Arylazolyl(azinyl)thioacetanilide. Part 9#: Synthesis and Biological Investigation of Thiazolylthioacetamides Derivatives as a Novel Class of Potential Antiviral Agents

Peng Zhan,Xinyong Liu,Liu Wang,Hong Liu,Xuwang Chen,Xiao Li,Xin Jiang,Qiangqiang Zhang,Christophe Pannecouque,Lieve Naesens,Erik De Clercq,Ailin Liu,Guanhua Du 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.6

In continuation of our endeavor to develop new, potent, selective and less toxic antiviral agents, a novel series of 2-(2-amino/chloro-4-(2,4-dibromophenyl) thiazol-5-ylthio)acetamide derivatives was synthesized via an expeditious route and evaluated for their anti-HIV activities against wild-type virus and clinically relevant mutant strains, and for their anti-influenza virus activities against influenza A (H1N1 and H3N2) and influenza B in cellular assays. The selected active compounds were also assayed for their enzymic inhibitory activities. The results showed that some 2-chloro substituted thiazolylthioacetamide derivatives possessed potent activity against wild type HIV-1 and several key mutant strains (E138K, K103N, L100I) of HIV-1 in MT-4 cells with EC50 values in micromolar range. Two 2-amino substituted thiazole derivatives 8a7 and 8a8 displayed significant potency against influenza A/H1N1 in MDCK cells with EC50 values much lower than that of oseltamivir carboxylate, ribavirin, amantadine and rimantadine. Though the mechanism of actions is still unclear, these novel thiazolylthioacetamides might serve as original leads for further pharmacological investigations as potential therapeutic agents against HIV-1 or influenza virus.

Knowledge Acquisition Approach Based on Rough Set in Online Aided Decision System for Food Processing Quality and Safety

Liu Peng,Liu Wen,Li Qiang,Yang Li,Duan Min,Dai Yue 보안공학연구지원센터 2014 International Journal of u- and e- Service, Scienc Vol.7 No.6

For the problem that the use effect of food processing information system is poor due to absence of knowledge acquisition measures and knowledge self-updating function, a knowledge acquisition approach based on rough set is put forward. First, the approach establishes a set of predicted samples for the relationship between food processing parameters and product quality; then uses the discretization of continuous attribute, attribute reduction and rule extraction algorithm of rough set to acquire automatically predicted knowledge from a large number of predicted sample sets, and then saves the predicted knowledge in the knowledge base of expert system; finally, realizes the extraction of knowledge of food processing process based on the inference engine, which greatly enhances the effectiveness and practicality of the acquired knowledge in online aided decision system of the food processing quality and safety.

Current Research Status and Implications of Entrepreneurship: Based on CiteSpace Software Visualisation and Analysis

Peng Liu,Chi Gong,Xue-Bo Sun K기업경영연구원 2023 KBM Journal(K Business Management Journal) Vol.7 No.3

Currently, due to multiple factors such as global inflation and geopolitical instability, the world economy continues to be in the doldrums, and Chinese enterprises are facing challenges in their development. In order to promote economic innovation and development, the key to implementing the innovation-driven development strategy lies in stimulating entrepreneurship. By analysing the literature related to entrepreneurship in China, it is possible to understand the research hotspots and future trends in this field and provide directions for future research on entrepreneurship. This study used CiteSpace software to visualise and analyse 2,344 articles related to entrepreneurship over the period 1993-2023. The results show that the number of publications in the field of entrepreneurship is generally on the rise, but the core authors have not formed a close co-operative relationship with each other. The research hotspots mainly focus on the following aspects: Firstly, the research on the development of small and medium-sized enterprises (SMEs) in the context of economic growth; Secondly, the research on innovation and entrepreneurship in the context of innovation for all; and the research related to entrepreneurship needed for the new business environment in the context of the digital economy. The future research trend mainly focuses on the research methodology of entrepreneurship in the context of business environment, such as the content of rooted theory and case analysis.

