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The linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation
Rodgers, Mary A.,Bowman, James W.,Fujita, Hiroaki,Orazio, Nicole,Shi, Mude,Liang, Qiming,Amatya, Rina,Kelly, Thomas J.,Iwai, Kazuhiro,Ting, Jenny,Jung, Jae U. The Rockefeller University Press 2014 The Journal of experimental medicine Vol.211 No.7
<P>Linear ubiquitination is a newly discovered posttranslational modification that is currently restricted to a small number of known protein substrates. The linear ubiquitination assembly complex (LUBAC), consisting of HOIL-1L, HOIP, and Sharpin, has been reported to activate NF-κB–mediated transcription in response to receptor signaling by ligating linear ubiquitin chains to Nemo and Rip1. Despite recent advances, the detailed roles of LUBAC in immune cells remain elusive. We demonstrate a novel HOIL-1L function as an essential regulator of the activation of the NLRP3/ASC inflammasome in primary bone marrow–derived macrophages (BMDMs) independently of NF-κB activation. Mechanistically, HOIL-1L is required for assembly of the NLRP3/ASC inflammasome and the linear ubiquitination of ASC, which we identify as a novel LUBAC substrate. Consequently, we find that HOIL-1L<SUP>−/−</SUP> mice have reduced IL-1β secretion in response to in vivo NLRP3 stimulation and survive lethal challenge with LPS. Together, these data demonstrate that linear ubiquitination is required for NLRP3 inflammasome activation, defining the molecular events of NLRP3 inflammasome activation and expanding the role of LUBAC as an innate immune regulator. Furthermore, our observation is clinically relevant because patients lacking HOIL-1L expression suffer from pyogenic bacterial immunodeficiency, providing a potential new therapeutic target for enhancing inflammation in immunodeficient patients.</P>
Janise E. Rodgers,Stephen A. Mahin 한국강구조학회 2011 International Journal of Steel Structures Vol.11 No.1
In the years since the 1994 Northridge earthquake, the profession has paid significant attention to the potential effects of various forms of deterioration in connection strength and stiffness that steel moment-resisting frames can experience during severe seismic excitations. The brittle connection fractures that a number of welded steel moment-resisting frame structures experienced during recent earthquakes have been the most extensively studied to date. However, cyclic testing of post-Northridge beam-column connections demonstrates that ductile connections may suffer other forms of deterioration. Negative post-yield tangent stiffness or capping, hereafter referred to as deformation softening, is a behavior of particular interest because it may have significant adverse effects on frame system behavior. The effects of deformation softening on frames subjected to pulse excitations were examined as part of an integrated experimental and analytical investigation of the effect of various forms of hysteretic deterioration on the overall system behavior of moment resisting steel frames. Pulse excitations, and the near-field ground motions they represent, can be highly damaging to structures and are therefore the primary focus of the results presented in this paper. The experimental portion of this study consisted of a series of thirty-two shaking table tests, which were performed on a one-third scale, two-story, one bay, steel moment frame with idealized, mechanical connections. These tests and subsequent analytical studies show that, in general, significant loss of connection strength capacity, whether from deformation softening or other types of deterioration, leads to large residual drifts and, for large pulse excitations with durations longer than the fundamental period of the structure, to collapse. In particular, frames with connections exhibiting negative post-yield stiffness tend to have substantially increased peak and residual displacements when subjected to pulse excitations.
Analog active valve control design for non-linear semi-active resetable devices
Geoffrey W. Rodgers,J. Geoffrey Chase,Sylvain Corman 국제구조공학회 2017 Smart Structures and Systems, An International Jou Vol.19 No.5
Semi-active devices use the building\'s own motion to produce resistive forces and are thus strictly dissipative and require little power. Devices that independently control the binary open/closed valve state can enable novel device hysteresis loops that were not previously possible. However, some device hysteresis loops cannot be obtained without active analog valve control allowing slower, controlled release of stored energy, and is presents an ongoing limitation in obtaining the full range of possibilities offered by these devices. This in silico study develops a proportional-derivative feedback control law using a validated nonlinear device model to track an ideal diamond-shaped force-displacement response profile using active analog valve control. It is validated by comparison to the ideal shape for both sinusoidal and random seismic input motions. Structural application specific spectral analysis compares the performance for the non-linear, actively controlled case to those obtained with an ideal, linear model to validate that the potential performance will be retained when considering realistic nonlinear behaviour and the designed valve control approach. Results show tracking of the device force-displacement loop to within 3-5% of the desired ideal curve. Valve delay, rather than control law design, is the primary limiting factor, and analysis indicates a ratio of valve delay to structural period must be 1/10 or smaller to ensure adequate tracking, relating valve performance to structural period and overall device performance under control. Overall, the results show that active analog feedback control of energy release in these devices can significantly increase the range of resetable, valve-controlled semi-active device performance and hysteresis loops, in turn increasing their performance envelop and application space.
Estimation of the Impact of Devaluation on Indonesian Aggregate Trade Performance
( Yana Van Der Meulen Rodgers ) 세종대학교 경제통합연구소 1995 Journal of Economic Integration Vol.10 No.4
This study evaluates the relationship between the real exchange rate and Indonesia`s aggregate trade performance between 1975 and 1990. I estimate structural import and export functions that are consistent with traditional empirical trade models, in which a rupiah devaluation leads rupiah import and export prices to increase relative to domestic prices. The study provides the first Indonesian import demand elasticity estimates, and it offers more precisely estimated non-oil export supply elasticities than previous work. Results add to the body of evidence that supports devaluation`s use in dampening imports and stimulating exports.
Desombre, Jonathan,Rodgers, Geoffrey W.,MacRae, Gregory A.,Rabczuk, Timon,Dhakal, Rajesh P.,Chase, J. Geoffrey Techno-Press 2011 Structural Engineering and Mechanics, An Int'l Jou Vol.37 No.4
The aim of this research is to model the behaviour of recently developed high force to volume (HF2V) passive energy dissipation devices using a simple finite element (FE) model. Thus, the end result will be suitable for use in a standard FE code to enable computationally fast and efficient analysis and design. Two models are developed. First, a detailed axial model that models an experimental setup is created to validate the approach versus experimental results. Second, a computationally and geometrically simpler equivalent rotational hinge element model is presented. Both models are created in ABAQUS, a standard nonlinear FE code. The elastic, plastic and damping properties of the elements used to model the HF2V devices are based on results from a series of quasi-static force-displacement loops and velocity based tests of these HF2V devices. Comparison of the FE model results with the experimental results from a half scale steel beam-column sub-assembly are within 10% error. The rotational model matches the output of the more complex and computationally expensive axial element model. The simpler model will allow computationally efficient non-linear analysis of large structures with many degrees of freedom, while the more complex and physically accurate axial model will allow detailed analysis of joint connection architecture. Their high correlation to experimental results helps better guarantee the fidelity of the results of such investigations.