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John Chulhoon Park,임신혁 생화학분자생물학회 2020 Experimental and molecular medicine Vol.52 No.-
Considerable evidence points to the critical role of the gut microbiota in physiology and disease. The administration of live microbes as a therapeutic modality is increasingly being considered. However, key questions such as how to identify candidate microorganisms and which preclinical models are relevant to recapitulate human microbiota remain largely unanswered. The establishment of a humanized gnotobiotic mouse model through the fecal microbiota transplantation of human feces into germ-free mice provides an innovative and powerful tool to mimic the human microbial system. However, numerous considerations are required in designing such a model, as various elements, ranging from the factors pertaining to human donors to the mouse genetic background, affect how microbes colonize the gut. Thus, it is critical to match the murine context to that of human donors to provide a continuous and faithful progression of human flora in mice. This is of even greater importance when the need for accuracy and reproducibility across global research groups are taken into account. Here, we review the key factors that affect the formulation of a humanized mouse model representative of the human gut flora and propose several approaches as to how researchers can effectively design such models for clinical relevance.
무인 굴착기 버츄얼 검증을 위한 자율 작업 시뮬레이션 기술 개발
이철훈(Chulhoon Lee),이제필(Jepil Lee),박흥근(Heungkeun Park),김창묵(Changmook Kim),김동목(Dongmok Kim) 한국자동차공학회 2020 한국자동차공학회 학술대회 및 전시회 Vol.2020 No.11
In addition to the recent development of autonomous vehicles, technologies for automation and unmanned construction equipment are being actively developed in order to increase work efficiency in the field of construction site as well as solve the problem of lack of skilled workers in construction equipment operation. Doosan Infracore is actively developing unmanned/automated equipment and site management solution called X-center as shown in Concept-X demonstrations in 2019. As part of this solution development, we are also developing a simulation technology for virtual verification of autonomous equipment. The unmanned excavator recognizes the work terrain and the surrounding environment of the equipment from the results sensed by Lidar and SVC (Stereo Vision Camera), and trajectory planner controller generates the work command of the excavator according to the work mode such as digging and loading, trenching and grading. Since the automated work is carried out in several stages and the system configuration is complicated, virtual verification through simulation before the actual vehicle test can increase the development efficiency and product reliability. In this paper, we developed the simulation technology and the process for autonomous Excavator by coupling perception system, trajectory planner controller, vehicle dynamics model, and virtual sensor and terrain.
굴삭기 선회 디바이스 기어의 Case Crushing 강도 평가 기술 개발 및 설계 최적화
이철훈(Chulhoon Lee),성두현(Doohyun Sung),김광수(Kwangsoo Kim),김경근(Kyeongkeun Kim),임규운(Gyuun Im),박흥근(Heungkeun Park) 한국자동차공학회 2018 한국자동차공학회 부문종합 학술대회 Vol.2018 No.6
Case Crushing failure mode may occur in hardened gears that are subjected to large torque, such as excavator swing device pinions and swing bearing gears. In Case Crushing failure mode, the crack is generated at case core boundary in hardened gears, unlike pitting or bending fatigue which is general gear failure modes. In this paper, the Case Crushing strength analysis methodology was developed and design optimization was performed to improve Case Crushing strength for large size excavator swing bearing gear. For more accurate result, the swing device system was modeled with considering the influence of pinion shaft deformation, roller bearing stiffness, and gear lead slope that is one of the micro geometry. The gear lead slope was optimized by using developed detail analysis model under various swing torque condition.
Microbial Components and Effector Molecules in T Helper Cell Differentiation and Function
이창혼,이혜나,Park John Chulhoon,임신혁 대한면역학회 2023 Immune Network Vol.23 No.1
The mammalian intestines harbor trillions of commensal microorganisms composed of thousands of species that are collectively called gut microbiota. Among the microbiota, bacteria are the predominant microorganism, with viruses, protozoa, and fungi (mycobiota) making up a relatively smaller population. The microbial communities play fundamental roles in the maturation and orchestration of the immune landscape in health and disease. Primarily, the gut microbiota modulates the immune system to maintain homeostasis and plays a crucial role in regulating the pathogenesis and pathophysiology of inflammatory, neuronal, and metabolic disorders. The microbiota modulates the host immune system through direct interactions with immune cells or indirect mechanisms such as producing short-chain acids and diverse metabolites. Numerous researchers have put extensive efforts into investigating the role of microbes in immune regulation, discovering novel immunomodulatory microbial species, identifying key effector molecules, and demonstrating how microbes and their key effector molecules mechanistically impact the host immune system. Consequently, recent studies suggest that several microbial species and their immunomodulatory molecules have therapeutic applicability in preclinical settings of multiple disorders. Nonetheless, it is still unclear why and how a handful of microorganisms and their key molecules affect the host immunity in diverse diseases. This review mainly discusses the role of microbes and their metabolites in T helper cell differentiation, immunomodulatory function, and their modes of action.