Ender정과 Knowles핀을 이용한 노인 대퇴골 전자부 골절의 치료

문명상,우영균,선두훈,남석현 최신의학사 1992 最新醫學 Vol.35 No.11

정형 및 외상외과영역의 구급의료와 의료과오

문명상,선두훈 대한의학협회 1990 대한의학협회지 Vol.33 No.11

골절과 탈구시의 전신적 합병증과 그에 대한 대책

문명상,선두훈 대한의학협회 1990 대한의학협회지 Vol.33 No.10

부산 가덕도 주변해역의 동물플랑크톤 군집의 조성과 분포

문두호,허만규,이상현 부산대학교 사범대학 1998 교사교육연구 Vol.36 No.-

Composition and distribution of zooplankton community of sea water of the Kaduk Island have been studied on the samples collected four times from March to December in 1997. 35 taxa and 4 unconfirmed species of zooplankton have been identified. It consisted of 28 species of Protozoa, 1 larva of Poriferan, 1 species of Annelida, 1 larva of Mollusca, 2 species of Rotifera, 4 species and 1 larva of Athropoda, and 1 larva of Phoronida. The occurrence of major species was showed that Ceratium fusus was dominantly occurred from March to June, Noctiluca milialis in September, and Copepoda larva in December, respectively. Zooplankton abundance was high in June (4,217 inds./ℓ) and low in March (340 inds./ℓ). Indices of dominance were ranged from 0.41 (in December) to 0.80 (in June). Species diversity indices were ranged from 1.18 (in June) to 2.23 (in December).

청소년의 스포츠활동 참여수준과 일탈수준과의 관계

염두승,이영민,윤상문 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.5

This study aimed to examine and analyze empirically juveniles' sports participation and deviation levels, by considering how much deviation level be influenced by juveniles' sports participation level and by considering pure-functional aspects of sports which sports participation would be effective to juveniles' deviation level, and furthermore to present an theoretical review and the basic data so as to compose any sports program for juveniles. Accordingly, as a result of survey and analysis of the 727 juvenile subjects who were living in Yeongdong Region, after dividing participation level into systematic participation and unsystematic participation and dividing deviation level into home life deviation and school life deviation and social life deviation in order to define deviation level according to sports activities participation level, this study had the following findings below. First, some difference was found in relationship between juveniles' sports activities participation level and home life deviation. Second, some difference was found in relationship between juveniles' sports activities participation level and school life deviation. Third, some difference was found in relationship between juveniles' sports activities participation level and social life deviation.

胎盤組織 Cytidine Deaminase에 關한 硏究 (Ⅰ) : Purification & Characterization

황병두,곽상태,임규,이재흔,백문기 충남대학교 의과대학 지역사회의학연구소 1984 충남의대잡지 Vol.11 No.2

Cytidine deaminase has been partially purified from human term placenta approximately 26-fold by combination of ammoninm sulfate saturation, sephacryl S-300, DEAE-cellulose and hydroxyapatite chromatography, and then its properties have been investigated. The enzyme shows a broad optimum pH from 5 to 9 and is heat-stable being, almost remained its activity by heat treatment at 70℃ for 8 minutes. The enzyme activity is inhibited to 23% and 77% by 2 mM of Cu^2+ and Co^2+, respectively, but, other cations do not affect the enzyme activity. The apparant Michaelis constant for cytidine and deoxycytidine are 74 uM and 69 uM, respectively. Kinetic analysis of cytidine deminase in presence of 0.25 mM Cu^2+ shows that the nature of the inhibition to cytidine deaminase is competitive, considering that Vmax is independent while km value is increased. The enzyme activity is completely inhibited by 0. 5 mM of p-hydroxymecuribenzoicacid(PHMB)but all of the activity is recovered in adding mercaptoethanol. The enzyme activity is decreased about 50% in prescence of 5 mM of polyamines. The enzyme activity is mainly located in the nuclei (80%) and cytosol(16%) fractions. he molecular weight of the enzyme is about 770, 000.