No Pains No Gains

Peng Liu 한국콘텐츠학회 2013 ICCC International Digital Design Invitation Exhib Vol.2013 No.-

Research on the Impact of Corporate Culture and Innovation Ability on Corporate Core Competitiveness from the Perspective of CSR: Based on the Investigation of Tianjin Agricultural Science and Technology Enterprises

Liu, Chun-peng,Li, Chun-Jie,Kim, Hyung-Ho The Institute of Internet 2022 International journal of advanced smart convergenc Vol.11 No.1

Corporate social responsibility (CSR) is the basic strategy for enterprises to obtain competitive advantages, and reflects the most basic value orientation and development concept of enterprises. The purpose of this study is to explore the relationship between corporate culture, innovation ability and core competitiveness of enterprises from the perspective of corporate social responsibility, and to establish a model and analyze the survey data of 32 agricultural science and technology enterprises in Tianjin by using SPSS23.0. As a result of the study, we found that corporate social responsibility (Ethical responsibility, Philanthropic responsibility) has a significant positive impact on corporate culture and innovation ability, corporate culture has a significant positive impact on innovation ability and corporate core competitiveness, and innovation ability has a significant positive impact on corporate core competitiveness. Therefore, it is suggested that agricultural science and technology enterprises should fulfill their social responsibilities, form a unique corporate culture, serve agriculture with science and technology, and constantly improve the ability of agricultural science and technology innovation, so as to enhance the core competitiveness of enterprises.

Flexible Iterative Learning Control Based Expert System and Its Application

Liu Zuojun,Liu Zhihu,Zu Linan,Yang Peng 한국지능시스템학회 2009 INTERNATIONAL JOURNAL of FUZZY LOGIC and INTELLIGE Vol.9 No.3

A scheme of expert system based on iterative learning control is proposed. Iterative learning control can obtain control experience from the historical data to build the knowledge base of expert system. Considering some uncertain factors, a flexible measure is adopted in iterative learning control (ILC). Simulation proves the feasibility and effect of the air conditioning control expert system based on flexible iterative learning control (F-ILC). Finally, a feedback compensation unit is incorporated against irregular heavy disturbance.

H-형태 양친매성 펜타블록 공중합체의 화학효소적 합성과 자기회합거동 평가

Peng Chen,Ya Peng Li,Can Jin Li,Xin Lei Meng,Bao Zhang,Ming Zhu,Yan-jing Liu,Jing Yuan Wang 한국고분자학회 2013 폴리머 Vol.37 No.3

H-shaped amphiphilic pentablock copolymers (PSt)2-b-PCL-b-PEO-b-PCL-b-(PSt)2 was synthesized via chemoenzymatic method by combining enzyme-catalyzed ring-opening polymerization (eROP) of ε-caprolactone (ε-CL) and atom transfer radical polymerization (ATRP) of styrene. By this process, we obtained copolymers with controlled molecular weight and low polydispersity. The structure and composition of the obtained copolymers were characterized by nuclear magnetic resonance (NMR), gel permeation chromatography (GPC) and infrared spectroscopy analysis (IR). The crystallization behavior of the copolymers was analyzed by differential scanning calorimetry (DSC) and X-ray diffraction (XRD). The crystallization behavior of the H-shaped block copolymers demonstrated a PCL dominate crystallization. The self-assembly behavior of the copolymers was investigated in aqueous media. The hydrodynamic diameters of the copolymer micelles in aqueous solution were measured by dynamic light scattering (DLS). The morphology of the copolymer micelles was observed by atomic force microscopy (AFM) and transmission electron microscopy (TEM). The hydrodynamic diameters of spherical micelles declined gradually with the increase of the hydrophobic chain lengths of the copolymers. The critical micelle concentration (CMC) values were determined from fluorescence emission, and it was found that the CMCs decreased with an increase of PSt hydrophobic block lengths.

