Phase transition, ferroelectric and piezoelectric properties of Ba1- xCaxTi1-yZryO3 lead-free ceramics

Wei Lin,Linli Fan,Dunmin Lin,Qiaoji Zheng,Ximing Fan,Hailing Sun 한국물리학회 2013 Current Applied Physics Vol.13 No.1

Lead-free piezoelectric ceramics Ba1xCaxTi1yZryO3þ1mol%CuO were prepared by an ordinary sintering technique and the effects of Ca2þ and Zr4þ on phase transition and electrical properties of the ceramics were studied. The results of X-ray diffraction show that the ceramics exhibit a pure perovskite structure at 0 x 0.175 and 0 y 0.175, suggesting that Ca2þ and Zr4þ diffuse into BaTiO3 lattices to form a solid solution. The substitution of Zr4þ for the B-site Ti4þ ions of BaTiO3 decreases greatly Curie temperature TC and strengthens the relaxor character of the ceramics, while the addition of Ca2þ has a weak influence on TC and leads to an inhibition of grain growth. Owing to the more possible polarization states resulting from the coexistence of tetragonal and orthorhombic phases near room temperature, the ceramics with x ¼ 0.075e0.125 and y ¼ 0.1 exhibit excellent piezoelectric properties: d33 ¼ 254e345 pC/N and kp ¼ 38.0e45.2%, respectively.

rs10505474 and rs7837328 at 8q24 Cumulatively Confer Risk of Prostate Cancer in Northern Han Chinese

Zhang, Lin-Lin,Sun, Liang,Zhu, Xiao-Quan,Xu, Yong,Yang, Kuo,Yang, Fan,Yang, Yi-Ge,Chen, Guo-Qiang,Fu, Ji-Cheng,Zheng, Chen-Guang,Li, Ying,Mu, Xiao-Qiu,Shi, Xiao-Hong,Zhao, Fan,Wang, Fei,Yang, Ze,Wang, Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.7

Aims: Genome-wide association studies (GWAS) have identified several risk variants for prostate cancer (pCa) mainly in Europeans, which need to be further verified in other racial groups. We selected six previously identified variants as candidates and to define the association with PCa in Northern Han Chinese. Methods: 749 subjects from Beijing and Tianjin in Northern China were included. Six variants (rs10505474, rs7837328, rs4242384, rs7813, rs486907 and rs1058205) were genotyped by high resolution melting (HRM) assays. The individual and cumulative contribution for of the risk of PCa and clinical covariates were analyzed. Results: Among the six candidate variants, onlyrs10505474, and rs7837328, both locating at 8q24 region, were associated with PCa in our population.rs10505474 (A) was associated with PCa ($OR_{recessive}=1.56$, p=0.006); and rs7837328 (A) was associated with PCa ($OR_{dominant}=1.38$, p=0.042/$OR_{recessive}=1.99$, p=0.003). Moreover, we observed a cumulative effects between them ($p_{trend}=2.58{\times}10^{-5}$). The joint population attributable risk showed the two variants might account for 71.85% of PCa risk. In addition, we found the homozygotes of rs10505474 (A) and rs7837328 (A) were associated with PCa clinical covariants (age at onset, tumor stage, respectively) ($p_{age}=0.046$, $P_{tumorstage}=0.048$). Conclusion: rs10505474 (A) and rs7387328 (A) at 8q24 are associated with PCa and cumulatively confer risk, suggesting the two variations could determine susceptibility to PCa in the Northern Chinese Han population.

New Pixel Circuit Compensating Poly-si TFT Threshold-voltage Shift for a Driving AMOLED

Ching-Lin Fan,Y. Y. Lin,B. S. Lin,J. Y. Chang,C. L. Fan,H. C. Chang 한국물리학회 2010 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.56 No.4

This study presents a novel pixel circuit that uses only n-type low-temperature polycrystallinesilicon (poly-Si) thin-film transistors (LTPS-TFTs) to simplify the fabrication process of activematrix organic light-emitting diode (AMOLED) displays. The proposed pixel circuit consists of five switching TFTs, one driving TFT (DTFT), and two capacitors. The output current and the OLED anode voltage error rates are about 3% and 0.7%, respectively. Thus, the pixel circuit can realize uniform output current with high immunity to the poly-Si TFT threshold voltage deviation. The proposed novel pixel design has great potential for use in large-size, high-resolution AMOLED displays.

