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European 1: A globally important clonal complex of Mycobacterium bovis
Smith, N.H.,Berg, S.,Dale, J.,Allen, A.,Rodriguez, S.,Romero, B.,Matos, F.,Ghebremichael, S.,Karoui, C.,Donati, C.,Machado, A.d.C.,Mucavele, C.,Kazwala, R.R.,Hilty, M.,Cadmus, S.,Ngandolo, B.N.R.,Habt Elsevier Science 2011 Infection, genetics and evolution Vol.11 No.6
We have identified a globally important clonal complex of Mycobacterium bovis by deletion analysis of over one thousand strains from over 30 countries. We initially show that over 99% of the strains of M. bovis, the cause of bovine tuberculosis, isolated from cattle in the Republic of Ireland and the UK are closely related and are members of a single clonal complex marked by the deletion of chromosomal region RDEu1 and we named this clonal complex European 1 (Eu1). Eu1 strains were present at less than 14% of French, Portuguese and Spanish isolates of M. bovis but are rare in other mainland European countries and Iran. However, strains of the Eu1 clonal complex were found at high frequency in former trading partners of the UK (USA, South Africa, New Zealand, Australia and Canada). The Americas, with the exception of Brazil, are dominated by the Eu1 clonal complex which was at high frequency in Argentina, Chile, Ecuador and Mexico as well as North America. Eu1 was rare or absent in the African countries surveyed except South Africa. A small sample of strains from Taiwan were non-Eu1 but, surprisingly, isolates from Korea and Kazakhstan were members of the Eu1 clonal complex. The simplest explanation for much of the current distribution of the Eu1 clonal complex is that it was spread in infected cattle, such as Herefords, from the UK to former trading partners, although there is evidence of secondary dispersion since. This is the first identification of a globally dispersed clonal complex M. bovis and indicates that much of the current global distribution of this important veterinary pathogen has resulted from relatively recent International trade in cattle.
Macaulay, E,Nichol, R C,Bacon, D,Brout, D,Davis, T M,Zhang, B,Bassett, B A,Scolnic, D,Mö,ller, A,D’Andrea, C B,Hinton, S R,Kessler, R,Kim, A G,Lasker, J,Lidman, C,Sako, M,Smith, M,Sullivan, M,Abbo Oxford University Press 2019 MONTHLY NOTICES- ROYAL ASTRONOMICAL SOCIETY Vol.486 No.2
<B>ABSTRACT</B><P>We present an improved measurement of the Hubble constant (H0) using the ‘inverse distance ladder’ method, which adds the information from 207 Type Ia supernovae (SNe Ia) from the Dark Energy Survey (DES) at redshift 0.018 < z < 0.85 to existing distance measurements of 122 low-redshift (z < 0.07) SNe Ia (Low-z) and measurements of Baryon Acoustic Oscillations (BAOs). Whereas traditional measurements of H0 with SNe Ia use a distance ladder of parallax and Cepheid variable stars, the inverse distance ladder relies on absolute distance measurements from the BAOs to calibrate the intrinsic magnitude of the SNe Ia. We find H0 = 67.8 ± 1.3 km s−1 Mpc−1 (statistical and systematic uncertainties, 68 per cent confidence). Our measurement makes minimal assumptions about the underlying cosmological model, and our analysis was blinded to reduce confirmation bias. We examine possible systematic uncertainties and all are below the statistical uncertainties. Our H0 value is consistent with estimates derived from the Cosmic Microwave Background assuming a ΛCDM universe.</P>
Fukui, Y.,Kawamura, A.,Wong, T.,Murai, M.,Iritani, H.,Mizuno, N.,Mizuno, Y.,Onishi, T.,Hughes, A.,Ott, J.,Muller, E.,Staveley-Smith, L.,Kim, S. IOP Publishing 2009 The Astrophysical journal Vol.705 No.1
