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- 저자 : R. Miranda (검색결과 9 건)
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Jose I. Martínez-Quesada,Javier E. Anaya-Ayala,Santiago Mier y Terán-Ellis,Montserrat Miranda-Ramírez,Luis H. Arzola,Christopher Ruben-Castillo,Juan C. Aramburo,Jesus M. de los Ríos,Carlos A. Hinojosa 대한혈관외과학회 2022 Vascular Specialist International Vol.38 No.2
Chronic limb-threatening ischemia is rarely associated with previous traumatic injury. We present a case of a 28-year-old male with progressive digit ulcers, a weak pulse, cyanosis, and a cold limb. Eight months prior, he had a motorcycle accident resulting in a right clavicle fracture and brachial plexus injury. Computed tomography angiography revealed occlusion of the right subclavian artery near a surgically implanted reduction plate. The patient underwent an open subclavianbrachial bypass with a reversed saphenous vein graft. His postoperative recovery was uneventful. After 3 months, he had a euthermic right hand with a palpable pulse and his ulcers had completely healed. This case reinforces the need for patients with a neurological deficit in the upper extremity caused by blunt trauma to undergo thorough vascular examination to identify potential arterial injury and compromised perfusion.
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The Photocycle and Proton Translocation Pathway in a Cyanobacterial Ion-Pumping Rhodopsin
Miranda, M.R.M.,Choi, A.R.,Shi, L.,Bezerra, A.G.,Jung, K.H.,Brown, L.S. Biophysical Society ; Published for the Biophysica 2009 Biophysical journal Vol.96 No.4
The genome of thylakoidless cyanobacterium Gloeobacter violaceus encodes a fast-cycling rhodopsin capable of light-driven proton transport. We characterize the dark state, the photocycle, and the proton translocation pathway of GR spectroscopically. The dark state of GR contains predominantly all-trans-retinal and, similar to proteorhodopsin, does not show the light/dark adaptation. We found an unusually strong coupling between the conformation of the retinal and the site of Glu<SUP>132</SUP>, the homolog of Asp<SUP>96</SUP> of BR. Although the photocycle of GR is similar to that of proteorhodopsin in general, it differs in accumulating two intermediates typical for BR, the L-like and the N-like states. The latter state has a deprotonated cytoplasmic proton donor and is spectrally distinct from the strongly red-shifted N intermediate known for proteorhodopsin. The proton uptake precedes the release and occurs during the transition to the O intermediate. The proton translocation pathway of GR is similar to those of other proton-pumping rhodopsins, involving homologs of BR Schiff base proton acceptor and donor Asp<SUP>85</SUP> and Asp<SUP>96</SUP> (Asp<SUP>121</SUP> and Glu<SUP>132</SUP>). We assigned a pair of FTIR bands (positive at 1749 cm<SUP>-1</SUP> and negative at 1734 cm<SUP>-1</SUP>) to the protonation and deprotonation, respectively, of these carboxylic acids.
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3-Dimensional fasciectomy: A highly efficacious common ground approach to Dupuytren's surgery
Miranda, Benjamin H,Elliott, Charlotte,Kearsey, Christopher C,Haughton, David N,Webb, Mark R,Harvey, Ian,Fahmy, Fahmy S Korean Society of Plastic and Reconstructive Surge 2018 Archives of Plastic Surgery Vol.45 No.6
Background Numerous Dupuytren's fasciectomy techniques have been described, each associated with unique surgical challenges, complications and recurrence rates. We describe a common ground surgical approach to Dupuytren's disease; 3-dimensional fasciectomy (3DF). 3DF aims to address the potential contributors to the high recurrence rate of Dupuytren's disease and unite current limited fasciectomy practice that varies considerably between surgeons. Methods We describe the 3DF principles; raising thin skin flaps (addressing dermal involvement), excising diseased palmar fascia with a 3-5 mm clearance margin (treating highly locally recurrent conditions) and excising the vertical septae of Legueu and Juvara (providing deep clearance, hence addressing all potentially involved pathological tissue). The surgical outcomes between traditional limited fasciectomy (LF) and 3DF are compared. Results From the 786 operations included (n=585), postoperative recurrence rates were significantly lower for the 3DF group (2/145, 1.4%) than the LF group (72/641, 11.2%) (P= 0.001), and the time to recurrence was significantly longer ($5.0{\pm}0years$ vs. $4.0{\pm}0.2years$; P<0.0001). With recurrence excluded, there were no differences between the postoperative complication rates for 3DF (5/145, 3.5%) and LF (41/641, 6.4%) (P=0.4). Conclusions Our results suggest that 3DF leads to lower recurrence rates and a longer disease-free period for patients, without increasing complications. 3DF provides a safe, efficacious, common ground surgical approach in the treatment of Dupuytren's flexion deformity.