A Comparison Study of Sport Medicine Research Trend Before and After the 4th Industrial Revolution: A Systematic Review

Tenglong Fan(Tenglong Fan),Man-Hsu Lin(Man-Hsu Lin),Kijin Kim(Kijin Kim) 대한운동학회 2023 아시아 운동학 학술지 Vol.25 No.1

OBJECTIVES The purpose of the study is to explore the changing trend of research keywords in the field of sports medicine the contributions of outstanding authors, institutions, and countries participating in the research, and the technologies directly related to the 4th Industrial Revolution (4IR) in the field of 4IR sports medicine before and after 4IR. METHODS The sample data of this study was retrieved from all the bibliographic information of the top two journals in the sports medicine field (i.e. Sports Medicine and British Journal of Sports Medicine). A bibliometric analysis was carried out by using CiteSpace, and python was used for further text mining on the key nodes in the analysis results. RESULTS The study has found that cardiovascular disease has always been popular in the research field of sports medicine; improving people’s quality of life and avoiding the risk of disease through physical activity, as long as research related to cruciate ligament may appear frequently again in the next few years. After 4IR, the field of sports medicine began to shift from a single study of epidemiology to multidimensional research of epidemiology, preventive medicine and psychology; the population characteristics of the researches began to be more segmented. Also, more collaboration between authors, institutions and institutions involved in sports medicine research has found. Germany and hospitals have become emerging forces after 4IR, and meta-analysis and systematic review are common concerns of Germany and hospitals. The impact of 4IR on sports medicine is mainly manifested in the application of sensors, intelligent monitoring, metabolomics and genomics, which having a great prospect in application. CONCLUSIONS The study sorted out the changes in research trends in the field of sports medicine before and after 4IR, and at the same time proved that the impact of 4IR on sports medicine has already existed, and more scholars need to pay attention. 4IR has brought new forces and new trends to the field of sports medicine, which deepened the research cooperation in this field. Wearable devices, intelligent monitoring, metabolomics, and genomics have applied and had a positive developing trend in sports medicine field.

The effects of cigarettes and alcohol on intestinal microbiota in healthy men

Lin Renbin,Zhang Yawen,Chen Luyi,Qi Yadong,He Jiamin,Hu Mengjia,Zhang Ying,Fan Lina,Yang Tao,Wang Lan,Si Misi,Chen Shujie 한국미생물학회 2020 The journal of microbiology Vol.58 No.11

Human intestinal microbiota is affected by the exogenous microenvironment. This study aimed to determine the effects of cigarettes and alcohol on the gut microbiota of healthy men. In total, 116 healthy male subjects were enrolled and divided into four groups: non-smoking and non-drinking (Group A), smoking only (Group B), drinking only (Group C), and smoking and drinking combined (Group D). Fecal samples were collected and sequenced using 16S rRNA to analyze the microbial composition. Short-chain fatty acid (SCFAs) levels in feces were determined by gas chromatography. We found that cigarette and alcohol consumptions can alter overall composition of gut microbiota in healthy men. The relative abundances of phylum Bacteroidetes and Firmicutes and more than 40 genera were changed with cigarette and alcohol consumptions. SCFAs decreased with smoking and alcohol consumption. Multivariate analysis indicated that when compared with group A, group B/C/D had higher Bacteroides, and lower Phascolarctobacterium, Ruminococcaceae_ UCG-002, Ruminococcaceae_UCG-003, and Ruminiclostridium_ 9 regardless of BMI and age. Additionally, the abundance of Bacteroides was positively correlated with the smoking pack-year (r = 0.207, p < 0.05), the abundance of predicted pathway of bacterial toxins (r = 0.3672, p < 0.001) and the level of carcinoembryonic antigen in host (r = 0.318, p < 0.01). Group D shared similar microbial construction with group B, but exerted differences far from group C with lower abundance of Haemophilus. These results demonstrated that cigarette and alcohol consumption separately affected the intestinal microbiota and function in healthy men; furthermore, the co-occurrence of cigarette and alcohol didn’t exacerbate the dysbiosis and cigarette played the predominated role on the alteration.

Simulation on hysteresis characteristic of squeeze mode magneto-rheological damper based on non-convex constitutive relation

Fan Wang,Zi-Xiang Ying,Lin-Xiang Wang 한국유변학회 2021 Korea-Australia rheology journal Vol.33 No.3

Magneto-Rheological (MR) fluid is a controllable material upon the applied magnetic field, and various MR dampers with different structures are designed to take advantage of this unique property. In the current paper, the squeeze mode MR damper is analyzed. The two-dimensional MR fluid squeeze flow in the damper is simulated using the Navier–Stokes’ equations. The shear stress of MR fluid is characterized by a non-convex constitutive relation, which is capable of capturing the solid-like to liquid-like switching. The two-dimensional velocity field and pressure distribution of MR fluid are obtained, from which the damping force of the MR damper is obtained. The unique hysteresis characteristic of the force versus velocity relation of the MR damper is captured. Further, the dependence on the loading rate and the field strength of the hysteresis characteristic is studied in the current paper.

Thermometry for Dirac Fermions in Graphene

Fan-Hung Liu,Chang-Shun Hsu,Shun-Tsung Lo,Chiashain Chuang,Lung-I Huang,Tak-Pong Woo,Chi-Te Liang,Y. Fukuyama,Y. Yang,R. E. Elmquist,Pengjie Wang,Xi Lin 한국물리학회 2015 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.66 No.1

We use both the zero-magnetic-field resistivity and the phase coherence time determined by weaklocalization as independent thermometers for Dirac fermions (DF) in multilayer graphene. In thehigh current (I) region, there exists a simple power law TDF / I0.5, where TDF is the effective Diracfermion temperature for epitaxial graphene on SiC. In contrast, TDF / I1 in exfoliated multilayergraphene. We discuss possible reasons for the different power laws observed in these multilayergraphene systems. Our experimental results on DF-phonon scattering may find applications ingraphene-based nanoelectronics.

