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- 저자 : Li Yansheng (검색결과 3 건)
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The rapid synthetic strategy of [11C]PIB via disposable column cartridge purification
이지혜,Yansheng Li,이상윤,IDOTATSUO 대한방사성의약품학회 2020 Journal of radiopharmaceuticals and molecular prob Vol.6 No.2
PIB is the first amyloid plaque PET image tracer reported for the first time in 2003, and is considered to be the best and is still being utilized due to its very high uptake and kinetic properties. Initially, it was synthesized by radioisotope labeling using a precursor containing a methoxy methyl protection group, but now it is synthesized using a 6-OH precursor that can be easily synthesized in one step using [11C]methyl triflate. Carbon-11 has several limitations in clinical studies using PET because its half-life is as short as 20 minutes. In this study, in order to overcome the difficulty of this half-life, a rapid method using Sep-Pak was adopted instead of HPLC purification to significantly reduce the burden of the purification process and attempted synthesis. As a result, the synthesis time was shortened by more than 50%, and the yield of the final compound was higher than the previous result and showed relatively high specific radioactivity, confirming that it is a strategic method with high applicability for various precursors having primary amines.
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Yongshang Tian,Shuiyun Li,Bingqian Zhang,Yansheng Gong,Peng Liu,Xiongjie Hu,Qiangshan Jing 한양대학교 세라믹연구소 2022 Journal of Ceramic Processing Research Vol.23 No.4
The electrical properties of piezoelectric ceramics are temperature-dependent, which affects their potential for applications inenvironments with temperature variation. In this work, Yb3+ and Tm3+ co-doped Ba0.95Ca0.05Ti0.90Zr0.10O3 (BCTZ-YT) denselead-free ceramic was prepared using a modified polymeric precursor route. On the basis of structural and electricalmeasurements at various temperatures, the mechanism of a lack of oxygen vacancies, small structural defects, and small defectdipoles was deduced. This study reveals that the ferroelectricity and piezoelectricity are temperature-dependent, whereas thecapacitance is essentially unchanged with increasing temperature owing to the presence of a pure orthorhombic phase. Thecapacitance of the BCTZ-YT ceramic was essentially constant at ~4.5 nF, the thermal expansion coefficient was 8.57 × 10−6 K−1below 75 oC, and the piezoelectric response (d33*) was above 416 pm/V in a wide temperature range (-20 to 40 oC), suggestingthe results of this study are expected to inform future research.
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Discontinuation Rate of Newly Prescribed Donepezil in Alzheimer's Disease Patients in Asia
박기형,양영순,Chen Christopher,심용수,Domingueze Jacqueline C.,이찬녕,강경훈,김희진,정슬기,정지향,Hong Zhen,윤수진,Zhang Zhen-Xin,김은주,장재원,Li Yansheng,Xu Yun,Lin Yu-Te,Qu Qiumin,Hu Chaur-Jong,Chou Chih-Ho,Fan Dongsheng,Kandiah N 대한신경과학회 2021 Journal of Clinical Neurology Vol.17 No.3
Background and Purpose The rate of donepezil discontinuation and the underlying reasons for discontinuation in Asian patients with Alzheimer’s disease (AD) are currently unknown. We aimed to determine the treatment discontinuation rates in AD patients who had newly been prescribed donepezil in routine clinical practice in Asia. Methods This 1-year observational study involved 38 institutions in seven Asian countries, and it evaluated 398 participants aged 50–90 years with a diagnosis of probable AD and on newly prescribed donepezil monotherapy. The primary endpoint was the rate of donepezil discontinuation over 1 year. Secondary endpoints included the reason for discontinuation, treatment duration, changes in cognitive function over the 1-year study period, and compliance as assessed using a clinician rating scale (CRS) and visual analog scale (VAS). Results Donepezil was discontinued in 83 (20.9%) patients, most commonly due to an adverse event (43.4%). The mean treatment duration was 103.67 days in patients who discontinued. Among patients whose cognitive function was assessed at baseline and 1 year, there were no significant changes in scores on the Mini-Mental State Examination, Montreal Cognitive Assessment, and Trail-Making Test–Black and White scores, whereas the Clinical Dementia Rating score increased significantly (p<0.001). Treatment compliance at 1 year was 96.8% (306/316) on the CRS and 92.6±14.1% (mean±standard deviation) on the VAS. Conclusions In patients on newly prescribed donepezil, the primary reason for discontinuation was an adverse event. Cognitive assessments revealed no significant worsening at 1 year, indicating that continuous donepezil treatment contributes to the maintenance of cognitive function.
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