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Glucocorticoids : Anti-inflammation and Immunosuppression
김현표 한국생화학분자생물학회 1990 생화학분자생물학회 소식 Vol.10 No.4
Glucocorticoid derivatives have been clinically used to treat inflammatory andor immune-malfunctional diseases. Glucocorticoid derivatives bind to cytosolic receptor protein, which is transformed to DNA-binding form. This glucocorticoid-receptor complex moves and binds to GRE region of nulear DNA. Through transcriptional control of various proteins, glucocorticoidal, anti-inflammatory and immunosuppressive activities are expressed. The mechanism of anti-inflammation by glucocorticoid derivatives involves alteration of inflammation-related cell traffics and regulation of production of inflammatory mediators from these cells. And production of lipocortin having PLA, inhibitory action might be an important factor in antiinflammatory activity of glucocorticoids. Glucocorticoids affect more profoundly on cellular immuniy than humoral immunity. And regulation of cytokine production and excretion is one of the essential mechanism in immunosuppressive effect of the derivatives. Glucocorticoid derivatives having anti-inflammatory and/or immune suppressive activity might show adverse systemic side-effects, expecially when prolonged therapy or massive dose therapy is used. To overcome this problem, local anti-inflammatory steroid derivatives have been developed, which may lead to safer use of anti-inflammatoty steroids.
Urokinase Immobilized on Cellulose Membrane
김현표,김남득,염영일,변시명,Kim, Hyun-Pyo,Kim, Nam-Deuk,Yeom, Young-Il,Byun, Si-Myung 생화학분자생물학회 1986 한국생화학회지 Vol.19 No.2
인공신장기에 쓰이는 셀룰로오즈 막에 시아노겐 브로마이드방법을 이용한 공유 결합법으로 혈전용해 효소인 유로키나제을 고정화 시켰다. 단순 흡착시킨 유로키나제가 $17-30{\times}10^{-3}$ CTA unit/cm의 활성을 냈으나 계속 사용할 수 없었고 안정성이 전혀 없는 반면, 고정화된 유로키나제는 $19-38{\times}10^{-3}$ CTA unit/cm 의 활성을 보유하였으며, 높은 안정성을 갖고 있는 것으로 판명되어 임상적 사용의 가능성을 높여 주었다. Urokinase was covalently immobilized to a cellulose hollow fiber membrane with the method of CNBr-activation. The resulted immobilized urokinase showed $19-38{\times}10^{-3}$ CTA unit/cm fiber compared to $17-30{\times}10^{-3}$ CTA unit/cm fiber of the simply adsorbed urokinase which showed the least stability during repeated use. The fibrinolytic activity of the immobilized one was very stable and the immobilized fiber promised a potential clinical use.
Corporate Risk-management Behavior and Earnings Management: Evidence from firms Using Derivatives
김현표,임채창,임성택 한국경영컨설팅학회 2023 경영컨설팅연구 Vol.23 No.3
This study investigates the effect of corporate risk-management behavior through derivatives usage on earnings management. Firms take either a risk-taking position or a risk-averse position, and they use derivatives to control their business risks based on their corporate risk-management behavior. We question whether corporate risk-management behavior affects the firm’s decision-making such as earnings management. In this study, corporate risk-management behavior is measured by the methodology detailed in Zhang’s (2009) paper. Using 3,645 Korean firm data from 2001 to 2012, we find that the firms with risk-taking position through derivatives are more likely to involve earnings management. The empirical results support the argument that firms manage their earnings by veiling their risk-taking activities. We believe that this study contributes to the accounting literature by identifying the relationship between the firm’s risk-taking activities. Also, our comprehensive results provide insight into earnings management which can be employed to hide the firm's risk-taking activities.
김현표,변시명,김남득,염영일 생화학분자생물학회 1991 BMB Reports Vol.19 No.2
Urokinase was covalently immobilized to a cellulose hollow fiber membrane with the method of CNBr-activation. The resulted immobilized urokinase showed 19-38×10^(-3) CTA unit/cm fiber compared to 17-30×10^(-3) CTA unit/㎝ fiber of the simply adsorbed urokinase which showed the least stability during repeated use. The fibrinolytic activity of the immobilized one was very stable and the immobilized fiber promised a potential clinical use.
여드름균에 의해 염증 반응이 유도된 인간 단핵구 세포에서 알칼로이드화합물 berberine의 항염증 효과
김현표,윤영걸 한국응용생명화학회 2018 Journal of Applied Biological Chemistry (J. Appl. Vol.61 No.2
본 연구에서는 인간 단핵구 세포인 THP-1 세포를 이용하여berberine의 항염증 활성을 조사 하였다. Propionibacterium acnes의 감염은 THP-1 세포에서 산화질소(NO)와 TNF-α, IL-8 및 IL-1β와 같은 전 염증성 사이토카인의 생산을 유도했다. 그러나, P. acnes에 의해 유도된 THP-1 세포에 berberine을 처리했을 때, 전 염증성 사이토카인 및 NO의 생성이 유의하게 감소하였다. 또한 우리는 berberine의 항 염증 기능의 신호 전달경로를 분석하여 berberine이 P. acnes 유도 세포에서 ERK1/2, JNK 및 p38의 인산화를 억제하고 NF-κB p65의 발현 및 핵이동을 억제한다는 것을 발견했다. 이러한 결과로부터 berberine 은 인간 단핵구 세포에서 NF-κB 및 MAPK 신호 전달 경로를억제함으로써 항 염증 활성을 효과적으로 발휘할 수 있다고 결론지었다. 또한, 이러한 결과는 P. acnes에 의해 유발된 염증성질환의 치료를 위해 천연물 소재에서 유래한 알칼로이드 화합물인 berberine을 사용하여 천연 치료제를 개발할 수 있는 가능성을 제시하였다. In this study, we investigated the anti-inflammatory activity of berberine using human monocytes. Infection of Propionibacterium acnes induced the production of nitric oxide (NO) and the pro-inflammatory cytokines such as, TNF-α, IL-8 and IL-1β in THP-1 monocytic cells. However, when berberine was supplemented in these P. acnes-induced THP-1 cells, the production of pro-inflammatory cytokines and NO was significantly reduced. We also analyzed signaling pathways of the antiinflammatory function of berberine and found that berberine suppressed the phosphorylation of ERK1/2, JNK and p38 and the expression and nuclear translocation of NF-κB p65 in the P. acnes-induced cells. From these results, we concluded that berberine can effectively exert the anti-inflammatory activity via suppressing the NF-κB and mitogen-activated protein kinases signaling pathways in human monocytes. Moreover, these results suggest the feasibility of developing natural therapeutics using berberine for the treatment of P. acnes-induced inflammatory diseases.
Therapeutic Potential of Medicinal Plants and Their Constituents on Lung Inflammatory Disorders
김현표,임현,권용수 한국응용약물학회 2017 Biomolecules & Therapeutics(구 응용약물학회지) Vol.25 No.2
Acute bronchitis and chronic obstructive pulmonary diseases (COPD) are essentially lung inflammatory disorders. Various plant extracts and their constituents showed therapeutic effects on several animal models of lung inflammation. These include coumarins, flavonoids, phenolics, iridoids, monoterpenes, diterpenes and triterpenoids. Some of them exerted inhibitory action mainly by inhibiting the mitogen-activated protein kinase pathway and nuclear transcription factor-κB activation. Especially, many flavonoid derivatives distinctly showed effectiveness on lung inflammation. In this review, the experimental data for plant extracts and their constituents showing therapeutic effectiveness on animal models of lung inflammation are summarized.