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The role of inflammation and matrix metalloproteinases in equine endometriosis
Luca Aresu,Silvia Benali,Diana Giannuzzi,Roberto Mantovani,Massimo Castagnaro,Maria Elena Falomo 대한수의학회 2012 Journal of Veterinary Science Vol.13 No.2
Equine endometriosis is a multifactorial disease considered to be a major cause of equine infertility. The purpose of this study was to evaluate the reliability of histomorphological grading for biopsy-like samples compared to entire uterine wall samples, to examine the association between the degree of endometriosis with animal age, and to investigate the role of inflammation in endometriosis and the expression of different matrix metalloproteinases in equine endometrium. Histomorphological lesions in 35 uterine samples were examined while comparing biopsy-like samples and entire-wall samples. Seventeen uterine samples were stained with antibodies against MMP-2, MMP-9, MMP-14, and TIMP-2. The morphologic evaluation results of the biopsy-like tissue and entire-wall samples were significantly correlated. Endometriosis in older mares (>12 years of age) was more severe than in young mares (2∼4 years of age), confirming the positive correlation between animal age and disease severity, while inflammation was poorly related to the degree of endometriosis. MMP-2 and MMP-14 were detected in stromal cells, while MMP-9 and TIMP-2 were both found in stromal and glandular epithelial cells. There were no significant differences in MMPs expression between the two groups (young vs. old mares). Additional studies on the activity of MMPs could further define the role of these enzymes in equine endometriosis.
Role of social media use in onset of functional gastrointestinal disorders in children
Cinquetti Mauro,Dargenio Vanessa,Fingerle Michele,Marchiotto Carolina,Biasin Marco,Pettoello Mantovani Massimo,Indrio Flavia 대한소아청소년과학회 2023 Clinical and Experimental Pediatrics (CEP) Vol.66 No.6
The use of social media has increased considerably in recent years. However, these tools are not always used consciously, and the stress that can result from their inappropriate use is often underestimated. Children, who tend to be heavy users of social media, are exposed to risks associated with their intensive use. Data on the consequences of social media on children’s health are extensive; however, few studies have examined the association between their use and functional gastrointestinal disorders (FGIDs). Our research showed that social media use is associated with adverse health outcomes such as stress, poor sleep quality, and gastrointestinal disorders in children and adolescents. FGIDs should be considered a group of biopsychosocial disorders involving gut dysfunction and psychological health. Stress may exacerbate the symptoms of these disorders and is associated with psychological comorbidities. Recent findings demonstrated a high prevalence of social media use and the incidence of psychological disorders, such as anxiety and depression, and decreased well-being in children with FGIDs. This review underlines that social media use is an emerging aspect of the psychosocial lives of children and adolescents; thus, it may be involved in FGID onset. Further studies in this field are needed to elucidate the link between social media and gastrointestinal health. Clinicians and politicians can play an important role in promoting the regulated and responsible use of digital platforms to protect the psychological health and preserve the well-being of children and adolescents.
Current status and outlook on the clinical translation of biodegradable metals
Han, Hyung-Seop,Loffredo, Sergio,Jun, Indong,Edwards, James,Kim, Yu-Chan,Seok, Hyun-Kwang,Witte, Frank,Mantovani, Diego,Glyn-Jones, Sion Elsevier 2019 Materials today Vol.23 No.-
<P><B>Abstract</B></P> <P>During the last decade, translational research on biodegradable metallic materials has shown the feasibility of these novel materials for use in the fields of cardiology and orthopedics. Implants prepared with biodegradable metals are significantly stronger than their polymer counterparts, and there is now convincing evidence demonstrating that these materials fully biodegrade <I>in vivo</I>, thus reducing the need for secondary surgery. Clinical trials of such novel materials show significant potential, with the prospect of a paradigm shift in the way musculoskeletal and cardiovascular conditions are treated. This work provides an overview of the rapidly advancing technology of biodegradable metals, as well as defining some challenges in the application of these new biodegradable materials in the medical field.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Carlotta Pia Cristalli,Chiara Zannini,Giorgia Comai,Olga Baraldi,Vania Cuna,Maria Cappuccilli,Vilma Mantovani,Niccolò Natali,Giuseppe Cianciolo,Gaetano La Manna 한국유전학회 2017 Genes & Genomics Vol.39 No.7
Gene polymorphisms involved in homocysteine- methionine pathway result in hyperhomocysteinemia, a predisposing condition to several diseases. Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in folate and homocysteine metabolism. The two known functional polymorphisms of MTHFR gene, 677C>T and 1298A>C have been implicated in a variety of multifactorial diseases: cardio-cerebrovascular and neurodegenerative disorders, autoimmune diseases, birth defects, diabetes, neuropsychiatric disorders, cancer and renal disease. C667T, and to a lesser extent A1298C polymorphisms, have been also reported to have a pharmacogenetic role in predicting drug toxicity in cancer and rheumatoid arthritis treatment. We review here the principal effects of the MTHFR gene variations in different clinical conditions.