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Hanna D,Miranda,Loida E,Mojica,Jeanette Angeline B,Madamba,Normito R,Zapata Jr The International Academy of Global Business and T 2017 The International Academy of Global Business and T Vol.13 No.1
IAS/PAS 41, a set of accounting standards which regulates the accounting treatment of agricultural activities, provides the accounting benchmark relative to agricultural activity and includes the transformation of biological assets to agricultural produce. In the Philippines, it was implemented in 2005, but many companies were not yet compliant then with the required accounting treatment. Given that there is a dearth of studies about IAS/PAS 41 compliance, this study was conducted to assess the accounting practices of cattle farms based on the provisions of IAS/PAS 41, including their IAS/PAS 41 compliance relative to past international studies, determine the factors that influence adoption of such accounting practices and capture cattle farmer perceptions on IAS/PAS 41. A descriptive research design was employed involving the conduct of a survey of 81 cattle farms, frequency analysis and an evaluation of compliance vis-à-vis an IAS 41 checklist. Study findings show diversity in the accounting practices of cattle farms depending on the size of operation, business organization and nature of business. Backyard farmers did not maintain records and, therefore, were not IAS/PAS 41 compliant but used the fair market value approach utilized by commercial farms in the valuation of cattle inventories.
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3-Dimensional fasciectomy: A highly efficacious common ground approach to Dupuytren’s surgery
Benjamin H Miranda,Charlotte Elliott,Christopher C Kearsey,David N Haughton,Mark R Webb,Ian Harvey,Fahmy S Fahmy 대한성형외과학회 2018 Archives of Plastic Surgery Vol.45 No.6
Background Numerous Dupuytren’s fasciectomy techniques have been described, each associated with unique surgical challenges, complications and recurrence rates. We describe a common ground surgical approach to Dupuytren’s disease; 3-dimensional fasciectomy (3DF). 3DF aims to address the potential contributors to the high recurrence rate of Dupuytren’s disease and unite current limited fasciectomy practice that varies considerably between surgeons. Methods We describe the 3DF principles; raising thin skin flaps (addressing dermal involvement), excising diseased palmar fascia with a 3−5 mm clearance margin (treating highly locally recurrent conditions) and excising the vertical septae of Legueu and Juvara (providing deep clearance, hence addressing all potentially involved pathological tissue). The surgical outcomes between traditional limited fasciectomy (LF) and 3DF are compared. Results From the 786 operations included (n=585), postoperative recurrence rates were significantly lower for the 3DF group (2/145, 1.4%) than the LF group (72/641, 11.2%) (P= 0.001), and the time to recurrence was significantly longer (5.0±0 years vs. 4.0±0.2 years; P<0.0001). With recurrence excluded, there were no differences between the postoperative complication rates for 3DF (5/145, 3.5%) and LF (41/641, 6.4%) (P=0.4). Conclusions Our results suggest that 3DF leads to lower recurrence rates and a longer disease- free period for patients, without increasing complications. 3DF provides a safe, efficacious, common ground surgical approach in the treatment of Dupuytren’s flexion deformity.
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AVOIDING LATE ADOPTION OF DIGITAL INNOVATIONS: A CONFIGURATIONAL PERSPECTIVE
Sara F. Jahanmir,Gra?a Miranda Silva,J?r?my K?per,Luis Filipe Lages 글로벌지식마케팅경영학회 2018 Global Marketing Conference Vol.2018 No.07
Although researchers have explored mobile commerce (e.g. Ngai & Gunasekaran, 2007), literature on diffusion and adoption of digital innovations lacks an investigation of late adoption and possible solutions to avoid late adoption. This study applies fsQCA and proposes that disparate configurations of causal factors (resistance to innovation, skepticism, traditional mindset, perceived risk, and product simplicity) are equifinal to predict the negation of late adoption of mobile taxi app [mytaxi]. The first path suggests that lower perceived risk and lower resistance to innovation result in the negation of late adoption of the mobile application my taxi. The second and third configurations show that low level of perceived risk with low level of skepticism or low level of perceived risk with low level of traditional mindset also result in negation of late adoption. These three paths are aligned with existing literature, which presents resistance to innovation, skepticism and traditional mindset as characteristics of late adopters (Jahanmir and Lages, 2016; Laukkanen, 2016; Moore, 2014). Finally, low level of resistance to innovation with low level of traditional mindset, low level of skepticism, and low level of perceived product simplicity also lead to the negation of late adoption. This finding is also in line with prior research regarding late adopters’ preference for simple product (Jahanmir and Lages, 2016). The study also presents managerial implications. Results show that in order to avoid late adoption, firms should primarily focus on lowering consumers’ perceived risk as well as their resistance toward their digital innovations. Shifting consumers’ focus from risk to utility and performance of the digitized products is one way of lowering their resistance and increasing the rate of adoption.
