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RISS 인기검색어
- 검색키워드
- 저자 : Miky, Jehane A.A. (검색결과 215 건)
- 무료
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Synthesis of some pyridinethione derivatives and their biological activity
Miky, Jehane A.A.,Zahkoug, Samir A.M. The Korean Society of Pharmacognosy 1997 Natural Product Sciences Vol.3 No.2
Aminolysis, hydrazinolysis and alkylation of 4-methoxy and 4,9-dimethoxy-6-cyano-7-thione-5-methyl-7H furo [3,2-g] [1] benzopyridine (1 a-b) yielded 7N-substituted furobenzopyridine derivatives (2 a-e or the possible isomers 3 a-e and 4 a-b), (5 a,b and 6 a,b) and the ester (8 a,b). Hydrolysis of (la) with acetic acid gave the corresponding pyridone derivatives (7). Furobenzopyridinyl-7-thioacetyl hydrazide (9 a,b) have been prepared via alkylation of furobenzopyridine thione (1 a-b) with ethyl chloroacetate followed by condensation with hydrazine hydrate. Schiff base (11) was prepared by reacting (9a) with p. N,N-dimethyl aminobenzaldehyde in boiling ethanol. Treatment of (8a) with anthranilic acid gave the corresponding 7-substituted-4H-3,1-benzoxazine-4-one (10). We found that compound (11) increased bleeding, coagulating time, the total count of white blood cells, blood glucose level (cause hyperglycemia), enzymes (GOT, GPT) activities, concentration of urea and creatinine. On the other hand it decreased red blood cells number, haemoglobin content and haematocrite value.
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Perspective of Small-Molecule AdipoR Agonist for Type 2 Diabetes and Short Life in Obesity
Miki Okada-Iwabu,Masato Iwabu,Kohjiro Ueki,Toshimasa Yamauchi,Takashi Kadowaki 대한당뇨병학회 2015 Diabetes and Metabolism Journal Vol.39 No.5
Obesity associated with unhealthy diet and lack of exercise is shown to contribute to the onset and/or aggravation of the metabolic syndrome and diabetes, thus placing affected individuals at increased risk of cardiovascular disease and cancer. Plasma adiponectin levels are decreased in obesity, which causes insulin resistance and diabetes. Therefore, we identified adiponectin receptors (AdipoRs) as the therapeutic target. It was suggested that, similarly to caloric restriction and exercise, activation of the AdipoRs may have the potential not only to improve lifestyle-related diseases but to contribute to prolonged the shortened lifespan on a high caloric unhealthy diet. To this end, we have identified “AdipoRon” as an adiponectin receptor agonist. Indeed, AdipoRon ameliorated diabetes associated with obesity as well as to increase exercise endurance, thus prolonging shortened lifespan of obese mice fed on a high fat diet. Additionally, we have recently determined the crystal structures of the human AdipoRs. The seven-transmembrane helices of AdipoRs are structurally distinct from those of G-protein coupled receptors. It is expected that these findings will contribute not only to the elucidation of the AdipoR-related signal transduction but to the development and optimization of AdipoR-targeted therapeutics for obesity-related diseases such as diabetes.
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Review : Proposal of Cooperative Study Toward Establishing Asiacatalyst
( Miki Niwa ) 한국화학공학회 1997 Korean Journal of Chemical Engineering Vol.14 No.6
Cooperative studies on $quot;Reference Catalyst$quot; in Japan have proven to be very important and useful not only for characterization of catalysts but also for standardization of characterization techniques. This recognition has motivated us to propose $quot;Asiacatalyst$quot;, an extended version of Reference Catalyst, for similar cooperative activities in Asian countries.
