Safety and efficacy of salvage conventional re-irradiation following stereotactic radiosurgery for spine metastases

Marcus A. Florez(Marcus A. Florez ),Brian De(Brian De ),Bhavana V. Chapman(Bhavana V. Chapman ),Anussara Prayongrat(Anussara Prayongrat ),Jonathan G. Thomas(Jonathan G. Thomas ),Thomas H. Beckham(Thom 대한방사선종양학회 2023 Radiation Oncology Journal Vol.41 No.1

Purpose: There has been limited work assessing the use of re-irradiation (re-RT) for local failure following stereotactic spinal radiosurgery (SSRS). We reviewed our institutional experience of conventionally-fractionated external beam radiation (cEBRT) for salvage therapy following SSRS local failure. Materials and Methods: We performed a retrospective review of 54 patients that underwent salvage conventional re-RT at previously SSRS-treated sites. Local control following re-RT was defined as the absence of progression at the treated site as determined by magnetic resonance imaging. Results: Competing risk analysis for local failure was performed using a Fine-Gray model. The median follow-up time was 25 months and median overall survival (OS) was 16 months (95% confidence interval [CI], 10.8–24.9 months) following cEBRT re-RT. Multivariable Cox proportional-hazards analysis revealed Karnofsky performance score prior to re-RT (hazard ratio [HR] = 0.95; 95% CI, 0.93– 0.98; p = 0.003) and time to local failure (HR = 0.97; 95% CI, 0.94–1.00; p = 0.04) were associated with longer OS, while male sex (HR = 3.92; 95% CI, 1.64–9.33; p = 0.002) was associated with shorter OS. Local control at 12 months was 81% (95% CI, 69.3–94.0). Competing risk multivariable regression revealed radioresistant tumors (subhazard ratio [subHR] = 0.36; 95% CI, 0.15–0.90; p = 0.028) and epidural disease (subHR = 0.31; 95% CI, 0.12–0.78; p =0.013) were associated with increased risk of local failure. At 12 months, 91% of patients maintained ambulatory function. Conclusion: Our data suggest that cEBRT following SSRS local failure can be used safely and effectively. Further investigation is needed into optimal patient selection for cEBRT in the retreatment setting.

The United States, the WTO, and APEC

( Marcus Noland ) 연세대학교 동서문제연구원 1995 East and West Studies Series Vol.35 No.-

MOOCs from the Viewpoint of an Instructional Designer and Eight Ways to Improve Them

( Marcus D. Childress ) 한국교육공학회 2014 한국교육공학회 학술대회발표자료집 Vol.2014 No.2

Massive open online courses (MOOCs) have garnered worldwide attention. The MOOC experiment has now moved from an exploration in open course delivery to a distance education movement. Institutions of higher education are embracing MOOCs as the platform of the future and as a way to create brand extension and broader education access. From the viewpoint of instructional design, the typical MOOC lacks proven instructional design elements. In addition, standard MOOCs violate many principles of instruction. This paper will address the brisk rise in popularity of MOOCs. Instructional challenges of MOOCs will be explored through the lens of instructional design. The paper will conclude by making recommendations for ways to improve MOOCs.

Mobilization Functions of the Bacteriocinogenic Plasmid pRJ6 of Staphylococcus aureus

Marcus Lívio Varella Coelho,Hilana Ceotto,Danielle Jannuzzi Madureira,Ingolf F. Nes,Maria do Carmo de Freire Bastos 한국미생물학회 2009 The journal of microbiology Vol.47 No.3

Plasmid pRJ6 is the first known bacteriocinogenic mobilizable (Mob) plasmid of Staphylococcus aureus. Its Mob region is composed of four mob genes (mobCDAB) arranged as an operon, a genetic organization uncommon among S. aureus Mob plasmids. oriTpRJ6 was detected in a region of 431 bp, positioned immediately upstream of mobC. This region, when cloned into pCN37, was able to confer mobilization to the recombinant plasmid only in the presence of pRJ6. The entire Mob region, including oriTpRJ6, is much more similar to Mob regions from several coagulase-negative staphylococci plasmids, although some remarkable similarities with S. aureus Mob plasmids can also be noted. These similarities include the presence within oriTpRJ6 of the three mcb (MobC binding sites), firstly described in pC221 and pC223, an identical nick site also found in these same plasmids, and a nearly identical srapC223 site (sequence recognized by MobA). pRJ6 was successfully transferred to S. epidermidis by conjugation in the presence of the conjugative plasmid pGO1. Altogether these findings suggest that pRJ6 might have been originally a coagulase-negative staphylococci plasmid that had been transferred successfully to S. aureus.

A Computer Vision System for Pallets Verification in Quality Control

Marcus Vinicius Barbosa de Morais,Sara Dereste dos Santos,Ricardo Pires 한국정밀공학회 2023 International Journal of Precision Engineering and Vol.24 No.7

Flexible manufacturing systems have gained their place in industries thanks to the possibility of being adapted to a particular task. A robotized palletizing cell is an example of such a system, which is responsible for organizing and stacking loads to be transported. A key part in this process is the pallet and if it presents a problem, the whole cell may stop. Furthermore, it is possible that manipulator robots, transported loads, and any other part of the cell suffer damage. To avoid these problems, the objective of this work is to develop an artificial vision system capable of selecting wood pallets that are in good condition, which means free of defects such as splinters, cracks and broken or out of dimensions elements. The artificial vision system has been developed based on image processing and machine learning techniques and presented better results compared to the past studies. Image processing parameters of Canny and Hough Transform have been adjusted, followed by comparisons among Support-Vector Machines with different kernels and their parameters. An accuracy of 100% in the classification has been obtained based on the Support-Vector Machine with radial basis function kernel.

