Correction: Manipulation of cell adhesion and dynamics using RGD functionalized polymers

Li, Juyi,Yu, Yingjie,Kim, Myungwoong,Li, Kao,Mikhail, John,Zhang, Linxi,Chang, Chung-Chueh,Gersappe, Dilip,Simon, Marcia,Ober, Christopher,Rafailovich, Miriam Royal Society of Chemistry 2017 Journal of Materials Chemistry B Vol. No.

<P>Correction for ‘Manipulation of cell adhesion and dynamics using RGD functionalized polymers’ by Juyi Li <I>et al.</I>, <I>J. Mater. Chem. B</I>, 2017, DOI: 10.1039/c7tb01209h.</P>

Effect of External Support on Bank Default and Operating Risks: Does Country Strength Matter?

Yu-Li Huang,Chung-Hua Shen,Kun-Li Lin 한국증권학회 2018 Asia-Pacific Journal of Financial Studies Vol.47 No.4

This study investigates how two forms of external support, namely, government and foreign ownership, affect bank default and operating risks. The results show, first, that government ownership reduces default risk and increases operating risk, while foreign ownership reduces both default and operating risks. Second, government ownership decreases default risk especially for banks from advanced countries and countries with better national governance. Third, foreign ownership from countries with better sovereign ratings decreases both default and operating risks. Our results suggest that Asian countries should increase income or national governance for more effective government support and open the domestic bank market.

콘택트렌즈 보존 용기 유래 Acanthamoeba lugdunensis KA/L5주의 내공생세균

정동일,공현희,김태호,황미열,유학선,윤호철,설성용 경북대학교 의학연구소 1999 경북대학교병원의학연구소논문집 Vol.3 No.1

콘택트렌즈 보존 용기 유래 가시아메바 KA/L5주의 세포질 내에 존재하는 bacterial endosymbiont(내공생세균)를 투과전자현미경으로 관찰하여 확인하였다. 숙주인 가시아메바 KA/L5주는 형태학적으로 제2군에 속하였고, rDNA PCR-RFLP 결과 A. lugdunensis로 동정되었다. 미토콘드리아 DNA RFLP와 동위효소 분석상 이 충주는 국내 콘택트렌즈 보존용기에서 가장흔히 분리되는 type인 KA/Ll주, 국내 임상 분리주 중 하나인 KA/E2주, 내공생세균을 가지는 것으로 보고된 병원 냉각수 유래 KA/W4주 및 L3a주와 동일하거나 매우 유사한 성적을 보였다. 내공생세균은 약 1.38× 0.507㎛의 크기였고, 아메바 세포질 내에 불규칙하게 분포하고 있었으며. 그 표면에 아메바의 ribosome이 부착되어 있었다. 내공생세균을 둘러싼 lacunae나 막과 같은 구조는 관찰되지 않았다. Legionella 특이 primer를 이용한 효소중합반응(PCR)에서 내공생세균의 염색체 DNA는 증폭되지 않았다. A. lugdunensis의 우리말 이름을 담수가시아메바로 제안한다. Transmission electron microscopy of an Acanthamieba isolate (KA/L5) from a contact lens case revealed bacterial endosymbionts within cytoplasm of the amoebae, The Acanthamoeba isolate belonged to the morphological group II. Based on the polymerase chain reaction (PCR) - restriction fragment length Polymorphism (RFLP) of 18S ribosomal RNA coding DNA (rDNA), the Isolate was identified as A. lugdunensis. Strain typing by isoenzyme analysis using isoelectric focusing (IEF) and mitochondrial (Mt) DNA RFLP revealed that the isolate was closely related with KA/Ll , the most predominant type of isolates from contact lens storage cases, KA/E2, a clinical isolate, KA/W4, preciously reported to host endosymbionts, and L3a strains of A. lugdunensis. The endosymbionts were similar to those of KA/W4 In aspects that they were randomly distributed in both trophozoites and cysts, and were rod-shaped bacteria measuring approximately 1.38x 0.50㎛. But the number of endosymbionts per amoeba was significantly lower than that of KA/W4. They were neither limited by phagosomal membranes nor included In lacunae- like structure.

From microchannels to microphysiological systems: Development of application specific devices

Yu, James,Lim, Jungeun,Choi, MunSeok,Chung, Minhwan,Jeon, Noo Li Elsevier 2018 MICROELECTRONIC ENGINEERING Vol.202 No.-

<P><B>Abstract</B></P> <P>Microphysiological systems are an emerging field of biomimetic technologies which utilize microfluidics to reconstitute tissue functions within an <I>in vitro</I> environment. Microfluidic organ-on-a-chip platforms exist at the intersection of biology and engineering, straddling the forefront of cutting edge biological research, fluidics, and microfabrication technologies to emulate complex <I>in vitro</I> tissue systems within a highly controllable, accessible, and observable, <I>in vitro</I> environment. Although the advance of cell culture technologies from comparatively rudimentary conventional 2D petri dish based cultures to sophisticated 3D tissue engineering may seem futuristic, the microfluidic engineering concepts behind organ-on-a-chip technologies have deep historical roots which span over half a century. In this paper, we will discuss the shortcomings of conventional cell culture and organ modeling platforms which contributed to the demand for <I>in vitro</I> tissue engineering, as well as provide a background in the technological foundations of microfluidics. We will further recount a brief history of microfluidic cell culture, with emphasis on important developments in fabrication practices and methods of engineering biologically relevant microenvironmental conditions, before discussing the present state of organ specific microfluidic platforms and the future directions that the field may take to overcome present challenges.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

