Histopathological and genetic changes proved the anti‑cancer potential of free and nano‑capsulated sinapic acid

Doaa A. Badr,Mohamed E. Amer,Wagih M. Abd‑Elhay,Mohamed S. M. Nasr,Tamer M. M. Abuamara,Harbi Ali,Aly F. Mohamed,Maha A. Youssef,Nasser S. Awwad,Yi‑Hsu Ju,Ahmed E. Fazary 한국응용생명화학회 2019 Applied Biological Chemistry (Appl Biol Chem) Vol.62 No.5

Cancer is known to be a fierce disease that causes a large percentage of the deaths worldwide. The common cancer treatments; chemotherapy, radiotherapy and surgery are known for their severe side effects; therefore scientists are working on finding solutions to reduce these drawbacks. One of these treatment systems is the sustained released drugs formulations, these systems depend on the encapsulation of the chemotherapy within an emulsifying agent, in order to obtain a slow drug release of low doses over long time intervals. In this study, the anti-cancer effects of free and encapsulated sinapic acid was tested against lung (A549), and colon (CaCo2) cancer cell lines, along with normal fibroblast cells (HFB4) as a negative control. MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay was performed for IC50 evaluation, also cell cycle assay was performed to detect cell cycle arrest status and related anti-apoptotic and pro-apoptotic; Blc-2, BAX, and P53 gene profile fold changes post cellular treatment. Data recorded revealed that encapsulated SA showed a lower toxicity than the free form to both cell lines and also to the normal cells. The cell cycle analysis showed a cell cycle arrest at the G2/M phase post cell treatment with the free and encapsulated sinapic acid accompanied with up regulation of Bax and P53 and a down regulation of Blc-2 genes in both cell lines. The data suggest a promising anti-cancer and anti-proliferative potential of free and encapsulated sinapic acid. Also they show that the anti-cancer effect of free and encapsulated sinapic acid is quite close.

Synthesis and Three-dimensional Qualitative Structure Selectivity Relationship of 3,5-Disubstituted-2,4- Thiazolidinedione Derivatives As COX2 Inhibitors

Ali, Ahmed M.,Saber, Gamal E.,Mahfouz, Nadia M.,EI-Gendy, Mahmoud A.,Radwan, Awwad A.,Hamid, Mohamed A.-EI. 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.10

In our effort for synthesis of selective COX2 inhibitors, certain new 2,4-thiazolidinedione derivatives were synthesized. It necessitates preparation of potassium salt of 2,4-thiazolidinedione 2, which condensed with intermediate 4a. The resulting 3-[2-(4-methylphenyl)-2-oxo-1-phenylethyl]-2,4-thiazolidinedione 8 was condensed with appropriate aldehyde to afford compounds 10a, 10i-I, 10o and 10p. Compounds (9a-I, 10a-n, 10p, 11 and 12) were obtained through the preparation of 5-arylmethylidene-2,4-thiazolidinediones 6a-p and reaction of its potassium salt 7a-p with compounds 4a, 4b, and 5. Some compounds displayed significant analgesic activity as compared to reference standards. The anti-inflammatory activity of the synthesized compounds revealed that intermediate 8 and compounds 9c, 10c and 10d showed good results. Compound 10c produced no significant mucosal injury. HipHop methodology of Catalyst program was used to build up hypothetical model of selective COX2 inhibitors followed by fitting the synthesized compounds to this model. Compounds 10c and 10d were suspected to be promising selective COX2 inhibitors. Also, compounds (6c, 8, 9a,c,d,k, 10a,c,d,k, 11 and 12) were docked into COX1 and COX2 X-ray structures, using DOCK6 program. Docking results suggested that several of these derivatives are active COX inhibitors with a significant preference for COX2.

