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민경우,이경석,박옥현,윤관주,김도술,박세일,정원삼,이대행,조영관,Min, Kyoung-Woo,Lee, Kyoung-Soek,Park, Ok-Hyun,Yoon, Kwan-Ju,Kim, Do-Sool,Park, Se-Il,Jeung, Won-Sam,Lee, Dae-Hang,Cho, Young-Gwan 한국환경보건학회 2015 한국환경보건학회지 Vol.41 No.3
Objectives: This study aimed to survey the characteristics of air quality and meteorological conditions in a greenway park. Methods: We measured meteorological and health related factors, including noise, particulate matter ($PM_{10}$) and selected gaseous air pollutants at three locations in a greenway park and on a general roadside as comparison. The measurements were repeated four times from April to October 2014. Results: The average air temperature in the greenway park was $20.7^{\circ}C$ which was $1-2^{\circ}C$ lower than on the general roadside. The average $PM_{10}$ concentration in the greenway park was $85.0{\mu}g/m^3$, a level 2-3 times lower than that at the roadside. The noise level at the greenway site was 4.4 dB(A)- 23.0 dB(A) lower than at the roadside. The average CO, $CO_2$, $SO_2$ and NOx concentrations in the greenway park were lower than at the roadside. The average phytoncide and anions concentrations in the greenway park were higher than at the roadside. Conclusions: The urban forest of the greenway park may have some impact on air quality and meteorological conditions.
박정훈 ( Junghun Park ),조원일 ( Won-il Jo ),변대흥 ( Dae-heung Byeon ),강소영 ( So Young Kang ),남충현 ( Choong-hyun Nam ),서경우 ( Kyoung-woo Seo ),박준규 ( Jun-kyu Park ) 한국공업화학회 2022 공업화학 Vol.33 No.5
급격한 고령화 사회로의 진입과 서구화된 식습관에 의해 협심증, 심근경색증, 고혈압 등에 의한 심장질환자의 수가 5년간 10만명 이상 증가했다. 심장질환은 지난 8년간 꾸준히 국내 사망원인 2위를 기록 중이며, 이로 인해 연간 소모되는 의료비는 6조원에 달한다. 증가한 환자와 함께 다양한 치료법이 제시되고 있는 가운데, 현재 보편화 된 관상동맥 중재시술 중 스텐트 삽입술의 단점인 재협착이나 장기간 이중항혈소판제 복용으로 인한 출혈의 위험 증가 등의 문제점을 보완하기 위해 약물코팅풍선카테터가 개발되어 점차 상용화되고 있는데, 국내에선 2010년 ‘SeQuent Please<sup>Ⓡ</sup> (비브라운코리아)’라는 제품이 처음 출시되면서 약물코팅풍선카테터를 사용한 시술이 시작되었고, 이후 2012년 보험급여가 적용되면서 그 사용량이 본격적으로 늘어났다. 약물코팅풍선치료는 국내뿐만 아니라 전 세계적으로 사용이 증가하고 있는데, 특히 일본을 포함한 아시아태평양 지역에서 그 사용량이 급격히 증가하고 있다. 현재까지 국산 제품의 수요가 증가하고 있는 상황이며 향후, 동물시험 및 임상시험에서의 성능이 입증된다면 위험성이 높은 스텐트 삽입술에 비해 효과적인 시술이 될 것이라 예상한다. As a result of the rapid entry into an aging society and westernized eating habits, the number of heart disease patients caused by angina pectoris, myocardial infarction, and high blood pressure has increased by more than 100,000 over five years. Heart disease has consistently ranked second in the cause of death in Korea over the past eight years, and medical expenses consumed annually reach 6 trillion won. While various treatments are being proposed for more patients, drug-coated balloon catheters have been developed and gradually commercialized to solve the disadvantages of stent implantation such as restenosis and increased risk of bleeding due to long-term double antiplatelet medication. In Korea, it began to use a drug-coated balloon catheter with the first release of it called “SeQuent Please<sup>Ⓡ</sup> (Bibrown Korea)” in 2010. Its demand increased gradually as insurance benefits were applied in 2012. Drug-coated balloon angioplasty is increasing in use not only in Korea but also around the world, especially in the Asia-Pacific region, including Japan. Until now, the demand for domestic products is increasing, and if the efficiency in vivo and clinical trials is proven in the future, it is expected to be an effective procedure compared to high-risk stent implantation.
