of HpCAD is highly homologous to the sinapyl alcohol dehydrogenase and the plant CAD with well-conserved residues involved in catalysis and zinc binding. However, the NADP(H) binding mode of the HpCAD has been found to be significantly different from those of plant CADs.</P><P><B>Structured summary of protein interactions</B></P><P><B>HpCAD</B> and <B>HpCAD</B> bind by x-ray crystallography (<U>View interaction</U>)</P>
Seo, Ji-Hyun,Park, Jung Je,Lim, Jae-Young,Jun, Jin-Su,Park, Chan-Hoo,Woo, Hyang-Ok,Youn, Hee-Shang,Kwon, Young-Cheol,Kang, Hyung-Lyun,Baik, Seung-Chul,Lee, Woo-Kon,Cho, Myung-Je,Rhee, Kwang-Ho,Kim, Wo The Korean Academy of Medical Sciences 2013 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.28 No.1
<P>To observe how anti-group A rotavirus antibody seropositivity rates and levels have changed in the western region of Gyeongnam Province, 2,030 serum samples collected at four collection periods (1989-1990, 1994-1995, 1999-2000, and 2004-2005) were tested by Enzyme-Linked Immunosorbent Assay for IgG, and IgA antibodies reacting to recombinant VP6 protein. The seroprevalences exhibit no regular patterns over a 16-yr period. For all four collection periods, the anti-rVP6 IgG levels rose steadily during the first 5 months of life, after which they remained high. However, the 2-9 yr and 10-39 yr groups had significantly higher IgG levels in 1999-2000 and 2004-2005, respectively, than in the other collection periods. The 1-5 mo, 40- ≥ 60 yr, and 4-29 yr groups had significantly higher IgA levels in 1989-1990, 1999-2000, and 2004-2005, respectively. The 4 yr (25.0%), 5-9 yr (18.8%), 10-14 yr (41.1%), 20-29 yr (35.0%), and 30-39 yr (20.0%) groups in 2004-2005 had significant higher IgA seropositivity rate compared to the other three collection periods. These observations suggest that in the western region of Gyeongnam Province since the late 1990s, rotavirus reinfection has occurred more frequently than previously, with all ages being at risk.</P>
Kang, Doo Seok,Yang, Jun Hyuek,Kim, Hyun Soo,Koo, Bon Kon,Lee, Cheol Min,Ahn, Yeon-Soon,Jung, Jong-Hyeon,Seo, Young Rok Korean Society of Cancer Prevention 2018 Journal of cancer prevention Vol.23 No.3
<P>As industry develops in modern society, many chemicals are being used. The safety of chemicals is an important issue because humans are constantly exposed to chemicals throughout their daily life. Through a risk assessment, the hazardous human effects of chemicals can be identified. Recently, the adverse outcome pathway (AOP) framework has been used to predict the adverse effects of chemicals. As a conceptual framework for organizing existing biological knowledge, the AOP consists of a molecular initiating event, key events, and an adverse outcome. These independent elements represent biological responses and are connected by key event relationships. This AOP framework provides intuitive hazard identification that can be helpful for carcinogenic risk assessment of chemicals. In this review, we introduce the application of the AOP framework to risk assessment for predicting carcinogenicity of chemicals and illustrate the utility of this approach for cancer prevention.</P>