Synthesis of Cobalt-Iron Prussian Blue Analogues Nanotubes by CTAB Soft-Template Method

Peng Liu,Chuanghui Liang,Jianfeng Xu,Jian Fang,Jihua Zhao,Weiguo Shen 대한화학회 2010 Bulletin of the Korean Chemical Society Vol.31 No.5

Three cobalt-iron Prussian Blue Analogues (PBAs) nanotubes contained with different alkali metal cations of K, Rb or Cs, respectively, were prepared by using cetyltrimethylammonium bromide (CTAB)/ethanol-water micelles as soft templates. The products were characterized by energy-dispersive X-ray spectroscopy (EDS), X-ray diffraction (XRD), transmission electron microscopy (TEM) and scanning electron micrograph (SEM), which confirmed the composition of the substances and their unique nanotube structures. Furthermore, the formation mechanism of the PBAs nanotubes was discussed and provided useful insight for further synthesis of nanotubes of other Prussian blue analogues.

New Insights into mTOR Signal Pathways in Ovarian-Related Diseases: Polycystic Ovary Syndrome and Ovarian Cancer

Liu, Ai Ling,Liao, Hong Qing,Li, Zhi Liang,Liu, Jun,Zhou, Cui Lan,Guo, Zi Fen,Xie, Hong Yan,Peng, Cui Ying Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.12

mTOR, the mammalian target of rapamycin, is a conserved serine/threonine kinase which belongs to the phosphatidyl-linositol kinase-related kinase (PIKK) family. It has two complexes called mTORC1 and mTORC2. It is well established that mTOR plays important roles in cell growth, proliferation and differentiation. Over-activation of the mTOR pathway is considered to have a relationship with the development of many types of diseases, including polycystic ovary syndrome (PCOS) and ovarian cancer (OC). mTOR pathway inhibitors, such as rapamycin and its derivatives, can directly or indirectly treat or relieve the symptoms of patients suffering from PCOS or OC. Moreover, mTOR inhibitors in combination with other chemical-molecular agents may have extraordinary efficacy. This paper will discuss links between mTOR signaling and PCOS and OC, and explore the mechanisms of mTOR inhibitors in treating these two diseases, with conclusions regarding the most effective therapeutic approaches.

Noncoherent Relaying in Energy Harvesting Communication Systems

Peng Liu,Gazor, Saeed,Il-Min Kim,Dong In Kim IEEE 2015 IEEE TRANSACTIONS ON WIRELESS COMMUNICATIONS Vol.14 No.12

<P>In energy harvesting (EH) relay networks, the coherent communication requires accurate estimation/tracking of the instantaneous channel state information (CSI) which consumes extra power. As a remedy, we propose two noncoherent EH relaying protocols based on the amplify-and-forward (AF) relaying, namely, power splitting noncoherent AF (PS-NcAF) and time switching noncoherent AF (TS-NcAF), which do not require any instantaneous CSI. We develop a noncoherent framework of simultaneous wireless information and power transfer (SWIPT), embracing PS-NcAF and TS-NcAF in a unified form. For arbitrary <I>M</I>-ary noncoherent frequency-shift keying (FSK) and differential phase-shift keying (DPSK), we derive maximum-likelihood detectors (MLDs) for PS-NcAF and TS-NcAF in a unified form, which involves integral evaluations yet serves as the optimum performance benchmark. To avoid expensive integral computations, we propose a closed-form detector using the Gauss-Legendre approximation, which achieves almost identical performance as the MLD but at substantially lower complexity. These EH-based noncoherent detectors achieve full diversity in Rayleigh fading. Numerical results demonstrate that our proposed PS-NcAF and TS-NcAF may outperform the conventional grid-powered relay system under the same total power constraint. Various insights which are useful for the design of practical SWIPT relaying systems are obtained. Interestingly, PS-NcAF outperforms TS-NcAF in the single-relay case, whereas TS-NcAF outperforms PS-NcAF in the multi-relay case.</P>