Effect of Shearing Stress on Rheological Properties of Hydrophilic Polymers

Park DS,Kim BH,Kwon SY,Chi SC,Park ES 대한약학회 2000 大韓藥學會 總會 및 學術大會 Vol.49 No.-

사지단지증의 1예

박동신(DS Park),박소효(SH Park),이지환(JH Lee) 대한산부인과학회 1975 Obstetrics & Gynecology Science Vol.18 No.6

저자들은 사지단지증아 1예를 경험하였기에 문헌적 고찰과 함께 보고하는 바이다. Authors reports a case of achondroplasia of who was delivered by a 38 year old, para 5 at our hospital. The fetus was expired immediately after delivery. A brief review of literature on this case was made.

점상연골 이형성증 ( Rhizomelic Type ) 1 례

오도산(DS Oh),김형석(HS Kim),고경수(KS Ko),박정희(JH Park),박종두(JD Park),이준형(JH Lee),이의진(EJ Lee) 대한산부인과학회 1996 Obstetrics & Gynecology Science Vol.39 No.7

Chondrodysplasia Punctata has been reported recently by an antenatal sonographic findings. It is a rare congenital disorder of bone in infant, which is characterized by radiographic manifestation of premature depositionof punctata calcific density in epiphyseal area, preformed in cartilage. Chondrodysplasia punctata has two different types: a rhizomelic, and nonrhizomelic type(Conradi-Hunermann syndrome). We present a case of rhizomelic chondrodysplasia punctata which has been delivered by Cesarean section.

과립-난포막 세포종의 임상병리학적 연구

박대순(DS Park),김인재(IJ Kim),윤희종(HC Yoon),노덕영(DY Ro),송기창(KC Song),김도강(DK Kim),남궁성은(SE Namkoong) 대한산부인과학회 1989 Obstetrics & Gynecology Science Vol.32 No.10

1980년 가톨릭의대 산부인과에 입원한 난소의 과립-난포막세포종 환자중 수술후 항암화학요 법을 시행하고 그 기간중 혈청 estradiol 농도를 추적검사한 6예를 대상으로 다음과 같은 결 론은 얻었다. 1. 연령분포는 6세부터 70세까지 다양하였으며 평균 43세이었다. 2. 임상기는 Ia에서 IIc까지 있었다. 3. 수술은 환측부속기 절제술 또는 전자궁적출술 및 양측부속기절제술과 함께 골반임파절생 검까지 하였으며 전예에서 수술후 항암화학요법을 시행하였다. 4. 기초 estradiol 치는 92 pg/ml에서 527pg/ml로 평균 261pg/ml이었고 수술후에는 25pg/ml에 서 217pg/ml 로 평균 81pg/ml이엇으며 1예에서는 부분반응후 재발이 의심되어 항암화학요법 의 전향으로 완전반응을 보였다. 이상으로 과립-난포막세포증 환자들의 치료효과 판정과 관리에 있어서 혈청 estradiol농도의 측정은 유용하다고 생각된다. The clinicopathological study with follow up of serum estradiol concentration were made on 6 patients with ovarian granulosa theca cell tumor. The patients were operated and all of them were perfomred of postoperative combinatin chemotherapy. The results were as follows; 1. The age distribution of those 6 patients was between 6 and 70 years. The mean age was 43 years. 2. The clinical stages were distributed between Ia and IIc. 3. The operation performed were unilateral salpingo-oophorectomy total hysterectomy with bilateral salpingo-oophorectomy or with pelvic lymph node biopsies. All patients were obtained postoperative combination chemotherapy with vincristine, actinomycin-D and cyclophosphamide or vinblastin bleomycin and cisplatin 4. The preoperative serum estradiol concnetration were distributed between 92 pg/ml and 527 pg/ml (the mean value was 261 pg/ml) the postopertive serum estradiol concetrtion were distributed between 25 pg/ml and 217 pg/ml 5. the combination chemotherapy with vincristine actinomycin-D and cyclophosphamide was effective in 5 patients and 1 patients was switched the chemotherapy from vincristine ,actionomycin-D and cyclophosphamide to vinblastin bleomycin and cis-platin because of elevated serum estradiol concnetration and satisfactory effect was showed.

자궁체부에 발생한 혼합 중배엽성 육종 1 예

양두석(DS Yang),강상목(SM Kang),박인배(IB Park),김동규(DK Kim),박승보(SB Park) 대한산부인과학회 1986 Obstetrics & Gynecology Science Vol.29 No.11

저자들은 최근 본원 산부인과에서 자궁체부에 발생한 혼합 중배엽성 육종 1례를 경험하였으며, 전자궁 적출술과 양측 난소 난관 절제술을 시행했으나 추후관찰이 되었으면 하는 아쉬움으로 남는다 originating from M llerian potential and mesenchymal tissue It consists of epithelial & stromal elements According to stromal elements, it is divided to homologous type (carcinosarcoma)and heterologous type (mixed mesenchymal tumor) Diagnosis is difficult & prompt treatment must be required Prognosis is very poor due to frequent metastasis and recurrence We experienced a case of mixed mesodermal tumor of the uterine corpus and report with a brief reviews of literature