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Human Papilloma Virus Detection by INNOLiPA HPV in Prostate Tissue from Men of Northeast Mexico
Rodriguez, Martha I Davila,Morales, Cesar V Ignacio,Tovar, Anel R Aragon,Jimenez, Delia Olache,Maldonado, Edmundo Castelan,Miranda, Sandra Lara,Gutierrez, Elva I Cortes Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.11
Background: Prostatic adenocarcinoma by Prosate cancer (PCa) is the most prevalent cancer and the second cause of cancer-related death among men in the Western world. Human papilloma virus (HPV) may be considered as a preventable risk factor. In this study, we assessed the frequencies of HPV infection in prostatic adenocarcinoma and benign prostatic hyperplasia (BPH) cases in Northeast Mexico. Materials and Methods: A total of 87 paraffin-embedded blocks (from 25 and 62 patients with definite diagnoses of BPH and adenocarcinoma, respectively) were selected and subjected to INNOLiPA HPV Genotyping to detect 28 high- and low-risk HPV types. The rates of infection were compared in the two studied groups. Results: INNOLiPA HPV demonstrated great sensitivity for HPV detection on paraffin-embedded tissue. Global prevalence was 14.9% (13/87). HPV infection was positive in 19.4% (12/62) of patients with adenocarcinoma and 4.0% (1/25) of patients with BPH. HPV-11, which is considered to be low risk, was more prevalent. Interestingly, one patient with BPH and six with prostate cancer showed examples considered to be high risk (HPV-18, -51, -52, and -66). Conclusion: A higher rate of HPV infection among Mexican patients with prostatic carcinoma than among those with BPH was observed. HPV infections may thus contribute to the risk of prostate cancer. Further studies are required to elucidate any roles of HPV infection in prostate disease in Mexico and the effect of prevention and treatment of HPV infection on prostatic adenocarcinoma.
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Marina Tucci Gammaro Baldavira Ferreira,Igor Braga Ribeiro,Diogo Turiani Hourneaux de Moura,Thomas R. McCarty,Alberto Machado da Ponte Neto,Galileu Ferreira Ayala Farias,Antônio Afonso de Miranda Neto 대한소화기내시경학회 2021 Clinical Endoscopy Vol.54 No.6
Background/Aims: The endoscopic management of primary sclerosing cholangitis (PSC)-associated dominant strictures remainschallenging. This systematic review and meta-analysis aimed to compare balloon dilation and stent placement in the treatment ofdominant strictures among PSC patients. Methods: Literature searches on MEDLINE, EMBASE, Cochrane CENTRAL and Lilacs/Bireme were performed for studiespublished until December 2020. Measured outcomes included clinical efficacy, stricture recurrence, cumulative recurrencefree rate,transplant rate, 5-year survival rate, and adverse events (i.e., pancreatitis, cholangitis, bleeding, perforation and death). Results: A total of 5 studies (n=467) were included. Based on pooled analyses, there were no differences in clinical efficacy (riskdifference [RD], -0.13; 95% confidence interval [CI], -0.58 to 0.33; I2=93%) or transplant rates (RD, -0.09; 95% CI, -0.19 to 0.01;I2=0%); however, the risk of occurrence of adverse events was lower with balloon dilatation than with stent placement (RD,-0.34; 95% CI, -0.45 to -0.23; I2=61%). Among the types of adverse events reported, only the rates of cholangitis/bacteremia weresignificantly lower in balloon dilation patients (RD, -0.19; 95% CI, -0.25 to -0.13; I2=51%). Conclusions: Compared to balloon dilation, stent placement for dominant strictures in PSC appeared to have higher complicationrates without significant differences in efficacy.
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