A LightGBM and XGBoost Learning Method for Postoperative Critical Illness Key Indicators Analysis

( Lei Han ),( Yiziting Zhu ),( Yuwen Chen ),( Guoqiong Huang ),( Bin Yi ) 한국인터넷정보학회 2023 KSII Transactions on Internet and Information Syst Vol.17 No.8

Accurate prediction of critical illness is significant for ensuring the lives and health of patients. The selection of indicators affects the real-time capability and accuracy of the prediction for critical illness. However, the diversity and complexity of these indicators make it difficult to find potential connections between them and critical illnesses. For the first time, this study proposes an indicator analysis model to extract key indicators from the preoperative and intraoperative clinical indicators and laboratory results of critical illnesses. In this study, preoperative and intraoperative data of heart failure and respiratory failure are used to verify the model. The proposed model processes the datum and extracts key indicators through four parts. To test the effectiveness of the proposed model, the key indicators are used to predict the two critical illnesses. The classifiers used in the prediction are light gradient boosting machine (LightGBM) and eXtreme Gradient Boosting (XGBoost). The predictive performance using key indicators is better than that using all indicators. In the prediction of heart failure, LightGBM and XGBoost have sensitivities of 0.889 and 0.892, and specificities of 0.939 and 0.937, respectively. For respiratory failure, LightGBM and XGBoost have sensitivities of 0.709 and 0.689, and specificity of 0.936 and 0.940, respectively. The proposed model can effectively analyze the correlation between indicators and postoperative critical illness. The analytical results make it possible to find the key indicators for postoperative critical illnesses. This model is meaningful to assist doctors in extracting key indicators in time and improving the reliability and efficiency of prediction.

Trends in Specific Immunotherapy for Allergic Rhinitis: A Survey of Chinese ENT Specialists

Han Zhou,Qi-Lei Tao,Jun-Min Wei,Geng Xu,Lei Cheng 대한천식알레르기학회 2014 Allergy, Asthma & Immunology Research Vol.6 No.4

Purpose: Specific immunotherapy (SIT) is a suitable but uncommon treatment option for allergic rhinitis (AR) in China. The current understandingand attitude of Chinese ENT (ear, nose, and throat) specialists in regards to SIT is unclear. This study investigates current trends in the awarenessand application status of SIT among Chinese ENT specialists. Methods: We performed a nationwide, cross-sectional survey with a specially designedquestionnaire given to 800 ENT specialists in China. A member of the trained research group conducted face-to-face interviews with eachrespondent. Results: Most of the respondents considered AR (96.0%) and allergic asthma (96.0%) the most suitable indications for SIT. Of all respondents,77.0% recommended the application of SIT as early as possible; in addition, SIT was considered ‘relatively controllable and safe’ bymost respondents (80.6%). The highest allergen-positive rate in AR was associated with house dust mite (47.7%) and obvious differences existedamong geographical regions. Conventional subcutaneous immunotherapy was the most highly recommended treatment option (96.2%). ‘The highcost of SIT’ (86.6%) and ‘lack of patient knowledge of SIT’ (85.2%) were probably the main reasons for the lower clinical use of SIT in China. Conclusions:Most cases showed that the opinions of Chinese ENT specialists appeared to be in agreement with recent SIT progress and internationalguidelines; however, many areas still need to enhance the standardization and use of SIT in China. Clinical guidelines for SIT require improvement;in addition, Chinese ENT specialists need continuing medical education on SIT.

Improved Work Function of Preferentially Oriented Indium Oxide Films Induced by the Plasma Exposure Technique

Lei Yang,Shuai Guo,Qiuling Yang,Yuankun Zhu,Bing Dai,Hailing Yu,Pei Lei,Jiecai Han,Ying Hou,Jiaqi Zhu 대한금속·재료학회 2015 ELECTRONIC MATERIALS LETTERS Vol.11 No.6

The preferentially oriented In2O3 thin films were prepared on glass substrates by conventional magnetron sputtering with Ar+ plasma exposure at room temperature. Based on the x-ray diffraction, x-ray photoelectron spectroscopy, and UV photoelectron spectroscopy results, it was found that the Ar+ plasma exposure not only enhanced the low-temperature crystallization of In2O3 thin films, but also led to a dramatic improvement in the work function. Furthermore, it demonstrated that the shift mechanism of the work function in In2O3 thin films mainly combined with theelimination of oxygen defects and the change of the preferential orientation of In2O3 film surface.

논문(論文) : 종사건범주도사건명사(從事件範疇到事件名詞)

한뢰 ( Lei Han ) 고려대학교 중국학연구소 2011 中國學論叢 Vol.31 No.-

As a philosophical and cognitive concept, event is a secondary category derived from the thing and the action, and has the fused features of time and space, dynamic and static. For most languages, the mapping from the pragmatic reference category and the semantic event category to the grammatical noun form is a marked one. Comparing English and Chinese, during the connective process from the event sentence to pure event noun, English has rich forms of nominalization with slightly difference approaching to event noun, which cannot be found in Chinese. So how the event category is mapped in Chinese nouns should be paid more attention to.