<P>We compare the CO (J = 1-0) and HI emission in the Large Magellanic Cloud in three dimensions, i.e., including a velocity axis in addition to the two spatial axes, with the aim of elucidating the physical connection between giant molecular clouds (GMCs) and their surrounding Hi gas. The CO J = 1-0 data set is from the second NANTEN CO survey and the HI data set is from the merged Australia Telescope Compact Array ( ATCA) and Parkes Telescope surveys. The major findings of our analysis are as follows: (1) GMCs are associated with an envelope of HI emission, (2) in GMCs [average CO intensity] proportional to [ average Hi intensity](1.1 +/- 0.1), and (3) the HI intensity tends to increase with the star formation activity within GMCs, from Type I to Type III. An analysis of the HI envelopes associated with GMCs shows that their average line width is 14 km s(-1) and the mean density in the envelope is 10 cm(-3). We argue that the HI envelopes are gravitationally bound by GMCs. These findings are consistent with a continual increase in the mass of GMCs via HI accretion at an accretion rate of 0.05 M-circle dot yr(-1) over a timescale of 10 Myr. The growth of GMCs is terminated via dissipative ionization and/or stellar-wind disruption in the final stage of GMC evolution.</P>
Physical properties of giant molecular clouds in the Large Magellanic Cloud
Hughes, A.,Wong, T.,Ott, J.,Muller, E.,Pineda, J. L.,Mizuno, Y.,Bernard, J.-P.,Paradis, D.,Maddison, S.,Reach, W. T.,Staveley-Smith, L.,Kawamura, A.,Meixner, M.,Kim, S.,Onishi, T.,Mizuno, N.,Fukui, Y. Blackwell Publishing Ltd 2010 Monthly notices of the Royal Astronomical Society Vol.406 No.3
<P>ABSTRACT</P><P>The Magellanic Mopra Assessment (MAGMA) is a high angular resolution <SUP>12</SUP>CO (<I>J</I>= 1 → 0) mapping survey of giant molecular clouds (GMCs) in the Large Magellanic Cloud (LMC) and Small Magellanic Cloud using the Mopra Telescope. Here we report on the basic physical properties of 125 GMCs in the LMC that have been surveyed to date. The observed clouds exhibit scaling relations that are similar to those determined for Galactic GMCs, although LMC clouds have narrower linewidths and lower CO luminosities than Galactic clouds of a similar size. The average mass surface density of the LMC clouds is 50 M<SUB>⊙</SUB> pc<SUP>−2</SUP>, approximately half that of GMCs in the inner Milky Way. We compare the properties of GMCs with and without signs of massive star formation, finding that non-star-forming GMCs have lower peak CO brightness than star-forming GMCs. We compare the properties of GMCs with estimates for local interstellar conditions: specifically, we investigate the H <SMALL>I</SMALL> column density, radiation field, stellar mass surface density and the external pressure. Very few cloud properties demonstrate a clear dependence on the environment; the exceptions are significant positive correlations between (i) the H <SMALL>I</SMALL> column density and the GMC velocity dispersion, (ii) the stellar mass surface density and the average peak CO brightness and (iii) the stellar mass surface density and the CO surface brightness. The molecular mass surface density of GMCs without signs of massive star formation shows no dependence on the local radiation field, which is inconsistent with the photoionization-regulated star formation theory proposed by McKee. We find some evidence that the mass surface density of the MAGMA clouds increases with the interstellar pressure, as proposed by Elmegreen, but the detailed predictions of this model are not fulfilled once estimates for the local radiation field, metallicity and GMC envelope mass are taken into account.</P>
The sensitivity of harassment to orbit: mass loss from early-type dwarfs in galaxy clusters
