Nocturia is the Lower Urinary Tract Symptom With Greatest Impact on Quality of Life of Men From a Community Setting

Eduardo de Paula Miranda,Cristiano Mendes Gomes,Fábio César Miranda Torricelli,José de Bessa Júnior,José Everton de Castro,Bruno Roberto da Silva Ferreira,Ariel Gustavo Scafuri,Homero Bruschini,Miguel 대한배뇨장애요실금학회 2014 International Neurourology Journal Vol.18 No.2

Purpose: Lower urinary tract symptoms are numerous, but the specific impact of each of these symptoms on the quality of life (QoL) has not been evaluated in community-dwelling men. An assessment of these symptoms and their effects on QoL was the focus of this study. Methods: We performed a cross-sectional study with 373 men aged >50 years from a community setting. Patients completed the International Prostate Symptom Score questionnaire, which includes questions on each of the specific urinary symptoms and a question addressing health-related QoL that are graded from 0 to 5. We used the Pearson correlation test to assess the impact of each symptom on QoL. Results: Nocturia (58.9%) was the most prevalent urinary symptom. The mean score was 0.9±1.4 for incomplete emptying, 1.0±1.5 for frequency, 0.9±1.3 for intermittency, 0.8±1.3 for urgency, 1.0±1.5 for weak stream, 0.5±1.0 for straining, and 2.0±1.6 for nocturia. Nocturia and frequency were the only symptoms associated with poorer QoL, with nocturia showing a stronger association. Conclusions: Nocturia affects 50% of community dwelling men aged >50 years, and is the lower urinary tract symptom with the greatest negative impact on QoL.

A Preoperative Marking Template for Deep Inferior Epigastric Artery Perforator Flap Perforators in Breast Reconstruction

Miranda, Benjamin H.,Pywell, Matthew,Floyd, David Korean Society of Plastic and Reconstructive Surge 2014 Archives of Plastic Surgery Vol.41 No.2

Preoperative perforator marking for deep inferior epigastric artery perforator flaps is vital to the success of the procedure in breast reconstruction. Advances in imaging have facilitated accurate identification and preselection of potentially useful perforators. However, the reported imaging accuracy may be lost when preoperatively marking the patient, due to 'mapping errors', as this relies on the use of 2 reported vectors from a landmark such as the umbilicus. Observation errors have been encountered where inaccurate perforator vector measurements have been reported in relation to the umbilicus. Transcription errors have been noted where confusing and wordy reports have been typed or where incorrect units have been given (millimetres vs. centimetres). Interpretation errors have also occurred when using the report for preoperative marking. Furthermore, the marking process may be unnecessarily time-consuming. We describe a bespoke template, created using an individual computed tomography angiography image, that increases the efficiency and accuracy of preoperative marking. The template is created to scale, is individually tailored to the patient, and is particularly useful in cases where multiple potential suitable perforators exist.

Civil Society, International Relations and the Promotion of Environmental Cooperation in East Asia

Miranda A. Schreurs 한국학술연구원 2005 Korea Observer Vol.36 No.1

환경보호, 기술혁신 및 녹색 일자리 - 독일식 모델을 중심으로 한 고찰

Miranda Schreurs 한국노동연구원 2008 국제노동브리프 Vol.6 No.12

Factors influencing decision-making around opportunistic salpingectomy: a nationwide survey

Miranda P. Steenbeek,Laura A.M. van Lieshout,Johanna W.M. Aarts,Jurgen M.J. Piek,Sjors F.P.J. Coppus,Leon FAG Massuger,Rosella P.M.G. Hermens,Joanne A. de Hullu 대한부인종양학회 2019 Journal of Gynecologic Oncology Vol.30 No.1

Objective: To explore current practice and influencing factors on adoption of the opportunistic salpingectomy (OS), particularly regarding the decision making, to eventually enhance the development and implementation of clear guidelines. Methods: This nationwide cross-sectional survey study was conducted in all hospitals in the Netherlands. An anonymous online survey was sent to gynecologists with special interest in gynecological oncology, gynecological endoscopy or urogynecology and all Dutch gynecology trainees. The survey mainly focused on current practice regarding OS and identification of influencing factors on the level of innovation, organization, healthcare professional and individual patient. Results: The response rate was 348 out of 597 gynecologists (58.3%) and 142 out of 340 trainees (41.8%). Current practice of discussing and performing the OS varied widely, with ovarian cancer (OC) risk reduction as most important supportive factor on innovation level. Supportive factors on the level of organization and healthcare provider were; working in a non-training hospital, knowledge of current literature and extensive work experience (in years and annual number of hysterectomies). On individual patient level, a vaginal approach of hysterectomy, negative family history for OC and the presence of firm adhesions were suppressive factors for the OS. Conclusion: In this study we evaluated the current practice regarding the opportunistic salpingectomy in the Netherlands and identified influencing factors on different levels to raise awareness and attribute to development of a targeted implementation strategy, on both national and international level.