지역기후기능을 고려한 주거단지계획기법에 관한 연구 - 바람길을 중심으로 -
김태욱,정응호,류지원,박지혜,Kim, Dae-Wuk,Jung, Eung-Ho,Ryu, Ji-Won,Park, Ji-Hye 한국주거학회 2007 한국주거학회 논문집 Vol.18 No.2
This research has been implemented based on the area of #369 Dowon-dong, Dalseo-gu, Dae-gu which is considered as a place with satisfactory characteristics for the flow of fresh air into the city. Simulations of the target area both prior to the development plan and after apartment complex blocking were analyzed in regard to blocking planning and pilotis based on the main direction of wind, $90^{\circ}$ (east wind) and $180^{\circ}$ (south wind). In addition, congested wind corridor flow in the target place was identified through a pollution spread simulation according to the wind corridor. Therefore, the flow of wind in the one area is affected by the blocking of the complex and the main direction of the wind. Also blocking, in regard of pilotis, provides a better flow of wind. This study was implemented based on wind formation by apartment complex planning, so further study on the other factors affecting the flow of a wind corridor along with block planning and pilotis need to be carried out. Sustainable environmental factors through analysis of the environmental factors have to be analyzed. Moreover, building and complementing fundamental resources and systematic devices should be supported.
최용훈 ( Yong Hun Choi ),원철희 ( Chul Hee Won ),박운지 ( Woon Ji Park ),신민환 ( Min Hwan Shin ),신재영 ( Jea Young Shin ),이수인 ( Su In Lee ),최중대 ( Joong Dae Choi ) 한국물환경학회 ( 구 한국수질보전학회 ) 2012 한국물환경학회지 Vol.28 No.3
In this study, Song-Cheon river Basin located at Dae-kwan-lyong Meyn in Kang-Won Province was monitored to analyze characteristics of non-point source pollution during the snowmelt period. The characteristics of NPS pollution such as runoff, change in water quality and pollutant loads by snowmelt were investigated from 23th February 2010 to 27th April 2010. The results showed that The climate change effects flow, turbidity and concentration of SS and COD with showing similar trend of fluctuation. Daily pollutant loads per unit area were SS 74.43 kg/ha/day, COD 1.25 kg/ha/day, BOD 0.21 kg/ha/day, TN 0.717 kg/ha/day, TP 0.141 kg/ha/day and the flow weight mean concentration has been SS 985.97 mg/L, COD 16.28 mg/L, BOD 2.67 mg/L, TN 9.302 mg/L, TP 1.834 mg/L, respectively. The flow and pollutant loads both of SS and of COD significantly increased during the snowmelt period. Because structurally loosen soil by freezing and thawing deteriorates water quality, research and management measures will be needed.
우리나라 노인여성의 골다공증성 척추골절로 인한 경제적 부담 추계
강혜영,강대룡,장영화,박성은,최원정,문성환,양규현,Kang, Hye-Young,Kang, Dae-Ryong,Jang, Young-Hwa,Park, Sung-Eun,Choi, Won-Jung,Moon, Seong-Hwan,Yang, Kyu-Hyun 대한예방의학회 2008 예방의학회지 Vol.41 No.5
Objectives : To estimate the economic burden of osteoporotic vertebral fracture (VF) from a societal perspective. Methods : From 2002 to 2004, we identified all National Health Insurance claims records for women ${\geq}50$ years old with a diagnosis of VF. The first 6-months was defined as a "clearance period," such that patients were considered as incident cases if their first claim of fracture was recorded after June 30, 2002. We only included patients with ${\geq}$ one claim of a diagnosis of, or prescription for, osteoporosis over 3 years. For each patient, we cumulated the claims amount for the first visit and for the follow-up treatments for 1 year. The hospital charge data from 4 hospitals were investigated to measure the proportion of the non-covered services. Face-to-face interviews were conducted with 106 patients from the 4 study sites to measure the out-of-pocket spending outside of hospitals. Results : During 2.5 years, 131,453 VF patients were identified. The patients had an average of 3.38 visits, 0.40 admissions and 6.36 inpatient days. The per capita cost was 1,909,690 Won: 71.5% for direct medical costs, 20.6% for direct non-medical costs and 7.9% for indirect costs. The per capita cost increased with increasing age: 1,848,078 Won for those aged 50-64, 2,084,846 Won for 65-74, 2,129,530 Won for 75-84and 2,121,492 Won for those above 84. Conclusions : Exploring the economic burden of osteoporotic VF is expected to motivate to adopt effective treatment options for osteoporosis in order to prevent the incidence of fracture and the consequent costs.
