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( Min Ju Kim ),( Jeong Won Jang ),( Jung Hyun Kwon ),( Chan Ran You ),( Nam Ik Han ),( Chang Don Lee ),( Hyun Suk Jung ),( Dong Wook Jekarl ),( Seung Ok Lee ),( Kyu Won Chung ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1
Background: Although alterations in cytokine profile after therapy can affect the outcome and prognosis of cancer patients, there are no comprehensive data on multiple cytokine profiles during transarterial chemotherapy (TACE). Methods: Cytometric bead immunoassay was used to simultaneously measure 13 cytokines (interleukin [IL]-12p70, IFN-γ, IL-17A, IL-2, IL-10, IL-9, IL-22, IL-6, IL-13, IL-4, IL-5, IL-1β, and TNF-α) in the sera of 83 patients with hepatocellular carcinoma (HCC) and 18 healthy controls. Those cytokines were serially monitored at baseline, day 3, day 7, and 2 months after TACE in 63 evaluable patients. Results: Serum levels of IL-17A and IL-5 were higher in HCC patients than healthy controls, whereas IL-22 and IL-1β levels were lower in HCC patients. Although the overall patterns of cytokine changes were diverse at each set date, certain cytokines specifically increased after TACE, with the early-phase increase in IL-6 and IL-22 levels and late-phase increase in IL-4, IL-6, and IL-10 levels. With relatively minor changes of cytokines after TACE, Childs B/C group had higher IL-6 and lower IL-22 levels than Childs A group. Patients with larger tumors (>5 cm) had higher IL-6 levels at baseline and showed a transient but significant early-phase increase in IL-6 levels as well as late-phase increase in IL-4, IL-10, and IL-13 levels after TACE. With regard to hepatic events, IL-2 and IL-22 levels at baseline were predictive of grade 3 or more hepatic toxicity, while those levels of IL-6 and IL-13 significantly increased at day 3 in patients suffering from post- TACE hepatic morbidity. Conclusions: TACE induces various changes of multiple cytokines. Distinct panels of cytokine changes are not uniform, influenced by treatment-induced inflammation, underlying liver function, and HCC stage. The increased Th2 cytokine profiles after TACE suggests the immune suppression in patients with large tumor and post-treatment hepatitis.
Producing Full-length Botulinum Neurotoxin (BoNT) Using Protein Conjugation
Minju KIM,Jihwan CHUN,Wonbeom PARK,SeungJoo KIM,Yong Hwan LEE,Nayoon CHOI,Dae-Hyuk KWEON 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10
Botulinum neurotoxin is the most lethal biological toxin in nature. Regarding its mechanism of action, BoNT has been greatly favored not only for cosmetic purposes, but also for disease treatment. Conventionally, production of BoNT relied on the tedious cultivation of C. botulinum, which yielded BoNT complex containing NAPs (nontoxic neurotoxin-associated proteins). However, the existence of NAPs is detrimental since 1) it greatly increases the molecular weight of the final product (about 900 kDa), and 2) it may reduce the efficacy of BoNT by facilitating resistance development. To resolve such issues, we designed a novel approach to produce BoNT by expressing separated fragments of BoNT (LC-HN and HC domains) followed by protein conjugation. Each domain was fused with conjugative protein fragments and the conjugation efficiency under various conditions including molar ratio, temperature, and time. As a result, we confirmed that the maximal reaction efficiency is achieved when equivalent amount of protein fragments were combined and incubated at 37℃ for 10 min. Moreover, specific sequences of LC-HN were almost completely cleaved by thrombin treatment, confirming the formation of a disulfide bond between the separated LC and HN domains. In this study, we suggest that BoNT can be produced more safely and efficiently through a novel approach employing protein conjugation and specific cleavage.
Evaluation of Pain Reduction and Clinical Efficacy of Feedback-Controlled Ultrasonic Scaler
Min-ju Kim,Hee-jung Lim,Myoung-hee Kim,Young-sun Hwang,Im-hee Jung 한국치위생과학회 2023 치위생과학회지 Vol.23 No.2
Background: Recently, a piezoelectric ultrasonic scaler based on a feedback control mechanism was introduced for pain relief. This study aimed to investigate the effects of a new ultrasonic scaler in reducing pain and discomfort in adults.Methods: A newly introduced ultrasonic scaler (Master 700Ⓡ) was used as the test device and a conventional ultrasonic scaler device (PIEZONⓇ) was used as the control device. Forty-one healthy adults visited the dental clinic for dental scaling but did not undergo scaling or periodontal treatment within 6 months. Intraoral examinations were performed before scaling and 3 months later; before scaling, both devices were randomly assigned on the left or right side of each dentition (split-mouth model) and scaling was performed by a registered dental hygienist. The levels of pain and discomfort during scaling were evaluated subjectively and objectively using the visual analog scale (VAS) and physiological monitoring of the heart rate (HR), respectively. Time was measured for each device. Results: All clinical indicators, except bleeding on probing, significantly improved with both devices. The treatment times were 7 minutes, 13 minutes (control) and 6 minutes, 59 minutes (test). VAS scores for pain were 4.89±2.12 (control) and 4.58±2.77 (test) points out of 10; for noise, these were 4.68±2.33 (control) and 4.55±2.55 (test), and for vibration, the values were 4.26±2.0 (control) and 4.18±2.48 (test). HR averages were 72.34±3.39 (control) and 75.97±9.78 (test) beats/min. No statistically significant differences were observed between the devices. Conclusion:The pain, discomfort levels, and scaling time of the new piezoelectric ultrasonic scaler did not differ from those of the conventional device. Further research and development are necessary for more prominent pain-relief effects of scaling devices.
