의약정보담당자(MR)의 기능 및 역할에 관한 연구

이동일,제해관,윤석준,안형식,문영배 한국의료QA학회 2003 한국의료질향상학회지 Vol.10 No.1

Background : Aim of this study is focused on the analysis of the needed abilities of medical representatives resulting in building up the market and increasing sales. It is to propose methods to increase this ability ensuring continuous growth in market share and profit. Methods : A survey was conducted between January 6 and May 31, 2003. Using SPSS(Version 10.0), the collected data was analyzed by Hotelling T2, factor analysis. Some hypotheses were selected to include the conclusion. Some questionnaires for physicians working in hospitals or clinics and the medical representatives working in a pharmaceutical company were created and asked to them to either prove or reject those hypotheses. The results were analyzed to find the primary factors that effect the interactions between physician and the medical representatives. These factors were also studied along with the theoretical research based on published references. Results : The results were as follows. The main reasons for the physician to meet with a medical representatives were collection of product informations needed for patient treatment and collection of informations on current medical issue and as well as personal interests. The main parameters by which physicians evaluate the medical representatives are human relationship including sincerity and manners and supply of accurate and unbiased information on products. Overall, the medical representatives’ perception on the importance of medical knowledge and ability to deliver it are lower than that expected by physicians. Conclusion : Medical and pharmaceutical companies’ environment are changed rapidly. And those changes forced medical representatives to set new roles and competency. In order to drive away from the past ‘rule of thumb’ and ‘adaptation to circumstance’, optimal method and systemic development to train and support the medical representatives should be quipped. They will help ,medical representatives to be specialists in medical knowledge and to understand the exact need of health care professions. Product competitiveness will be increased and eventually successful business can be achieved through it.

Acoustic Duct 내부에 장착된 아이오노머의 이온기 변화에 따른 흡음패턴 측정

장순석,김준섭,이제형,박재철 조선대학교 전자정보통신연구소 2001 電子情報通信硏究所論文誌 Vol.4 No.2

Nowadays, as the industrial technology and instrumentation are developed, the interest of the characteristic improvement of sound absorbing materials is rising. Recently new sound absorbing materials are being developed and manufactured for commercialization. But most of sound absorbing materials are polymer-typed or are fabricated by polymers (mixtures of polymer and glass fiber, asbestos...) for better physical characteristic. However, there was not much research about sound absorption change by the change of the ionic nature. In this paper, I composed polymers that include alkaline or acid, or other polymer that have the ionic nature to improve sound absorption characteristic and searched the characteristic pattern of the sound absorption of polymer. I used probe microphone instead of 1/4 condenser microphone such as two- microphone method in order to measure in-duct absorption coefficient of specimen of ionomers that are thin and small so that measuring absorption coefficient is not well defined.

움직이는 물체의 거리 및 속도 측정을 위한 고전력 쏘나 시스템 개발

장순석,안홍구,이제형 조선대학교 에너지.자원신기술연구소 1999 에너지·자원신기술연구소 논문지 Vol.21 No.2

This paper aims for the development of the high power sonar system for measuring the distance and the velocity of a moving object. The high power sonar system transmits two gated 190 KHz sinusoidal signals with 1.6〔ms〕 time interval to the moving object. Then the sonar system detects and calculates the changed time delay of the reflected ultrasonic signals in order to derive the velocity of the moving object. The transmission part uses a high power amplifier so that 250W gated sinusoidal signals can be transmitted to the transmitter. 1M RAM is utilized for transmitting and storing of the ultrasonic signals. The time delay is calculated by the cross-correlation technique between the transmitted signals and the received signals. The measured value from the high power sonar system is compared with directly measured values by photo diodes. The result confirms the adjacency to 0.3% error.

Pilot Study About the Effects of the Soma Experiencing Motion (Soma e-Motion) Program on Interoceptive Awareness and Self-Compassion

Mi-Sun Lee(Mi-Sun Lee),Sun Je Kim(Sun Je Kim),Jeong-Ho Chae(Jeong-Ho Chae),Soo-Young Bhang(Soo-Young Bhang),Mimi Lee(Mimi Lee),Hyeong Beom Kim(Hyeong Beom Kim),Hyu Jung Huh(Hyu Jung Huh) 대한신경정신의학회 2023 PSYCHIATRY INVESTIGATION Vol.20 No.3

Objective The purpose of this study was to examine the effects of the Soma experiencing motion (Soma e-motion) program on interoceptive awareness and self-compassion among novices. Methods A total of 19 adults (clinical group=9, non-clinical group=10) participated in the intervention. Psychological and physical changes after program were qualitatively analyzed using in-depth interviews. The Korean Multidimensional Assessment of Interoceptive Awareness (K-MAIA) and the Korean version of the Self-Compassion Scale (K-SCS) were used as quantitative measures. Results The non-clinical group showed statistically significant differences in the K-MAIA scores (z=-2.805, p<0.01) and K-SCS scores (z=-2.191, p<0.05); however, the clinical group showed no significant differences (K-MAIA: z=-0.652, p>0.05; K-SCS: z=-0.178, p>0.05). According to the in-depth interviews, the results of the qualitative analysis were categorized into five dimensions (psychological and emotional, physical, cognitive, behavioral, and aspects participants found challenging and needs improvement). Conclusion The Soma e-motion program was feasible for improving interoceptive awareness and self-compassion in the non-clinical group. However, further research is needed to investigate the clinical efficacy of the Soma e-motion program for clinical group.

