ABSTRACTS ; TRENDS IN MOLECULAR BIOLOGY : HUMAN GENOME PROJECT AND APPLICATIONS

Mathias Uhlen 한국생화학분자생물학회 (구 한국생화학회) 1995 추계학술대회집 Vol.- No.-

Progressive Multifocal Leukoencephalopathy after Ibrutinib Therapy for Chronic Lymphocytic Leukemia

Mathias Lutz,Arik B. Schulze,Elisabeth Rebber,Stefanie Wiebe,Tarek Zoubi,Oliver M. Grauer,Torsten Keßler,Andrea Kerkhoff,Georg Lenz,Wolfgang E. Berdel 대한암학회 2017 Cancer Research and Treatment Vol.49 No.2

Progressive multifocal leukoencephalopathy (PML) is a devastating neurological disease observed nearly exclusively in immunocompromised patients. Recently, the introduction of monoclonal antibodies significantly inhibiting the immune system such as rituximab has led to an increase in PML cases. Although rituximab-based immunochemotherapy remains the standard of treatment for chronic lymphocytic leukemia (CLL), the importance of Bruton’s tyrosine kinase inhibitors such as ibrutinib is steadily increasing. However, long-term experiences regarding possible side effects of these new substances are rare. Here, we report the development of eventually fatal PML possibly associated with ibrutinib therapy for CLL after multiple prior treatment lines, including rituximab. To the best of our knowledge, this is the first study to report such findings. Since the last course of rituximab was applied over 3 years ago, it is conceivable that the strong B cell inhibition by ibrutinib led to PML. With increased awareness of this potential side effect, further clinical studies are certainly warranted to evaluate this possible association.

Iterative approach for anchor configuration of positioning systems

Mathias Pelka,Grigori Goronzy,Horst Hellbr¨uck 한국통신학회 2016 ICT Express Vol.2 No.1

With anchor positions and measurements of distances between an object and anchors, positioning algorithms calculate the position of an object, e.g. via lateration. Positioning systems require calibration and configuration prior to operation. In the past, approaches employed reference nodes with GPS or other reference location systems to determine anchor positions. In this article, we propose an approach to determine anchor positions without prior knowledge. We evaluate our approach with simulations and real data based on the Decawave DW1000 radio and show that the error is proportional to the mean error of the distance estimation.

Towards Automated 3D reconstruction in SME factories and Digital Twin Model generation

Mathias Minos-Stensrud,Ole Henrik Haakstad,Olav Sakseid,Baard Westby,Alex Alcocer 제어로봇시스템학회 2018 제어로봇시스템학회 국제학술대회 논문집 Vol.2018 No.10

This paper presents preliminary results towards the development of digital twin models for Small to Medium Enterprise (SME) factories in a partially automated and cost-effective manner. In many cases it is desirable to obtain a 3D model of a factory floor and machinery, that can be used for visualization of Digital Twin models. Current commercial 3D reconstruction solutions involve the use of high-end LiDAR sensors which increase the cost of the 3D scanning process and suppose a barrier for SME factories on their path towards Industry 4.0. The paper presents a comparison of 3D reconstruction results using low-cost sensors including a Zenfone AR mobile phone, an Intel RealSense ZR300 and a Kinect v2. The small size and weight of the sensors make it possible to be mounted on small unmanned aerial vehicles and enable future 3D reconstruction in an autonomous manner. The data was processed using an open source Simultaneous Localization and Mapping (SLAM) library RTAB-Map. The results were compared with a professional 3D scan using a GeoSLAM LiDAR. Experimental results from a scanning of a university research lab with a small simulated production line and two UR3 industrial manipulators is presented. The obtained 3D model was used to generate a simple Digital Twin model that can be visualized using a VR headset.

Disease progression and recurrence in women treated for vulvovaginal intraepithelial neoplasia

Mathias K. Fehr,Marc Baumann,Michael Mueller,Daniel Fink,Siegfried Heinzl,Patrick Imesch,Konstantin Dedes 대한부인종양학회 2013 Journal of Gynecologic Oncology Vol.24 No.3

Objective: The malignant potential of intraepithelial neoplasia of the vulva and vagina after treatment is not well defined. Our objective was to examine risk factors for recurrence and invasive disease. Methods: Four hundred sixty-four women with biopsy proven high-grade intraepithelial neoplasia of the vulva and vagina were identified in the electronic databases of four colposcopy clinics. Inclusion criteria were a follow-up of more than one year, no history of invasive cancer and no invasive cancer within the first year after initial treatment. We investigated the potential factors associated with recurrence and progression using a logistic regression analysis to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Results: Of the 411 eligible patients, 123 patients (29.9%) recurred later than one year after initial treatment and 24 patients (5.8%) progressed to invasive disease. According to multivariate analyses, the risk factors associated with recurrence were multifocality (OR, 3.33; 95% CI, 2.02 to 5.51), immunosuppression (OR, 2.51; 95% CI, 1.09 to 5.81), excision as initial treatment (vs. laser evaporation; OR, 1.79; 95% CI, 1.11 to 2.91) and smoking (OR, 1.61; 95% CI, 1.02 to 2.55). Risk factors for progression to invasive disease were immunosuppression (OR, 4.00; 95% CI, 1.30 to 12.25), multifocality (OR, 3.05; 95% CI, 1.25 to 7.43) and smoking (OR, 2.97; 95% CI, 1.16 to 7.60), but not treatment modality. Conclusion: Laser evaporation combined with extensive biopsy is at least as efficacious as initial treatment of intraepithelial neoplasia with excision. Smoking is a risk factor for both recurrence and progression to invasive disease. Hence, smoking cessation should be advised and maintaining a long follow-up period due to late relapses is necessary.