Marcela S. Tsuboy,Juliana C. Marcarini,Alecsandra O. de Souza,Nata´lia A. de Paula,Daniel J. Dorta,Ma´rio S. Mantovani,Lucia R. Ribeiro 한국식품영양과학회 2014 Journal of medicinal food Vol.17 No.2
Several studies have demonstrated that a balanced diet can contribute to better human health. For this reason, soy-based food and pure isoflavones (pills) are one of the most consumed. The association of this consumption and lower risks of chronic diseases and cancer is well established for the Asian population and has been attracting thw attention of people worldwide, especially women at menopause who seek to alleviate the symptoms associated with the lack of estrogen. Despite positive epidemiological data, concerns still exist because of conflicting results found in scientific literature with relation to the role of isoflavones in breast and hormone-related cancers. The aim of our study was to investigate the cytotoxicity, induction of apoptosis, and changes in apoptosis-related genes of maximal physiological serum levels of the isoflavone genistein (Gen) in MCF-7 tumoral cells and in HB4a non-tumoral cells. In addition, induction of cell cycle arrest was also investigated. Only supraphysiological levels of Gen (50 and 100 lM) were cytotoxic to these cell lines. Concentrations of 10 and 25 lM did not induce apoptosis and significant changes in expression of the studied genes. Positive results were found only in cell cycle analysis: G0/G1 delay of MCF-7 cells in both concentrations of Gen and at 25 lM in HB4a cells. It is the first study investigating effects of Gen in the HB4a cell line. Thus, despite the lack of apoptosis induction (generally found with high concentrations), Gen at physiologically relevant serum levels still exerts chemopreventive effects through the modulation of cell cycle.
VETERINARY PUBLIC HEALTH IN DISASTER SITUATIONS
알.비. 그리피쓰(R.B. Griffiths),엠.에치. 힌턴(M.H. Hinton),지.에이. 카씨나(G.A. Cassina),에이. 만토바니(A. Mantovani) 한국예방수의학회 1989 예방수의학회지 Vol.13 No.2
最近 數年동안, 本來 自然發生的이거나 또는 人爲的으로 形成된 慘禍에 對한 獸醫師의 活躍에 關한 要求가 增加되어 왔다. 食糧農業機構, 國際獸疫會議事務局, 世界保健機構 그리고 유럽 여러나라의 專門家들이 參席하여 1984년 11월에 로마에서 國際硏鑽會가 開催된 바 있다. 이 會議의 目的은 災難狀況에 있어서의 獸醫業務의 責任性을 確認하고자 하는 것이었으며, 活動指針과 같은 敎育用 資料를 마련하고자 하는 것이었다. 根本的인 두가지의 樣相이 確定되었는 바 가, 應急狀況이 持續되는 時期 즉 時急性과 2次活動 및 長期的 目的에 있어서의 獸醫 業務 責任에 對한 確認同定, 나, 政策立案, 技術計劃 그리고 現場狀況에 있어서의 活動을 期待하는 獸醫 應急 對處組織에 對한 定義 被害받은 地域에 있어서의 獸醫 機動打擊 業務가 베풀어져야한다는 것이 期待되는 것이며 主要活動인 것으로 論議된 바 있는데, 즉 陸軍 獸醫團, 民間 自願團體 또는 國際機構等과 같은 團體의 役割을 일컫는 것이다. 또한, 다음과 같은 事項이 特別事項으로 考慮된 바 있다.