Ultraviolet-assisted synthesis of encapsulating adhesives and their application for lifetime improvement of organic light emitting diodes

Chen-Ming Chen,Ming-Hua Chung,Tsung-Eong Hsieh,Bohr-Ran Huang,Huai-En Hsieh,Fuh-Shyang Juang,Yu-Sheng Tsai,Mark O. Liu,Jen-Lien Lin 한국물리학회 2009 Current Applied Physics Vol.9 No.4

The lifetimes of organic light emitting diodes (OLEDs) have been successfully enhanced with the modulation of LiF thickness and the utilization of encapsulating adhesives, which have been successfully and quickly synthesized with UV irradiation. Experimental results demonstrate that LiF and lab-made encapsulating adhesives can block the invasion of moisture as well as oxygen in the atmosphere into the OLEDs so that the lifetimes of devices with their encapsulation are 18-folds longer than those without encapsulation. The lifetimes of organic light emitting diodes (OLEDs) have been successfully enhanced with the modulation of LiF thickness and the utilization of encapsulating adhesives, which have been successfully and quickly synthesized with UV irradiation. Experimental results demonstrate that LiF and lab-made encapsulating adhesives can block the invasion of moisture as well as oxygen in the atmosphere into the OLEDs so that the lifetimes of devices with their encapsulation are 18-folds longer than those without encapsulation.

Experimental studies of circular composite bridge piersfor seismic loading

Sheng-Jin Chen,Kuo-Chen Yang,K.M. Lin,C.C. Wang 국제구조공학회 2012 Steel and Composite Structures, An International J Vol.12 No.3

This study proposes and examines a circular composite bridge pier for seismic resistance. The axial and flexural strengths of the proposed bridge pier are provided by the longitudinal reinforcing bars and the concrete, while the transverse reinforcements used in the conventional reinforced concrete pier are replaced by the steel tube. The shear strength of this composite pier relies on the steel tube and the concrete. This system is similar to the steel jacketing method which strengthens the existing reinforced concrete bridge piers. However, no transverse shear reinforcing bar is used in the proposed composite bridge pier. A series of experimental studies is conducted to investigate the seismic resistant characteristics of the proposed circular composite pier. The effects of the longitudinal reinforcing bars, the shear span-to-diameter ratio, and the thickness of the steel tube on the performance of strength, ductility, and energy dissipation of the proposed pier are discussed. The experimentalresults show that the strength of the proposed circular composite bridge pier can be predicted accurately by the similar method used in the reinforced concrete piers with minor modification. From these experimental studies, it is found that the proposed circular composite bridge pier not only simplifies the construction work greatly but also provides excellent ductility and energy dissipation capacity under seismic lateral force.

Effective Antiviral Activity of the Tyrosine Kinase Inhibitor Sunitinib Malate against Zika Virus

Lin Chen-Sheng,Huang Su-Hua,Yan Bo-Yu,Lai Hsueh-Chou,Lin Cheng-Wen 대한감염학회 2021 Infection and Chemotherapy Vol.53 No.4

Introduction: Zika virus (ZIKV), a mosquito-borne flavivirus, causes the outbreaks of Latin America in 2015 - 2016, with the incidence of neurological complications. Sunitinib malate, an orally bioavailable malate salt of the tyrosine kinase inhibitor, is suggested as a broadspectrum antiviral agent against emerging viruses like severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2. Materials and Methods: This study investigated the antiviral efficacy and antiviral mechanisms of sunitinib malate against ZIKV infection using cytopathic effect reduction, virus yield, and time-of-addition assays. Results: Sunitinib malate concentration-dependently reduced ZIKV-induced cytopathic effect, the expression of viral proteins, and ZIKV yield in supernatant with 50% inhibitory concentration (IC50) value of 0.015 μM, and the selectivity index of greater than 100 against ZIKV infection, respectively. Sunitinib malate had multiple antiviral actions during entry and post-entry stages of ZIKV replication. Sunitinib malate treatment at entry stage significantly reduced the levels of ZIKV RNA replication with the reduction of (+) RNA to (-) RNA ratio and the production of new intracellular infectious particles in infected cells. The treatment at post-entry stage caused a concentration-dependent increase in the levels of ZIKV (+) RNA and (-) RNA in infected cells, along with enlarging the ratio of (+) RNA to (-) RNA, but caused a pointed increase in the titer of intracellular infectious particles by 0.01 and 0.1 μM, and a substantial decrease in the titer of intracellular infectious particles by 1 μM. Conclusion: The study discovered the antiviral actions of sunitinib malate against ZIKV infection, demonstrating a repurposed, host-targeted approach to identify potential antiviral drugs for treating emerging and global viral diseases.