Is Surgical Resection Justified for Hepatocellular Carcinoma with Portal Vein Tumor Thrombus? (A Systematic Review and Meta-Analysis)

( Liang Lei ),( Xin-fei Xu ),( Jiong-jie Yu ),( Ju-dong Li ),( Zhen-li Li ),( Jun Han ),( Han Zhang ),( Hao Xing ),( Han Wu ),( Ming-da Wang ),( Chao Li ),( Zheng Wang ),( Feng Shen ),( Meng-chao Wu ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: The prognosis of hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT) is very poor. According to the BCLC treatment recommendations, sorafenib or other palliative treatment (PT) is recommended as the first-line therapy when it happens. In real world, however, a significant number of selected patients with HCC and PVTT suffered from surgical resection (SR). Methods: PubMed, Embase, Medline and Cochrane library were searched for studies comparing SR with PT (including TACE, sorafenib, etc.) for HCC with PVTT, which were published before September 2017. Results: 4,810 patients from 7 studies were enrolled in this meta-analysis, which divided into the SR group (n = 2,344) and the PT group (n = 2476). When compared with the PT group, the pooled hazard ratio (HR) for the 1, 3 and 5-year OS rates of the SR group were 0.56 (95% CI 0.52-0.60, P=0.03), 0.56 (95% CI 0.53-0.59, P<0.001) and 0.55 (95% CI 0.54-0.57, P<0.001). For subgroup analysis, when compared with the mere TACE group, the pooled HR for the 1, 3 and 5-year OS rates of the SR group were 0.54 (95% CI 0.43-0.67, P=0.81), 0.75 (95% CI 0.65-0.87, P=0.25) and 0.76 (95% CI 0.67-0.88, P=0.25). Conclusions: This meta-analysis demonstrated SR had better OS than TACE or other palliative therapy for HCC with PVTT. SR may be suitable as the first-line treatment for selected patients with resectable HCC and removable PVTT.

The Numerical Simulation Analysis of Flow Field in Level Control Valve of Water Storage Tank

Yaping Wang,Lei Gao,Jianghua Ge,Han Gao,Jing Zhang 보안공학연구지원센터 2014 International Journal of Control and Automation Vol.7 No.10

Level control valve of water storage tank is installed in the outlet of tank, which control the water level of water storage tank by adjusting the water emissions, which make great significance for the safe operation of the super (super) criticality thermal power unit boiler . Complete the simulation analysis of internal flow field by the method of numerical simulation ,in order to achieve structure improvements of level control valve of water storage tank, that make level control valve of water storage tank better meet the work requirements. Establish flow channel model and mesh models of level control valve of water storage tank in various stages of the open process. Make three dimensional viscous numerical simulation of the internal complex flow field by the computational fluid dynamics software of ANSYS CFX. The error between the simulation values of the flow coefficient and the theoretical values , trial values is less than 5% ,which verifies the correctness of the simulation results . Get pressure contour , velocity streamline diagrams and outlet mass flow of level control valve of water storage tank in various stages of the open process. According to the pressure contours and velocity streamline diagrams, make detailed analysis of the flow field of level control valve of water storage tank. According to the dates of outlet mass flow, fit the flow characteristic curve of level control valve of water storage tank. Provide a theoretical basis for the structural design of level control valve of water storage tank.

LTS Semantics Model of Event-B Synchronization Control Flow Design Patterns

Han Peng,Chenglie Du,Lei Rao,Zhouzhou Liu 한국정보처리학회 2019 Journal of information processing systems Vol.15 No.3

The Event-B design pattern is an excellent way to quickly develop a formal model of the system. Researchershave proposed a number of Event-B design patterns, but they all lack formal behavior semantics. This makesthe analysis, verification, and simulation of the behavior of the Event-B model very difficult, especially for thecontrol-intensive systems. In this paper, we propose a novel method to transform the Event-B synchronouscontrol flow design pattern into the labeled transition system (LTS) behavior model. Then we map the designpattern instantiation process of Event-B to the instantiation process of LTS model and get the LTS behaviorsemantic model of Event-B model of a multi-level complex control system. Finally, we verify the linear temporallogic behavior properties of the LTS model. The experimental results show that the analysis and simulation ofsystem behavior become easier and the verification of the behavior properties of the system become convenientafter the Event-B model is converted to the LTS model.