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Development of Technology for Determining Rice Amylose Content using Near-infrared Spectroscopy
( Miki Matsuo ),( Shuso Kawamura ),( Mizuki Kato ),( Edenio Olivares Diaz ),( Shigenobu Koseki ) 한국농업기계학회 2018 한국농업기계학회 학술발표논문집 Vol.23 No.1
Rice is staple food for people in the large part of the world, especially in Asian countries. The major chemical constituent contents of rice are moisture, protein and starch (amylose and amylopectin). Those chemical constituents associate with eating quality of rice. Near-infrared (NIR) spectroscopy is one of the non-destructive methods for determining grain chemical contents. Moisture and protein contents can be measured with high accuracy using NIR spectrometer at rice grain elevator in Japan. However, the accuracy to measure amylose content is not sufficient. Thus, there is a strong need for the highly accurate measurement of rice amylose content using non-destructive method. The overall objective of this study was to develop non-destructive techniques to determine rice amylose content for practical use at rice grain elevator. Amylose content measurement was performed using an auto-analyzer for reference (chemical) analysis. Spectra data of rice were obtained using an NIR spectrometer with a wavelength range of 850 to 1048 nm. Calibration model to determine amylose content was developed using non-waxy Japonica-type rice samples (calibration set, n=974, including 14 cultivars) grown in Japan from 2008 to 2016. Partial least squares (PLS) regression analysis was used to develop calibration model. The accuracy of the model was validated using other rice samples (validation set, n=95, including 10 cultivars) grown in 2017. There are two cultivar groups of non-waxy Japonica-type rice produced in Japan. One is ordinary amylose content rice cultivar and the other is low amylose content rice cultivar. The accuracy of determination of rice amylose content was improved by increasing production years of calibration sample set. When one calibration model to determine amylose content was developed using all cultivars together, validation statistics were shown: coefficient of determination (r<sup>2</sup>) was 0.72, bias was -0.04%, standard error of prediction (SEP) was 0.92%, and ratio of SEP to standard deviation of reference data (RPD) was 1.90. To improve the accuracy of determination of rice amylose content, two calibration models were developed using ordinary amylose content rice cultivars or low amylose content rice cultivars, respectively. As a result, the accuracy of two calibration models was better than that of one calibration model. Validation statistics of the two calibration models were shown: coefficient of determination (r<sup>2</sup>) was 0.93, bias was 0.01%, standard error of prediction (SEP) was 0.64%, and ratio SEP to standard deviation of reference data (RPD) was 2.76. The production year of validation set (2017) was different from those of calibration set (2008 to 2016). This is the same condition as practical use of this non-destructive method at rice grain elevator. The result obtained in this study indicated that the two calibration models enables non-destructive determination of rice amylose content at rice grain elevator.
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Genetics and Biomarkers of Moyamoya Disease: Significance of RNF213 as a Susceptibility Gene
Miki Fujimura,Shinya Sonobe,Yasuo Nishijima,Kuniyasu Niizuma,Hiroyuki Sakata,Shigeo Kure,Teiji Tominaga 대한뇌졸중학회 2014 Journal of stroke Vol.16 No.2
Moyamoya disease is characterized by a progressive stenosis at the terminal portion of the internal carotid artery and an abnormal vascular network at the base of the brain. Although its etiology is still unknown, recent genome-wide and locus-specific association studies identified RNF213 as an important susceptibility gene of moyamoya disease among East Asian population. A polymorphism in c.14576G>A in RNF213 was identified in 95% of familial patients with moyamoya disease and 79% of sporadic cases, and patients having this polymorphism were found to have significantly earlier disease onset and a more severe form of moyamoya disease, such as the presentation of cerebral infarction and posterior cerebral artery stenosis. The exact mechanism by which the RNF213 abnormality relates to moyamoya disease remains unknown, while recent reports using genetically engineered mice lacking RNF213 by homologous recombination provide new insight for the pathogenesis of this rare entity. Regarding biomarkers of moyamoya disease, moyamoya disease is characterized by an increased expression of angiogenic factors and pro-inflammatory molecules such as vascular endothelial growth factors and matrix metalloproteinase-9, which may partly explain its clinical manifestations of the pathologic angiogenesis, spontaneous hemorrhage, and higher incidence of cerebral hyperperfusion after revascularization surgery. More recently, blockade of these pro-inflammatory molecules during perioperative period is attempted to reduce the potential risk of surgical complication including cerebral hyperperfusion syndrome. In this review article, we focus on the genetics and biomarkers of moyamoya disease, and sought to discuss their clinical implication.
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( Miki Hirabayashi ) 아세아여성법학연구소 2008 아세아여성법학 Vol.11 No.-
In Japan, under Article 772 of Civil Code, a baby born within 300 days of its mother`s divorce will be regarded as the child of the previous husband, even if the child`s biological father is the mother`s current husband. So the government do not accept baby` birth registration as it stipulated that its mother`s current husband is the baby`s father. The children denied baby`s birth registration can not have it`s passport and accept various benefit. Many woment and her children face such problems. It is called "The 300 Days Problem" in Japan. Even if a woman can prove that her current husband is her baby`s biological father, she has to clear a legal hurdle to record the baby in his family register. She has to ask her previous husband to testify in court the baby is not his child. But not every ex-husband is cooperative. So such women and children urge the government to improve the situation as so as possible. For example, now, the Ministry of Foreign Affairs of Japan issues passport for such children. However the name on passport in not biological but their mother`s previous husband`s. And the Ministry of Justice recognizes babies born within 300 days of the mother`s divorce as those of their new spouses or as illegitimate children, provided the mothers can prove they became pregnant after divorce. As such, the presumend legitimate father of the child can be changed without a trial. However, even the ministry suspects that only 10 percent of such children were saved. The radical solution is to revise the Civil Law. However, to do so, various other problems arise. If we abolish Article 772, we cannot give baby ist father without DNA test. It is an unfortunate decision for majority of children. Therefore we should maintain and make the most of the current system. If a woman wants to record her child in its biological father`s family register, she gets him to go through a legal procedure to recognize the child as his own, This trial does not need participate of her previous husband.
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