OPEN SERVICE INNOVATION: PROPOSED ANTECEDENTS AND MODERATORS FROM KNOWLEDGE-BASED VIEW

Fu-Sheng Tsai,Julia L. Lin,Yu-Chia Chen 글로벌지식마케팅경영학회 2016 Global Marketing Conference Vol.2016 No.7

The present paper discusses the interrelationship among knowledge creation, heterogeneity, and open service innovation – an important theme of marketing research. Drawing on the literature of knowledge based innovation, we argue that both researchers and practitioners should extend the functionality of created knowledge into open and service-oriented innovation context. Our conceptual framework represent the following major points. First, the four classic knowledge creation mode each has different influences on open service innovation, given employee and customer knowledge is a cornerstone of service innovation. Specifically, socialization positively, externalization positively, combination positively, and internalization negatively predicts open service innovation. Second, knowledge heterogeneity moderates in the above mentioned relationships. Implication are discussed

Fabrication of a Biodegradable Multi-layered Polyvinyl Alcohol Stent

Mei-Chen Lin,Ching-Wen Lou,Jan-Yi Lin,Ting An Lin,Yueh-Sheng Chen,Jia-Horng Lin 한국섬유공학회 2018 Fibers and polymers Vol.19 No.8

This study aims to develop biodegradable vascular stents that prevent permanent damage caused by rejection of the immune system of the human body. Polyvinyl alcohol (PVA) yarns are twisted to enhance their strength. The twisted yarns are braided and then coated with chitosan (CS). The CS-coated PVA vascular stents are chemically crosslinked with genipin (GP) to improve their flexibility and biodegradability. Their morphological characteristics are also observed using a stereoscopic microscope, and their properties are evaluated through scanning electron microscopy, Fourier transform infrared, bending test, biodegradability test, drug release measurement, and MTT assay. Results reveal that wet PVA-CS-GP vascular stents coated with multiple CS layers can maintain a tubular structure when they are bent. After crosslinking is performed, the compressive strength of the PVA-CS-GP stents is 17.04 times higher than that of pure PVA. The weight loss rate of the PVA-CS-GP vascular stents as <3 % after 30 days. The PVA-CS-GP vascular stents composed of 0.10 % heparin sodium show a good drug release effect. Biological activity test indicates that these stents exhibit good proliferation, and our structural model verifies that they are good vascular stents.

The Design and Application of an Automatic Optical Inspection System for the Advanced Fiber Coupler Assembly Manufacturing Process

Chern-Sheng Lin,Jen Min Tsai,Kai-Sheng Chen,Yun-Long Lay,Nin-Chun Chang 한국정밀공학회 2014 International Journal of Precision Engineering and Vol. No.

In this paper an automatic optical inspection system for the advanced fiber coupler assembly manufacturing process is presented. Coupling efficiency variations were compared with axial displacement. The main standard components of light peak fiber couplerswere used in the experiment to determine the corresponding offset and position of the optimal optical coupling efficiency in order toachieve a positioning effect. This study used the parameters of lens curvature, focal length and light source for validation using opticaldesign software. An infrared CCD camera was used to extract the coupled light spot images. The curve fitting method and couplingsimulation database were used for image processing and to calculate optimal coupling efficiency. Under optimal coupling efficiency,the minimum amount of movement of the translation stages was used to calculate the offset of each axle or the coupling efficiencywhen tilted. Moreover, a coupling efficiency database was established. The optical axle center offset in the alignment was calculatedby comparing the data in the database. Finally, the optical axle center offset or tilt direction was identified through the program toachieve the position of optimal coupling efficiency.

Portable Laser Doppler Flowmeter for Microcirculation Detection

Chang-Lin Hu,Meng-Lin Li,Zhan-Sheng Lin,Yen-Yu Chen,Yuan-Hsiang Lin 대한의용생체공학회 2013 Biomedical Engineering Letters (BMEL) Vol.3 No.2

Purpose The microcirculatory system of the human body is closely related to its physiological conditions. The laser Doppler flowmeter can detect symptoms through variations in the microcirculation; however, the present commercial Doppler flowmeter is very expensive, heavy, and inconvenient to carry. Therefore, an inexpensive, small, and portable laser Doppler flowmeter is proposed. Methods In this study, we designed a laser Doppler flowmeter transmitting receiving module based on the fundamental principles of laser Doppler, using a common computer for flow calculation. A self-designed correction system was used to validate the portable laser Doppler flowmeter. Results The coefficient of correlation between the mean frequency offset <ω> of the flowmeter and the actual mimicked blood flow rate reached a high value of R = 0.99, and the variations in microcirculation flow could be accurately measured. Conclusions The results proved that the low-cost portable laser Doppler flowmeter can be used extensively in early symptom detection for disease prevention and control.

