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Nam, Su Youn,Kim, Joo Sung,Kim, Jung Mogg,Lee, Jong Yeul,Kim, Nayoung,Jung, Hyun Chae,Song, In Sung The Society 2008 Experimental biology and medicine Vol.233 No.2
<P>Previously, we have shown that DA-6034, a synthetic derivative of flavonoid eupatilin, inhibited NF-kappaB activation in colon epithelial cells and prevented trinitrobenzene sulfonic acid-induced rat colitis. The aim of this study was to investigate the preventive and therapeutic effect of DA-6034 on dextran sulfate sodium (DSS)-induced colitis and on inflammation-related cancer. C57BL/6 mice were given 4% DSS for 5 days with and without DA-6034 in the acute preventive model. In the acute therapeutic model, mice were given 4% DSS for 5 days followed by rectal administration of DA-6034. Colitis was quantified by body weight, disease activity index (DAI), colon length, and histology. In the inflammation-related cancer model, mice were given a single intraperitoneal injection of azoxymethane, then three cycles of 2% DSS for 5 days, then 2 weeks of free water consumption. Apoptosis was determined by in situ terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling assay, and the expression of Ki-67, phospho-kappaB kinase alpha (IKKalpha), and COX-2 were evaluated by immunohistochemistry. In both the acute preventive and acute therapeutic models, DA-6034 significantly attenuated DSS-induced weight loss, an increase in DAI, and a shortening of colon length. DA-6034-treated mice maintained crypt architecture and revealed a scanty infiltration of inflammatory cells in both the preventive and therapeutic models. In the inflammation-related cancer model, DA-6034 reduced the number of colon tumors and ameliorated weight loss and shortening of colon length. DA-6034 strongly enhanced apoptosis and inhibited the expression of COX-2 and phospho-IKKalpha in inflammation-related colon cancer models. Our results suggest that DA-6034 prevents acute murine colitis and inhibits inflammation-related colon carcinogenesis. DA-6034 could be a potential therapeutic agent for inflammatory bowel disease.</P>
In Vitro Evaluation of Hydraulic Characteristics of Prototype Implantable Intrathecal Infusion Pump
Nam, Kyoung Won,Sung, Mun Hyun,Ho Kim, Hyun,Gi Kim, Kwang,Kim, Dae Hyun,Lee, Byeong Han,Jo, Yung Ho SAGE Publications 2010 The International journal of artificial organs Vol.33 No.12
<P>The use of the intrathecal infusion pump for therapeutic treatment and pain management is increasing. For example, one such application is the pain treatment of cancer patients suffering from severe chronic pain, where all other treatment methods have failed. This method is gaining popularity because of its high cure effect with low dosage. In this study, we developed a prototype implantable intrathecal infusion pump and evaluated its mechanical and hydraulic characteristics in vitro to determine how its performance varied under different environmental conditions. The data are reported as means (standard deviations). In the experiments, the prototype pump could control the micro-scale infusion amount, and its performance was affected by ambient temperature and pressure conditions. In a temperature change test, at a constant pressure of 1.0 atm, the minimal amounts of a bolus were 4.44 (1.07), 5.06 (1.17), and 5.54 (0.90) uL for the temperature of 27.5, 36.5, and 42°C, respectively. In a pressure change test, at a constant temperature of 36.5°C, the minimal amounts of a bolus were 5.06 (1.17), 5.94 (0.67), and 6.13 (0.39) uL for pressures of 1.0, 0.9 and 0.8 atm, respectively. These experimental results demonstrate the possibility of using the prototype pump as an implantable micro-volumetric infusion device. However, this prototype pump will have to undergo further design enhancement before being clinically feasible for such an application.</P>
Sang-Suk Lee,Jong-Gu Choi,Il-Ho Son,Keun-Ho Kim,Dong-Hyun Nam,You-Sik Hong,Woo-Beom Lee,Do-Guwn Hwang,Jang-Roh Rhee 한국자기학회 2011 Journal of Magnetics Vol.16 No.4
A wrist wearable cuffless pulsimeter with a portable and small size apparatus using Hall effect is fabricated. The analysis of the pulse wave measured by the testing product of pulsimeter is done to measure the pulse rate and blood pressure. The blood pressure obtained by the puslimeter is compared with the practical values measured by electronic or mercury liquid blood pressure meters. The detail analysis of a pulse wave measured by a wrist wearable cuffless pulsimeter detecting the changes of the magnetic field can be used to develop a new diagnostic algorithm of blood pressure applying for oriental medical apparatus.
Hyun, Youbong,Choi, Sungwook,Hwang, Hyun-Ju,Yu, Jihyeon,Nam, Sang-Jip,Ko, Jaeyoung,Park, Ju-Young,Seo, Young Sam,Kim, Eun Yu,Ryu, Stephen Beungtae,Kim, Woo Taek,Lee, Yong-Hwan,Kang, Heonjoong,Lee, Ilh Elsevier 2008 Developmental cell Vol.14 No.2
<P><B>Summary</B></P><P>Jasmonic acid (JA) plays pivotal roles in diverse plant biological processes, including wound response. Chloroplast lipid hydrolysis is a critical step for JA biosynthesis, but the mechanism of this process remains elusive. We report here that <I>DONGLE</I> (<I>DGL</I>), a homolog of <I>DEFECTIVE IN ANTHER DEHISCENCE1</I> (<I>DAD1</I>), encodes a chloroplast-targeted lipase with strong galactolipase and weak phospholipase A<SUB>1</SUB> activity. <I>DGL</I> is expressed in the leaves and has a specific role in maintaining basal JA content under normal conditions, and this expression regulates vegetative growth and is required for a rapid JA burst after wounding. During wounding, <I>DGL</I> and <I>DAD1</I> have partially redundant functions for JA production, but they show different induction kinetics, indicating temporally separated roles: <I>DGL</I> plays a role in the early phase of JA production, and <I>DAD1</I> plays a role in the late phase of JA production. Whereas <I>DGL</I> and <I>DAD1</I> are necessary and sufficient for JA production, phospholipase D appears to modulate wound response by stimulating <I>DGL</I> and <I>DAD1</I> expression.</P>
Nam, Duk Hyun,Lee, Kyu Hong,Lee, Sung Hak Trans Tech Publications, Ltd. 2007 Key engineering materials Vol.345 No.-
<P>The present study is concerned with the improvement of hardness and wear resistance in (Cr3C2,CrB)/carbon steel surface composites fabricated by high-energy electron beam irradiation. Two kinds of powder mixtures, 50Cr3C2-50STS304 and 50CrB-50STS304 (wt.%), were placed on a plain carbon steel substrate, which was then irradiated with electron beam. The surface composite layer of 1.0~1.3 mm in thickness was successfully formed without defects, and contained a large amount (up to 58 vol.%) of Cr7C3 or Cr1.65Fe0.35B0.9 particles in the austenite or martensite matrix. The hardness and wear resistance of the surface composites were 2~3 times higher than those of the steel substrate according to hard particles. Particularly, the surface composite fabricated with CrB powders showed excellent wear resistance because selective wear of the matrix was considerably reduced.</P>