Matrix metalloproteinase-13 downregulation and potential cartilage protective action of the Korean Red Ginseng preparation

Lee, Je Hyeong,Shehzad, Omer,Ko, Sung Kwon,Kim, Yeong Shik,Kim, Hyun Pyo The Korean Society of Ginseng 2015 Journal of Ginseng Research Vol.39 No.1

Background: The present study was designed to prepare and find the optimum active preparation or fraction from Korea Red Ginseng inhibiting matrix metalloproteinase-13 (MMP-13) expression, because MMP-13 is a pivotal enzyme to degrade the collagen matrix of the joint cartilage. Methods: From total red ginseng ethanol extract, n-BuOH fraction (total ginsenoside-enriched fraction), ginsenoside diol-type-enriched fraction (GDF), and ginsenoside triol-type-enriched fraction (GTF) were prepared, and ginsenoside diol type-/F4-enriched fraction (GDF/F4) was obtained from Panax ginseng leaf extract. Results: The n-BuOH fraction, GDF, and GDF/F4 clearly inhibited MMP-13 expression compared to interleukin-$1{\beta}$-treated SW1353 cells (human chondrosarcoma), whereas the total extract and ginsenoside diol-type-enriched fraction did not. In particular, GDF/F4, the most effective inhibitor, blocked the activation of p38 mitogen-activated protein kinase (p38 MAPK), c-Jun-activated protein kinase (JNK), and signal transducer and activator of transcription-1/2 (STAT-1/2) among the signal transcription pathways involved. Further, GDF/F4 also inhibited the glycosaminoglycan release from interleukin-$1{\alpha}$-treated rabbit cartilage culture (30.6% inhibition at $30{\mu}g/mL$). Conclusion: Some preparations from Korean Red Ginseng and ginseng leaves, particularly GDF/F4, may possess the protective activity against cartilage degradation in joint disorders, and may have potential as new therapeutic agents.

Matrix metalloproteinase-13 downregulation and potential cartilage protective action of the Korean Red Ginseng preparation

Je Hyeong Lee,Omer Shehzad,Sung Kwon Ko,Yeong Shik Kim,Hyun Pyo Kim 고려인삼학회 2015 Journal of Ginseng Research Vol.39 No.3

Background: The present study was designed to prepare and find the optimum active preparation or fraction from Korea Red Ginseng inhibiting matrix metalloproteinase-13 (MMP-13) expression, because MMP-13 is a pivotal enzyme to degrade the collagen matrix of the joint cartilage. Methods: From total red ginseng ethanol extract, n-BuOH fraction (total ginsenoside-enriched fraction), ginsenoside diol-type-enriched fraction (GDF), and ginsenoside triol-type-enriched fraction (GTF) were prepared, and ginsenoside diol type-/F4-enriched fraction (GDF/F4) was obtained from Panax ginseng leaf extract. Results: The n-BuOH fraction, GDF, and GDF/F4 clearly inhibited MMP-13 expression compared to interleukin-1b-treated SW1353 cells (human chondrosarcoma), whereas the total extract and ginsenoside diol-type-enriched fraction did not. In particular, GDF/F4, the most effective inhibitor, blocked the activation of p38 mitogen-activated protein kinase (p38 MAPK), c-Jun-activated protein kinase (JNK), and signal transducer and activator of transcription-1/2 (STAT-1/2) among the signal transcription pathways involved. Further, GDF/F4 also inhibited the glycosaminoglycan release from interleukin-1a-treated rabbit cartilage culture (30.6% inhibition at 30 μg/mL). Conclusion: Some preparations from Korean Red Ginseng and ginseng leaves, particularly GDF/F4, may possess the protective activity against cartilage degradation in joint disorders, and may have potential as new therapeutic agents.