Professionals’ experiences and attitudes toward use of Traditional Chinese Medicine in hospice palliative inpatient care units: A multicenter survey in Taiwan

Yu-Jia Lin,Hsiao-Ting Chang,Ming-Hwai Lin,Ru-Yih Chen,Ping-Jen Chen,Wen-Yuan Lin,Jyh-Gang Hsieh,Ying-Wei Wang,Chung-Chieh Hu,Yi-Sheng Liou,Tai-Yuan Chiu,Chun-Yi Tu,Yi-Jen Wang,Bo-Ren Cheng,Tzeng-Ji Ch 한국한의학연구원 2021 Integrative Medicine Research Vol.10 No.2

Background: Medical staff may have difficulties in using conventional medicine to manage symptoms among terminally ill patients, including adverse effects of the treatment. Traditional Chinese medicine (TCM) is regarded as a complementary or alternative medicine, and has been increasingly used in the field of palliative medicine in recent years. This study aimed to investigate the experiences of and attitudes toward using TCM among palliative care professionals, and to provide preliminary information about its use in palliative care. Methods: This was a cross-sectional survey study conducted in eight inpatient hospice wards in Taiwan between December 2014 and February 2016. The questionnaire was self-administered, and was analyzed with descriptive statistics including Pearson’s Chi-square test and Fisher’s exact test. Results: A total of 251 palliative care professionals responded to the questionnaire, of whom 89.7% and 88.9% believed that the use of TCM could improve the physical symptoms and quality of life in terminally ill patients, respectively. Overall, 59.8%, of respondents suggested that TCM had rare side effects, and 58.2% were worried that TCM could affect the liver and kidney function of patients. In total, 89.7% and 88.0% of professionals agreed there were no suitable clinical practice guidelines and educational programs, respectively, for TCM use in palliative care. Conclusions: Most of the respondents agreed there was insufficient knowledge, skills-training, and continuing education on the use of TCM in terminally ill patients in Taiwan. These results show that to address patient safety considerations, guidelines about use of TCM in palliative care should be established.

Probing Insulator-quantum Hall Transitions by Current Heating

Kuang Yao Chen,N. Aoki,Y. Ochiai,K. A. Cheng,Li-Hung Lin,C. F. Huang,Yu-Ru Li,Yen Shung Tseng,Chun-Kai Yang,Po-Tsun Lin,Jau-Yang Wu,Sheng-Di Lin,C.-T. Liang 한국물리학회 2009 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.55 No.1

We report a magneto-transport study on the two-dimensional electron system (2DES) in an Al- GaAs/GaAs heterostructure. The direct insulator to quantum Hall conductor transition is observed at low temperatures by increasing the magnetic field B perpendicular to the 2DES. We can also observe the transition by varying the current I and find a relation Te~Ia between electron effective temperature Te and current. Here, a denotes the exponent for the power law. The exponent a, however, can have different values on the two sides of the transition point, which indicates different inelastic scattering mechanisms in the low-field insulator and in the quantum Hall conductor. We report a magneto-transport study on the two-dimensional electron system (2DES) in an Al- GaAs/GaAs heterostructure. The direct insulator to quantum Hall conductor transition is observed at low temperatures by increasing the magnetic field B perpendicular to the 2DES. We can also observe the transition by varying the current I and find a relation Te~Ia between electron effective temperature Te and current. Here, a denotes the exponent for the power law. The exponent a, however, can have different values on the two sides of the transition point, which indicates different inelastic scattering mechanisms in the low-field insulator and in the quantum Hall conductor.

Enhanced Phase Relaxation in a Hybrid Ferromagnet/Semiconductor System

Kuang Yao Chen,Chun-Kai Yang,N. Aoki,Y. Ochiai,Y. Ujiie,K. A. Cheng,Li-Hung Lin,C. F. Huang,Yu-Ru Li,Yen Shung Tseng,Po-Tsun Lin,Jau-Yang Wu,Sheng-Di Lin,C.-T. Liang 한국물리학회 2009 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.55 No.1

Hybrid ferromagnet/semiconductor systems have been the focus of considerable attention because of the transport properties of two-dimensional electron systems and their potential applications to magnetic storage and sensing devices. We use the weak localization effect to probe the dephasing mechanism at low temperatures. In our study, the zero-temperature phase-relaxation rate can be enhanced in a hybrid ferromagnet/semiconductor system, which may be due to the inhomogeneous magnetic field emanating from the Ni film. The result may improve understanding of the issue of zero-temperature dephasing in disordered systems. Hybrid ferromagnet/semiconductor systems have been the focus of considerable attention because of the transport properties of two-dimensional electron systems and their potential applications to magnetic storage and sensing devices. We use the weak localization effect to probe the dephasing mechanism at low temperatures. In our study, the zero-temperature phase-relaxation rate can be enhanced in a hybrid ferromagnet/semiconductor system, which may be due to the inhomogeneous magnetic field emanating from the Ni film. The result may improve understanding of the issue of zero-temperature dephasing in disordered systems.