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Essential Oil Constituents of Swertia chirata Buch.-Ham.
Gyawali, Rajendra,Ryu, Keun-Young,Shim, Sung-Lye,Kim, Jun-Hyoung,Seo, Hye-Young,Han, Kyu-Jae,Kim, Kyong-Su The Korean Society of Food Science and Nutrition 2006 Preventive Nutrition and Food Science Vol.11 No.3
The essential oil of Swertia chirata Buch.-Ham. was extracted by solvent extraction (n-pentane:diethylether, 1:1) method using simultaneous distillation-extraction (SDE) apparatus and analyzed by gas chromatography-mass spectrometry (GC/MS). The yield of essential oil obtained from S. chirata was 236.47 mg/kg. Seventy seven compounds of the essential oil belonging to chemical classes of acid (4), alcohol (21), aldehyde (15), ester (3), furan (3), hydrocarbon (7), ketone (17) and miscellaneous (7) were tentatively identified. The major volatile compounds ranged in content order were as follows: undecanoic acid (28.63%), 2-buten-2-one (20.42%), camphor (18.40%), 2-heptadecanone (14.72%), and cedrol (13.07%).
Essential Oil Constituents of Swertia chirata Buch.-Ham
Rajendra Gyawali,Keun-Young Ryu,Sung-Lye Shim,Jun-Hyoung Kim,Hye-Young Seo,Kyu-Jae Han,Kyong-Su Kim 한국식품영양과학회 2006 Preventive Nutrition and Food Science Vol.11 No.3
The essential oil of Swertia chirata Buch.-Ham. was extracted by solvent extraction (n-pentane:diethylether, 1:1) method using simultaneous distillation-extraction (SDE) apparatus and analyzed by gas chromatographymass spectrometry (GC/MS). The yield of essential oil obtained from S. chirata was 236.47 ㎎/㎏. Seventy seven compounds of the essential oil belonging to chemical classes of acid (4), alcohol (21), aldehyde (15), ester (3), furan (3), hydrocarbon (7), ketone (17) and miscellaneous (7) were tentatively identified. The major volatile compounds ranged in content order were as follows: undecanoic acid (28.63%), 2-buten-2-one (20.42%), camphor (18.40%), 2-heptadecanone (14.72%), and cedrol (13.07%).
Prabin Gyawali,Jyoti Shrestha Takanche,Raj Kumar Shrestha,Prem Bhattarai,Kishor Khanal,Prabodh Risal,Rajendra Koju 대한당뇨병학회 2015 Diabetes and Metabolism Journal Vol.39 No.1
Background: Thyroid dysfunction (TD) and metabolic syndrome (MetS) are known risk factors for atherosclerotic cardiovascular disease (ASCVD). TD is risk factor for ASCVD mediated by the effects of thyroid hormones on lipid metabolism and blood pressure hence the components of MetS. It is possible that coexistence of these two disease entities and unrecognized TD in patients with MetS might substantially increase ASCVD risk. Moreover, little is known about the relationship between TD and the components of MetS. Thus, the purpose of this study was to evaluate the pattern of TD in patients with MetS and its relationship with components of the MetS. Methods: A total of 358 previously diagnosed patients with MetS were recruited in the study. The thyroid function test parameters were measured to classify TD at Dhulikhel Hospital-Kathmandu University Hospital, Dhulikhel, Nepal. Statistical analyses were performed using SPSS version 16.0 to evaluate pattern and relationship. Results: The overall prevalence of TD in patients with MetS was 31.84% with high prevalence of subclinical hypothyroidism (29.32%). We found no evidence of a relationship between TD and components of MetS, although there was significant difference in waist circumference between four groups of TD. Conclusion: Patients with MetS had subclinical hypothyroidism greatly. Although there was no evidence of any relationship between thyroid status and all components of MetS, TD should be taken into account when evaluating and treating patients with MetS to reduce the impending risk.
( Prabin Gyawali ),( Jyoti S Takanche ),( Bijay Krishna Prajapati ),( Rajendra Koju ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1
Background: Thyroid dysfunction (TD) and metabolic syndrome (Met S) are known risk factors for atherosclerotic cardiovascular disease (ASCVD). TD is risk factor for ASCVD mediated by the effects of thyroid hormones on lipid metabolism and blood pressure hence the components of Met S. Although traditional lipid profile parameters are used to manage ASCVD in patients with Met S, there are no reliable biochemical parameters that can be used in early prediction, diagnosis and primary prevention. Nevertheless, recent studies have recognized serum lipid ratios, atherogenic index of plasma (AIP) and non- HDL Cholesterol (non-HDL-C) as a stronger predictive marker of coronary atherosclerosis and ASCVD events than isolated parameters used independently. Thus, the purpose of this study was to evaluate -the pattern of TD in patients with Met S and - serum lipid ratios, non-HDL cholesterol, and AIP as a predictor of ASCVD in patients with Met S. Methods: Between, October 2012 and March 2014, total of 358 previously diagnosed patients with Met S and 341 healthy controls, who visited diabetes and endocrine clinic at Dhulikhel Hospital, Dhulikhel, Nepal were recruited in the study. The thyroid function test parameters were measured to classify TD and the serum lipid concentrations were measured to calculate the lipid ratios, non-HDL-C and AIP. Results: The overall prevalence of TD in patients with Met S was 31.84 % with high prevalence of subclinical hypothyroidism. Patients with Met S had significantly higher significantly higher lipid ratio`s, non-HDL-C (165.78±48.66 vs 135.21±47.88), and AIP levels (0.810±0.023 vs 0.546±0.014) compared to healthy controls (P < 0.05). Conclusions: Patients with Met S develop sub-clinical hypothyroidism greatly. The measurements of serum lipid ratios, non HDL-C, and AIP level predicts high risk of developing ASCVD in patients with Met S.