Public Sector Workers' Mental Health: Comparative Psychometrics of the Perceived Stress Scale

Miranda Agustín,Scotta Ana,Méndez Ana,Serra Silvana,Soria Elio 대한예방의학회 2020 예방의학회지 Vol.53 No.6

Objectives: Given that Argentinian public-sector workers are highly exposed to stressful conditions, and that the psychometric properties of the widely used Perceived Stress Scale (PSS) should be evaluated in different settings, this work aimed to compare the psychometric properties of the Latin American Spanish PSS-10 and PSS-4 and to identify the optimal scale for stress assessment. Methods: A sample of 535 participants was randomly divided into 2 groups to evaluate dimensionality by exploratory and confirmatory factor analyses. The reliability of both scales was also evaluated. Convergent validity was estimated using the Executive Complaints Questionnaire, the average variance extracted, and the composite reliability. Discriminant validity was based on the correlation with the Utrecht Work Engagement Scale and the phi-square correlation between the components. Results: The factor analyses supported bidimensionality of the PSS-10 (stress and coping), which showed a better fit than the PSS-4. Moreover, the reliability of the PSS-10 was higher, whereas the PSS-4 did not achieve adequate values of internal consistency. The PSS-10 was also correlated significantly with all validation scales, and presented proper internal convergent and divergent validity. Conclusions: The PSS-10 is a reliable and structurally valid instrument to measure perceived stress and coping in a Latin American Spanish-speaking population with high work demands, and the findings of this study expand our knowledge on the geographical and sociocultural applicability of the PSS.

Complete Genome Sequence of the RNAs 3 and 4 Segments of Rice stripe virus Isolates in Korea and their Phylogenetic Relationships with Japan and China Isolates

Miranda Gilda Jonson,최홍수,김정수,최일영,김국형 한국식물병리학회 2009 Plant Pathology Journal Vol.25 No.2

The complete genome sequences of RNA3 and RNA4 of the 13 different Rice stripe virus (RSV) isolates were determined and characterized in this study to address the possible causes of the recent re-emergence of RSV that affected many rice fields in Korea. The genome size of each RNA segment varied among isolates and significant differences were observed in the intergenic region. There was up to 4% average divergence in the RNA4 nucleotide sequence among 13 Korean isolates and only 1.4% in the RNA3. Phylogenetic relationships among different Korean isolates revealed that there were at least 2 types of RNA3 and 4 distinct types of RNA4 genomes present in Korea. However, Korean isolates with one type of RNA3 predominate over the other while the occurrences of the RSV Korean isolates with the 4 types of RNA4 genome were not correlated to specific geographical areas. Results further indicate that RNA4 had diverged more than RNA3 and these differences in accumulation of mutations in the individual RNA segments indicate that genetic reassortment were likely to contribute to the genetic divergence in the 13 Korean isolates. All of the Korean-RNA3 sequences except for one isolate grouped with Chinese isolates (JY and Z). In contrast, the RNA 4 sequences segregated together with either Chinese (JY and Z) and Japanese (M and T) isolates but genetic relationships of Korean isolates- RNAs 3 and 4 segments to Chinese-Y isolate were low. Altogether, these results suggest that the occurrence of mixtures of RNAs 3 and 4 genotypes in the natural population of RSV may have contributed to the sudden outbreak in Korea.