The use of FNA samples for whole-exome sequencing and detection of somatic mutations in breast cancer surgical specimens : FNA for WES in Breast Cancer Specimens

Lee, Han-Byoel,Joung, Je-Gun,Kim, Jisun,Lee, Kyung-Min,Ryu, Han Suk,Lee, Hae-Ock,Moon, Hyeong-Gon,Park, Woong-Yang,Noh, Dong-Young,Han, Wonshik Wiley (John WileySons) 2015 Cancer cytopathology Vol.123 No.11

Matrix metalloproteinase-13 downregulation and potential cartilage protective action of the Korean Red Ginseng preparation

Je Hyeong Lee,Omer Shehzad,고성권,김영식,김현표 고려인삼학회 2015 Journal of Ginseng Research Vol.39 No.1

Background: The present study was designed to prepare and find the optimum active preparation orfraction from Korea Red Ginseng inhibiting matrix metalloproteinase-13 (MMP-13) expression, becauseMMP-13 is a pivotal enzyme to degrade the collagen matrix of the joint cartilage. Methods: From total red ginseng ethanol extract, n-BuOH fraction (total ginsenoside-enriched fraction),ginsenoside diol-type-enriched fraction (GDF), and ginsenoside triol-type-enriched fraction (GTF) wereprepared, and ginsenoside diol type-/F4-enriched fraction (GDF/F4) was obtained from Panax ginseng leafextract. Results: The n-BuOH fraction, GDF, and GDF/F4 clearly inhibited MMP-13 expression compared tointerleukin-1b-treated SW1353 cells (human chondrosarcoma), whereas the total extract and ginsenosidediol-type-enriched fraction did not. In particular, GDF/F4, the most effective inhibitor, blocked theactivation of p38 mitogen-activated protein kinase (p38 MAPK), c-Jun-activated protein kinase (JNK), andsignal transducer and activator of transcription-1/2 (STAT-1/2) among the signal transcription pathwaysinvolved. Further, GDF/F4 also inhibited the glycosaminoglycan release from interleukin-1a-treatedrabbit cartilage culture (30.6% inhibition at 30 mg/mL). Conclusion: Some preparations from Korean Red Ginseng and ginseng leaves, particularly GDF/F4, maypossess the protective activity against cartilage degradation in joint disorders, and may have potential asnew therapeutic agents.

2 Cases of a Benign Pulmonary Metastasizing Leiomyoma

Lee, Eun Joo,Jeong, Hye Cheol,Lee, Sung Yong,Kim, Je Hyeong,Lee, Sang Yeub,Shin, Chol,Shim, Jae Jeong,In, Kwang Ho,Kang, Kyung Ho,Yoo, Se Hwa,Lee, Sang Hoon,Kim, Han-Kyeom,Oh, Yu Whan The Korean Academy of Tuberculosis and Respiratory 2009 Tuberculosis and Respiratory Diseases Vol.67 No.6

A benign pulmonary metastasizing leiomyoma is a recognized clinical entity that has been infrequently reported in the medical literature. We report two cases of a benign pulmonary metastasizing leiomyoma. A 35-year-old woman who underwent myomectomy and a cesarean section approximately 6 years earlier visited our hospital for further evaluation of incidentally revealed multiple lung nodules. A diagnostic percutaneuous biopsy was performed. Finally she was diagnosed with a benign metastasizing leiomyoma. The patient then received LH-RH and has been followed up since. The other 44-year-old woman presented after an initial radiology evaluation revealed the presence of multiple, small-sized lung nodules. She underwent a right middle lung wedge resection to confirm the diagnosis. Finally she diagnosed with a benign metastasizing leiomyoma. The multiple lung nodules have been followed up closely.

5-Lipoxygenase Inhibition of the Fructus of Foeniculum vulgare and Its Constituents

( Je Hyeong Lee ),( Dong Ung Lee ),( Yeong Shik Kim ),( Hyun Pyo Kim ) 한국응용약물학회 2012 Biomolecules & Therapeutics(구 응용약물학회지) Vol.20 No.1

The fruits of Foeniculum vulgare (Foeniculi Fructus) have been widely used in Chinese medicine as an antiemetic, ameliorating stomach ailments and as an analgesic. In order to establish its potential for antiallergic use, inhibitory actions of the fruit on 5-lipoxgenase (5-LOX) and β-hexosaminidase release were evaluated. The 70% ethanol extract of this plant material (FR) considerably inhibited 5-LOX-catalyzed leukotriene production from A23187-induced rat basophilic leukemia (RBL)-1 cells. The IC50 was 3.2 μg/ ml. From this extract, 12 major compounds including sabinene, fenchone, γ-terpinene, α-pinene, limonene, p-anisylacetone, panisylaldehyde, estragole (4-allylanisole), trans-anethole, scopoletin, bergapten and umbelliferone were isolated. And it was found that several terpene derivatives including γ-terpinene and fenchone as well as phenylpropanoid, trans-anethole, showed considerable inhibitory action of 5-LOX. In particular, the IC50 of trans-anethole was 51.6 μM. In contrast, FR and the isolated compounds did not show considerable inhibitory activity on the degranulation reaction of β-hexosaminidase release from antigen-treated RBL-2H3 cells. Against arachidonic acid-induced ear edema in mice, FR and trans-anethole showed significant inhibition by oral administration at doses of 100-400 mg/kg. In conclusion, FR and several major constituents are 5-LOX inhibitors and they may have potential for treating 5-LOX-related disorders.