Households' dietary habits and food consumption patterns in Hamishkoreib locality, Kassala State, Sudan

Fatima A. Khalid,Awadia K.M. Ali,Siteldar A. Ali,Zemzem Y.A. Mosmar,Sarah S.M. Salih,Tahani K. Salman,Mohammed A. Desogi,Mohammed A. Soghaier,Eltayeb E. Mohammed,Abdalla A. Mohammed 한국식품연구원 2017 Journal of Ethnic Foods Vol.4 No.3

Background: Hamishkoreib is among the localities that have suffered most from chronic food insecurity in Kassala State, Sudan. This study was designed to determine the dietary habits and food consumption patterns in this locality. Methods: A descriptive cross-sectional survey was conducted among 403 households in the Hamishkoreib locality from June 2014 to February 2015. Sociodemographic and dietary information was collected through a modified food frequency questionnaire. The collected data were analyzed using SPSS 16.0 to estimate the frequency of variables. Results: Among 403 households, the incidence of informal education and illiteracy was 93.3%. Charcoal production and firewood cutting as the main source of income was reported by 66.6%. Three meals per day were consumed by 83.4% of households. They depended largely on cereal foods, particularly sorghum in the form of kissra and assida. Milk and dairy products were dominant in breakfast and dinner. Meat was consumed by 67.7% of households just once per week. However, chicken, fish, and eggs were rarely consumed (1.5%, 0.7%, and 19.8% respectively). Most (85.3%) households related poor or rare consumption of these protein- rich foods to culture, while 14.7% related it to financial reasons or illness. These types of food were mainly consumed by men and were not allowed to be consumed by women and children. Tea and coffee were excessively consumed in the morning and during the day. Fruit and vegetable consumption was low. Conclusion: The study revealed consumption of an unbalanced diet with insufficient proteins and micronutrients. There was excessive consumption of tea and coffee, which had a negative impact on food intake and absorption. The paper recommends launching a major nutrition program to encourage diversity of food consumption and to improve the capacity building of households.

Seismic response evaluation of fixed jacket-type offshore structures by random vibration analysis

Shehata E. Abdel Raheem,Elsayed M. Abdel Aal,Aly G.A. AbdelShafy,Mohamed F.M. Fahmy 국제구조공학회 2022 Steel and Composite Structures, An International J Vol.42 No.2

Offshore platforms in seismically active areas must be designed to survive in the face of intense earthquakes without a global structural collapse. This paper scrutinizes the seismic performance of a newly designed and established jacket type offshore platform situated in the entrance of the Gulf of Suez region based on the API-RP2A normalized response spectra during seismic events. A nonlinear finite element model of a typical jacket type offshore platform is constructed taking into consideration the effect of structure-soil-interaction. Soil properties at the site were manipulated to generate the pile lateral soil properties in the form of load deflection curves, based on API-RP2A recommendations. Dynamic characteristics of the offshore platform, the response function, output power spectral density and transfer functions for different elements of the platform are discussed. The joints deflection and acceleration responses demands are presented. It is generally concluded that consideration of the interaction between structure, piles and soil leads to higher deflections and less stresses in platform elements due to soil elasticity, nonlinearity, and damping and leads to a more realistic platform design. The earthquake-based analysis for offshore platform structure is essential for the safe design and operation of offshore platforms.

Production of Smart Cotton-nickel Blend Fibers Using Functional Polymers Comprising Ammonium Polyphosphate and Silicone Rubber

Mehrez E. El-Naggar,Ola A. Abu Ali,Dalia I. Saleh,K. M. Abu-alnja,Abd-allah M. Mnsour,Mohammed A. Abu-Saied,Tawfik A. Khattab 한국섬유공학회 2022 Fibers and polymers Vol.23 No.6

