http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
종양과 구강각질세포주에서 Celecoxib과 Indomethacin의 Cyclooxygenase-2 비의존적 기전에 의한 억제 효과
노종렬,성명훈,김광현,김동영,하정훈,박찬일 충남대학교 암연구소 2005 암연구소 업적집 Vol.4 No.-
Background and Objectives : Overexpression of cyclooxygenase-2 (COX-2), a rate-limiting enyme in the generation of prostanoids from arachidonic acid, has known to be closely related to tumorigenesis, tumor growth, angiogenesis, and metastasis. Selective or non-selective COX-2 inhibitors have been used for the growth inhibition of cancers with preventative intents ; however, it has been suggested recently that cancer cells have COX-2-independent mechanisms. Materials and Method : Using MTT assat and cell counts, we observed the growth inhibition of SCC VII, CT-26 and B16F10 murine cancer cell lines when treated by celecoxib and indomethacin. SNU-1041 and HOK 16B were used as controls for comparing with the murine cell lines. The COX-2 expression of these cell lines was analyzed by western blotting and compared with the degree of inhibition by the drugs. Results : The growth inhibition of the cell lines by the drugs was clearly demonstrated in a concentration-dependent manner and depended on the type of cell lines and test drug. The in vitro viability assay revealed that CT-26 expressing COX-2 protein was slightly inhibited but SCC Vn and B16F10 without COX-2 expression were moderate-to-highly inhibited by the drug treatment. Celecoxib and indomethacin appeared to have no close relation with the COX-2 expression of cell lines in their growth inhibition, HOK 16B showed a resistance by concentrations less than 25 μM of celecoxib, which implies that celecoxib has a more selective effect on tumor cells and is safer than indomethacin Conclusion : The growth of cancer cells was inhibited by celecoxib and indomethacin treatment, which depends on the type of cancer, treated drug, and its concentration. Their suppressive effect is not closely related to the COX-2 expression of cancer cells. (Korean J Otolaryngol 2004;47:562-8)
종양과 구강각질세포주에서 Celecoxib과 Indomethacin의 Cyclooxygenase-2 비의존적 기전에 의한 억제 효과
노종렬,성명훈,김광현,김동영,하정훈,박찬일 충남대학교 암공동연구소 2005 암공동연구소 업적집 Vol.4 No.
Background and Objectives : Overexpression of cyclooxygenase-2 (COX-2), a rate-limiting enyme in the generation of prostanoids from arachidonic acid, has known to be closely related to tumorigenesis, tumor growth, angiogenesis, and metastasis. Selective or non-selective COX-2 inhibitors have been used for the growth inhibition of cancers with preventative intents ; however, it has been suggested recently that cancer cells have COX-2-independent mechanisms. Materials and Method : Using MTT assat and cell counts, we observed the growth inhibition of SCC VII, CT-26 and B16F10 murine cancer cell lines when treated by celecoxib and indomethacin. SNU-1041 and HOK 16B were used as controls for comparing with the murine cell lines. The COX-2 expression of these cell lines was analyzed by western blotting and compared with the degree of inhibition by the drugs. Results : The growth inhibition of the cell lines by the drugs was clearly demonstrated in a concentration-dependent manner and depended on the type of cell lines and test drug. The in vitro viability assay revealed that CT-26 expressing COX-2 protein was slightly inhibited but SCC Vn and B16F10 without COX-2 expression were moderate-to-highly inhibited by the drug treatment. Celecoxib and indomethacin appeared to have no close relation with the COX-2 expression of cell lines in their growth inhibition, HOK 16B showed a resistance by concentrations less than 25 μM of celecoxib, which implies that celecoxib has a more selective effect on tumor cells and is safer than indomethacin Conclusion : The growth of cancer cells was inhibited by celecoxib and indomethacin treatment, which depends on the type of cancer, treated drug, and its concentration. Their suppressive effect is not closely related to the COX-2 expression of cancer cells. (Korean J Otolaryngol 2004;47:562-8)
Myung-Whun Chang,이종면 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.53 No.3
A method for enhancing the light extraction efficiency is analyzed theoretically and experimentally in side-view light-emitting diodes with a textured top surface of an encapsulant. A prism-type textured surface is proposed in order to increase the extraction efficiency, which is calculated by using ray-tracing simulations. According to the simulation results, the extraction efficiency can be enhanced by up to 35 % compared with that of conventional LEDs. By using a soft-lithography technique to texture the top surface of an encapsulant, we have fabricated a prism-structure array. The experimental enhancement of the light extraction eciency is 14 %.
연구논문 : 기후변화와 의사소통의 합리성-한국과 미국 언론의 기후변화 뉴스 프레임 비교연구를 중심으로-
지명훈 ( Myung Whun Jee ) 한국동서철학회 2015 동서철학연구 Vol.76 No.-
기후변화가 지구촌의 화두로 떠오르면서 국가 차원의 능동적인 대응책이 절실하다. 이 대응책에는 국민의 여론이 충분히 반영돼야 하고 이를 위해서는 사회적 논의와 토론이 활발히 이뤄져야 한다. 하지만 한국이 여론 형성을 위한 바람직한 담론 구조를 가지고 있는지 회의적이다. 미국 등 서구사회에서는 기후변화 옹호론자와 회의론자들이 활발한 논쟁을 벌이고 있지만 우리는 그렇지 못하다. 기후게이트 같은 기후변화 역사에서 가장 큰 회의론적 논란이 발생했을 때 우리 언론은 이런 이슈를 국내에 거의 소개조차 하지 않았다. 이런 편향적이고 다양성 없는 정보로 인해 한국 국민들은 기후변화의 전체적인 모습을 균형있게 인식할 수 있었다고 보기 어렵다. 더구나 정부는 녹색정책을 추진해 기후변화 논란이 발디 딜 틈을 주지 않았다. 본 논문은 이런 한국 사회의 기후변화 담론의 편향성이 뉴스 보도의 편향성에 기인한다는 가설을 세웠다. 언론의 침묵과 동시에 전문가 집단인 과학자들도 자신의 생각을 얘기하기를 꺼렸다. 최소한 기후변화와 관련해 침묵의 나선이 우리 사회에 점령했었다고 보아도 과언은 아니다. 이 논문은 최대의 논쟁적 이슈였던 기후게이트 발생 시점인 지난 2009년 11월을 전후해 2년간의 한국과 미국신문 통해 뉴스 프레임의 국제 비교를 통해 가설을 입증해 봤다. 하버마스의 의사소통행위이론을 통해 한국 언론의 문제점도 되짚어보는 계기를 제공했다. Since emergence of climate change as a hot global issue, active countermeasures at the national level are urgently needed. These countermeasures should reflect public opinion resulting from active debate within society. However, it is doubtful that Korea has a structure for an active debate and discussion. This is because while diverse debates are taking place in the U.S. different from Koeran society. This paper set up a hypothesis that the biased abd one-sided news reporting on climate change in Korea resulted in absence of debate on the issue. This paper will verify the hypothesis through comparative research on the Koean and American media frame in climate change news. Also it will provide us to criticize the Korean media through Jurgen habermas``s theory of communicative action.