The EGF/hnRNP Q1 axis is involved in tumorigenesis via the regulation of cell cycle-related genes

Yu-Chu Wang,Kung-Chao Chang,Bo-Wen Lin,Jenq-Chang Lee,Chien-Hsien Lai,Li-Jyuan Lin,Yun Yen,Chang-Shen Lin,Shiang-Jie Yang,Peng-Chan Lin,Chung-Ta Lee,Liang-Yi Hung 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-

Heterogeneous nuclear ribonucleoprotein (hnRNP) Q1, an RNA-binding protein, has been implicated in many posttranscriptional processes, including RNA metabolism and mRNA splicing and translation. However, the role of hnRNP Q1 in tumorigenesis remains unclear. We previously performed RNA immunoprecipitation (RIP)-seq analysis to identify hnRNP Q1-interacting mRNAs and found that hnRNP Q1 targets a group of genes that are involved in mitotic regulation, including Aurora-A. Here, we demonstrate that altering the hnRNP Q1 level influences the expression of the Aurora-A protein, but not its mRNA. Stimulation with epidermal growth factor (EGF) enhances both binding between hnRNP Q1 and Aurora-A mRNA as well as the efficacy of the hnRNP Q1-induced translation of Aurora-A mRNA. The EGF/hnRNP Q1-induced translation of Aurora-A mRNA is mediated by the mTOR and ERK pathways. In addition, we show that hnRNP Q1 up-regulates the translation of a group of spindle assembly checkpoint (SAC) genes. hnRNP Q1 overexpression is positively correlated with the levels of Aurora-A and the SAC genes in human colorectal cancer tissues. In summary, our data suggest that hnRNP Q1 plays an important role in regulating the expression of a group of cell cycle-related genes. Therefore, it may contribute to tumorigenesis by up-regulating the translation of these genes in colorectal cancer.

Changes in prostate-specific antigen kinetics during androgen-deprivation therapy as a predictor of response to abiraterone in chemonaïve patients with metastatic castration-resistant prostate cancer

Chung-Lin Lee,Ying-Hsu Chang,Chung-Yi Liu,Ming-Li Hsieh,Liang-Kang Huang,Yuan-Cheng Chu,Hung-Cheng Kan,Po-Hung Lin,Kai-Jie Yu,Cheng-Keng Chuang,Chun-Te Wu,See-Tong Pang,I-Hung Shao 대한비뇨의학회 2022 Investigative and Clinical Urology Vol.63 No.5

Purpose: Metastatic castration-resistant prostate cancer (mCRPC) has a poor prognosis. Abiraterone acetate (AA), enzalutamide, and chemotherapy are first-line treatments for patients with mCRPC. This study examined prognostic factors for AA response in the form of prostate-specific antigen (PSA) kinetics throughout androgen-deprivation therapy (ADT) in chemonaïve patients with mCRPC. Materials and Methods: We retrospectively included data from 34 chemonaïve patients with mCRPC who had received AA at some point between January 2017 and December 2018. We separated patients into two study arms according to the decrease in PSA percentages after use of AA for 3 months. We correlated PSA kinetics parameters with response and compared the two study groups with respect to PSA kinetics. Results: The patients’ median age was 77 years. In the total group of patients, 64% had a response to AA, whereas 35% did not. The ratio of the PSA level at nadir to the level during ADT was significantly higher in the AA-sensitive group (19.78 vs. 1.03, p=0.019). Conclusions: Patients who experienced a dramatic change in PSA level during ADT were more likely to be resistant to AA after progression to mCRPC. Chemotherapy rather than AA might be more suitable as a first-line treatment for these patients.

Protective Factors of Demoralization among Cancer Patients in Taiwan: An Age-matched and Gender-matched Study

Yu-Chi Li,Chung-Han Ho,Hsiu-Hung Wang 한국간호과학회 2017 Asian Nursing Research Vol.11 No.3