송연우,Sabina Shrestha,Rajendra Gyawali,이동선,김소미 한국응용생명화학회 2015 Applied Biological Chemistry (Appl Biol Chem) Vol.58 No.2
The pharmaceutical potential of the methanolic extract of Citrus unshiu leaves (MECL) was assessed through analysis of its inhibitory effect on cancer cells. The antiproliferative activities of the leaves were evaluated using several cancer cell lines and considerable cytotoxicity was observed in human gastric adenocarcinoma AGS cells. Inhibition of AGS cell viability was both time- and dose-dependent, and MECL induced non-apoptotic cell death. AGS cells treated with MECL increased the formation of acidic vesicular organelles and GFP-LC3 puncta. Pretreatment with an autophagy inhibitor, 3-methyladenine, inhibited MECLinduced cell death. These results indicated that themechanism underlying the anticancer effects ofMECLinAGScells could be via the induction of autophagic cell death. The major compounds of MECL were identified as phytol, 4-ethenyl-2- methoxyphenol, hexadecanoic acid, 2,3-dihydro-3,5-dihydroxy- 6-methyl-4H-pyran-4-one, and vitamin E using gas chromatography–mass spectrometry. These results indicate that C. unshiu leaves can be exploited for numerous pharmaceutical applications as a source of anticancer ingredients.
Md. Ramjan Ali,문정용,Rajendra Gyawali,Ashik Mosaddik,Youn-Chul Ryu,김소미 한국응용생명화학회 2012 Applied Biological Chemistry (Appl Biol Chem) Vol.55 No.3
Flesh and peel extracts of five mango varieties were compared for their antioxidant and antiproliferative activities. Fozli peel (FP) extract was found to have the highest antioxidant activity and to significantly inhibit the proliferation of HeLa human cervical carcinoma cells in a dose-dependent manner. Hoechst 33342 staining revealed apoptotic nuclei with condensed chromatin, and cell growth arrest was confirmed by flow cytometry. Apoptotic signaling induced by FP extract was characterized by an increased Bax/Bcl-2 ratio and down-regulation of Bcl-2. Moreover, FP extract treatment triggered the proteolytic activation of caspases-3, -8, and -9 and the degradation of poly ADP-ribose polymerase in HeLa cells. These results indicate that FP is an excellent source of phenolic and/or flavonoid compounds, and may have applications in the treatment of human cervical carcinoma and as an antioxidant in the food and pharmaceutical industries. Gas chromatography-mass spectrometry analysis of FP extract revealed that 2,5-dihydroxyphenol was detected with highest amount and other compounds such as 5-hydroxymethyl-2-furancarboxaldehyde, pentadecanoic acid, (Z,Z)-9,12-octadecadienoic acid, and 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one were also found in high amounts.
Ali, Md. Ramjan,Yong, Moon-Jeong,Gyawali, Rajendra,Mosaddik, Ashik,Ryu, Youn-Chul,KimCho, So-Mi The Korean Society for Applied Biological Chemisty 2012 Journal of Applied Biological Chemistry (J. Appl. Vol.58 No.3
Flesh and peel extracts of five mango varieties were compared for their antioxidant and antiproliferative activities. Fozli peel (FP) extract was found to have the highest antioxidant activity and to significantly inhibit the proliferation of HeLa human cervical carcinoma cells in a dose-dependent manner. Hoechst 33342 staining revealed apoptotic nuclei with condensed chromatin, and cell growth arrest was confirmed by flow cytometry. Apoptotic signaling induced by FP extract was characterized by an increased Bax/Bcl-2 ratio and down-regulation of Bcl-2. Moreover, FP extract treatment triggered the proteolytic activation of caspases-3, -8, and -9 and the degradation of poly ADP-ribose polymerase in HeLa cells. These results indicate that FP is an excellent source of phenolic and/or flavonoid compounds, and may have applications in the treatment of human cervical carcinoma and as an antioxidant in the food and pharmaceutical industries. Gas chromatography-mass spectrometry analysis of FP extract revealed that 2,5-dihydroxyphenol was detected with highest amount and other compounds such as 5-hydroxymethyl-2-furancarboxaldehyde, pentadecanoic acid, (Z,Z)-9,12-octadecadienoic acid, and 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one were also found in high amounts.
Song, Yeon Woo,Shrestha, Sabina,Gyawali, Rajendra,Lee, Dong-Sun,Cho, Somi Kim The Korean Society for Applied Biological Chemistr 2015 Applied Biological Chemistry (Appl Biol Chem) Vol.58 No.2
The pharmaceutical potential of the methanolic extract of Citrus unshiu leaves (MECL) was assessed through analysis of its inhibitory effect on cancer cells. The antiproliferative activities of the leaves were evaluated using several cancer cell lines and considerable cytotoxicity was observed in human gastric adenocarcinoma AGS cells. Inhibition of AGS cell viability was both time- and dose-dependent, and MECL induced non-apoptotic cell death. AGS cells treated with MECL increased the formation of acidic vesicular organelles and GFP-LC3 puncta. Pretreatment with an autophagy inhibitor, 3-methyladenine, inhibited MECL-induced cell death. These results indicated that themechanism underlying the anticancer effects of MECL in AGS cells could be via the induction of autophagic cell death. The major compounds of MECL were identified as phytol, 4-ethenyl-2-methoxyphenol, hexadecanoic acid, 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one, and vitamin E using gas chromatography-mass spectrometry. These results indicate that C. unshiu leaves can be exploited for numerous pharmaceutical applications as a source of anticancer ingredients.