Cisplatin에 의한 흰쥐 공장의 alkaline phosphatase 활성변화에 미치는 SOD의 영향

김성목,현성희,전영희,문원진,백두진 한양대학교 의과대학 1995 한양의대 학술지 Vol.15 No.1

Cisplatin has been widely used as an effective anticancer platinum compound. Cisplatin incorporates with intrastrand or interstrand of the DNA and it inhibits the synthesis of the nucleic acid and protein. During the treatment of cancer patients, cisplatin acts on normally proliferating cells, which results in nephrotoxicity, nausea, vomiting, anorexia, bone marrow suppression and inner ear damage. These toxicities are related to oxygen free radicals formation by cisplatin, which inhibits the activity of the catalase and admages the mitochondria. The author has demonstrated the effect of superoxide dismutase(SOD), one of the antioxidant enzymes, on changes of alkaline phosphatase activities in the jejunum of the cisplatin treated rats. A total of 60 healthy Sprague-Dawley rats weighing about 200gm were used as an experimental animals. Cisplatin(6mg/kg) was administered intraperitoneally with pretreatment of 15000unit/kg of SOD or not. The experimental animals are sacrificed at 6 hours, 12 hours, 24 hours and 3 days after the administration of cisplatin. A part of jejunum were obtained and fixed in 10%-neutral formalin at 4℃. The speciments were sectioned 16㎛ thickness in frozen cryostat. The activity of alkaline phosphatase was evaluated histochemically by Gomori's method and incubation time of sections of specimens was 30minutes. The results were as follows. 1. SOD increase the activity of alkaline phosphatase in the epithelium of jejunum of the rat. 2. The activities of alkaline phosphatase of the epithelium of the mucosa decrease in jejunum of 6 hours and 12 hours of cisplatin treated rats. In the 24 hours and 3 days, activities of alkaline phosphatase of the epithelium increase. The atrophied villi are observed in the 12 hours and 24 hours of cisplatin treated group. 3. The activities of alkaline phosphatase increase in 12 hours and 3 days of cisplatin treated group with SOD pretreatment, the activities decrease in 6 hours of cisplatin treated group with SOD pretreatment. The activities of alkaline phosphatase in the 24 hours of cisplatin treated group with SOD pretreatment show a decided decrease over those of control group with SOD pretreatment. The atrophied villi are seen in the 12 hours and 24 hours of cisplatin treated group with SOD pretreatment. 4. The activities of alkaline phosphatase in the cisplatin treated group with SOD pretreatment are higher than those in the cisplatin treated group, except 24 hours of cisplatin treated group. 5. There are very little changes of alkaline phosphatase activities in the lamina propria, submucosa and muscle layer of all groups. Consequently, these results suggests that cisplatin decreases the activity of the alkaline phosphatase and SOD pretreatment decreases the range of the change in alkaline phosphatase activity of jejunum of the cisplatin treated rats.