Charlotte’s Web: Reproduction and Subversion of American 1950s Gender Ideology

Miranda Kerkhove 한국영미문학교육학회 2018 영미문학교육 Vol.22 No.3

This essay analyses ambivalent perspectives on E. B. White’s Charlotte’s Web. The book shows how one human girl character and an anthropomorphised animal character conform to heteronormative behavioural expectations of women, particularly in Charlotte’s taking care of a male piglet who is about to be culled. Such a literary representation closely corresponded to the gender ideology of the United States for middle-class white women in the 1950s. White seems to prepare the little girl Fern to live up to the 1950s’ standards of becoming a caring mother. Spider Charlotte seemingly has the same function within the narrative, showing girl readers what Fern’s life is likely to develop into. At the same time, however, the narrative presents an alternative subversive message with its liminal characters. On a deeper level and with a focus on morality according to ethics-of-care theories, we cannot but notice how minor characters are deployed to oppose the restricting societal norms and values in terms of gender and social class. The insight and success of those deviant characters tell a different tale of exclusion and how to empower oneself. With the main character Charlotte who faithfully follows the societal expectation and the few minor animal characters who open up the subversive potentials, White succeeds in epitomizing the marginalised in society as well as the mainstream ideal of America through the successful portrayal of fantasy-reality mixture. By focusing the dialectic aspects of the novel, I will try to explain the ways in which White has encouraged the child reader to look beyond the obvious and create a space for oneself in a heteronormative world.

Scar Revision Surgery: The Patient's Perspective

Miranda, Benjamin H,Allan, Anna Y,Butler, Daniel P,Cussons, Paul D Korean Society of Plastic and Reconstructive Surge 2015 Archives of Plastic Surgery Vol.42 No.6

Background Insufficient satisfaction outcome literature exists to assist consultations for scar revision surgery; such outcomes should reflect the patient's perspective. The aim of this study was to prospectively investigate scar revision patient satisfaction outcomes, according to specified patient-selection criteria. Methods Patients (250) were randomly selected for telephone contacting regarding scar revisions undertaken between 2007-2011. Visual analogue scores were obtained for scars pre- and post-revision surgery. Surgery selection criteria were; 'presence' of sufficient time for scar maturation prior to revision, technical issues during or wound complications from the initial procedure that contributed to poor scarring, and 'absence' of site-specific or patient factors that negatively influence outcomes. Patient demographics, scar pathogenesis (elective vs. trauma), underlying issue (functional/symptomatic vs. cosmetic) and revision surgery details were also collected with the added use of a real-time, hospital database. Results Telephone contacting was achieved for 211 patients (214 scar revisions). Satisfaction outcomes were '2% worse, 16% no change, and 82% better'; a distribution maintained between body sites and despite whether surgery was functional/symptomatic vs. cosmetic. Better outcomes were reported by patients who sustained traumatic scars vs. those who sustained scars by elective procedures (91.80% vs. 77.78%, P=0.016) and by females vs. males (85.52% vs. 75.36%, P<0.05), particularly in the elective group where males (36.17%) were more likely to report no change or worse outcomes versus females (16.04%) (P<0.01). Conclusions Successful scar revision outcomes may be achieved using careful patient selection. This study provides useful information for referring general practitioners, and patient-surgeon consultations, when planning scar revision.

The Photocycle and Proton Translocation Pathway in a Cyanobacterial Ion-Pumping Rhodopsin

Miranda, M.R.M.,Choi, A.R.,Shi, L.,Bezerra, A.G.,Jung, K.H.,Brown, L.S. Biophysical Society ; Published for the Biophysica 2009 Biophysical journal Vol.96 No.4

The genome of thylakoidless cyanobacterium Gloeobacter violaceus encodes a fast-cycling rhodopsin capable of light-driven proton transport. We characterize the dark state, the photocycle, and the proton translocation pathway of GR spectroscopically. The dark state of GR contains predominantly all-trans-retinal and, similar to proteorhodopsin, does not show the light/dark adaptation. We found an unusually strong coupling between the conformation of the retinal and the site of Glu<SUP>132</SUP>, the homolog of Asp<SUP>96</SUP> of BR. Although the photocycle of GR is similar to that of proteorhodopsin in general, it differs in accumulating two intermediates typical for BR, the L-like and the N-like states. The latter state has a deprotonated cytoplasmic proton donor and is spectrally distinct from the strongly red-shifted N intermediate known for proteorhodopsin. The proton uptake precedes the release and occurs during the transition to the O intermediate. The proton translocation pathway of GR is similar to those of other proton-pumping rhodopsins, involving homologs of BR Schiff base proton acceptor and donor Asp<SUP>85</SUP> and Asp<SUP>96</SUP> (Asp<SUP>121</SUP> and Glu<SUP>132</SUP>). We assigned a pair of FTIR bands (positive at 1749 cm<SUP>-1</SUP> and negative at 1734 cm<SUP>-1</SUP>) to the protonation and deprotonation, respectively, of these carboxylic acids.