( Dae Won Jun ),( Jun Young Song ),( Woo Seog Kim ),( Sung Gye Lee ),( Jong Sin Lee ),( Eun Kyung Baek ),( Ki San Joo ),( Myung Sook Yoon ),( Young Lim ),( Yook Kim ),( Il Kwon Park ),( Young Cheol Ju 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Previous reports demonstrated that carnitine restore mitochondrial and liver function in various liver diseases. We aimed to assess various metabolic profiles after 3 months carnitine-orotate complex (Godex<sup>Ⓡ</sup>) treatment in patients with metabolic disease. Methods: We reviewed the records of 544 outpatients (type 2 diabetes, dyslipidemia, and hypertension) from 31 primary or secondary care clinics from January 2015 to May 2016 in Korea. The key inclusion criteria were such as following; i) participants who were prescribed antidiabetic, antihypertension, or lipid-lowering drugs, ii) elevated alanine aminotransferase activity more than 40 IU/L, iii) who were newly prescribed carnitine-orotate complex. Biochemical parameters (liver enzyme, glycated hemoglobin, lipid profile) as well as anthropometric markers observed for 3 months. Results: There was no significant weight change between before and after treatment with carnitine-orotate complex (71.55±12.19 kg vs. 71.1±11.8 kg, P=0.5367). After 3 months of combined treatment with carnitine-orotate complex, the rates of normalization of serum ALT and AST levels were 68.2 % and 63.2%, respectively. Mean change in serum ALT levels from before at 3 months was -44.07±36.15 IU/L (P<0.0001) while it was -33.28±39.46 IU/L in serum AST levels (P<0.0001). Carnitine-orotate complex showed improvement in HbA1c level with 0.74 % decrease (P<0.0001) in diabetes. Serum triglyceride level significantly decreased 54.22 mg/dl compare to baseline in dyslipidemic subjects (P<0.0001). Systolic and diastolic blood pressure also significantly decrease in hypertensive subjects (-6.84 mmHg vs. -3.86 mmHg, respectively, P<0.0001). Conclusions: Three months of treatment with carnitine-orotate complex effectively decreased liver enzyme in patients with various metabolic diseases.