Smith, R.,Sá,nchez-Janssen, R.,Beasley, M. A.,Candlish, G. N.,Gibson, B. K.,Puzia, T. H.,Janz, J.,Knebe, A.,Aguerri, J. A. L.,Lisker, T.,Hensler, G.,Fellhauer, M.,Ferrarese, L.,Yi, S. K. Oxford University Press 2015 Monthly notices of the Royal Astronomical Society Vol.454 No.3
P2Y1 receptor signaling is controlled by interaction with the PDZ scaffold NHERF-2
Fam, S. R.,Paquet, M.,Castleberry, A. M.,Oller, H.,Lee, C. J.,Traynelis, S. F.,Smith, Y.,Yun, C. C.,Hall, R. A. Proceedings of the National Academy of Sciences 2005 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.102 No.22
<P>P2Y(1) purinergic receptors (P2Y(1)Rs) mediate rises in intracellular Ca(2+) in response to ATP, but the duration and characteristics of this Ca(2+) response are known to vary markedly in distinct cell types. We screened the P2Y(1)R carboxyl terminus against a recently created proteomic array of PDZ (PSD-95/Drosophila Discs large/ZO-1 homology) domains and identified a previously unrecognized, specific interaction with the second PDZ domain of the scaffold NHERF-2 (Na(+)/H(+) exchanger regulatory factor type 2). Furthermore, we found that P2Y(1)R and NHERF-2 associate in cells, allowing NHERF-2-mediated tethering of P2Y(1)R to key downstream effectors such as phospholipase Cbeta. Finally, we found that coexpression of P2Y(1)R with NHERF-2 in glial cells prolongs P2Y(1)R-mediated Ca(2+) signaling, whereas disruption of the P2Y(1)R-NHERF-2 interaction by point mutations attenuates the duration of P2Y(1)R-mediated Ca(2+) responses. These findings reveal that NHERF-2 is a key regulator of the cellular activity of P2Y(1)R and may therefore determine cell-specific differences in P2Y(1)R-mediated signaling.</P>
NEUTRONICS MODELING AND SIMULATION OF SHARPFOR FAST REACTOR ANALYSIS
W. S. YANG,M. A. SMITH,C. H. LEE,A. WOLLABER,D. KAUSHIK,A. S. MOHAMED 한국원자력학회 2010 Nuclear Engineering and Technology Vol.42 No.5
This paper presents the neutronics modeling capabilities of the fast reactor simulation system SHARP, which ANL isdeveloping as part of theU.S. DOE’s NEAMS program. We discuss the three transport solvers (PN2ND, SN2ND, and MOCFE)implementedin the UNIC code along with the multigroup cross section generation code MC2-3. We describe the solution methodsand modelingcapabilities, and discuss the improvement needs for each solver, focusing on massively parallel computation.We present the performance test results against various benchmark problems and ZPR-6 and ZPPR critical experiments. We alsodiscuss weakand strong scalability results for the SN2ND solver on the ZPR-6 critical assembly benchmarks.
Misrepresentation of the IPCC CO2 emission scenarios
Manning, M. R.,Edmonds, J.,Emori, S.,Grubler, A.,Hibbard, K.,Joos, F.,Kainuma, M.,Keeling, R. F.,Kram, T.,Manning, A. C.,Meinshausen, M.,Moss, R.,Nakicenovic, N.,Riahi, K.,Rose, S. K.,Smith, S.,Swart, Springer Science and Business Media LLC 2010 Nature geoscience Vol.3 No.6
Hierarchical Multiscale Modeling Method for Head/Disk Interface
Jhon, M S,Smith, R,Vemuri, S H,Pil Seung Chung,Dehee Kim,Biegler, L T IEEE 2011 IEEE transactions on magnetics Vol.47 No.1
<P>Multiscale modeling opens a new paradigm by providing a novel methodology of establishing molecular design criteria and potentially gives several orders of magnitude advances in nanotechnology. The head/disk interface (HDI) in the hard disk drive system investigated here can be used as a benchmark for multiscale modeling. Our approach, stemmed from the novel middle-out approach in modern multiscale modeling using the lattice Boltzmann method (LBM) as the centerpiece formulation, marches towards continuum level (top) and molecular level (bottom). This approach will become an extremely valuable tool in generating design criteria of HDI.</P>