Prolyl endopeptidase remodels macrophage function as a novel transcriptional coregulator and inhibits fibrosis

Lin Shuang-Zhe,Wu Wei-Jie,Cheng Yu-Qing,Zhang Jian-Bin,Jiang Dai-Xi,Ren Tian-Yi,Ding Wen-Jin,Liu Mingxi,Chen Yuan-Wen,Fan Jian-Gao 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-

Macrophages are immune cells crucial for host defense and homeostasis maintenance, and their dysregulation is involved in multiple pathological conditions, such as liver fibrosis. The transcriptional regulation in macrophage is indispensable for fine-tuning of macrophage functions, but the details have not been fully elucidated. Prolyl endopeptidase (PREP) is a dipeptidyl peptidase with both proteolytic and non-proteolytic functions. In this study, we found that Prep knockout significantly contributed to transcriptomic alterations in quiescent and M1/M2-polarized bone marrow-derived macrophages (BMDMs), as well as aggravated fibrosis in an experimental nonalcoholic steatohepatitis (NASH) model. Mechanistically, PREP predominantly localized to the macrophage nuclei and functioned as a transcriptional coregulator. Using CUT&Tag and co-immunoprecipitation, we found that PREP was mainly distributed in active cis-regulatory genomic regions and physically interacted with the transcription factor PU.1. Among PREP-regulated downstream genes, genes encoding profibrotic cathepsin B and D were overexpressed in BMDMs and fibrotic liver tissue. Our results indicate that PREP in macrophages functions as a transcriptional coregulator that finely tunes macrophage functions, and plays a protective role against liver fibrosis pathogenesis.

Survival Analysis of Oral Squamous Cell Carcinoma in a Subgroup of Young Patients

Fan, Yi,Zheng, Lei,Mao, Ming-Hui,Huang, Ming-Wei,Liu, Shu-Ming,Zhang, Jie,Li, Sheng-Lin,Zheng, Lei,Zhang, Jian-Guo Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.20

Oral squamous cell carcinoma (OSCC) is predominantly a disease of middle-aged men with long-term exposure to tobacco and alcohol. An increasing trend has been reported at a younger age worldwide. Clinical records of 100 patients under the age of 45 years treated specifically for oral cavity SCC in our hospital during a 10-year period were retrospectively analyzed to calculate the survival rates. An obvious male predominance coincided with smoking trend among Chinese young individuals and female patients were more likely to have no traditional risk factors such as smoking or drinking. The 5-year overall survival rate and disease-free survival rate were 61.0% and 75.5%, respectively, consistent with other published series over the decade showing a relatively better survival among the young. No significant differences clearly correlated with outcome when comparing non-smokers non-drinkers to ever-smokers and ever drinkers (P>0.05). Overall survival rate and disease free survival rate was found to be significantly higher in patients with early-stage disease than with advanced stage disease (P=0.001, P=0.009 respectively). The strong influence of clinical stage on prognosis emphasizes the importance of early diagnosis and treatment of oral malignancies for this unique clinical subgroup.

Effect of Concentrate Feeding Frequency versus Total Mixed Ration on Lactational Performance and Ruminal Characteristics of Holstein Cows

Fan, Yang-Kwang,Lin, Yaun-Lung,Chen, Kuen-Jaw,Chiou, Peter Wen-Shyg Asian Australasian Association of Animal Productio 2002 Animal Bioscience Vol.15 No.5

This study was conducted to determine a proper feeding regime for lactating Holstein cows during the warm season in Taiwan. In Feeding Trial, 21 lactating Holstein cows were randomly allotted into three feeding regimes in a Completely Randomized Design. The feeding regimes were roughage fed ad libitum along with concentrate fed either twice daily (2C) or four times daily (4C), and total mixed ration (TMR) for 8 weeks. No significant differences among the three feeding regimes were found in body weight changes, and intakes in terms of dry matter, crude protein and net energy. For milk yield and 4% FCM yield, 4C were higher than the other two feeding regimes (p<0.05). No significant differences were found in milk compositions or differences noted in the yields of the respective milk components. TMR was worse than 2C and 4C (p<0.05) in milk production efficiencies in terms of dry matter intake per kg milk yield, crude protein intake per kg milk protein yield, as well as dry matter intake, net energy intake and crude protein intake per kg 4% FCM yield. Three ruminally fistulated Holstein dry cows were randomly assigned into the same three feeding regimes in a 3${\times}$3 Latin Square Design. No significant differences were found among the feeding regimes in ruminal pH, ammonia nitrogen, total VFA concentration, molar percentages of VFA, and acetic acid: propionic acid ratio (C$_2$/C$_3$). Taken all together, roughage fed ad libitum and concentrate fed four times daily was the better feeding regime for lactating cows during the warm season in Taiwan.