Haloperidol, Lithium 및 Amitriptyline이 인체에서 HLA type에 미치는 영향에 대한 예비연구 : in vivo

김문두,강병조,정성훈 대한생물치료정신의학회 1996 생물치료정신의학 Vol.2 No.1

저자는 정신분열증 환자, 주요우울장애 환자, 양극성장애 환자들의 치료에 사용되는 haloperidol, amitriptyline 및 lithium이 이런 환자들에서 HLA type에 어떠한 영향을 미치는 지를 알아보고자 본연구를 시험하였다. 향정신성 약물을 사용한 경험이 없는 환자 4명을 대상으로하여, 약물을 투여하기 전에 말초 혈액을 채혈하여 HLA 항원형을 결정하였고, 상기의 약물을 2개월 이상 치료용량으로 사용한 후 다시 HLA 항원형을 조사하여 다음과 같은 결과를 얻었다. haloperidol에서는 약물투여전과 약물투여후의 HLA항원형의 변화가 없었다. lithium에서는 HLA B60, HLA Cwl 항원이 소실되었다. amitriptyline에서는 HLA B55 항원이 소실되었고, HLA B75 항원이 발현되었다. 이상의 결과는 인체에서도 amitriptyline 및 lithium이 치료적 용량으로 충분히 사용한 이후 HLA 항원형에 변화를 가져올 수 있다는 것을 알수 있었다. To examine the effects of haloperidol, amitnptyline and lithium on HLA type in vivo, the author conducted microlymphocytotoxicity test on lymphocytes drawn from 4 psychiatric disordered patients, including 2 schizophrenic patients, 1 bipolar disordered patient and 1 major depressive disordered patient before administration of haloperidol, lithium and amitriptyline. After 2 months later, drug therapy was done sufficiently, we reexamine the HLA type on lymphocytes drawn from same patients. The results were as follows : 1) There is no significant changes on HLA type before and after 2 months long halopendol therapy in 2 schizophrenic patients. 2) It was shown that the disappearance of HLA B60 and HLA Cw1 antigen after 2 months long lithium therapy in l bipolar I disordered patient. 3) It was shown that the revelation of HLA B75 antigen and the disappearance of HLA B55 antigen after 2 months long amitriptyline therapy in 1 ma]or depressive disordered patient From the results of present study, we may draw a conclusion that the lithium and amitriptyline therapy cause a revelation of new HLA type and loss of some existed HLA antigens so that these drugs have an effect on HLA typing in vivo experiment.

중학교 생물교수전략으로서의 마인드 맵 활용 효과

오성미,김동렬,문두호 부산대학교 사범대학 과학교육연구소 2005 科學敎育硏究報 Vol.32 No.-

Mind mapping is a new creative note taking method by using colors, symbols, lines, and sketches to express main image and key words. The object of this research was to prove how effective the science lesson was for middle school students when it was done using mind map. Experimental group was composed of seventy students who were participated in mind map activity, and control group was composed of seventy students who were participated in traditional teaching method. To analyze the influence of the mind mapping, pretest and posttest for science achievement, inquiry process skill and science-related attitude were applied to both groups. Also the response of students regarding mind mapping strategies was investigated. According to the analysis of these tests, in the pretest the differences of science achievement, inquiry process skill, science-related attitude between two groups were not significant(p>.05). In the posttests on science achievement, inquiry process skill, the scores of the experimental group was higher than those of control group(p<05). In the mind mapping strategy, the students of experimental group were more efficient than those of control group. Most students of experimental group exhibited positive attitude towards the mind mapping strategy. Therefore, mind mapping strategies made a positive effect on students' science achievement, inquiry process skill.

스포츠도박 참여유형과 중독성향 및 사회적응력의 관계

염두승,윤상문 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.6

This study mostly aims to accumulate the empirical bass of survey for the relationship between involvement type(bicycle .horse racing) and addiction propensity and social adaptation in sports gambling, and to identify the relationship between involvement type(bicycle ' horse racing) and addiction propensity in sports gambling and the relationship between involvement type(bicycle ' horse racing) and social adaptation in sports gambling on the basis of previous theses related to addiction propensity and social adaptation so as to establish the participation into healthy pastime. Among the questionnaire data collected to accomplish the objective of this study, the researcher excluded from analysis what was judged as short of written content, or short of confidence of responded content in the data retrieval process. After encoding the analyzable data into computer, one made a processing according to the objective of data analysis through SPSS 10.0 for Window Program The statistical techniques of analysis used in this study for the sake of data analysis are frequency analysis, factor analysis, correlation analysis, and multi-regression analysis. The following were the conclusion drawn through the above-mentioned study method and consequence analysis. First, there were significant differences between involvement type and addiction propensity in sports gambling In other words, it was indicated that there was statistically significant influence in compulsion and withdrawal symptom, Second, there were significant differences between involvement type and social adaptation in sports gambling. In other words, it was indicated that there was statistically significant influence in responsibility.