System Identification of the Arabidopsis Plant Circadian System

Mathias Foo,David E. Somers,김판준 한국물리학회 2015 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.66 No.4

The circadian system generates an endogenous oscillatory rhythm that governs the daily activitiesof organisms in nature. It offers adaptive advantages to organisms through a coordination of theirbiological functions with the optimal time of day. In this paper, a model of the circadian systemin the plant Arabidopsis (species thaliana) is built by using system identification techniques. Priorknowledge about the physical interactions of the genes and the proteins in the plant circadian systemis incorporated in the model building exercise. The model is built by using primarily experimentallyverifieddirect interactions between the genes and the proteins with the available data on mRNAand protein abundances from the circadian system. Our analysis reveals a great performance of themodel in predicting the dynamics of the plant circadian system through the effect of diverse internaland external perturbations (gene knockouts and day-length changes). Furthermore, we found thatthe circadian oscillatory rhythm is robust and does not vary much with the biochemical parametersexcept those of a light-sensitive protein P and a transcription factor TOC1. In other words, thecircadian rhythmic profile is largely a consequence of the network’s architecture rather than itsparticular parameters. Our work suggests that the current experimental knowledge of the geneto-protein interactions in the plant Arabidopsis, without considering any additional hypotheticalinteractions, seems to suffice for system-level modeling of the circadian system of this plant and topresent an exemplary platform for the control of network dynamics in complex living organisms.

Improving the Precision of Specifications by Evaluating the Influence of Test Parameters on Tribological Results

Mathias Woydt,Hartwig Weber 한국트라이볼로지학회 2003 한국트라이볼로지학회 학술대회 Vol.37 No.-

A series of cooperative interlaboratory tests (round robins) was conducted in 1997, 1998, 1999, 2000, 2001, 2002 and 2003 by the DIN 51834 Working Group on Tribological Tests in Translatory Oscillation Apparatus. The statistical analysis of these test results shows the influence of cleaning solvent, machine model and evaluation criteria on the tribological properties of the lubricants tested. Coefficients of friction and wear results are ranked according to the effects of ten different cleaning solvents, where isopropanol gave the lowest values and isoparaffin solvents the highest. The effect of machine model on coefficients of friction varied from about 0.2 % to 0.9 % of the mean. Wear results were not affected. The tests also showed that the seizure criteria and methods of measuring wear required for in the test procedure do not provide a suitable measure of the tribological properties of some lubricants. The precision was improved by introducing a grease apply caliper as well as an increased stroke to 1,5 mm and running-in. The temperature does not affect the precision of the oil test procedure.

SRV®-Testing of the Tribosystem Piston Ring and Cylinder Liner Outside the Engine

Mathias Woydt,Johannes Ebrecht 한국트라이볼로지학회 2005 한국트라이볼로지학회 학술대회 Vol.2005 No.11

An OEM driven working group started in January 2004 to elaborate the philosophies, concepts and test procedures for testing piston ring and cylinder liner materials as well as engine oils outside the engine using the SRV® test equipment. The different SRV® test philosophies in use by OEMs are compiled. The working group focuses on a.) ASTM sequence VIB (Fuel economy by aging oils), b.) friction and wear in the top dead region under mixed/boundary lubrication, c.) extreme pressure load under under mixed/boundary lubrication and d.) hydrodynamic friction. Tribological test results and precision data are presented.

The efficiency of passive confinement in CFT columns

Mathias Johansson 국제구조공학회 2002 Steel and Composite Structures, An International J Vol.2 No.5

The paper describes the mechanical behavior of short concrete-filled steel tube (CFT) columns with circular section. The efficiency of the steel tube in confining the concrete core depending on concrete strength and the steel tube thickness was examined. Fifteen columns were tested to failure under concentric axial loading. Furthermore, a mechanical model based on the interaction between the concrete core and the steel tube was developed. The model employs a volumetric strain history for the concrete, characterized by the level of applied confining stress. The situation of passive confinement is accounted for by an incremental procedure, which continuously updates the confining stress. The post-yield behavior of the columns is greatly influenced by the confinement level and is related to the efficiency of the steel tube in confining the concrete core. It is possible to classify the post-yield behavior into three categories: strain softening, perfectly plastic and strain hardening behavior. The softening behavior, which is due to a shear plane failure in the concrete core, was found for some of the CFT columns with high-strength concrete. Nevertheless, with a CFT column, it is possible to use high-strength concrete to obtain higher load resistance and still achieve a good ductile behavior.

SRV<SUP>®</SUP>-Testing of the Tribosystem Piston Ring and Cylinder Liner Outside the Engine

Mathias Woydt,Johannes Ebrecht 한국트라이볼로지학회 2005 KSTLE International Journal Vol.6 No.2

An OEM driven working group started in January 2004 to elaborate the philosophies, concepts and test procedures for testing piston ring and cylinder liner materials as well as engine oils outside the engine using the SRV<SUP>®</SUP> test equipment. The different SRV<SUP>®</SUP> test philosophies in use by OEMs are compiled. The working group focuses on a.) ASTM sequence VIB (Fuel economy by aging oils), b.) friction and wear in the top dead region under mixed/boundary lubrication, c.) extreme pressure load under mixed/boundary lubrication and d.) hydrodynamic friction. Tribological test results and precision data are presented.