구글 파업 실리콘밸리에 큰 변화를 가져올 것인가

Marcus Courtney,David Kusnet 한국노동연구원 2019 국제노동브리프 Vol.17 No.3

Energy Consumption Model for Additive-Subtractive Manufacturing Processes with Case Study

Marcus A. Jackson,Arik Van Asten,Justin D. Morrow,Sangkee Min,Frank E. Pfefferkorn 한국정밀공학회 2018 International Journal of Precision Engineering and Vol.5 No.4

There has been a growing trend in industry towards the development of integrated manufacturing centers that combine several manufacturing processes, such as the mill-turn center. As additive manufacturing becomes a more widely adopted technology, combining additive with subtractive manufacturing in one machine is a logical evolution to provide the benefits of final parts made from raw materials with the dimensional tolerance and surface finish expected in many applications. An energy consumption model was created that accounted for the energy consumption during primary metal production, deposition, and machining phases of wire-based and powder-based additive-subtractive manufacturing processes. This model was applied to a case study where the energy consumption to produce sub-sized, sheet type, and plate type (size) tensile bars was calculated. It was found that the wire-based process consumed less energy during deposition, whereas powder-based was less energy consumptive during primary metal production and machining. The findings suggest that given the present understanding of the respective technologies’ capabilities, the desired final net shape will dictate the preferred manufacturing process with respect to energy consumption considerations.

Die Kleine Aktiengesellschaft

( Marcus Lutter ),권기범 서울시립대학교 법학연구소 1997 서울법학 Vol.4 No.0

Approach for a smart device for active vibration suppression as an add-on for robot-based systems

Marcus Perner,Christian Krombholz,Hans Peter Monner 대한기계학회 2014 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.28 No.11

Robot-based systems are defined by the capabilities of links and joints that form the robot arm, the control including drive engines andthe endeffector. In particular, articulated robots have a serial structure. They have to carry the drive engine of each ongoing axis, whichresults in higher susceptibility to vibration. To compensate weak precision the German Aerospace Center (DLR) integrates a qualityimproving sensor system on the robot platform. A vibration monitoring system detects vibrations that affect the precision during motiontasks. Currently, higher precision is achieved by slowing down the speed in production. Therefore, a compromise is given between speedand precision. To push the limits for these two conflicting process properties, we propose an approach for an additional smart device todecouple the process-sensitive unit from disturbances arising through motion of the kinematic structure. The smart device enables activevibration suppression by use of a piezo-based actuator with a lever mechanism connected to a motion platform. The lever mechanismprovides the required force and displacement adaption. The platform provides mounting and steering of the process-sensitive components. First, an insight into the automation task is given within this paper. Secondly, the system design is illustrated. Based on simulation resultsthe characteristic of the proposed mechanism is shown. Besides the mechanical properties like stiffness and lever amplification, dynamicalissues like the smallest eigenfrequency are discussed. To verify simulation results initial measurements are presented and discussed. The paper sums up with the discussion of an implementation of a closed-loop control system to achieve vibration-free and fast motion.

Jugendarbeit in Österreich

Marcus Beranek 한국가톨릭신학학회 2011 가톨릭신학 Vol.0 No.18

In diesem Referat wird die Thematik “Jugendarbeit in Österreich“, vor allem einige Überlegungspunkte und Beispiele aus meiner Arbeit als Pfarrer und davor als Jugendseelsorger gehandelt. Dazu wird eine Skizze von der österreichischen Tradition und Situation im Bezug auf Jugendarbeit beigebracht und Zukunftsperspektive benennt. Die katholischen Kirche und Gesellschaft in Österreich befinden sich in einem starken Umbruch. Einge Entwicklungen beschleunigten den Vorgang, in dem katholische Kirche ihre lange Zeit unhinterfragte Selbstverständlichkeit verliert. Die traditionellen Formen des kirchlichen Lebens (besonders Gottesdienstes) sind vielen Menschen nicht mehr vertraut oder sie sind ihnen fremd geworden. Es gilt auch den Jugendliche in Kirche. Viel mehr als früher stellen sich Jugendliche und nicht nur sie im Bezug auf Kirche, aber auch auf andere Bereiche, in denen sie sich engagieren können die Frage: was bringt es mir? Jugendliche machen so in ihrem Alltag oft die Erfahrung, dass sie als überzeugt Christen in der Minderheit sein, dass sie belächelt oder hinterfragt werden. Die Kirchliche Jugendarbeit ist nicht als ein Sonderbereich von Seelsorge, sondern als der Bereich, wo sich zukünftige Entwicklungen besonders deutlich und auch mit hoher Geschwindigkeit abzeichnen. Es geht also darum, eine Vielfalt attraktiver Angebote und unterschiedlicher Zugänge für jugendliche zu entwickeln, die ihnen helfen, tiefer ihren eigenen Glauben zu erfassen und auf diesem Hintergrund Impulse für ihr Leben zu erhalten. Dafür sind die folgende Ansatzpunkte wichtig : Gemeinschaft erleben, Soziale Projekte, Engagement für Jugendliche in Randgruppen, Events, Gemeinsam den Glauben leben und vertiefen und Internet. “Die Jugendlichen” gibt es nicht. Jugendliche haben unterschiedliche soziale Hintergründe, Bildungsniveaus und Interessen. Nicht Institutionen und Organisationen sind vor allem gefragt, sondern konkrete Menschen, und zwar konkrete Jugendliche, die ihren Glauben auf persönlichstimmige Weise leben und die mit viel Wohlwollen und Offenheit als GesprächspartnerInnen zur Verfügung stehen. Kirche ist nicht nur für sich selber da. Wo Kirche sich in vielfältiger Weise für das gute Leben, für Gerechtigkeit und Menschlichkeit einsetzt, dort wird sie für andere und auch für jugenliche glaubhaft.