Park, Young Min,Lee, Won Jai,Yun, In Sik,Lee, Dong Won,Lew, Dae Hyun,Lee, Jeon Mi,Ha, Jong-Gyun,Kim, Won Shik,Koh, Yoon Woo,Choi, Eun Chang Raven Press 2013 Annals of surgical oncology Vol.20 No.3
<P>We performed robot-assisted neck dissection (RAND) via a modified face-lift (MFLA) or retroauricular approach for neck management and carried out free flap reconstruction via these approaches in patients with head and neck cancer. We assessed the feasibility of free flap reconstruction in patients who had undergone transoral resection of a primary lesion and RAND via these approaches.</P>
( Dae Won Jun ),( Byung Ik Kim ),( Yong Kyun Cho ),( Hong Ju Kim ),( Young Oh Kwon ),( Soo Young Park ),( Sang Young Han ),( Yang Hyun Baek ),( Sung Wook Lee ),( Yong Jin Jung ),( Hwi Young Kim ),( Wo 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1
Background: Carnitine and vitamin complex (Godex®) is widely used in patients with chronic liver disease who show elevated liver enzyme in South Korea. The purpose of this study is to identify the efficacy and safety of carnitine from entecavir combination therapy in ALT elevated Chronic Hepatitis B (CHB) patients. Methods: 130 treatment-naive patients with CHB were enrolled from 13 sites. The patients were randomly selected to the entecavir and entecavir and carnitine complex. The primary endpoint of the study is ALT normalization level after 12 months, and the secondary endpoints are rate of less than HBV DNA 300 Copies/ml and adverse event rate. Results: Among the 130 patients, 119 patients completed the study treatment. The ALT normalization at 3 months was 58.9% for the monotherapy and 95.2% for the combination therapy (P<0.0001). ALT normalization rate at 12 months was 85.7% for the monotherapy and 100% for the combination group(P=0.0019). The rate of less than HBV DNA 300 copies/ ml at 12 months was 75.9 % for the monotherapy, 70.7% for the combination and it was not statistically significant. Quantification of HBsAg level was not different between the monotherapy( 10,443 IU/mL) and combination(8,621 IU/mL) at 12 months. Changes of ELISPOT value to evaluate the INF-γ secretion by HBsAg showed the increasing trend of combination therapy compare to mono-treatment(53.3 vs. 22.2, P=0.03). There were 9 SAEs during the study period but they were not related to the study medication. In addition, there were 57 AEs with 2 minor skin rashes and 2 dyspepsias, but they were controlled by not decreasing the carnitine dose. Conclusions: ALT normalization rate was higher in carnitine complex combination group than entecavir group in CHB. And combination group is faster than entecavir mono-treatment group on ALT normalization rate. HBV DNA normalization rate and serum HBV-DNA level were not changed by carnitine complex treatment.
Park, So Young,Nho, Chu Won,Kwon, Dae Young,Kang, Young-Hee,Lee, Ki Won,Park, Jung Han Yoon Cambridge University Press 2013 The British journal of nutrition Vol.109 No.2
<P>Maslinic acid is found in various natural sources, most notably in pomace olive oil, and exerts pro-apoptotic activities in various cancer cells <I>in vitro.</I> In the present study, DU145 human prostate cancer cells were cultured with 0-25 μm-maslinic acid to examine the effects of maslinic acid on the metastatic capacity of prostate cancer cells. Maslinic acid significantly (<I>P <</I>0·05) inhibited the basal and epidermal growth factor (EGF)-induced migration (27-64 %), invasion (23-60 %) and adhesion (8-40 %) of DU145 cells. Maslinic acid significantly (<I>P <</I>0·05) down-regulated both basal and EGF-stimulated secretion of matrix metalloproteinase (MMP)-9 (25-67 %), MMP-2 (50-86 %), urokinase-type plasminogen activator (uPA, about 100 %), vascular endothelial growth factor (VEGF, 98-100 %) and tissue inhibitors of metalloproteinases (TIMP)-1, as well as expression of uPA receptor (uPAR), intercellular adhesion molecules (22-33 %), vascular cell adhesion molecules (23-46 %) and E-cadherin, whereas it increased TIMP-2 secretion. Maslinic acid dramatically reduced the levels of hypoxia-inducible factor-1α (HIF-1α) protein and mRNA; the reduction was accompanied by reduced stability, nuclear levels and transcriptional activity of HIF-1α. The levels of phospho-Akt and phospho-extracellular signal-related kinase (ERK) were reduced in cells treated with maslinic acid, and the phosphoinositide 3-kinase inhibitor LY294002 and the mitogen-activated protein kinase kinase inhibitor PD98059 reduced HIF-1α levels and VEGF secretion. The results show that maslinic acid markedly inhibited the migration, invasion and adhesion of DU145 prostate cancer cells. Suppressing HIF-1α activation by inhibiting Akt and ERK activation may be part of the mechanism by which maslinic acid inhibited uPAR, E-cadherin, VEGF and MMP expression in DU145 cells.</P>