Despite the fact that Pyrovatex is widely used as a commercial flame-retardant, the release of toxic formaldehyderemains a serious problem. Fluorine-based compounds, on the other hand, have been employed to impart hydrophobic textilesurfaces, although they are exceedingly costly and poisonous. Based on those difficulties, we describe a simple one-stepmethod for coating electrically conductive cotton-nickel (Cot-Ni) blend fabric providing flame-retardant and water-repellentcharacteristics. A nickel ribbon was firstly bent around a cotton yarn as a core, and then woven into an electrically conductiveCot-Ni blend fabric, which was created by weaving the cotton-nikel hybrid threads with regular cotton yarns. The conductivefabric was coated with a composite consisting of silicone rubber (RTV) and ammonium polyphosphate (APP). The strongbinding of RTV with both APP and cotton fibres increased the flame-retardant action of cotton, according to the findings. Asa result, varied concentrations of APP were used in the composite to show that only 100 g/l of APP combined with RTVimproved the fire-retardancy. Depending on the concentration of APP, distinct hierarchical morphologies appeared on thesurface of the coated Cot-Ni fabrics. RTV also improved the hydrophobic character of the blend surface. Measurements of airpermeability, surface roughness, and stiffness were used to investigate the comfort qualities of the coated Cot-Ni blends. Eventually, those multifunctional (Cot-Ni)/RTV-APP textiles might be used in a variety of applications, such as grain storagecontainers, car seat mats, and firefighters' uniforms.

Synthesis and Three-dimensional Qualitative Structure Selectivity Relationship of 3,5- Disubstituted-2,4-Thiazolidinedione Derivatives As COX2 Inhibitors

Ahmed M. Ali,Gamal E. Saber,Nadia M. Mahfouz,Mahmoud A. El-Gendy,Awwad A. Radwan,Mohamed A.-El. Hamid 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.10

In our effort for synthesis of selective COX2 inhibitors, certain new 2,4-thiazolidinedione derivatives were synthesized. It necessitates preparation of potassium salt of 2,4-thiazolidinedione 2, which condensed with intermediate 4a. The resulting 3-[2-(4-methylphenyl)-2-oxo-1-phenylethyl]- 2,4-thiazolidinedione 8 was condensed with appropriate aldehyde to afford compounds 10a, 10i-l, 10o and 10p. Compounds (9a-l, 10a-n, 10p, 11 and 12) were obtained through the preparation of 5-arylmethylidene-2,4-thiazolidinediones 6a-p and reaction of its potassium salt 7a-p with compounds 4a, 4b, and 5. Some compounds displayed significant analgesic activity as compared to reference standards. The anti-inflammatory activity of the synthesized compounds revealed that intermediate 8 and compounds 9c, 10c and 10d showed good results. Compound 10c produced no significant mucosal injury. HipHop methodology of Catalyst program was used to build up hypothetical model of selective COX2 inhibitors followed by fitting the synthesized compounds to this model. Compounds 10c and 10d were suspected to be promising selective COX2 inhibitors. Also, compounds (6c, 8, 9a,c,d,k, 10a,c,d,k, 11 and 12) were docked into COX1 and COX2 X-ray structures, using DOCK6 program. Docking results suggested that several of these derivatives are active COX inhibitors with a significant preference for COX2.

C<SUP>*</SUP>-compactness in L-Fuzzy Topological Spaces

Ali Kandil Saad,Osama A. E. Tantawy,Mohammed Mostafa Yakout,Salem Ali M. Saleh 한국지능시스템학회 2009 INTERNATIONAL JOURNAL of FUZZY LOGIC and INTELLIGE Vol.9 No.4

In this paper we introduce stronger form of the notion of cover so-called p-cover which is more appropriate. According to this cover we introduce and study another type of compactness in L-fuzzy topology so-called C<SUP>*</SUP>-compact and study some of its properties with some interrelation.