Tranexamic Acid가 부인암 세포주 및 생쥐 신피막하에 이식된 암조직 성장에 미치는 영향

박태철(TC Park),박대순(DS Park),윤희종(HC Yoon),한상균(SK Han),박종섭(JS Park),김도강(DK Kim),남궁성은(SE Namkoong) 대한산부인과학회 1989 Obstetrics & Gynecology Science Vol.32 No.11

저자들은 자궁경부암, 난소암, 융모상피암 세포주들의 배양액에 각기 다른 농도의 tranexamic acid를 첨가하여 배양액내에서 종양의 성장억제효과로 세포수의 감소와 형태학적 변화를 관찰하였고, 생체실험으로서 장액성 난소암조직을 tranexamic acid 가 첨가된 배양액 에 처리한 후 마우스의 신피막하에 이종이식된 종양조직절편에서 감수성의 결정을 조직학적 판정점수로 측정하여 보조적인 항암치료제로 tranexamic acid 의 효용성을 밝히고자 실험했 떤 바 다음과 같은 결론은 얻었다. 1. 난소암 세포주는 tranexamic acid 농도의 증가에 비례하여 세포수의 감소와 종양세포의 파괴가 증가되면서 세포성장의 억제가 관찰되었다. 자궁경부암 및 융모상피암 세포주는 배양액내에 tranexamic acid를 첨가하엿으나 세포증식의 억제효과는 없었다. 2. 생체내 신피막하 이식 4일후 장액성난소암조직의 변화는 사전처리된 tranexamic acid 농 도의 증가에 비례하여, 조직학적 판정기준에 의한 점수가 감소됨이 관찰되었다. 이상의 결과로 tranexamic acid 는 장액성 난소암조직에 대한 성장억제효과가 있었으며 따라 서 악성난소암의 보조적인 치료제로서 임상적가치가 있을것으로 사료된다. After treating the carcinoma of uterine cervix ovarian carcinoma and choriocarcinoma cell lines with tranexamic acid in different concentration we obaserved effects of tranexamic acid on the growth inhibition of gynecologic cancer cell lines in vitro And we tried to find out the antitumor effects of tranexamic acid by evaluating morphologic changes of the ovarian carcinoma tissue which was xenografted in the subrenal capsule of immunocompetent mice. The results are as follows; 1. We observed the inhibition of the tumr cell proliferation in serous cystadeno carcinoma cell line of ovary , by the proportion to the tranexamic acid concentration . But squamous carcinoma cell line of uterine cervix and choriocarcinoma cell line were added by tranexamic acid in a culture fluid, but there was no any phenomena of restraint against the tumor cell proliferation. 2. The morphologic changes of the serous cystadenocarcinoma tissue of ovary four days after the subrenal capsular xenograft in immunocompetent mice showed decreased of the histologic score by the proportion to the tranexamic acid concentration was well observed. These results suggest that, the tranexamic acid is associated with the inhibition of the tumor cell proliferation in serous cystadenocarcinoma of ovary , it is of clinical value as an adjuvant antitumor chemotherapeutic agent.

프로스타글란딘 E2질정에 의한 유도분만 효과에 관한 임상적 고찰

박진익(JI Park),박성철(SC Park),조삼현(SH Cho),황윤영(YY Hwang),문형(H Moon),이재억(JA Lee),김두상(DS Kim) 대한산부인과학회 1989 Obstetrics & Gynecology Science Vol.32 No.1