Unplanned Reoperation Rate at a Government-Designated Regional Trauma Center in Gangwon Province
( Minju Kim ),( Seongyup Kim ) 대한외상학회 2021 大韓外傷學會誌 Vol.34 No.1
Purpose: Determining appropriate ways to assess health care quality within the National Health Insurance System is of interest to both the Korean government and the medical community. However, in the trauma field, the number of indicators used to evaluate surgical quality is limited. Using data collected over 5 years at Wonju Severance Christian Hospital Trauma Center in Korea, this study aimed to determine whether the unplanned reoperation rate in the field of trauma surgery could be used to assess the quality of an institution’s surgical care. Methods: In total, 665 general surgical procedures were performed at the Trauma Center in 453 patients with abdominopelvic injuries from January 2015 to December 2019. Data were collected from the Trauma Center’s data registry and medical records, and included information regarding patients’ demographic characteristics, the type of index operation, and the reason for unplanned reoperations. Results: A total of 453 index operations were evaluated. The proportion of patients with an Injury Severity Score (ISS) >15 was 48-70% over the 5-year period, with an unplanned reoperation rate of 2.1-9.3%. Patients had an average ISS score of 17.5, while the average Abbreviated Injury Scale Score was 2.87. Unplanned reoperations were required in about 7% of patients. The most common complications requiring reoperation were recurrent bleeding (26.9%), wound problems (26.9%), intestinal infarction (15.4%), and anastomosis site leakage (7.7%). The procedures most frequently requiring unplanned reoperations were bowel surgery (segmental resection, primary repair, enterostomy, etc.) (24.5%) and preperitoneal pelvic packing (10.6%). Conclusions: The proportion of reoperations was confirmed to be affected by injury severity.
Min Ju Kim,Kyung Won Kim 한국영양학회 2015 Nutrition Research and Practice Vol.9 No.5
BACKGROUND/OBJECTIVES: Calcium is important but deficient in diets of young adult women. This study aimed to examine if cognitive factors and eating behaviors differ according to calcium intake based on the Social Cognitive Theory. SUBJECTS/METHODS: Subjects were female college students in Seoul, Korea. Three hundred students completed the questionnaire regarding calcium intake, nutrition knowledge, outcome expectations, self-efficacy and eating behaviors. Data on 240 students were analyzed using t-test or χ²-test. Subjects were categorized into two groups, high calcium intake (HC, ≥ 650 ㎎/day) and low calcium intake (LC, < 650 ㎎/day), according to recommended intakes of calcium for women aged 19-29 years. RESULTS: The LC group constituted 77.9% of total subjects. Nutrition knowledge was not different according to calcium intake. Three out of 12 outcome expectations items were significantly different between the HC and LC groups. Subjects in the HC group agreed more strongly with the practical benefits of consuming calcium-rich foods, including ‘taste’ (P < 0.01) and ‘going well with other snacks’ (P < 0.05), compared to those in the LC group. Negative expectations of ‘indigestion’ were stronger in the LC group than HC group (P < 0.001). Among self-efficacy items, perceived ability of ‘eating dairy foods for snacks’ (P < 0.001), ‘eating dairy foods every day’ (P < 0.01), and ‘eating calcium-rich side dishes at meals’ (P < 0.05) differed significantly between the HC and LC groups. Eating behaviors including more frequent consumption of dairy foods, fruits or fruit juice (P < 0.001), anchovy, seaweeds, green vegetables, protein-rich foods (P < 0.05), and less frequent consumption of sweets or soft drinks (P < 0.01) were significantly related to calcium intake. CONCLUSIONS: This study found that outcome expectations, self-efficacy in consuming calcium-rich foods, and eating behaviors are important in explaining calcium intake. Nutrition education needs to address practical benefits, reduce negative expectations of calcium-rich foods, increase self-efficacy, and modify eating behaviors contributing to calcium intake.
Anti-inflammatory and antioxidant activities of Sargassum horneri extract in RAW264.7 macrophages
( Min Ju Kim ),( Hee Geun Jo ),( Chilakala Ramakrishna ),( Seung-jae Lee ),( Dong-sung Lee ),( Sun Hee Cheong ) 한국운동영양학회 2021 Physical Activity and Nutrition (Phys Act Nutr) Vol.25 No.4
[Purpose] In this study, we investigated whether a 70% ethanolic (EtOH) extract of Sargassum horneri had antioxidant and anti-inflammatory effects in lipopolysaccharide (LPS)-stimulated macrophage-like RAW 264.7 cells. [Methods] The proximate composition, fatty acids, amino acids, and dietary fiber of S. horneri , various biologically active compounds, and antioxidant activity were analyzed. [Results] The DPPH and ABTS free radical scavenging activities, as well as the reduction power, of the S. horneri extract used here were significantly increased in a concentration-dependent manner. This indicates that S. horneri contains bioactive compounds, such as phenols and flavonoids, that have excellent antioxidant activity. The cellular viability and metabolic activity results confirmed that the extract had no discernible toxicity at concentrations up to 100 μg/mL. The levels of nitrites and cytokines (PGE<sub>2</sub>, TNF-α and IL-6), which mediate pro-inflammatory effect, were significantly inhibited by treatment with either 50 or 100 μg/mL S. horneri extract, whereas that of IL-1β was significantly inhibited by treatment with 100 μg/mL of the extract. Similarly, the expression of iNOS and COX-2 proteins also decreased according to 50 or 100 μg/mL extract concentrations. NF-κB binding to DNA was also significantly inhibited by treatment with 100 μg/mL of extract. [Conclusion] These results suggest that 70% EtOH extracts of S. horneri can relieve inflammation caused by disease or high intensity exercise.