Association of Plasma Ghrelin Levels with Insulin Resistance in Type 2 Diabetes Mellitus among Saudi Subjects

Ali Ahmed Al Qarni,Faris Elbahi Joatar,Nagalla Das,Mohamed Awad,Mona Eltayeb,Ahmed Gasim Al-Zubair,Muhalab E. Ali,Abdulaziz Al Masaud,Abdirashid M. Shire,Khalid Gumaa,Hayder A. Giha 대한내분비학회 2017 Endocrinology and metabolism Vol.32 No.2

Background: Although the exact mechanism of insulin resistance (IR) has not yet been established, IR is the hallmark characteristic of type 2 diabetes mellitus (T2DM). The aim of this study was to examine the relationship between plasma ghrelin levels and IR in Saudi subjects with T2DM. Methods: Patients with T2DM (n=107, cases) and non-diabetic apparently healthy subjects (n=101, controls) from Saudi Arabia were included in this study. The biochemical profiles and plasma insulin levels of all subjects were analyzed, and IR was estimated using the homeostatic model assessment of insulin resistance (HOMA-IR) index. Active ghrelin levels in plasma were measured using the radioimmunoassay technique. Results: Only 46.7% (50 of 107) of the T2DM subjects had IR, including 26% (28 of 107) with severe IR (HOMA-IR ≥5), while 5.9% (six of 101) of the controls had moderate IR (3≤ HOMA-IR <5). HOMA-IR values were not associated with age, disease duration, or gender. Importantly, T2DM itself and the co-occurrence of IR with T2DM were significantly associated with low plasma ghrelin levels. However, ghrelin levels were inversely correlated with the HOMA-IR index, body weight, and fasting plasma insulin levels, mainly in the control subjects, which was indicative of the breakdown of metabolic homeostasis in T2DM. Conclusion: The prevalence of IR was relatively low, and IR may be inversely associated with plasma ghrelin levels among Saudi patients with T2DM.

Synthesis, Characterization and Spectrophotometric Studies of Seven Novel Antibacterial Hydrophilic Iron(II) Schiff Base Amino Acid Complexes

Shaker, Ali M.,Nassr, Lobna A.E.,Adam, Mohamed S.S.,Mohamed, Ibrahim M.A. Korean Chemical Society 2013 대한화학회지 Vol.57 No.5

A series of new Iron(II) Schiff base amino acid complexes derived from the condensation of amino acid and sodium 2-hydroxybenzaldehyde-5-sulfonate have been synthesized. The complexes were characterized by elemental, electronic, IR spectral analyses and conductance measurements. The stability and solubility of the prepared complexes were determined. Two spectral methods used to determine the stoichiometry of the prepared complexes which exhibited divalent tridentate coordination and formed chelates of octahedral structures. The antibacterial activity of the prepared complexes has been tested against Bacillus cereus, Pseudomonas aeruginosa and Micrococcus bacteria. The effect of HCl on investigated complexes studied spectrophotometrically.

Damped forced vibration analysis of layered functionally graded thick beams with porosity

Ali Alnujaie,Şeref D. Akbaş,Mohamed A Eltaher,Amr E. Assie 국제구조공학회 2021 Smart Structures and Systems, An International Jou Vol.27 No.4

The following article presents the damped forced vibration of layered functionally graded thick beams including material porosities. In case of very thick beams, beam theories fail to satisfy boundary conditions and to predict the mechanical response accurately. So, the two-dimensional (2D) plane continuum model is exploited to model a thick functionally graded layered beam. The beam is composed from three- layers with functionally graded porous materials. The porosity is described by three different distribution models through the layer thickness. Applied forces to the functionally graded beam are assumed to be sinusoidal harmonic point load in time domain. The Kelvin—Voigt viscoelastic constitutive model is used to simulate damping effect. The governing equations are obtained by using Lagrange's equations. In frame of finite element analysis, twelve .node 2D plane element is exploited to discretize the space domain of thick beam. In the solution of the dynamic problem, the Newmark average acceleration method is used. Numerical studies illustrate effects of porosity distribution, stacking sequence, and graduation constant on the dynamic responses of layered functionally graded porous thick beams. The results show that the porosity function, stacking sequences and the damping ratio have a vital role in dynamic response of functionally graded beams. The proposed model can be used in nuclear, marine, and aerospace technologies.