한양대학병원 산부인과에 입원하여 분만한 산모 312예를 자연적으로 분만한 113예를 대조 군, 프로스타글란딘 E2질정을 투여한 99예를 연구 1군, 옥시토신 정맥내 점적투여한 100예 를 연구 2군으로 구분하고, 이들 각군을 Bishop score <=4 와 =>5그리고 초산모와 경산모를 분류하여 이들의 임상적 양상으로 프로스타글란딘 E2질정의 효용성을 비교 평가하여 다음 과 같은 결론은 얻었다. 1. Bishop score 에 따른 분만 제 1기의 소요기간 1) bishop score 4점 이하 ; (1) 초산모에서 대조군에 비하여 연구 1군 (p=0.000)과 연구 2군 (p=0.005)에서 유의한 분만시 간 단축이 잇었으나 두 연구군 간에 유의한 차이는 없었따. (2) 경산모에서도 대조군에 비하여 연구 1군(p=0.046)과 연구 2군(p=0.000)에서 유의한 분만시 간 단축이있었으나 두 연구군간에 유의한 차이는 없었다. 2)Bishop score 5점이상; (1) 초산모에서 대조군에 비하여 연구 1군(P=0.002) 과 연구 2군(p=0.033)에서 유의한 분만시 간 단축이 있었다. (2) 경산모에서는 대조군에 비하여 연구 1군에서는 대조군과 유의한차이가 없었으나 연구 2 군(p=0.003)에서는 유의한 분만시간 단축이있었다. 2. Friedman curve에 의한 비교관찰 연구1군은 대조군에 비하여 시간적 단축은 있었으나 그 양상이 대조군과 유사한 반면 연구 2군은 시간적 단축뿐 아니라 그 양상도 대조군과 차이가 있었다. 즉 옥시토신 투여군에 비 하여 프로스타글란딘 E2질정 투여군에서 자연진통 과 유사한 분만 과정을 보여주었다. 이상의 결과로 유도분만을 위하여 프로스타글란딘 E2질정 투여는 비교적 간편하여 큰 부작 용이 없는 유용한 방법으로 사료된다. Induction of labor with prostagladin E2 vaginal suppositories offers the advantage of inducing further cervical ripening as well as promoting myometrial contractility . A retrospective randomized study was undertaken comparing the efficacy of a 3mg prostagladin E2 vaginal suppository (study group1 , n=99) with intravenous oxytocin for the elective induction of labor (study group 2, n=100) between May 1986 and April 1988. the results of above two study group were also compared with normal spontaneous labor group (control group n=113) as a control. The results were as follows; 1. The duration of the first stage of labor was significantly shortened in the group 1 and 2 parturients compared with that of control (p=0.000 p=0.033, respectively, for nulliparous) who had a Bishop`s score of 5 or more. And the duration of the first stage of labor was also shortened in the group 2 among the parous parturients (p=0.003). 3. The pattern of Friedman`s curve in the group 1 was similar to that of control . Above results show that local prostagladin E2 administration by means of vaginal suppositories was a simple, nonivasive method , and may be a useful alternative to oxytocin for induction of labor.

제왕절개술후 복벽반흔에 발생한 자궁내막증의 임상적 고찰

박정엽(JY Park),홍성률(SR Hong),이태엽(TY Lee),공두식(DS Kong),박윤정(YJ Park),서영욱(YU Suh),조창호(CH Jo) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.4

Objective Endometriosis in the abdominal scar following cesarean section is very rare condition among the extrapelvic endometriosis. Recently, patients with endometriosis in the abdominal scar were increased but its clinical significances were not well-known. The purpose of this study is to evaluate clinical significant factor of endometriosis in the abdominal scar following cesarean section. Methods We retrospectively studied 19 patients who were histologically confirmed endometriosis in the abdominal scar following cesarean section. We reviewed physical findings, operative findings, histologic findings and analyzed menstrual history[menarche, menstrual cycle, menstrual duration] and interval between cesarean section and endometriosis. Results 1] All patients[100%] complained mass palpation, local pain at operation site and 5 patients[21.7%] complained menorrhalgia. 2] All patients[100%] had firm mass, 19 patients[92.3%] had irregular mass margin. 3] Two patients[8.7%] had peritoneal invasion, one patient[4.4%] was involved posterior wall of uterus and one patient[4.4%] was involved right ovary. 4] According to menarche, menstrual duration and interval between cesarean section and endometriosis, the incidence of endometriosis was not different[p>0.05]. But patients with regular menstrual cycle were more common than patients with irregular menstrual cycle and patients with mormal menstrual duration[2-6 days] were more common than patients with longer menstrual duration[>7 days][p<0.05]. Conclusion We probably suggested that menarche and interval between cesarean section and endometriosis may be not significant factor but menstrual cycle and menstrual duration may be significant factor in patients with endometriosis in the abdominal scar following cesarean section.

인공유산과 전치태반간의 연관성에 관한 연구 : 환자 대조군 연구

박진익(JI Park),최보율(BY Choi),박문일(MI Park),문형(H Moon),김두상(DS Kim) 대한산부인과학회 1991 Obstetrics & Gynecology Science Vol.34 No.3

To assess the relationship between eight risk factors(5 previous and 3 present obstetric histories) and the development of placenta previa, case-control study was done using multiple logistic regression analysis. The age and parity were used as confounding factors. One hundred and fifty placenta previa patients were included in this study. After stratification of age with the interval of 5 and same parity, the records of 300 normal patients were choosed and analysed. The risk ratio(odds ratio) of each factors were as follows; The history of induced abortion 1.66, the history of spontaneous abortion 1.60, the history of previous cesarean section 1.15, the history of previous perinatal death 1.82, the history of placenta previa 17.99, the fetal sex 0.98, and the congenital malformation 9.07. Among above factors, the histories of induced abortion, spontaneous abortion, perinatal death, and previous placenta previa were statistically significant in the development of placenta previa. And the congenital malformation of present pregnancy was also significant statistically. Endometrial scarring would tend to predispose to development of placenta previa.

급성 관상동맥 증후군 환자에서 저분자량 헤파린과 혈소판 당단백 IIb/IIIa 억제제의 병합요법의 장기 임상효과

김주한,정명호,류제영,양보라,심두선,임상엽,홍영준,박옥영,박우석,김원,안영근,문용,조정관,박종춘,강정채 대한순환기학회 2003 Korean Circulation Journal Vol.33 No.7