Transcriptome reveals genes involving in black skin color formation of ducks

Lei Wang,Hehe Liu,Bo Hu,Jiwei Hu,Hengyong Xu,Hua He,Chunchun Han,Bo Kang,Lili Bai,Rongping Zhang,Jiwen Wang,Shengqiang Hu,Liang Li 한국유전학회 2021 Genes & Genomics Vol.43 No.2

Background Skin color is colorful for birds, which has been reported to be associated with multi-biological functions, such as crypsis, camoufage, social signaling and mate choice, but little is known about its underlying molecular mechanism. Objective Studies on the major genes afecting the black skin color of ducks. Methods For this purpose, Silver ammonia staining and RNA-seq analysis were carried out to identify the diferences in tissue morphology and gene expressions between black and yellow skin ducks. Results The silver ammonia dyes slice results showed that in the development of black duck, the content of melanin in black skin gradually increased and then decreased, and the content of melanin in yellow and black skin was signifcantly diferent. Through transcriptome, a total of 102 and 84 diferentially expressed genes (DEGs) were identifed in beak skin and web skin, respectively. These DEGs were enriched in melanin biosynthesis and play a critical role in melanogenesis pathway. Co-expression analysis showed that EDNRB2 was the only gene associated with black skin color in DEGs, which was also consistent with qRT-PCR. Conclusions The melanin synthesis pathway dominated by EDNRB2 up-regulated the amount of melanin synthesis, leading to the formation of black skin in ducks.

Y-Single Nucleotide Polymorphisms Diversity in Chinese Indigenous Horse

Han, Haoyuan,Zhang, Qin,Gao, Kexin,Yue, Xiangpeng,Zhang, Tao,Dang, Ruihua,Lan, Xianyong,Chen, Hong,Lei, Chuzhao Asian Australasian Association of Animal Productio 2015 Animal Bioscience Vol.28 No.8

In contrast to high genetic diversity of mitochondrial DNA (mtDNA), equine Y chromosome shows extremely low variability, implying limited patrilines in the domesticated horse. In this study, we applied direct sequencing and restriction fragment length polymorphism (RFLP) methods to investigate the polymorphisms of 33 Y chromosome specific loci in 304 Chinese indigenous horses from 13 breeds. Consequently, two Y-single nucleotide polymorphisms (SNPs) (Y-45701/997 and Y-50869) and one Y-indel (Y-45288) were identified. Of those, the Y-50869 (T>A) revealed the highest variation frequency (24.67%), whereas it was only 3.29% and 1.97% in Y-45288 (T/-) and Y-45701/997 (G>T) locus, respectively. These three mutations accounted for 27.96% of the total samples and identified five Y-SNP haplotypes, demonstrating genetic diversity of Y chromosome in Chinese horses. In addition, all the five YSNP haplotypes were shared by different breeds. Among 13 horse breeds analyzed, Balikun horse displayed the highest nucleotide diversity (${\pi}=5.6{\times}10^{-4}$) and haplotype diversity (h = 0.527), while Ningqiang horse showed the lowest nucleotide diversity (${\pi}=0.00000$) and haplotype diversity (h = 0.000). The results also revealed that Chinese horses had a different polymorphic pattern of Y chromosome from European and American horses. In conclusion, Chinese horses revealed genetic diversity of Y chromosome, however more efforts should be made to better understand the domestication and paternal origin of Chinese indigenous horses.

Lack of Effects of HER-2/neu on Prognosis in Colorectal Cancer: a Meta-analysis

Han, Jun,Meng, Qing-Yang,Liu, Xiao,Xi, Qiu-Lei,Zhuang, Qiu-Lin,Wu, Guo-Hao Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.14

Background: The prognostic value of human epidermal growth factor receptor-2 (HER-2/neu) for survival of patients with colorectal cancer (CRC) is still ambiguous. We therefore performed a meta-analysis to evaluate its prognostic significance. Materials and Methods: We searched the MEDLINE and EMBASE databases for published literature investigating associations between HER-2/neu status and overall survival of patients with CRC. A meta-analysis was performed using a DerSimonian-Laird model and publication bias was investigated by Begg's and Egger's tests. Subgroup analysis was also conducted according to the study design type, study quality score, cut-off value for HER-2/neu overexpression, publication region, patient number and publication year. Results: A total of 17 eligible studies involving 2,347 patients were identified for this meta-analysis. The combined hazard ratio (HR) was 1.31 (95% confidence interval (CI): 0.96-1.79), suggesting that HER-2/neu overexpression was not significantly associated with overall survival of patients with CRC. However, subgroup analysis revealed that HER-2/neu overexpression had an unfavorable impact on survival when the analysis was restricted to subgroups of study quality score ${\leq}5 $(HR=1.56, 95%CI: 1.17-2.10), Asian patients (HR=1.74, 95%CI: 1.22-2.49), patient number ${\leq}106$ (HR=1.57, 95%CI: 1.01-2.44), publication year before 2003 (HR=1.59, 95%CI: 1.02-2.49), and prospectively designed study (HR=3.62, 95%CI: 1.42-9.24). The effect disappeared in subgroups of study quality scores > 5 (HR=0.69, 95%CI: 0.33-1.44), non Asian patients (HR=1.14, 95%CI: 0.77-1.70), patients' number > 106 (HR=1.07, 95%CI: 0.67-1.72), publication year after 2003 (HR=1.13, 95%CI: 0.76-1.69), and retrospectively designed study (HR=1.22, 95%CI: 0.89-1.67). Conclusions: Our meta-analysis suggests that HER-2/neu overexpression might not be a significantly prognostic indicator for patients with CRC. Further studies are required to confirm these results.