Purpose: This study aimed to explore the protective factors of demoralization in cancer patients via investigation of cancer patients' demographic and disease characteristics. Methods: This was a cross-sectional descriptive study. We used a structured questionnaire, which contained items on demographic and disease characteristics, as well as the Demoralization Scale Mandarin Version (DS-MV), with a cutoff of 30 or more indicating high demoralization. Data were analyzed with age-matched and gender-matched conditional logistic regression analysis. For the study, 428 questionnaires were delivered and 411 were recovered. After being age-matched and gender-matched, 182 participants of high demoralization (DS-MV > 30) and low demoralization (DS-MV 30) were obtained respectively, for a total of 364 participants. Results: Cancer patients' demoralization was significantly related to family support (p = .019), education (p = .049), and monthly income (p = .001). Family support [odds ratio = 0.38; p = .028; 95% confidence interval (0.16, 0.91)] and monthly income [odds ratio = 0.49; p = .009; 95% confidence interval (0.29, 0.84)] were protective factors of demoralization in cancer patients. Conclusion: Early and appropriate demoralization assessment of cancer patients' demographic and disease characteristics is very important in clinical settings. Healthcare providers might regularly monitor demoralization in cancer patients, and develop related nursing care guidelines or treatment for demoralization in cancer patients. The study results can be a reference for healthcare providers who work with cancer patients.

Molecular Identification of Diphyllobothrium latum from a Pediatric Case in Taiwan

Yu-Chin An,Chia-Cheng Sung,Chih-Chien Wang,Hsin-Chung Lin,Kuang-Yao Chen,Fu-Man Ku,Ruei-Min Chen,Mei-Li Chen,Kuo-Yang Huang 대한기생충학열대의학회 2017 The Korean Journal of Parasitology Vol.55 No.4

MANAGING INNOVATION PERFORMANCE: A SERVICE-DOMINANT LOGIC VIEW

Li-Wei Wu,Chung-Yu Wang,Ya-Ting Wu 글로벌지식마케팅경영학회 2014 Global Marketing Conference Vol.2014 No.7

Partnerships have become an important research topic. However, the amount of empirical attention devoted to determining how firms intensively co-produce with alliance partners to improve their innovation performance is lacking. In response to the growing importance of co-production in the partnerships, this study addresses how firms integrate their alliance partners as co-creators into the innovation process. Specifically, this study not only integrates the three dimensions of social capital and examines their separate effects on co-production but also incorporates the roles of absorptive capacity and self-efficacy and investigates their influences on innovation. That is, co-production may operate through absorptive capacity and self-efficacy to increase innovation because knowledge is exchanged and utilized and firms are willing to select challenging goals and remain firmly committed to fulfill them within the network. The proposed model is tested with a structural equation model(SEM). Findings indicate positive relationships between social capital and co-production. Moreover, co-production has positive effects on innovation, absorptive capacity, and self-efficacy. Absorptive capacity and self-efficacy enhance innovation. As such, we suggest that co-production should be considered explicitly in the management of a partnership and should be developed through mentioned above platform, encouraging and enabling both parties to work together for the implementation of innovation.

중국 교사자격제도의 의제설정 과정 분석

여유연(Li Yu Yan),장선희(Jang Seon Hee),정제영(Chung Jae Young) 한국비교교육학회 2018 比較敎育硏究 Vol.28 No.4

본 연구는 1978년부터 2018년까지 중국 교사자격제도의 의제설정 과정을 어느 집단이 주도하였는지에 대해 Cobb과 Elder(1972)와 Cobb 등(1976)의 이론모형을 활용하여 분석하였다. 1978년부터 2018년까지 약 40여 년의 기간을 교사자격제도 도입기(1978∼1992), 교사자격제도 과도기(1993∼1998), 교사자격제도 안정기(1999∼현재)로 구분하여 시기별 교사자격제도의 의제설정과정을 분석하였다. 연구 결과, 중국 교사자격제도의 의제설정 과정을 주도한 집단은 시기에 따라 다르게 나타났다. 교사자격제도 도입기는 정책결정자 및 정부가 주도한 ‘내부접근형’, 교사자격제도 과도기는 중국 정부 및 교육부가 주도한 ‘동원형’, 교사자격제도 안정기는 대중매체, 연구자, 정부 등 다양한 집단이 주도한 ‘외부주도형’으로 나타났다. 이를 통해 중국 교사자격제도의 의제설정 과정이 중국 사회의 발전정도에 따라 민주화되는 방향으로 변화하고 있으며, 중국교사자격에 대한 질 관리도 강화되고 있음을 확인하였다. The purpose of this study is to analyze which group led the process of agenda setting of teacher’s certification system in China from 1978 to 2018 using the Cobb & Elder’s theoretical model. The period of about 40 years from 1978 to 2018 is divided into the introduction period of teacher’s certification period (1978∼1992), transition period (1993∼1998), and stabilization stage (1999∼2018). The agenda setting process was analyzed. As a result, the group that led the process of agenda setting of the Chinese teacher’s certification system varied according to the period. The introduction period of teacher’s certification system was analyzed as ‘Inside Access Model’ led by policy makers and government, and the transition period was confirmed as ‘Mobilization Model’ led by Chinese government and Ministry of Education. The stabilization period was analyzed as ‘Outside Initiative Model’ led by various groups such as mass media, researchers, and government. It was found that the process of agenda setting of teacher’s certification system had been changing toward democratization according to the degree of development of Chinese society, and the quality control of teacher certifications had been strengthened.